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Moleucle action mechunisms of NM-3 on human gastric cancer SGC-7901.Cells in vivo or in vitro

World Journal of Gastroenterology 2003年第10期9卷 2366-2369页

作者： Jin-Shui zhu Bo Shen Jin-Lian {1. Guo-Qiang {1. Xiao-Hu Yu Hua-Fang Yu Zu-Ming zhu, Affiliated Sixth People’s Hospital, shanghai Jiaotong university, shanghai 200233, china Guo-Qiang {1., shanghai Experimental Animal Center, Chinese Academy of Sciences, shanghai 200233, china department of Gastroenterology Affiliated Sixth People's Hospital Shanghai Jiaotong University Shanghai 200233 China. zhujs1803@***

AIM: To study the moleucle action mechunisms of NM-3 on the growth of human gastric cancer SGC-7901.cells in vivo or in ***: SGC-7901.from human non-differentiated gastric cancer cell line was cultured with NM-3 at 1.0 mg/ml for 24 h. We observed its inhibitory rate and the density of micro-vascular growth in grafted mice with human gastric cancer SGC-7901. The apoptosis of human gastric cancer SGC-7901.was revealed in NM-3 treatment group by using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-fluorescene nick end labeling (TUNEL)method and flow cytometry ***: The growth of SGC-7901.cells was markedly inhibited compared with control growp, which was smaller than that in normal saline control group (4.1. g±0.22 g VS 9.45 g±1.38 g, P＜0.01.. The level of apoptosis of human gastric cell line SGC-7901.was obviously increased in NM-3treatment group at 1.mg.L-1.for 24 h. NM-3 inducing apoptotic index in NM-3 plus carboplatin group was 3.5 times that of carboplatin control group (TUNEL: 27.98±6.1. % VS 1..94±2.1. %, FACScan: 26.86±5.69 % VS1..86±1.09 %,P＜0.01.. Western blot analysis showed that the apoptotic index of human gastric cancer was elevated for 1., 24 and 36 h with an evident time-effect relationship in groups at 1.0 mg.L-L. NM-3 enhanced the inhibitive effects and sensitivity of chemotherapy for human gastric cancer in nude mice. These results suggested that NM-3 played a key inhibitive role in the growth of grafted human gastric cancer in nude ***: NM-3 can inhibit the growth of human gastric cancer cell line SGC-7901. and enhance the sensitivity of carboplatin on SGC-7901.and induced its apoptosis.

关键词：胃癌分子机制 SGC-7901.胞微血管形成 TUNEL法细胞凋亡 NM-3

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Roadmap for rechargeable batteries:present and beyond

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Science china Chemistry 2024年第1期67卷 13-42页

作者： Sen Xin Xu Zhang Lin Wang Haijun Yu Xin Chang Yu-Ming Zhao Qinghai Meng Pan Xu chen-Zi Zhao Jiahang chen Huichao Lu Xirui Kong Jiulin Wang Kai chen Gang Huang Xinbo Zhang Yu Su Yao Xiao Shu-Lei Chou Shilin Zhang Zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing Zhao Liubing Dong Dong Zhou Feiyu Kang Hu Hong Chunyi Zhi Zhizhang Yuan Xianfeng Li Yifei Mo Yizhou zhu Dongfang Yu Xincheng Lei Jianxiong Zhao Jiayi Wang Dong Su Yu-Guo Guo Qiang Zhang Jun chen Li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China university of Chinese Academy of Sciences.Beijing 1.0049 China Institute of Advanced Battery Materials and Devices Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationBeijing University of TechnologyBeijing 100124China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Chemistry and Utilization of Carbon-Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China department of Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChangchun 130022China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaide 5000Australia Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China College of Chemistry and Materials Science Jinan UniversityGuangzhou 511443China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Division of Energy Storage Dalian National Laboratory for Clean Energy(DNL)Dalian Institute of Chem

Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate *** to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable *** efforts are made to developing the next-generation post-Li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow *** the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a *** roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable *** computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research.

