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De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients

World Journal of Gastroenterology 2011年第43期17卷 4804-4809页

作者： Xiao-Hong Fan Jian-Zhang Geng Li-Fen Wang ying-ying zheng Hai-ying lu Jing Li Xiao-Yuan Xu Department of Infectious Diseases Peking University First Hospital Beijing 100034 China

AIM:To investigate the appropriate time for combination therapy in HBeAg positive chronic hepatitis B(CHB) patients with decompensated ***:Thirty HBeAg positive CHB patients with decompensated cirrhosis were enrolled in the *** of the patients were given 48 wk combination therapy with lamivudine(LAM) and adefovir dipivoxil(ADV) .Briefly,10 patients were given the de novo combination therapy with LAM and ADV,whereas the other 20 patients received ADV in addition to LAM after hepatitis B virus(HBV) genetic ***:Serum alanine aminotransferase and total bilirubin were both improved in the two groups at 4,12,24 and 48 wk after *** albumin was also improved at 24 and 48 wk after combination therapy in both *** serum HBV DNA level wasstill detectable in every patient in the two groups at 4 and 12 wk after combination ***,in the de novo combination group,serum HBV DNA levels in 4(40%) and 9(90%) patients was decreased to below 1×10 3 copies/mL at 24 and 48 wk after the combination treatment,*** parallel,serum HBV DNA levels in 2(20%) and 8(40%) patients in the add-on combination group became undetectable at 24 and 48 wk after combination treatment,***,6(60%) patients in the de novo combination group achieved HBeAg seroconversion after 48 wk treatment,whereas only 4(20%) patients in the add-on combination group achieved ***-Pugh score of patients in the de novo combination group was better than that of patients in the add-on combination group after 48 wk ***,patients in the de novo combination group had a significantly decreased serum creatinine level and elevated red blood cell ***:De novo combination therapy with LAM and ADV was better than add-on combination therapy in terms of Child-Pugh score,virus inhibition and renal function.

关键词： Hepatitis B Chronic Cirrhosis Decompensated De novo combination Lamivudine Adefovir dipivoxil

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Selection of reference genes for RT-qPCR analysis of Phenacoccus solenopsis(Hemiptera: Pseudococcidae) sex-dimorphic development

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Journal of Integrative Agriculture 2019年第4期18卷 854-864页

作者： zheng lu-ying ZHANG Zhi-jun ZHANG Jin-ming LI Xiao-wei HUANG Jun LIN Wen-cai LI Wei-di LI Chuan-ren lu Yao-bin College of Agriculture Yangtze University Institute of Plant Protection and Microbiology Zhejiang Academy of Agricultural Sciences

Mealybugs, such as Phenacoccus solenopsis, are highly sexually dimorphic. Winged adult males present such remarkable morphological differences from females that, to the untrained eye, conspecific adults of both sexes of P. solenopsis may be considered as two different insect species. A method to investigate sex-dimorphic mechanisms is by evaluating gene expression using RT-qPCR. However, the accuracy and consistency of this technique depend on the reference gene(s) selected. In this study, we analyzed the expression of 10 candidate reference genes in male and female P. solenopsis at different development stages, using common algorithms including the ?Ct method, NormFinder, geNorm, BestKeeper, and a web-based analysis tool, RefFinder. The results showed that EF1-β, RP-L32 and RP-18 S were selected as the most stable genes by both the ?Ct method and NormFinder; TUB-α was the most stable gene identified by BestKeeper; and RP-L40 and RP-L32 were the most stable genes ranked by geNorm. RefFinder, a comprehensive analysis software, ranked the ten genes and determined EF1-β and RP-L32 as the most suitable reference genes for the various developmental stages in male and female P. solenopsis. Furthermore, the two most suitable reference genes were validated by examining expression of the juvenile hormone acid O-methytransferase(JHAMT) gene. Results of the validation portion of the study showed that JHAMT expression was sex-biased towards males and exhibited a dynamic and classic expression pattern among the P. solenopsis developmental stages. The results can help further our knowledge on the molecular mechanisms underlying sexual dimorphic development in P. solenopsis.

