检索结果-南通市图书馆

LPA_(1) antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities

Nano Research 2024年第10期17卷 9095-9102页

作者： jingyue Yan Diana D.Kang Chang Wang Xucheng Hou Shi Du Siyu Wang Yonger Xue zhengwei Liu Haoyuan Li Yichen Zhong Binbin Deng David W.McComb Yizhou Dong Division of Pharmaceutics&Pharmacology College of PharmacyThe Ohio State UniversityColumbusOH 43210USA Icahn Genomics Institute Precision Immunology InstituteDepartment of Immunology and ImmunotherapyDepartment of Oncological SciencesTisch Cancer InstituteBiomedical Engineering and Imaging InstituteFriedman Brain InstituteIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA Center for Electron Microscopy and Analysis The Ohio State UniversityColumbusOH 43212USA Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA

Activated fibroblasts are major mediators of pulmonary *** are generally found in the connective tissue but upon activation can generate excess extracellular matrix(ECM)in the lung interstitial ***,fibroblasts are one of the most targeted cells for treating idiopathic pulmonary fibrosis(IPF).Here,we develop an anti-fibrotic platform that can modulate both the lysophosphatidic acid receptor 1(LPA_(1))and the inflammatory pathway through tumor necrosis factorα-induced protein 3(TNFAIP3,also known as A20)in ***,we synthesized a series of LPA_(1) antagonists,AM095 and AM966,derived amino lipids(LA lipids)which were formulated into LA-lipid nanoparticles(LA-LNPs)encapsulating ***,LA5-LNPs,with AM966 head group and biodegradable acetal lipid tails,showed efficient A20 mRNA delivery to lung fibroblasts in vitro(80.2%±1.5%)and ex vivo(17.2%±0.4%).When treated to primary mouse lung fibroblasts(MLF),this formulation inhibited fibroblast migration and collagen production,thereby slowing the progression of ***,LA5-LNPs encapsulated with A20 mRNA is a novel platform offering a potential approach to regulate fibroblast activation for the treatment of IPF.

关键词： lysophosphatidic acid receptor 1(LPA_(1))antagonist tumor necrosis factorα-induced protein 3(A20) lung fibrosis lipid nanoparticles mRNA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

sLe^(x) expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator

引用

Cancer Biology & Medicine 2021年第2期18卷 477-489页

作者： Yawen Song Hui Sun Kailiang Wu Jianke Lyu jingyue Zhang Feng Gu Yongjie Ma Beibei Shen Chijuan Wang Xiaojiao Chen Jing Xu Weidong Li Fangfang Liu Li Fu Department of Breast Cancer Pathology and Research Laboratory Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationBreast Cancer Innovation Team of the Ministry of EducationState Key Laboratory of Breast Cancer ResearchTianjin 300060China

Objective: Mucin 1(MUC1/EMA) and sialyl Lewis X(sLe^(x)) indicate polarity reversal in invasive micropapillary carcinoma(IMPC). The purpose of this study was to evaluate the expression of MUC1/EMA and sLe^(x) and to assess their diagnostic and prognostic value in patients with ***: The expression of sLe^(x) and MUC1/EMA in 100 patients with IMPC and a control group of 89 patients with invasive ductal carcinoma not otherwise specified(IDC-NOS) were analyzed with IHC. Fresh tumor tissues were collected from patients with IMPC or IDC-NOS for primary culture and immunofluorescence ***: The rate of nodal metastasis was higher in patients with IMPC than those with IDC-NOS, and IMPC cells tended to express more sLe^(x) and MUC1/EMA in the cytomembranes(the stroma-facing surfaces of the micropapillary clusters) than IDC-NOS cells. In IMPC, high cytomembrane expression of sLe^(x), but not MUC1/EMA, indicated poor prognosis. In addition, among the 100 patients with IMPC, 10 patients had sLe^(x)+/EMA-expression patterns, and 8 patients had sLe^(x)-/EMA+ expression patterns. The primary IMPC cells were suspended, non-adherent tumor cell clusters, whereas the primary IDC cells were adherent tumor cells. Immunofluorescence analysis showed that MUC1/EMA and sLe^(x) were co-expressed on the cytomembranes in IMPC cell clusters and in the cytoplasm in IDC-NOS ***: sLe^(x) can be used as a prognostic indicator and can be combined with MUC1/EMA as a complementary diagnostic indicator to avoid missed IMPC diagnosis.

