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Efficient Synthesis of the Oxadiazole Biphenyl Tetrazoles

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有机化学 2003年第Z1期23卷 420-421页

作者： CHAO Shu-Jun QIU Zao-Zao HUI Xin-Ping XU Peng-Fei zheng rong-liang State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 Life School Lanzhou University Lanzhou 730000

Since the discovery of losartan[1](DUP 753), the leading non-peptide AT1 antagonist, several highly potent AT1 selective antagonists bearing heterocycles have been reported. [2] The tetrazole group is a common acidic ...

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X-ray excited Mn^(2+)-doped persistent luminescence materials with biological window emission for in vivo bioimaging

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Journal of Rare Earths 2024年第1期42卷 28-35,I0001页

作者： Hanrun zheng Lin Liu Yi’ang Li Rui rong liang Song Junpeng Shi Jing Teng Xia Sun Yun Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China University of the Chinese Academy of Sciences Beijing100049China Xiamen Hospital of Traditional Chinese Medicine Xiamen361015China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China

In recent years,persistent luminescence materials(PLMs)excited by X-rays and emitting in biological windows have received extensive attention in the field of high-sensitivity *** metal Mn^(2+)is an ideal emission center,but few studies focus on Mn^(2+)-doped PLMs with X-ray excitation and biological window ***,we report a Mn^(2+)-doped PLM,LiYGeO_(4):Mn^(2+)(LYGM),with excellent biological window persistent luminescence *** excitation by UV,LYGM produces a durable biological window of persistent luminescence emission at 660 nm for up to 20 *** *** can be repeatedly excited by X-rays,resulting in long-term biological window persistent luminescence *** addition,we obtain LYGM around 200 nm in diameter by ball milling and centrifugation and improve its biocompatibility by surface modification to apply it to in vivo imaging in *** LYGM are injected into mice through the tail vein,in situ excitation of X-rays can be *** the persistent luminescence decays,LYGM can be re-excited for repeated ***,LYGM shows potential prospects for in vivo deep tissue and long-term bioimaging.

关键词： Persistent luminescence X-ray Biological window In vivo imaging Rare earths

Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function

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National Science Review 2024年第2期11卷 145-154页

作者： Farong Ye Cheng Li Feng-liang Liu Xinliang Liu Peng Xu rong-Hua Luo Wenping Song Yong-Tang zheng Tianlei Ying Biao Yu Ping Wang Center for Chemical Glycobiology Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study School of Chemistry and Chemical Engineering Shanghai Jiao Tong University MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection Shanghai Institute of Infectious Disease and BiosecurityShanghai Engineering Research Center for Synthetic ImmunologySchool of Basic Medical Sciences Shanghai Medical College Fudan University Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Center for Biosafety Mega-Science Kunming Institute of ZoologyChinese Academy of Sciences State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shenzhen Research Institute of Shanghai Jiao Tong University

Vaccines have been the primary remedy in the global fight against coronavirus disease 2019（COVID-19）.The receptor-binding domain（RBD） of the spike protein, a critical viral immunogen, is affected by the heterogeneity of its glycan structures and relatively low immunogenicity. Here, we describe a scalable synthetic platform that enables the precise synthesis of homogeneously glycosylated RBD, facilitating the elucidation of carbohydrate structure–function relationships. Five homogeneously glycosylated RBDs bearing biantennary glycans were prepared, three of which were conjugated to T-helper epitope(Tpep) from tetanus toxoid to improve their weak immune response. Relative to natural HEK293-derived RBD, synthetic RBDs with biantennary N-glycan elicited a higher level of neutralising antibodies against SARS-CoV-2 in mice. Furthermore, RBDs containing Tpepelicited significant immune responses in transgenic mice expressing human angiotensin-converting enzyme 2. Our collective data suggest that trimming the N-glycans and Tpepconjugation of RBD could potentially serve as an effective strategy for developing subunit vaccines providing efficient protection.

