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Erratum to:Emergence of charge density wave and Ising superconductivity in centrosymmetric monolayer 1T-HfTe_(2)

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Nano Research 2023年第8期16卷 11544-11544页

作者： Dawei Wang jizheng Wu Chen Si Department of Medical Engineering Medical Supplies Center of PLA General HospitalBeijing 100853China School of Materials Science and Engineering Beihang UniversityBeijing 100191China

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异构智能网联汽车编队延迟补偿控制研究

汽车工程 2023年第9期45卷 1573-1582页

作者：刘济铮王震坡孙逢春张雷北京理工大学机械与车辆学院北京100081 电动车辆国家工程技术研究中心北京100081

智能网联汽车多车编队行驶可有效缩短跟车间距和提升交通系统通行效率,但多车编队控制须解决异构编队控制器的普适性问题,且能够在执行器响应延迟和通讯延迟情况下保证车辆编队的弦稳定性。本文提出一种面向异构智能网联汽车编队的延迟... 详细信息

智能网联汽车多车编队行驶可有效缩短跟车间距和提升交通系统通行效率,但多车编队控制须解决异构编队控制器的普适性问题,且能够在执行器响应延迟和通讯延迟情况下保证车辆编队的弦稳定性。本文提出一种面向异构智能网联汽车编队的延迟补偿控制方法,在无须获取他车系统动力学参数及控制输入前提下,利用他车加速度信息即可实现车辆编队纵向跟踪控制;此外,提出一种基于Smith预测器的延迟补偿控制架构,分别消除和降低了执行器响应延迟和通讯延迟对车辆编队弦稳定性的影响。典型工况仿真结果表明,相较常见车辆编队控制方法,本文提出的异构车辆编队延迟补偿控制器的跟车误差降低了80.7%,有效减小了最小车头时距和跟车间距。

关键词：智能网联汽车异构车辆编队延迟补偿弦稳定性

Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2822-2830页

作者： Yanbo Wang Xiaoju Zhu Xia-Ming Jiang Jingwei Guo zheng Fu Zhen Zhou Ping Yang Hongyuan Guo Xu Guo Gaoli Liang Ping Zeng Gengfu Xiao jizheng Ma Xin Yin Lei-Ke Zhang Chao Yan Chen-Yu Zhang Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy Chinese Academy of Medical Sciences Research Unit of Extracellular RNAState Key Laboratory of Pharmaceutical BiotechnologyJiangsu Engineering Research Center for MicroRNA Biology and BiotechnologyNJU Advanced Institute of Life Sciences(NAILS)NJU Institute of Al Biomedicine and BiotechnologyChemistry and Biomedicine Innovation Center(ChemBIC)School of Life SciencesNanjing UniversityNanjingChina State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanHubeiChina Department of Clinical Laboratory The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingChina The MOH Key Laboratory of Geriatrics Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijingChina The Research Center of Military Exercise Science The Army Engineering University of PLANanjingJiangsuChina

Elderly people and patients with comorbidities are at higher risk of COVID-19 infection,resulting in severe complications and high ***,the underlying mechanisms are *** this study,we investigate whether miRNAs in serum exosomes can exert antiviral functions and affect the response to COVID-19 in the elderly and people with diabetes.

关键词： patients mortality infection

Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy

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Protein & Cell 2019年第3期10卷 178-195页

作者： Lin Cao jizheng Chen Yaxin Wang Yuting Yang Jie Qing Zihe Rao Xinwen Chen Zhiyong Lou College of Pharmacy&State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China National Laboratory of Macromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China School of Medicine and Collaborative Innovation Center of Biotherapy Tsinghua UniversityBeijing 100084China Beijing No.166 High School Beijing 100006China

Hepatitis C virus(HCV)is a leading cause of liver disease *** several HCV protease/polymerase inhibitors were recently approved by ***,the combination of antivirals targeting multiple processes of HCV lifecycle would optimize anti-HCV therapy and against potential *** entry is an essential target step for antiviral development,but FDA-approved HCV entry inhibitor remains *** we identify serotonin 2A receptor(5-HT2aR)is a HCV entry factor amendable to therapeutic intervention by a chemical biology *** silencing of 5-HT2aR and clinically available 5-HT2aR antagonist suppress cell culture-derived HCV(HCVcc)in different liver cells and primary human hepatocytes at late endocytosis *** mechanism is related to regulate the correct plasma membrane localization of claudin 1(CLDN1).Moreover,phenoxybenzamine(PBZ),an FDAapproved 5-HT2aR antagonist,inhibits all major HCV genotypes in vitro and displays synergy in combination with clinical used anti-HCV *** impact of PBZ on HCV genotype 2a is documented in immune-competent humanized transgenic *** results not only expand the understanding of HCV entry,but also present a promising target for the invention of HCV entry inhibitor.