关键词： Invasive micropapillary carcinoma polarity reversal diagnostic indicator EMA sLe^(x)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical Simulation of Dynamic Response of Saturated Sand During Shield Construction

引用

施工技术（中英文） 2022年第9期51卷 98-105页

作者： WANG jingyue GE Xinsheng SHANG Zhuo WU Ping ZHANG Jun College of Civil Engineering Taiyuan University of TechnologyTaiyuanShanxi 030024China Taiyuan Taigong Tianhao Civil Engineering Testing Co. Ltd.TaiyuanShanxi 030024China Shanxi Transportation Research Institute Group Co. Ltd.TaiyuanShanxi 030024China

In order to study the disturbance of the liquefiable stratum caused by the vibration induced by construction of the shield machine,the construction process of the shield tunnel was simulated based on the finite difference software FLAC 3 D.A sinusoidal velocity boundary that simulates the vibration of shield construction is applied in the horizontal direction of the excavation surface,and dynamic response analysis is carried out to analyze the excess pore water pressure,acceleration,and vertical effective stress time-history *** research results show that in the liquefiable stratum,the vibration induced by shield construction will form a certain liquefaction area in the soil in front of the excavation *** area has not developed to the *** area where the vibration induced by shield construction has a great influence on the excess pore water pressure of the soil is below the excavation *** area is *** excess pore water pressure of the overlying soil layer on the excavation surface increases,and the vertical effective stress *** horizontal vibration wave induced by shield construction has no obvious attenuation in the horizontal direction,but has obvious attenuation during the propagation to the ground *** the area where the peak value of soil acceleration is large,the soil liquefaction is serious.

关键词： soil acceleration excess

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Highly active and sintering-resistant heteroepitaxy of Au nanoparticles on ZnO nanowires for CO oxidation

引用

Journal of Energy Chemistry 2016年第3期25卷 361-370页

作者： Jiaxin Liu Botao Qiao Yian Song Hailian Tang Yudong Huang jingyue(Jimmy) Liu College of Chemical Engineering and Technology Harbin Institute of Technology Department of Physics Arizona State University State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Gold was supported on commercial ZnO powders(P) and homemade ZnO nanowires(NWs) by a modified deposition–precipitation method. X-ray diffraction and transmission electron microscopy investigation indicated that the size of the Au nanoparticles(NPs) depended strongly on the calcination *** Au NPs were highly dispersed( 400 °C. Such unique anchoring mechanism accounts for the much better experimentally observed sintering resistance. X-ray photoelectron spectra showed that Au existed as both metallic Au0 and Auδ+species in all the synthesized catalysts with or without calcination treatment; the ratios of Auδ+/Au0,however, varied, depending on the treatment conditions. Catalytic tests showed that the activity for CO oxidation strongly depended on the size of the Au NPs. After calcination at 600 °C, the specific rate for CO oxidation at room temperature decreased about 30 times on Au/ZnO P but only about 4 times on Au/ZnO NW. Stability tests demonstrated that the Au/ZnO NW catalysts had better stability for CO oxidation.

