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电子商务对城乡居民消费差距的影响研究——基于地理区域视角的实证测度

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湖北工业大学学报 2024年第4期39卷 112-116页

作者：郑列冯颍颍湖北工业大学理学院湖北武汉430068

运用计量模型,选取了2012-2021年的面板数据,探讨电子商务在不同自然地理区域对城乡消费差距的作用。结果显示:2012-2021年我国电子商务的发展扩大了城乡居民消费差距,但是长期看来,比如东北、华东和华中地区,电子商务阻碍了城乡消费差... 详细信息

运用计量模型,选取了2012-2021年的面板数据,探讨电子商务在不同自然地理区域对城乡消费差距的作用。结果显示:2012-2021年我国电子商务的发展扩大了城乡居民消费差距,但是长期看来,比如东北、华东和华中地区,电子商务阻碍了城乡消费差距的扩大。因此,政府要坚持发展电子商务,且要因地制宜的发展特色电商,从而发挥好电子商务在城乡居民消费差距的积极作用。

关键词：电子商务城乡消费计量经济模型

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西安高新区多情景碳达峰预测及减排路径分析

环境科学 2024年第6期45卷 3412-3420页

作者：姜旭朋张强赵文婷原晓红樊亭亭郑烈龙刘跃廷西北大学榆林碳中和学院西安710127 西北大学城市与环境学院西安710127

第十三届全国人民代表大会第五次会议提出要致力于推进碳达峰碳中和工作,促进经济社会向全面绿色低碳转型,实现高质量发展.西安高新区作为陕西省重要的科技创新和产业聚集区,经济发展在很大程度上依赖于能源消耗,碳减排的任务就显得尤... 详细信息

第十三届全国人民代表大会第五次会议提出要致力于推进碳达峰碳中和工作,促进经济社会向全面绿色低碳转型,实现高质量发展.西安高新区作为陕西省重要的科技创新和产业聚集区,经济发展在很大程度上依赖于能源消耗,碳减排的任务就显得尤为艰巨.以西安高新区为研究对象,首先通过系统核算园区内碳排放,对不同能源种类和不同行业企业碳排放现状进行分析;然后利用Kaya模型设定多种独立的碳达峰情景,预测不同情景下的碳排放总量值及碳达峰时间;最后结合西安高新区发展特点科学甄选相应的碳减排路径,给出合理的减排建议.结果表明,目前电力消耗碳排放占比最多且份额呈逐年上升趋势,工业碳排量始终占主导地位且第三产业发展日益蓬勃;碳排放因子情景、能源强度情景和经济水平情景这3种情景下可于2030年达到碳达峰,其中经济发展水平对西安高新区未来碳达峰的峰值和时间影响最大,产业结构情景、能源结构情景和人口规模情景在2030年前没有出现峰值;未来减排路径主要从电力部门脱碳、经济稳健高质量发展、能源及产业结构绿色升级和构建绿色交通体系入手,可为实现碳中和预留更多的准备时间,也为我国工业园区低碳发展提供决策参考.

关键词：碳达峰多情景预测减排路径工业园区 Kaya模型

Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis

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World Journal of Gastroenterology 2023年第16期29卷 2380-2396页

作者： lie zheng Sheng-Lei Duan Department of Gastroenterology Shaanxi Hospital of Traditional Chinese MedicineXi’an 730000Shaanxi ProvinceChina

Ulcerative colitis(UC)is a chronic nonspecific inflammatory disease with complex *** main pathological changes were intestinal mucosal *** repeat-containing G protein coupled receptor 5(LGR5)-labeled small intestine stem cells(ISCs)were located at the bottom of the small intestine recess and inlaid among Paneth ***5+small ISCs are active proliferative adult stem cells,and their self-renewal,proliferation and differentiation disorders are closely related to the occurrence of intestinal inflammatory *** Notch signaling pathway and Wnt/β-catenin signaling pathway are important regulators of LGR5-positive ISCs and together maintain the function of LGR5-positive *** importantly,the surviving stem cells after intestinal mucosal injury accelerate division,restore the number of stem cells,multiply and differentiate into mature intestinal epithelial cells,and repair the damaged intestinal ***,in-depth study of multiple pathways and transplantation of LGR5-positive ISCs may become a new target for the treatment of UC.