关键词： energy storage rechargeable batteries battery materials electrochemistry

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A human-specific insertion promotes cell proliferation and migration by enhancing TBC1.8B expression

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Science china(Life Sciences) 2024年第4期67卷 765-777页

作者： Hui Zhao Lin-Lin Liu Jian Sun Lian Jin Hai-Bing Xie Jian-Bo Li Hui Xu Dong-Dong Wu Xiao-Lin zhuang Min-Sheng Peng Ya-Jun Guo Wei-zhu Qian Newton OOtecko Wei-Jie Sun Liang-Hu Qu Jie He Zhao-Li chen Rong Liu Ce-Shi chen Ya-Ping Zhang State Key Laboratory for Conservation and Utilization of Bio-resource School of Life SciencesSchool of Ecology and Environmental ScienceYunnan UniversityKunming 650091China School of Forensic Medicine Kunming Medical UniversityKunming 650500China Academy of Biomedical Engineering Kunming Medical UniversityKunming 650500China The Third Affiliated Hospital Kunming Medical UniversityKunming 650118China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China The Key Laboratory of Gene Engineering of the Ministry of Education State Key Laboratory for BiocontrolSun Yat-sen UniversityGuangzhou 510275China National Engineering Research Center for Antibody Medicine and shanghai Key Laboratory of Cell Engineering and Antibody Shanghai 201203China department of Thoracic Surgery Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Human-specific insertions play important roles in human phenotypes and *** we reported a 446-bp insertion(Insert-446)in intron 1. of the TBC1.8B gene,located on chromosome X,and traced its origin to a portion of intron 6 of the EBF1.gene on chromosome ***,Insert-446 was present in the human Neanderthal and Denisovans genomes,and was fixed in humans after human-chimpanzee *** have demonstrated that Insert-446 acts as an enhancer through binding transcript factors that promotes a higher expression of human TBC1.8B gene as compared with orthologs in *** addition,over-expression TBC1.8B promoted cell proliferation and migration through“a dual finger”catalytic mechanism(Arg538 and Gln573)in the TBC domain in vitro and knockdown of TBC1.8B attenuated tumorigenesis in *** of Insert-446 prevented cell proliferation and migration in cancer and normal *** results reveal that the human-specific Insert-446 promotes cell proliferation and migration by upregulating the expression of TBC1.8B *** findings provide a significant insight into the effects of human-specific insertions on evolution.

关键词： human-specific insertion enhancer gene expression cell proliferation and migration

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MR dynamic Gadolinium-enhanced fast multiplanar spoiled gradient-echo and spin-echo T1.weighted fat-suppressed techniques in diagnosis of pancreatic carcinoma

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Hepatobiliary & Pancreatic Diseases International 2002年第2期1卷 294-298页

作者： Meng-Su Zeng Fu-Hua Yan Kang-Rong Zhou zhu-Wan {1. Ji-Zhang Sun Cai-Zhong {1. Wei-Bing Shi From the Dapartment of Radiology, Zhongshan Hospital, Fudan university, shanghai 200032, china department of Radiology Zhongshan Hospital Fudan University Shanghai 200032 China. zmswq@***

Objective: To evaluate the value of MR dynamic Gadolinium-enhanced fast multiplanar spoiled gradi- ent-echo (FMPSPGR) and spin-echo (SE) T1. weighted fat-suppressed techniques in the diagnosis of pancreatic carcinoma. Methods: Eighteen cases of pancreatic carcinoma veri- fied by surgical and pathologic results were examined by MR, and the MR sequences included SE T1.I, FSE T2WI, SE T1.weighted fat-suppressed and dy- namic Gadolinium-enhanced FMPSPGR. Results: Of 1. pancreatic carcinomas, 1., 6, and 2 tumors showed respectively hypo-intensity, iso-inten- sity and hyper-intensity on SE T1.I, meanwhile, 8, 6, and 4 tumors displayed hyper-intensity, iso-inten- sity and hypo-intensity on FSE T2WI in comparison with the normal pancreatic tissue. All of the tumors showed hypo-intensity on SE T1.weighted fat-sup- pressed and also obvious non-enhancement or slight enhancement on MR dynamic Gadolinium-enhanced FMPSPGR images during the arterial dominant phase scanning. Conclusion: SE T1.weighted fat-suppressed and MR dynamic Gadolinium-enhanced FMPSPGR sequences could evidently improve the sensitivity and specificity in the diagnosis of pancreatic carcinoma.