关键词： Gold ZnO Nanowires Epitaxy CO oxidation Sintering Stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Robust Cultivated Land Extraction Using Encoder-Decoder

引用

Journal of New Media 2020年第4期2卷 149-155页

作者： Aziguli Wulamu jingyue Sang Dezheng Zhang and Zuxian Shi Department of Computer School of Computer and Communication EngineeringUniversity of Science and Technology Beijing(USTB)Beijing100083China Beijing Key Laboratory of Knowledge Engineering for Materials Science Beijing100083China 不详

Cultivated land extraction is essential for sustainable development and *** this paper,the network we propose is based on the encoder-decoder structure,which extracts the semantic segmentation neural network of cultivated land from satellite images and uses it for agricultural automation *** encoder consists of two part:the first is the modified Xception,it can used as the feature extraction network,and the second is the atrous convolution,it can used to expand the receptive field and the context information to extract richer feature *** decoder part uses the conventional upsampling operation to restore the original *** addition,we use the combination of BCE and Loves-hinge as a loss function to optimize the Intersection over Union(IoU).Experimental results show that the proposed network structure can solve the problem of cultivated land extraction in Yinchuan City.

关键词： Semantic segmentation encoder-decoder cultivated land extraction atrous convolution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of integrated Traditional Chinese and Western Medicine on Gout

引用

Journal of Traditional Chinese Medicine 2021年第5期41卷 806-816页

作者： LIU Wei WU Yuanhao XUE Bin JIN Yue ZHANG Shumin LI Peihao XIE Qing WANG Aihua GAO jingyue CAI Yue ZHANG Bo LIU Xiaoya WANG Yi DUAN Ran Department of Rheumatology and Immunology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China Tianjin Key Laboratory of Translational Research of Traditional Chinese Medicine Prescription and Syndrome Tianjin 300381China

OBJECTIVE:To evaluate the curative effect of integrated Traditional Chinese and Western Medicine on gout,and to investigate the therapy timing and exact treatment options of integrated ***:Totally 860 patients were enrolled,including 460 patients with intermittent gout,200 patients with active Traditional Chinese Medicine(TCM)syndrome(TCM syndrome score≥6)and200 patients with stable TCM syndrome(score<6).They were randomly divided into intervention and control *** control group was treated according to Western Medicine *** intervention group was treated with integrated Traditional Chinese and Western *** efficacy of TCM syndrome,joint pain score,joint swelling score,ESR,C-reactive protein,serum uric acid,liver and kidney function,and the duration of remission of TCM syndrome were compared between the two groups before and after ***:For the patients with stable TCM syndrome,there was no significant difference in the effective rate and inefficiency between the intervention group and the control *** the active type,the effective rate of the intervention group is better than the control group *** the stable type,there was no significant difference between the intervention group and the control group in improving the scores of joint pain and swelling,reducing the level of ESR,C-reactive protein,serum uric acid and improving liver and kidney *** the active type,the differences between the two groups were *** stable stage of gout in the intervention group was longer than the control ***:For the gout patients with stable TCM syndrome in the acute stage of gout,we can use TCM treatment or Western Medicine alternatively;for the patients with active TCM syndrome,the scheme of combination of Traditional Chinese and Western Medicine can be applied,with the better curative effect than any medicine alone.

关键词： gout integrative medicine diagnosis and treatment system curative effect

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Remote sensing of subtropical tree diversity:The underappreciated roles of the practical definition of forest canopy and phenological variation

引用

Forest Ecosystems 2023年第3期10卷 378-386页

作者： Yongchao Liu Ruyun Zhang Chen-Feng Lin Zhaochen Zhang Ran Zhang Kankan Shang Mingshui Zhao jingyue Huang Xiaoning Wang You Li Yulin Zeng Yun-Peng Zhao Jian Zhang Dingliang Xing Zhoushan Archipelago Observation and Research Station Institute of Eco-Chongming(IEC)Zhejiang Tiantong Forest Ecosystem National Observation Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai200241China Systematic&Evolutionary Botany and Biodiversity Group MOE Key Laboratory of Biosystems Homeostasis&ProtectionCollege of Life SciencesZhejiang UniversityHangzhou310058China Shanghai Chenshan Botanical Garden Shanghai201602China Tianmushan National Nature Reserve Management Bureau Hangzhou311311China

