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Plasma HGF and OPN as Potential Biomarkers of Pulmonary Arterial Hypertension in Congenital Heart Disease

Congenital Heart Disease 2021年第4期16卷 373-381页

作者： dongdong zheng Chi Shen Wenshi Liu Wenjing Lv Xiaofei Li Department of Cardiovascular Internal Medicine Affiliated Hospital of Nantong UniversityNantong226001China Department of Cardiovascular Internal Medicine Tongzhou People’s Hospital Affiliated to Nantong UniversityNantong226300China

Objectives:Pulmonary arterial hypertension in congenital heart disease(PAH-CHD)is the most common type of PAH and increases morbidity and mortality in patients with *** heart catheterization(RHC)is the standard method to diagnose ***,RHC is an invasive and complicated method with relatively high ***,feasible,and cost-efficient methods are urgently *** objective of this study was to evaluate three potential biomarkers of PAH-CHD:Hepatocyte growth factor(HGF),osteopontin(OPN),and suppression of tumorigenicity 2(ST2).Methods:Plasma samples were collected from patients with CHD(n=46)and healthy individuals(n=22)and divided into four groups according to the severity of *** levels of HGF,OPN,and ST2 were then analyzed using an enzyme-linked immunosorbent *** between HGF,OPN,ST2,and clinical parameters of PAH-CHD were ***:The plasma HGF levels in the moderate to the severe group were significantly higher than those in the mild group,nonPAH group,and healthy control group(p<0.05).Derived from a receiver operating characteristic(ROC)curve analysis,a cut-off value of 356.75 ng/ml for the HGF concentration was able to predict PAH-CHD with 53%sensitivity and 89%*** HGF level was positively related to pulmonary arterial systolic pressure(PASP)(r=0.36,p<0.05)and pulmonary vascular resistance(PVR)(r=0.36,p<0.05).Plasma OPN levels in the mild group were significantly higher than other groups and positively correlated with the pulmonary-systemic shunt ratio(Qp/Qs)(r=0.33,p<0.05).There was no statistically significant between-group difference in plasma soluble ST2(sST2)***:The plasma HGF level was elevated in PAH-CHD patients and can be used as a potential *** plasma OPN level was positively correlated with the Qp/Qs.

关键词： Congenital heart disease pulmonary hypertension hepatocyte growth factor osteopontin suppression of tumorigenicity 2 biomarker

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Identification and Control of Flexible Joint Robot Using Multi-Time-Scale Neural Network

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Journal of Shanghai Jiaotong university(Science) 2020年第5期25卷 553-560页

作者： zheng dongdong LI Pengcheng XIE Wenfang LI Dan Department of Mechanical Industrial&Aerospace EngineeringConcordia UniversityMontreal H3G 1M8Canada College of Mechanical Sz Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Electrical and Computer Engineering Concordia UniversityMontreal H3G 1M8Canada

In this paper,a new identification and control scheme for the flexible joint robotic manipulator is ***,by defining some new state variables,the commonly used dynamic equations of the flexible joint robotic manipulators are transformed into the standard form of a singularly perturbed ***,an optimal bounded ellipsoid algorithm based identification scheme using multi-time-scale neural network is proposed to identify the unknown system dynamic ***,by using the singular perturbation theory,an indirect adaptive controller based on the identified model is proposed to control the system such that the joint angles can track the given reference *** closed-loop stability of the whole system is proved,and the effectiveness of the proposed schemes is verified by simulations.