关键词： magnetic resonance image pancreatic carcinoma

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In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou chen Mo chen chengxuan Yu Huizhu Li Liman Sai Nguyen T.K.Thanh Yueming Wang Yan Wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei V.Zvyagin Hao De Min Tang Shiyi chen Yunxia Li Yuefeng Hao Sijia Feng Jun chen Sports Medicine Institute of Fudan university Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China department of {1. Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)*** Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

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电场极化条件对石英玻璃的电致二阶非线性光学效应的影响

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中国激光 1998年第1期25卷 56-60页

作者：陈红兵徐建华刘丽英余保龙朱从善陆兴泽干福熹中国科学院上海光机所复旦大学物理系

报道了电场极化条件对石英玻璃的电致二阶非线性光学效应的影响的研究结果。通过实验发现，石英玻璃经较高温度下的电场极化作用所产生的二次谐波发生与极化温度、极化电压具有相关性，并表现出一定的规律性：在一定的极化电压下，二次... 详细信息

报道了电场极化条件对石英玻璃的电致二阶非线性光学效应的影响的研究结果。通过实验发现，石英玻璃经较高温度下的电场极化作用所产生的二次谐波发生与极化温度、极化电压具有相关性，并表现出一定的规律性：在一定的极化电压下，二次谐波强度在某一适中的温度下达到极值；在一定的极化温度下，二次谐波强度随极化电压的增大而逐渐增强，并渐趋饱和。根据玻璃的电致二阶非线性极化的“偶极子取向”模型，解释了实验结果。

关键词：石英玻璃电场极化二次谐波发生偶极子取向

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HiFAST:An HIdata calibration and imaging pipeline for FAST

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Science china({1.,Mechanics & Astronomy) 2024年第5期67卷 182-199页

作者： Yingjie Jing Jie Wang chen Xu Ziming Liu Qingze chen Tiantian Liang Jinlong Xu Yixian Cao Jing Wang Huijie Hu Chuan-Peng Zhang Qi Guo Liang Gao Mei Ai Hengqian Gan Xuyang Gao Jinlin Han Ligang Hou Zhipeng Hou Peng Jiang Xu Kong Fujia Li Zerui Liu Li Shao Hengxing Pan Jun Pan Lei Qian Jinghai Sun Ningyu Tang Qingliang Yang Bo Zhang Zhiyu Zhang Ming zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 02206China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 55000China Max Planck Institute for Extraterrestrial physics Garching 85748Germany Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Institute of Computational Cosmology Department of PhysicsUniversity of DurhamDurham DHI 3LEUK CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Deep Space Exploration Laboratory/department of Astronomy University of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Astrophysics Department of PhysicsUniversity of OxfordOxford OX/3RHUK College of Earth Sciences Guilin University of TechnologyGuilin 541004China department of {1. Anhui Normal UniversityWuhu 241002China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityNanjing 20023China

The Five-hundred-meter Aperture Spherical radio Telescope(FAST)has the largest aperture and a 1.-beam L-band receiver,making it powerful for investigating the neutral hydrogen atomic gas(HI)in the *** present HiFAST(https://***),a dedicated,modular,and self-contained calibration and imaging pipeline for processing the H?data of *** pipeline consists of frequency-dependent noise diode calibration,baseline fitting,standing wave removal using an FFT-based method,flux density calibration,stray radiation correction,and gridding to produce data *** modules can be combined as needed to process the data from most FAST observation modes:tracking,drift scanning,On-The-Fly mapping,and most of their *** HiFAST,the root-mean-square(RMS)noises of the calibrated spectra from all 1. beams were only slightly(~5%)higher than the theoretical *** results for the extended source M33 and the point sources are consistent with the results from *** moment maps(0,1.and 2)of M33 agree well with the results from the Arecibo Galaxy Environment Survey(AGES)with a fractional difference of less than 1.%.For a common sample of 221.sources with signal-to-noise ratio S/N>1. from the Arecibo Legacy Fast ALFA(ALFALFA)survey,the mean value of fractional difference in the integrated flux density,Sint,between the two datasets is approximately 0.005%,with a dispersion of 1..4%.Further checks on the integrated flux density of 23 sources with seven observations indicate that the variance in the flux density of the source with luminous objects(Sint>2.5 Jy km s-1.is less than 5%.Our tests suggest that the FAST telescope,with the efficient,precise,and user-friendly pipeline HiFAST,will yield numerous significant scientific findings in the investigation of the H?in the universe.