关键词： Molecular regulation Mucosal injury Regeneration Ulcerative colitis

Research progress on the relationship between Paneth cellssusceptibility genes,intestinal microecology and inflammatory bowel disease

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World Journal of Clinical Cases 2023年第34期11卷 8111-8125页

作者： Qi-Ming Zhou lie zheng Department of Nephrology Lanxi Hospital of Traditional Chinese MedicineLanxi 321100Zhejiang ProvinceChina Department of Gastroenterology Shaanxi Hospital of Traditional Chinese MedicineXi’an 710003Shaanxi ProvinceChina

Inflammatory bowel disease(IBD)is a disorder of the immune system and intestinal microecosystem caused by environmental factors in genetically susceptible *** cells(PCs)play a central role in IBD pathogenesis,especially in Crohn's disease development,and their morphology,number and function are regulated by susceptibility *** the intestine,PCs participate in the formation of the stem cell microenvironment by secreting antibacterial particles and play a role in helping maintain the intestinal microecology and intestinal mucosal ***,PC proliferation and maturation depend on symbiotic flora in the *** paper describes the interactions among susceptibility genes,PCs and intestinal microecology and their effects on IBD occurrence and development.

关键词： Susceptibility gene Paneth cells Intestinal microecology Inflammatory bowel disease

Role of metabolites derived from gut microbiota in inflammatory bowel disease

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World Journal of Clinical Cases 2022年第9期10卷 2660-2677页

作者： lie zheng Xin-Li Wen Sheng-Lei Duan Department of Gastroenterology Shaanxi Hospital of Traditional Chinese MedicineXi’an 710003Shaanxi ProvinceChina

Over the past two decades,it is improved gut microbiota plays an important role in the health and disease ***,small molecules produced as intermediate or end products of microbial metabolism,is considered as one of the major interaction way for gut microbiota with the *** metabolisms of dietary substrates,modification of host molecules or bacteria are the major source of *** from microbial metabolites affect immune maturation and homeostasis,host energy metabolism as well as mucosal integrity *** on many researches,the composition and function of the microbiota can be changed,which is also seen in the metabolite profiles of patients with inflammatory bowel disease(IBD).Additionally,some specific classes of metabolites also can trigger *** this paper,definition of the key classes of microbialderived metabolites which are changed in IBD,description of the pathophysiological basis of association and identification of the precision therapeutic modulation in the future are the major contents.

关键词： Inflammatory bowel disease Microbial metabolites Short chain fatty acids Bile acids Tryptophan

Fecal microbiota transplantation in the metabolic diseases:Current status and perspectives

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World Journal of Gastroenterology 2022年第23期28卷 2546-2560页

作者： lie zheng Yong-Yi Ji Xin-Li Wen Sheng-Lei Duan Department of Gastroenterology Shaanxi Hospital of Traditional Chinese MedicineXi’an 710003Shaanxi ProvinceChina Department of Neurology Xi’an Hospital of Traditional Chinese MedicineXi’an 710021Shaanxi ProvinceChina

With the development of microbiology and metabolomics,the relationship between the intestinal microbiome and intestinal diseases has been *** microbiota transplantation(FMT),as a new treatment method,can affect the course of many chronic diseases such as metabolic syndrome,malignant tumor,autoimmune disease and nervous system *** the mechanism of action of FMT is now well understood,there is some controversy in metabolic diseases,so its clinical application may be *** transplantation is recommended by clinical medical guidelines and consensus for the treatment of recurrent or refractory Clostridium difficile infection,and has been gradually promoted for the treatment of other intestinal and extraintestinal ***,the initial results are varied,suggesting that the heterogeneity of the donor stools may affect the efficacy of *** success of FMT depends on the microbial diversity and composition of donor ***,clinical trials may fail due to the selection of ineffective donors,and not to faulty indication selection for FMT.A new understanding is that FMT not only improves insulin sensitivity,but may also alter the natural course of type 1 diabetes by modulating *** this review,we focus on the main mechanisms and deficiencies of FMT,and explore the optimal design of FMT research,especially in the field of cardiometabolic diseases.

关键词： Fecal microbiota transplantation Metabolic diseases Inflammatory bowel disease Type 1 diabetes Metabolic syndrome

Role of adherent invasive Escherichia coli in pathogenesis of inflammatory bowel disease

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World Journal of Clinical Cases 2022年第32期10卷 11671-11689页

作者： lie zheng Sheng-Lei Duan Yan-Cheng Dai Shi-Cheng Wu Department of Gastroenterology Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 322000Shaanxi ProvinceChina Department of Gastroenterology Shanghai Traditional Chinese Medicine Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Department of Proctology Gansu Academy of Traditional Chinese MedicineGansu Hospital of Traditional Chinese MedicineLanzhou 730050Gansu ProvinceChina

Gut microbiota imbalances play an important role in inflammatory bowel disease(IBD),but no single pathogenic microorganism critical to IBD that is specific to the IBD terminal ileum mucosa or can invade intestinal epithelial cells has been *** Escherichia coli(***)adhesion to macrophages is considered to be closely related to the pathogenesis of inflammatory bowel *** study of the specific biological characteristics of adherent invasive ***(AIEC)may contribute to a further understanding of IBD *** review explores the relationship between AIEC and the intestinal immune system,discusses the prevalence and relevance of AIEC in Crohn's disease and ulcerative colitis patients,and describes the relationship between AIEC and the disease site,activity,and postoperative ***,we highlight potential therapeutic strategies to attenuate AIEC colonization in the intestinal mucosa,including the use of phage therapy,antibiotics,and anti-adhesion *** strategies may open up new avenues for the prevention and treatment of IBD in the future.