关键词： Phenacoccus solenopsis RT-qPCR sexual dimorphic development reference gene gene stability

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消费者需求拓扑结构演化研究——以葡萄酒业为例

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北京工商大学学报（社会科学版） 2007年第3期22卷 35-40页

作者：卢政营天津财经大学商学院天津300222

消费者需求是动态变化和演进的,但每一段时期又具有相对稳定的需求结构。因此,从需求拓扑结构的视角,深入分析消费者需求拓扑结构演进的动力,需求拓扑结构在不同需求层次上变化的特点,可以深刻洞察我国葡萄酒消费者的需求波动规律,对于... 详细信息

消费者需求是动态变化和演进的,但每一段时期又具有相对稳定的需求结构。因此,从需求拓扑结构的视角,深入分析消费者需求拓扑结构演进的动力,需求拓扑结构在不同需求层次上变化的特点,可以深刻洞察我国葡萄酒消费者的需求波动规律,对于实现葡萄酒的需求定位和市场拓展具有重要意义。

关键词：消费者需求需求拓扑结构需求网需求流需求集成

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国外网络虚拟旅游研究述评:回顾与展望

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旅游学刊 2009年第12期24卷 83-89页

作者：卢政营天津财经大学旅游系天津300222

随着互联网络和信息技术的发展,旅游业作为信息密集型的行业正发生剧烈的变化,以Travelocity、Expedia等为代表的虚拟旅游公司及产业得到快速发展。本文通过对近期400余篇虚拟旅游研究的文献进行分类研究,重点对虚拟旅游的发展层次、关... 详细信息

随着互联网络和信息技术的发展,旅游业作为信息密集型的行业正发生剧烈的变化,以Travelocity、Expedia等为代表的虚拟旅游公司及产业得到快速发展。本文通过对近期400余篇虚拟旅游研究的文献进行分类研究,重点对虚拟旅游的发展层次、关键影响变量以及代表性的虚拟旅游评价模型进行分析,并对虚拟旅游领域进一步研究的重点进行探讨,以便为旅游企业竞争力的提升和旅游者虚拟旅游行为模式创新提供理论指导和经验借鉴。

关键词：虚拟旅游层次界定评价模型文献回顾

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跨境电子商务知识产权治理:困境、成因及解决路径

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中国流通经济 2017年第10期31卷 110-118页

作者：郑鲁英集美大学工商管理学院福建厦门361021

随着网络技术的迅猛发展,跨境电子商务业务呈"井喷"之势,其所涉及的知识产权问题错综复杂,在治理上也相应地出现许多困扰,这既有电子商务跨境需求与知识产权地域性保护之间冲突的根源性原因,又有技术创新加速与制度滞后、国际协调不足... 详细信息

随着网络技术的迅猛发展,跨境电子商务业务呈"井喷"之势,其所涉及的知识产权问题错综复杂,在治理上也相应地出现许多困扰,这既有电子商务跨境需求与知识产权地域性保护之间冲突的根源性原因,又有技术创新加速与制度滞后、国际协调不足之间冲突的现实性原因,也有效率与公平冲突的理念性原因。为有效突破这种困境,构建跨境电子商务合理的知识产权治理关系,需要"多利益相关者对话",通过政府、跨境电商平台、知识产权权利人、各类民间集体力量四个主要层面从境内、境外领域共同参与治理,并加强各治理主体之间的多元相互合作,尤其是跨境电子商务知识产权关系中相对弱势方应积极借助行业协会、商会、著作权集体管理组织等各类民间集体力量提升自身实力。

关键词：跨境电子商务知识产权权利人

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Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng zheng Wang Zhou ying Mo Biao zheng Miaomiao Han Qin Zhong Wenwen Yang Peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