关键词： fractional luminous correction

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张家界砂岩峰林景观成因机制

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山地学报 2005年第3期23卷 308-312页

作者：唐云松陈文光朱诚南京大学城市与资源学系湖南省地质环境监测总站南京大学城市与资源学系江苏南京21.093湖南省衡阳师范学院资旅系湖南衡阳421.08 湖南长沙41.007

通过实地考察,室内遥感影像分析,得出如下结论:张家界石英砂岩峰林地貌岩层产状平缓,地壳水平上升,流水沿构造破裂面的节理侵蚀及重力崩塌作用造就了石英砂岩峰林地貌的基本形态。地貌形态的物质基础是特定的岩性。石英砂岩峰林地貌主... 详细信息

通过实地考察,室内遥感影像分析,得出如下结论:张家界石英砂岩峰林地貌岩层产状平缓,地壳水平上升,流水沿构造破裂面的节理侵蚀及重力崩塌作用造就了石英砂岩峰林地貌的基本形态。地貌形态的物质基础是特定的岩性。石英砂岩峰林地貌主要由方山、台地、峰墙、峰丛、峰林、石门、天生桥及峡谷、嶂谷等构成。其岩石胶结良好,刚性强,节理发育。物理风化很强烈,风化物和土壤十分疏松,内聚力小,抗蚀能力弱。存在着水土流失的潜在地质条件。另外,石英砂岩峰林地貌本身的地貌特点,水文气象要素都促使其山体风化、崩塌,景观消亡。为了保证景区的可持续发展,环境保护意义重大。

关键词：石英砂岩峰林地貌岩性地质构造环境保护

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“野外生存生活训练”作为高校体育课程内容的意义

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体育学刊 2002年第6期9卷 86-87页

作者：张惠红陈作松严阎健朱伟强南京体育学院体育系江苏南京210014 华东师范大学体育与健康学院上海200062

野外生存生活训练作为高校体育课程内容 ,不仅体现了现代教育理念 ,符合我国高校体育课程改革的发展趋势 ,而且是实现我国高校体育课程目标的基本手段。开发野外生存生活课程内容是深化我国高校体育课程改革的需要。

关键词：野外生存生活高校体育体育课程

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A study of effects of using low dialysate calcium concentration (1.50 mmol/L) on blood pressure,serum concentrations of calcium,parathyroid hormone and aldosterone in chronic hemodialysis patients

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外科研究与新技术 2011年第3期 229-234页

作者：范凯文许晨朱敏 Dialysis Center Nephrology Department of Tongji Hospital Affiliated to Tongji University

Background: Dialysis centres around the world use different concentrations of calcium in dialysate solution,ranging from 1. 25 to 1. 75 mmol / L. However,a dialysate concentration of 1. 25 mmol / L is recommended. [1. Higher or lower dialysate calcium concentrations are indicated in patients,depending on their co-morbid factors. We explored the effects of using a calcium dialysate solution of 1. 50 mmol / L compared to a 1. 75 mmol / L calcium dialysate solution on the Blood Pressure (BP) ,serum concentrations of Calcium,Parathyroid Hormone (PTH) and Aldosterone in chronic hemodialysis (HD) patients. Method: 42 patients were enrolled in the study. First a 1. 50 mmol / L low calcium dialysate solution (LCDS) was used for 4 hour dialysis,and for the next session of HD,a 1. 75 mmol / L (NCDS) normal calcium dialysate solution was used. Blood pressure was measured at 5 intervals of time: pre HD,at 60,1.0,1.0 and 240 minutes into the HD session. Pre and post HD blood samples were taken for serum calcium,PTH and Aldosterone levels. Results: All 42 patients completed the study. With LCDS,the post HD serum calcium levels were (2. 51.± 0. 1.) mmol / L,compared to (2. 85 ± 0. 1.) mmol / L for NCDS (P 1. . A post HD serum PTH level of (80. 6 ± 1.4. 93) pg / ml was observed when using LCDS,whereas a (52. 25 ± 1.5. 89) pg / ml serum PTH level was noted with NCDS (P 1. . As for aldosterone,a post HD value of (1.1. 77 ± 80. 42) ng / L was obtained with LCDS and (1.5. 50 ± 78. 84) ng / L with NCDS (P 1. . The mean post HD systolic blood pressure was (1.9. 1. ± 25. 42) mmHg with LCDS dialysis compared to (1.2. 50 ± 20. 32) mmHg for NCDS dialysis (P 1. and the diastolic BP values observed were (75. 1. ±1.. 34) mmHg and (78. 26 ±1.. 63) mm Hg(P 1. ,respectively. Conclusion: LCDS can more effectively improve hypercalcemic status in dialysis patients than NCDS. Using LCDS stimulates the secretion of PTH more than when using NCDS. LCDS decreases aldosterone l

关键词： dialysate concentration hemodialysis parathyroid hormone calcium aldosterone

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