关键词： HCV serotonin 2A receptor entry antiviral drug

Histone deacetylase 4 inhibits NF-κB activation by facilitating IκBα sumoylation

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Journal of Molecular Cell Biology 2020年第12期12卷 933-945页

作者： Qi Yang Jielin Tang Chonghui Xu He Zhao Yuan Zhou Yanyi Wang Min Yang Xinwen Chen jizheng Chen Department of Gastroenterology Guangzhou Women and Children's Medical CenterGuangzhou 510623China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China

Protein modification by small ubiquitin-like modifier(SUMO)is an important regulatory mechanism for multiple cellular *** the canonical pathway involving the ubiquitylation or phosphorylation of IκBα has been well characterized,little is known about the sumoylation of IkBa in the control of NF-κB ***,we find that histone deacetylase 4(HDAC4)negatively regulates tumor necrosis factor-alpha-or lipopolysaccharide-triggered NF-κB ***4 belongs to the SUMO E3 ligase family and can directly sumoylate IκBα.The cytoplasm location of HDAC4 is essential for IκBα*** Cys292 of HDAC4 is a key site for its SUMO E3 ligase *** sumoylation of IkBc prevents its polyubiquitination and degradation be-cause these two modifications occur both at the *** findings reveal a previously undiscovered role for HDAC4 in the inflammatory response as a SUMO E3 ligase for IκBα*** work provides insight into mechanisms ensuring optimal mediation of the NF-κB pathway.

关键词： histone deacetylase 4 sumoylation IκBα NF-κB SUMO E3 ligase

Arginine methylation of ribose-5-phosphate isomerase A senses glucose to promote human colorectal cancer cell survival

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Science China(Life Sciences) 2020年第9期63卷 1394-1405页

作者： jizheng Guo Qixiang Zhang Ying Su Xiaochen Lu Yiping Wang Miao Yin Weiguo Hu Wenyu Wen Qun-Ying Lei Department of Biochemistry and Molecular Biology School of Basic Medical ScienceShanghai Medical CollegeFudan UniversityShanghai 200032China Fudan University Shanghai Cancer Center Department of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Institutes of Biomedical Sciences Shanghai Medical CollegeFudan UniversityShanghai 200032China State Key Laboratory of Medical Neurobiology Shanghai Medical College Fudan UniversityShanghai 200032China

Cancer cells remodel their metabolic network to adapt to variable nutrient availability. Pentose phosphate pathway(PPP) plays protective and biosynthetic roles by oxidizing glucose to generate reducing power and ribose. How cancer cells modulate PPP activity in response to glucose supply remains unclear. Here we show that ribose-5-phosphate isomerase A(RPIA), an enzyme in PPP, directly interacts with co-activator associated arginine methyltransferase 1(CARM1) and is methylated at arginine 42(R42). R42 methylation up-regulates the catalytic activity of RPIA. Furthermore, glucose deprivation strengthens the binding of CARM1 with RPIA to induce R42 hypermethylation. Insufficient glucose supply links to RPIA hypermethylation at R42, which increases oxidative PPP flux. RPIA methylation supports ROS clearance by enhancing NADPH production and fuels nucleic acid synthesis by increasing ribose supply. Importantly, RPIA methylation at R42 significantly potentiates colorectal cancer cell survival under glucose starvation. Collectively, RPIA methylation connects glucose availability to nucleotide synthesis and redox homeostasis.

关键词： ribose-5-phosphate isomerase A CARM1 arginine methylation pentose phosphate pathway ribulose-5-phosphate reactive oxygen species colorectal cancer

尤瑞克林联合阿替普酶溶栓治疗急性脑梗死患者的效果

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中国民康医学 2023年第20期35卷 23-26页

作者：王文芳胡吉征郑政太康县人民医院神经内科河南周口466000

目的:观察尤瑞克林联合阿替普酶溶栓治疗急性脑梗死(ACI)患者的效果。方法:选取2019年5月至2021年11月该院收治的84例ACI患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各42例。对照组给予阿替普酶溶栓治疗,观察组在对照... 详细信息