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NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou ying Xiaoli Si Naijia Xue Yi Liu Ran zheng ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie lu ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

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榄香烯对真核细胞翻译起始因子家族表达和血管生成的抑制作用

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中华耳鼻咽喉头颈外科杂志 2005年第11期40卷 840-845页

作者：陶磊周梁郑璐滢姚明复旦大学附属眼耳鼻喉科医院耳鼻咽喉科上海200031 上海市第二医科大学附属仁济医院病理科上海市肿瘤研究所实验病理研究室

目的探讨榄香烯对人喉鳞癌细胞株Hep2细胞荷瘤裸鼠移植瘤生长的抑制作用,以及荷瘤中真核细胞翻译起始因子(eukaryotic initiation factor,eIF)家族成员(eIF4E、eIF4G)与肿瘤新生血管有关的碱性纤维母细胞生长因子(basic fibroblast grow... 详细信息

目的探讨榄香烯对人喉鳞癌细胞株Hep2细胞荷瘤裸鼠移植瘤生长的抑制作用,以及荷瘤中真核细胞翻译起始因子(eukaryotic initiation factor,eIF)家族成员(eIF4E、eIF4G)与肿瘤新生血管有关的碱性纤维母细胞生长因子(basic fibroblast growthfactor,bFGF)、血管内皮生长因子(vascular endothelial growth factor,VEGF)的表达情况。方法利用人喉鳞癌细胞株Hep2细胞制造裸鼠喉癌模型(共7组42只)腹腔注射用药并观察肿瘤体积,生长曲线以及抑瘤率;使用免疫组织化学法检测榄香烯治疗后荷瘤中eIF4E、eIF4G、bFGF、VEGF的表达和微血管密度的变化。结果榄香烯可引起荷瘤体积和重量的减少,剂量越高作用越明显;榄香烯低、中、高剂量组抑瘤率分别为5.2%、41.7%和50.5%;榄香烯乳作用组eIF4E、eIF4G、bFGF、VEGF的表达较空白对照组低(P<0.05);榄香烯乳作用组的微血管密度低于其他各组(P<0.05)。榄香烯100mg/kg抑瘤效率与顺铂3mg/kg相似,榄香烯100mg/kg和顺铂3mg/kg联合用药抑瘤率为51.2%。结论榄香烯可抑制人喉鳞癌细胞荷瘤的生长,其作用机制不仅与直接抑制蛋白合成有关,而且还与eIF家族成员引起相关蛋白bFGF和VEGF表达下降,抑制肿瘤血管生成有关。榄香烯和顺铂联合用药具有药物协同作用。

关键词：喉肿瘤癌,鳞状细胞肽起始因子内皮生长因子小鼠,裸

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乡村节事旅游活动品牌形象的实证研究——以罗平油菜花节为例

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旅游学刊 2009年第5期24卷 61-66页

作者：卢政营张威唐静天津财经大学旅游系天津300222

乡村节事旅游成为地区经济发展的动力之一,但也面临着旅游目的地形象同质化的影响,亟需从产品竞争意识向品牌形象竞争意识转变。本文以罗平油菜花节为例,分析了该节事旅游活动在满足旅游者文化体验过程中的品牌形象问题,并利用SPSS15.0... 详细信息

乡村节事旅游成为地区经济发展的动力之一,但也面临着旅游目的地形象同质化的影响,亟需从产品竞争意识向品牌形象竞争意识转变。本文以罗平油菜花节为例,分析了该节事旅游活动在满足旅游者文化体验过程中的品牌形象问题,并利用SPSS15.0统计软件进行因子分析,得出了消费者关注的尊重度、熟悉度、关注度、归属度、信任度、忠诚度和发展度7个品牌形象因子,提出了改善罗平油菜花节品牌形象的对策建议。

关键词：节事旅游品牌形象因子分析

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