Tree species diversity is vital for maintaining ecosystem functions,yet our ability to map the distribution of tree diversity is limited due to difficulties in traditional field-based *** developments in spaceborne remote sensing provide unprecedented opportunities to map and monitor tree diversity more *** we built partial least squares regression models using the multispectral surface reflectance acquired by Sentinel-2 satellites and the inventory data from 74 subtropical forest plots to predict canopy tree diversity in a national natural reserve in eastern *** particular,we evaluated the underappreciated roles of the practical definition of forest canopy and phenological variation in predicting tree diversity by testing three different definitions of canopy trees and comparing models built using satellite imagery of different *** best models explained 42%–63%variations in observed diversities in cross-validation tests,with higher explanation power for diversity indices that are more sensitive to abundant *** models built using imageries from early spring and late autumn showed consistently better fits than those built using data from other seasons,highlighting the significant role of transitional phenology in remotely sensing plant *** results suggested that the cumulative diameter(60%–80%)of the biggest trees is a better way to define the canopy layer than using the subjective fixeddiameter-threshold(5–12 cm)or the cumulative basal area(90%–95%)of the biggest ***,these approaches resulted in contrasting diversity maps that call attention to canopy structure in remote sensing of tree *** study demonstrates the potential of mapping and monitoring tree diversity using the Sentinal-2 data in species-rich forests.

关键词： Canopy structure Multispectral remote sensing Seasonal phenology Subtropical forest Tree species diversity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer

引用

Signal Transduction and Targeted Therapy 2023年第3期8卷 1144-1158页

作者： Yao Long Jiaxing Guo Jielin Chen jingyue Sun Haiyan Wang Xin Peng Zuli Wang WeiWei Lai Na Liu Long Shu Ling Chen Ying Shi Desheng Xiao Shuang Liu Yongguang Tao Department of Pathology Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Xiangya HospitalCentral South UniversityChangshaHunan 410078China NHC Key Laboratory of Carcinogenesis of Ministry of Health(Central South University) Cancer Research InstituteSchool of Basic MedicineCentral South UniversityChangshaHunan 410078China Department of Pathology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Tumor Models and Individualized Medicine Department of Thoracic SurgerySecond Xiangya HospitalCentral South UniversityChangshaChina Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research Xiangya HospitalCentral South UniversityChangshaHunan 410008China

In the treatment of most malignancies,radiotherapy plays a significant ***,the resistance of cancer cells to ionizing radiation(IR)is the main reason for the failure of radiotherapy,which causes tumor recurrence and *** this study,we confirmed that GPR162,an orphan receptor in the G-protein-coupled receptor family,acted as a novel radiotherapy sensitizer by interacting with the stimulator of interferon genes(STING),which targeted DNA damage responses,activated IRF3,accelerated the activation of type I interferon system,promoted the expression of chemokines including CXCL10 and CXCL4,and inhibited the occurrence and development of ***,the activation of STING by overexpression of GPR162 was independent of the classical pathway of *** inhibitors could resist the antitumor effect of overexpression of GPR162 in IR-induced mouse *** addition,most solid tumors showed low expression of *** the higher expression of GPR162 indicated a better prognosis in patients with lung adenocarcinoma,liver cancer,breast cancer,*** summary,these results suggested that GPR162 may serve as a potential sensitizer of radiotherapy by promoting radiotherapy-induced STING-IFN production and increasing the expression of chemokines including CXCL10 and CXCL4 in DNA damage response,providing an alternative strategy for improving cancer radiotherapy.