关键词： flexible joint robotic manipulator multi-time-scale neural network singular perturbation adaptive controller

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Biomimetic nanoparticles drive the mechanism understanding of shear-wave elasticity stiffness in triple negative breast cancers to predict clinical treatment

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Bioactive Materials 2023年第4期22卷 567-587页

作者： dongdong zheng Jin Zhou Lang Qian XueJiao Liu Cai Chang Shuang Tang Hongbo Zhang Shichong Zhou Department of Ultrasound Fudan University Shanghai Cancer CenterShanghai200032PR China Pharmaceutical Sciences Laboratory Åbo Akademi UniversityFI-00520TurkuFinland Cancer Institute Fudan University Shanghai Cancer CenterShanghai200032PR China Institutes of Biomedical Sciences and Department of Chemistry Fudan UniversityShanghai200032PR China Department of Nuclear Medicine Fudan University Shanghai Cancer CenterShanghai200032PR China Turku Bioscience Center University of Turku andÅbo Akademi UniversityFI-00520TurkuFinland The First Affiliated Hospital of Wenzhou Medical University Wenzhou325000PR China

In clinical practice,we noticed that triple negative breast cancer(TNBC)patients had higher shear-wave elasticity(SWE)stiffness than non-TNBC patients and a higherα-SMA expression was found in TNBC tissues than the non-TNBC ***,SWE stiffness also shows a clear correlation to neoadjuvant response *** elaborate this phenomenon,TNBC cell membrane-modified polylactide acid-glycolic acid(PLGA)nanoparticle was fabricated to specifically deliver artesunate to regulate SWE stiffness through inhibiting CAFs functional *** tested in MDA-MB-231 and E0771 orthotopic tumor models,CAFs functional status inhibited by 231M-ARS@PLGA nanoparticles(231M-AP NPs)had reduced the SWE stiffness as well as attenuated hypoxia of tumor as tumor soil loosening agent which amplified the antitumor effects of paclitaxel and PD1 ***-cell sequencing indicated that the two main CAFs(extracellular matrix and wound healing CAFs)that produces extracellular matrix could influence the tumor SWE stiffness as well as the antitumor effect of ***,biomimetic nanoparticles inhibited CAFs function could attenuate tumor hypoxia by increasing proportion of inflammatory blood vessels and oxygen transport ***,our finding is fundamental for understanding the role of CAFs on affecting SWE stiffness and drugs antitumor effects,which can be further implied in the potential clinical theranostic predicting in neoadjuvant therapy efficacy through non-invasive analyzing of SWE imaging.

关键词： Cancer-associated fibroblasts Biomimetic nanoparticles Shear-wave elasticity imaging Theranostic prediction

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N, O-doped carbon foam as metal-free electrocatalyst for efficient hydrogen production from seawater

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Nano Research 2022年第10期15卷 8922-8927页

作者： Qian Liu Shengjun Sun Longcheng Zhang Yongsong Luo Qin Yang Kai Dong Xiaodong Fang dongdong zheng Abdulmohsen Ali Alshehri Xuping Sun Institute for Advanced Study Chengdu UniversityChengdu 610106China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Chemistry Department Faculty of ScienceKing Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China

Seawater electrolysis is the most promising technology for large scale hydrogen production due to the abundance and low cost of seawater in ***,compared with the traditional freshwater electrolysis,the issues of electrode poisoning and corrosion will occur during the seawater electrolysis process,and active and stable electrocatalysts for the hydrogen evolution reaction(HER)are thus highly *** this work,N,O-doped carbon foam in-situ derived from commercial melamine foam is proposed as a high-active metal-free HER electrocatalyst for seawater *** acidic seawater,our catalyst shows high hydrogen generation performance with small overpotential of 161 mV at 10 mA·cm^(−2),a low Tafel slop of 97.5 mV·dec^(−1),and outstanding stability.

关键词： carbon foam hydrogen evolution reaction seawater electrolysis electrocatalyst

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A novel mutation in <i>NF1</i>gene in a Chinese patient with Legius syndrome like caféau lait spots

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Case Reports in Clinical Medicine 2013年第2期2卷 141-142页

作者： dongdong zheng Xiaohong Duan Department of Oral Biology Clinic of Oral Rare Diseases and Genetic Diseases School of Stomatology The Fourth Military Medical University Xi’an China

Neurofibromatosis type I (NF1) (OMIM, 162200) and Legius syndrome (OMIM, 611431) both have multiple café au lait spots. It is a challenge to differentiate the two diseases. Here we report a Legius syndrome-like patient who finally was identified as NF1 with a novel mutation in NF1 exon1 (c.55G > T). The mutation caused a substitution of a glutamic acid (GAG) with a terminator codon (TAG). For those patients with only multiple café au lait macules, axillary and inguinal freckling, but without any other clinical signs in NF1 and Legius syndrome, a gene testing is necessary to give a final diagnose. We suggested to use “Neurofibromatosis type 1—like syndrome” to describe those patients just like our patient reported here.