关键词： peptide ligation glycosylation glycoprotein

Surfactant-metal-organic framework complexes and their derivatives: advances in electrocatalysis

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Science China Chemistry 2024年第10期67卷 3209-3222页

作者： Yining Liu Mengying Wang Zuozhong liang Haoquan zheng Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal University

Metal-organic frameworks(MOFs) and their derivatives received more and more attention due to the diverse morphologies, rich porous structures, and tunable metal active sites, which have been widely used in energy-related electrocatalytic ***, a class of compounds with hydrophilic and hydrophobic portions in the molecular structure, are able to modulate the properties of liquid and solid surfaces. Surfactants play a crucial role in controlling the shape and size of MOFs, which helps optimize electrocatalytic performance, especially in improving the exposure and accessibility of catalytic active sites. In this review, we first outline the types and applications of surfactants. Second, we describe the interface modulation and reaction mechanism of different surfactants during the forming of MOFs and their derivatives. Finally, we discuss the current applications of surfactant-modified MOFs and their derivatives in electrocatalysis. This review provides a better understanding of surfactantassistant structure regulation and electrocatalytic activity study of MOFs and their derivatives.

关键词： metal-organic frameworks surfactants interface modulation electrocatalysis

Microwave-induced thermoacoustic elastic imaging:A simulation study

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 1-11页

作者： Lin Huang zheng liang Shuaiqi Qiao Weipeng Wang School of Electronic Science and Engineering(National Exemplary School of Microelectronics)University of Electronic Science and Technology of China ChengduP.R.China Zhangjiang Laboratory 100 Haike Road Shanghai 201204P.R.China

Microwave-induced thermoacoustic imaging(MTI)has the advantages of high resolution,high contrast,non-ionization,and ***,MTI was used in the¯eld of breast cancer *** this paper,based on the¯nite element method(FEM)and COMSOL Multiphysics software,a three-dimensional breast cancer model suitable for exploring the MTI process is proposed to investigate the in°uence of Young's modulus(YM)of breast cancer tissue on *** is found that the process of electromagnetic heating and initial pressure generation of the entire breast tissue is earlier in time than the thermal expansion ***,compared with normal breast tissue,tumor tissue has a greater temperature rise,displacement,and pressure *** particular,YM of the tumor is related to the speed of thermal *** particular,the larger the YM of the tumor is,the higher the heating and contraction frequency is,and the greater the maximum pressure ***®erent Young's moduli correspond to di®erent thermoacoustic signal *** MTI,this study can be used to judge di®erent degrees of breast cancer based on elastic *** addition,this study is helpful in exploring the possibility of microwave-induced thermoacoustic elastic imaging(MTAE).

关键词： Thermoacoustic imaging breast cancer multi-physics simulation elastic imaging

π-conjugated chromophore functionalized high-nuclearity titanium-oxo clusters containing structural unit of anatase for photocatalytic selective oxidation of sulfides

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Rare Metals 2024年第4期43卷 1736-1746页

作者： Ling-rong Liao Dong-Chun zheng Pin-Xi Ou Qi-Xin Zhao Wei-Min Xuan Qi zheng State Key Laboratory for Modification of Chemical Fibers and Polymer Materials&College of Materials Science and Engineering Donghua UniversityShanghai201620China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials and College of Chemistry and Chemical Engineering Donghua UniversityShanghai 201620China

N-doping has significant influence in manipulating the properties of TiO_(2),and this has stimulated the development of N-donor-functionalized titanium-oxo clusters(TOCs)as molecular models to study the structure-property ***,the structural type and photoresponsive application are still limited for such TOCs,especially regarding the high-nuclearity TOCs that contain structure unit of TiO_(2)for ***,we showed the synthesis of a series of high-nuclearity TOCs 1-3 compounds usingπ-conjugated 1,10-phenanthroline(phen)as chromophore and N-donor functional *** 1 features cocrystal structure composed of one[Ti_(26)]~(2+)and half[Ti_(22)]~(2+),which renders it as the first cocrystallized TOC containing two positively charged species and phen-functionalized TOC showing the highest nuclearity up to 37 Ti *** adjusting the synthetic conditions,the individual{Ti_(22)}and{Ti_(26)}clusters can also be isolated as Compounds 2 and 3,*** core structure of{Ti_(22)}is mainly constructed from four lacunary{Ti_(4)}derived from pentagonal{Ti(Ti)_5}unit,while{Ti_(26)}is built from four complete{Ti(Ti)_5}***,a{Ti_8O_(14)}structure unit of anatase TiO_(2)can be identified in{Ti_(26)}.Based on the unique structural features and proper photophysical and photochemical properties of Compounds 1-3,they are applied for photocatalytic *** to the presence of anatase structure unit in{Ti_(26)}and the synergistic effect from{Ti_(22)}and{Ti_(26)},the catalytic performance presents in the order of Compound 1>Compound 3>Compound *** work provides excellent models to understand the structureproperty relationship from the perspective of cocrystallization and Ti-O binding model and will further promote the application of TOCs as functional catalysts for organic transformation.