关键词： damage interferon radiotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electrospun advanced nanomaterials for in situ transmission electron microscopy:Progress and perspectives

引用

InfoMat 2023年第12期5卷 1-27页

作者： jingyue Zhao Zulin Li Shiwen Lv Manxi Wang Chuanping Li Xuan Li Hongyang Chen Manxian Li Xiaochuan Chen Feifeng Wang Weiwei Fan Junxiong Wu Ziqiang Wang Xiaoyan Li Yuming Chen Engineering Research Center of Polymer Green Recycling of Ministry of Education Fujian Key Laboratory of Pollution Control&Resource ReuseCollege of Environmental and Resource Sciences and College of Carbon Neutral Modern IndustryFujian Normal UniversityFuzhouFujianthe People's Republic of China Department of Materials Science and Engineering and Department of Nuclear Science and Engineering Massachusetts Institute of TechnologyCambridgeMassachusettsUSA Institute of Materials Research Shenzhen International Graduate SchoolTsinghua UniversityShenzhenthe People's Republic of China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujianthe People's Republic of China

Electrospun nanofibers(NFs)have shown excellent properties including high porosity,abundant active sites,controllable diameter,uniform and designable structure,high mechanical strength,and superior resistance to external destruction,which are ideal nanoreactors for in situ *** various techniques,in situ transmission electron microscopy(TEM)has enabled operando observation at the atomic level due to its high temporal and spatial resolution combined with excellent sensitivity,which is of great importance for rational materials design and performance *** this review,the basic knowledge of in situ TEM techniques and the advantages of electrospun nanoreactors for in situ TEM characterization are first *** recent development in electrospun nanoreactors for studying the physical properties,structural evolution,phase transition,and formation mechanisms of materials using in situ TEM is then *** electrochemical behaviors of carbon nanofibers(CNFs),metal/metal oxide NFs,and solidelectrolyte interphase for different rechargeable batteries are ***,challenges faced by electrospun nanoreactors for in situ TEM characterization are discussed and potential solutions are proposed to advance this field.

关键词： batteries electrospun advanced nanofibers in situ transmission electron microscopy nanoreactors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

血清外泌体miRNAs联合CA72-4在胃癌诊断中的价值分析

引用

中国肿瘤临床 2022年第12期49卷 636-641页

作者：孙婧悦王啸苏州大学附属第一医院肿瘤科苏州市215006 苏州大学附属第二医院骨外科

目的:筛选胃癌患者及健康人血清外泌体miRNAs,探究miRNAs联合肿瘤标记物在胃癌诊断中的价值。方法:选取2020年4月至2021年4月在苏州大学附属第一医院确诊胃癌的46例患者为胃癌组,同期20例健康体检者为对照组,收集两组血清标本,行血清外... 详细信息

目的:筛选胃癌患者及健康人血清外泌体miRNAs,探究miRNAs联合肿瘤标记物在胃癌诊断中的价值。方法:选取2020年4月至2021年4月在苏州大学附属第一医院确诊胃癌的46例患者为胃癌组,同期20例健康体检者为对照组,收集两组血清标本,行血清外泌体miRNAs测序,筛选并验证差异性表达的miRNAs,将验证后的miRNAs表达水平、肿瘤标志物数值与胃癌诊断行Spearman相关分析,并绘制受试者工作特征(receiver operating characteristic,ROC)曲线,分别分析外泌体miRNAs、CA72-4及两者联合在胃癌诊断中的价值。结果:两组血清外泌体共筛选出376个差异表达的miRNAs,经q-PCR验证,仅4个miRNAs差异具有统计学意义,采用ROC曲线判断外泌体miRNAs在胃癌诊断中的效能:miR-1323、miR-26a-5p、miR-202-3p、miR-96-5p诊断胃癌的曲线下面积(area under curve,AUC)分别为0.908、0.815、0.570、0.547,灵敏度分别为71.7%、67.4%、30.4%、19.6%,特异度分别100%、85.0%、90.0%、100%。Spearman相关分析结果提示:miR-26a-5p、miR-1323和CA72-4与胃癌诊断相关,ROC曲线显示:miR-26a-5p、miR-1323和CA72-4三者联合诊断的曲线下面积为0.967,高于三者单独诊断效能,其灵敏度和特异度分别为87.0%、100%。结论:联合检测血清外泌体miR-26a-5p、miR-1323和CA72-4的表达水平,在胃癌诊断中具有潜在价值。

关键词：胃癌外泌体 miRNAs 诊断

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：