关键词： Legius Syndrome Neurofibromatosis Type I

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Fe-doped Co_(3)O_(4) nanowire strutted 3D pinewood-derived carbon: A highly selective electrocatalyst for ammonia production via nitrate reduction

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Nano Research 2024年第4期17卷 2276-2282页

作者： Xuwei Liu Chaozhen Liu Xun He zhengwei Cai Kai Dong Jun Li Xiaoya Fan Ting Xie Xiya Yang Yonglan Luo dongdong zheng Shengjun Sun Sulaiman Alfaifi Feng Gong Xuping Sun Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 211189China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Chemistry Department Frontier of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia

Nitrate(NO_(3)^(-)),a nitrogen-containing pollutant,is prevalent in aqueous solutions,contributing to a range of environmental and health-related *** electrocatalytic reduction of NO_(3)^(-)holds promise as a sustainable approach to both eliminating NO_(3)^(-)and generating valuable ammonia(NH_(3)).Nevertheless,the reduction reaction of NO_(3)^(-)(NO_(3)^(-)RR),involving 8-electron transfer process,is intricate,necessitating highly efficient electrocatalysts to facilitate the conversion of NO_(3)^(-)to NH_(3).In this study,Fe-doped Co_(3)O_(4) nanowire strutted three-dimensional(3D)pinewood-derived carbon(Fe-Co_(3)O_(4)/PC)is proposed as a high-efficiency NO_(3)^(-)RR electrocatalyst for NH_(3) *** within 0.1 M NaOH containing NO_(3)^(-),Fe-Co_(3)O_(4)/PC demonstrates exceptional performance,obtain an impressively large NH_(3) yield of 0.55 mmol·h^(-1)·cm^(-2) and an exceptionally high Faradaic efficiency of 96.5%at-0.5 V,superior to its Co_(3)O_(4)/PC counterpart(0.2 mmol·h^(-1)·cm^(-2),73.3%).Furthermore,the study delves into the reaction mechanism of Fe-Co_(3)O_(4) for NO_(3)^(-)RR through theoretical calculations.

关键词： Fe-doped Co_(3)O_(4) nanowire pinewood-derived carbon electrocatalytic NO_(3)-reduction NH_(3) synthesis density functional theory

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Ambient electrosynthesis of urea from carbon dioxide and nitrate over Mo_(2)C nanosheet

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Chinese Chemical Letters 2024年第8期35卷 319-323页

作者： Yue Zhang Xiaoya Fan Xun He Tingyu Yan Yongchao Yao dongdong zheng Jingxiang Zhao Qinghai Cai Qian Liu Luming Li Wei Chu Shengjun Sun Xuping Sun College of Chemistry and Chemical Engineering and Key Laboratory of Photonic and Electronic Bandgap MaterialsMinistry of EducationHarbin Normal UniversityHarbin 150025China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Institute for Advanced Study Chengdu UniversityChengdu 610106China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJi’nan 250014China

Electrocatalytic synthesis of urea through C-N bond formation,converting carbon dioxide(CO_(2))and ni-trate(NO_(3)^(-)),presents a promising,less energy-intensive alternative to industrial urea production *** this communication,we report the application of Mo_(2)C nanosheets-decorated carbon sheets(Mo_(2)C/C)as a highly efficient electrocatalyst for facilitating C-N coupling in ambient urea *** CO_(2)-saturated 0.2 mol/L Na_(2)SO_(4)solution containing 0.05 mol/L NO_(3)^(-),the Mo_(2)C/C catalyst achieves an impres-sive urea yield of 579.13μg h^(-1)mg^(-1)with high Faradaic efficiency of 44.80%at-0.5 V versus the reversible hydrogen *** theoretical calculations reveal that the multiple Mo active sites enhance the formation of^(∗)CO and^(∗)NH_(2)intermediates and facilitate their C-N *** research propels the use of Mo_(2)C-based electrodes in electrocatalysis and accentuates the capabilities of binary metal-based catalysts in C-N coupling reactions.