关键词： Titanium-oxo cluster Molecular model of anatase TiO_(2) High nuclearity π-conjugated chromophore Photocatalytic sulfoxidation

Comparison of Arrhythmias among Different Left Ventricular Geometric Patterns in Essential Hypertension

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第2期21卷 93-96页

作者：郑智周荣梁黔生 Department of Emergency Medicine Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan

The differences of arrhythmias among distinct left ventricular geometric patterns in the patients with essential hypertension were studied. 179 patients with essential hypertension received 24 h dynamic ECG recording, ambulatory blood pressure monitoring, echocardiography examination, etc. According to the examinations, left ventricular geometric patterns and arrhythmias were identified. The comparison of morbidity of arrhythmias between the left ventricular remodeling group and the normal geometric pattern group was performed. The multiple stepwise regression analysis was carried out to identify the independent determinants of arrhythmias. After these predictors were controlled or adjusted, the severity of arrhythmias among different left ventricular geometric patterns was compared. It was found that the morbidity of atrial arrhythmia, ventricular arrhythmia and complex ventricular arrhythmias in the left ventricular remodeling group was significantly higher than in the normal geometric pattern group respectively. There were many independent factors influencing on arrhythmias in essential hypertension. Of all these factors, some indices of left ventricular anatomic structure, grade of hypertension, left atrial inner dimension, E/A, diastolic blood pressure load value at night and day average heart rate and so on were very important. After the above mentioned factors were adjusted, the differences of the orders of arrhythmias between partial geometric patterns were reserved, which resulted from the differences of the geometric patterns. Many factors contributed to arrhythmias of essential hypertension, such as grade of hypertension, LVMI, LA, PWT and so on. The severity of arrhythmias was different in different left ventricular geometric patterns.

关键词： essential hypertension left ventricular remodeling arrhythmia echocardiography

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USB接口在汽车行驶记录仪中的应用

江苏大学学报（自然科学版） 2005年第5期26卷 393-396页

作者：郑荣良蒋云江苏大学汽车与交通工程学院江苏镇江212013

在汽车行车记录仪(VTDR)上应用嵌入式USB(通用串行总线)系统,从而弃用独立的PC机,实现USB技术的车载化.详细介绍采用USB芯片SL811HST和核心CPU芯片P89C669的接口电路和相关的通讯软件设计,并按照国标要求进行了抗汽车电点火干扰试验,试... 详细信息

在汽车行车记录仪(VTDR)上应用嵌入式USB(通用串行总线)系统,从而弃用独立的PC机,实现USB技术的车载化.详细介绍采用USB芯片SL811HST和核心CPU芯片P89C669的接口电路和相关的通讯软件设计,并按照国标要求进行了抗汽车电点火干扰试验,试验结果表明该系统具有实用性,能满足国家标准对于VTDR要有USB接口的规定要求.

关键词：汽车记录仪嵌入式系统 USB系统单片机

DLF-YOLOF:an improved YOLOF-based surface defect detection for steel plate

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Journal of Iron and Steel Research International 2024年第2期31卷 442-451页

作者： Guang-hu Liu Mao-xiang Chu rong-fen Gong Ze-hao zheng School of Electronic and Information Engineering University of Science and Technology LiaoningAnshan114051LiaoningChina

Surface defects can affect the quality of steel *** methods based on computer vision are currently applied to surface defect detection of steel ***,their real-time performance and object detection of small defect are still *** improved object detection network based on You Only Look One-level Feature(YOLOF)is proposed to show excellent performance in surface defect detection of steel plate,called ***,the anchor-free detector is used to reduce the network ***,deformable convolution network and local spatial attention module are introduced into the feature extraction network to increase the contextual information in the feature ***,the soft non-maximum suppression is used to improve detection accuracy ***,data augmentation is performed for small defect objects during training to improve detection *** show the average precision and average precision for small objects are 42.7%and 33.5%at a detection speed of 62 frames per second on a single GPU,*** shows that DLF-YOLOF has excellent performance to meet the needs of industrial real-time detection.

关键词： Steel surface defects detection YOLOF Anchor-free detector Small object detection Real-time detection