关键词： Adherent invasive Escherichia coli Inflammatory bowel disease Crohn's disease Ulcerative colitis Prevention

Network pharmacology and molecular docking reveal zedoary turmeric-trisomes in Inflammatory bowel disease with intestinal fibrosis

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World Journal of Clinical Cases 2022年第22期10卷 7674-7685页

作者： lie zheng Yong-Yi Ji Yan-Cheng Dai Xin-Li Wen Shi-Cheng Wu Department of Gastroenterology Shaanxi Hospital of Traditional Chinese MedicineShaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 730000Shaanxi ProvinceChina Department of Neurology Xi’an Hospital of Traditional Chinese MedicineXi’an 710021Shaanxi ProvinceChina Department of Gastroenterology Shanghai Traditional Chinese Medicine Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Department of Gastroenterology Shaanxi Hospital of Traditional Chinese MedicineXi’an 710003Shaanxi ProvinceChina Department of Proctology Gansu Academy of Traditional Chinese MedicineGanSu Hospital of Traditional Chinese MedicineLanzhou 730050Gansu ProvinceChina

BACKGROUND Inflammatory bowel disease(IBD) is a complex chronic IBD that is closely associated with risk factors such as environment, diet, medications and lifestyle that may influence the host microbiome or immune response to antigens. At present, with the increasing incidence of IBD worldwide, it is of great significance to further study the pathogenesis of IBD and seek new therapeutic targets. Traditional Chinese medicine(TCM) treatment of diseases is characterized by multiple approaches and multiple targets and has a long history of clinical application in China. The mechanism underlying the effect of zedoary turmerictrisomes on inducing mucosal healing in IBD is not *** To explore the effective components and potential mechanism of zedoary turmeric-trisomes in the treatment of IBD with intestinal fibrosis using network pharmacology and molecular docking *** The chemical constituents and targets of Rhizoma zedoary and Rhizoma sanarum were screened using the TCMSP database. The GeneCards database was searched to identify targets associated with intestinal fibrosis in IBD. The intersection of chemical component targets and disease targets was obtained using the Venny 2.1 online analysis platform, and the common targets were imported into the STRING 11.0 database to construct a protein interaction regulatory network. A “zedoary turmeric-trisomes-chemical composition-target-disease” network diagram was subsequently constructed using Cytoscape 3.7.2 software, and the topological properties of the network were analyzed using the “Network Analysis” plug-in. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analyses of the common targets were performed using the DAVID 6.8 database to elucidate the mechanism of zedoary turmeric-trisomes in the treatment of IBD. Subsequently, molecular docking of the compounds and targets with the highest intermediate values in the “zedoary turmeric-trisomes-chemical composition-target-dis

关键词： Network pharmacology Molecular docking Zedoary turmeric trisomes Inflammatory bowel disease Intestinal fibrosis

A Light-weight Deep Neural Network for Vehicle Detection in Complex Tunnel Environments

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Instrumentation 2023年第1期10卷 32-44页

作者： zheng lie REN Dandan Hubei University of Technology Wuhan 430000

With the rapid development of social economy,transportation has become faster and more *** an important part of goods transportation,the safe maintenance of tunnel highways has become particularly *** maintenance of tunnel roads has become more difficult due to problems such as sealing,narrowness and lack of ***,target detection methods are advantageous in detecting tunnel vehicles in a timely manner through ***,in order to prevent vehicle misdetection and missed detection in this complex environment,we propose aYOLOv5-Vehicle model based on the YOLOv5 *** model is improved in three ***,The backbone network of YOLOv5 is replaced by the lightweight MobileNetV3 network to extract features,which reduces the number of model parameters;Next,all convolutions in the neck module are improved to the depth-wise separable convolutions to further reduce the number of model parameters and computation,and improve the detection speed of the model;Finally,to ensure the accuracy of the model,the CBAM attention mechanism is introduced to improve the detection accuracy and precision of the *** results demonstrate that the YOLOv5-Vehicle model can improve the accuracy.

关键词： CBAM Depth-wise Separable Convolution MobileNetV3 Vehicle Detection YOLOV5