目的:观察尤瑞克林联合阿替普酶溶栓治疗急性脑梗死(ACI)患者的效果。方法:选取2019年5月至2021年11月该院收治的84例ACI患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各42例。对照组给予阿替普酶溶栓治疗,观察组在对照组基础上联合尤瑞克林治疗,比较两组临床疗效,治疗前后神经功能缺损[美国国立卫生研究院卒中量表(NIHSS)]评分、日常生活能力[Barthel指数评定量表(BI)]评分,血液流变学指标(血浆黏度、全血低切黏度、全血高切黏度、红细胞聚集指数)水平及不良反应发生率。结果:观察组治疗总有效率为90.48%,高于对照组的71.43%,差异有统计学意义(P0.05)。结论:尤瑞克林联合阿替普酶溶栓治疗ACI患者可提高临床疗效,提高神经功能和日常生活能力,改善血液流变学指标水平,效果优于单纯阿替普酶溶栓治疗。

关键词：尤瑞克林阿替普酶溶栓急性脑梗死神经功能血液流变学

Seasonal dynamic changes in bacterial compositions in the Inner Mongolia desert steppe

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Frontiers in Biology 2009年第2期4卷 187-191页

作者： Ping LU Wanli MA Hao LI Yongsheng WU Guifen LV jizheng HE College of Life Science and Technology Inner Mongolia Normal UniversityHuhhot 010022China Research Center of Ecology and Environment Chinese Academy of SciencesBeijing 100083China Planning and Design Academy of Forestry Products Industry State Forestry AdministrationBeijing 100714China

Polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE)technique was employed to examine the seasonal dynamic changes in bacterial community composition in the Inner Mongolia desert steppe using specific primers F954 and *** and reproducible bands were sequenced,and the phylogenic tree was *** results show that the bacterial community composition changed between different *** specific bands were different between the sampling sites with light and heavy levels of degraded *** main types of bacteria constituting the microbial community in the Inner Mongolia desert steppe belonged to the α,γ and δ-sub phyla of Proteobacteria,Bacteroidetes and *** unculturable bacteria accounted for 69%of the whole bacterial community of the Inner Mongolia desert steppe.

关键词： Polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE) Inner Mongolia desert steppe community composition seasonal dynamic change

Tumor necrosis factor a accelerates Hep-2 cells proliferation by suppressing TRPP2 expression

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Science China(Life Sciences) 2017年第11期60卷 1251-1259页

作者： Jing Wu jizheng Guo Yunyun Yang Feifei Jiang Shuo Chen Kaile Wu Bing Shen Yehai Liu Juan Du Department of Otorhinolaryngology Head and Neck Surgerythe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China School of Basic Medical Sciences Anhui Medical UniversityHefei 230022China Department of Pediatrics The People's Hospital of BozhouHefei 236800China

TRPP2, a Ca^(2+)-permeable non-selective cation channel, has been shown to negatively regulate cell cycle, but the mechanism underlying this regulation is unknown. Tumor necrosis factor a(TNF-α) is a proinflammatory cytokine extensively involved in immune system regulation, cell proliferation and cell survival. However, the effects and mechanisms for the role of TNF-αin laryngeal cancer remain unclear. Here, we demonstrated using western blot analyses and intracellular Ca^(2+) concentration measurements that TNF-α treatment suppressed both TRPP2 expression and ATP-induced Ca^(2+) release in a laryngeal cancer cell line(Hep-2). Knockdown of TRPP2 by a specific siRNA significantly decreased ATP-induced Ca^(2+) release and abolished the effect of TNF-α on the ATP-induced Ca^(2+) release. TNF-α treatment also enhanced Hep-2 cell proliferation and growth, as determined using cell counting and flow cytometry cell cycle assays. Moreover, TNF-α treatment down-regulated phosphorylated protein kinase R-like endoplasmic reticulum kinase(p-PERK) and phosphorylated eukaryotic translation initiation factor(p-eIF2α)expression levels, without affecting PERK and eIF2 a expression levels in Hep-2 cells. We concluded that suppressing TRPP2 expression and TRPP2-mediated Ca^(2+) signaling may be one mechanism underlying TNF-α-enhanced Hep-2 cell *** results offer new insights into the mechanisms of TNF-α-mediated laryngeal cancer cell proliferation, and provide evidences showing a potential role of TNF-α in the development of laryngeal cancer.

关键词： tumor necrosis factor α TRPP2 human laryngeal squamous cell carcinoma proliferation protein kinase R-Iike endoplasmic reticulum kinase eukaryotic translation initiation factor