关键词： Mo_(2)C Multiple active sites C-N coupling Electrocatalysis Urea synthesis Density functional theory calculation

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Electrocatalytic synthesis of C-N coupling compounds from CO_(2) and nitrogenous species

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SusMat 2024年第2期4卷 51-74页

作者： zheng Zhang Danyang Li Yunchuan Tu Jiao Deng Huiting Bi Yongchao Yao Yan Wang Tingshuai Li Yongsong Luo Shengjun Sun dongdong zheng Sónia A.C.Carabineiro Zhou Chen Junjiang Zhu Xuping Sun Hubei Key Laboratory of Biomass Fibers and Eco-Dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile UniversityWuhanHubeiChina School of Chemistry and Chemical Engineering Chongqing UniversityChongqingChina i-Lab Vacuum Interconnected NanotechWorkstation(Nano-X)Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhouJiangsuChina Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengduSichuanChina College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinanShandongChina LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de Lisboa2829-516 CaparicaPortugal College of Materials Xiamen UniversityXiamenFujianChina

The electrocatalytic synthesis of C-N coupling compounds from CO_(2) and nitrogenous species not only offers an effective avenue to achieve carbon neutral-ity and reduce environmental pollution,but also establishes a route to synthesize valuable chemicals,such as urea,amide,and *** innovative approach expands the application range and product categories beyond simple carbona-ceous species in electrocatalytic CO_(2) reduction,which is becoming a rapidly advancing *** review summarizes the research progress in electrocatalytic urea synthesis,using N_(2),NO_(2)^(-),and NO_(3)^(-)as nitrogenous species,and explores emerging trends in the electrosynthesis of amide and amine from CO_(2) and nitro-gen ***,the future opportunities in this field are highlighted,including electrosynthesis of amino acids and other compounds containing C-N bonds,anodic C-N coupling reactions beyond water oxidation,and the catalytic mechanism of corresponding *** critical review also captures the insights aimed at accelerating the development of electrochemical C-N coupling reactions,confirming the superiority of this electrochemical method over the traditional techniques.

关键词： C-N coupling CO_(2) reduction electrocatalysis nitrogenous species reaction mechanism

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Cauliflower-like Ni_(3)S_(2) foam for ultrastable oxygen evolution electrocatalysis in alkaline seawater

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Nano Research 2024年第8期17卷 6820-6825页

作者： Qiuying Dai Xun He Yongchao Yao Kai Dong Xuwei Liu Xiankun Guo Jie Chen Xiaoya Fan dongdong zheng Yongsong Luo Shengjun Sun Luming Li Wei Chu Asmaa Farouk Mohamed SHamdy Xuping Sun Bo Tang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Institute for Advanced Study Chengdu UniversityChengdu 610106China Department of Chemistry College of ScienceKing Khalid UniversityP.O.Box 900461413 AbhaSaudi Arabia Center for High Altitude Medicine West China HospitalSichuan UniversityChengdu 610041China Laoshan Laboratory Qingdao 266237China

It is of great importance to design and develop electrocatalysts that are both long-lasting and efficient for seawater ***,a three-dimensional porous cauliflower-like Ni_(3)S_(2) foam on Ni foam(Ni_(3)S_(2) foam/NF)is proposed as a high-performance electrocatalyst for the oxygen evolution reaction in alkaline *** as-synthesis Ni_(3)S_(2) foam/NF achieves exceptional efficacy,achieving a current density of 100 mA·cm^(−2)at mere overpotential of 369 ***,its electrocatalytic stability extends up to 1000 h at 500 mA·cm^(−2).

关键词： Ni_(3)S_(2)foam oxygen evolution reaction seawater electrolysis electrocatalyst

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Significantly enhanced ion-migration and sodium-storage capability derived by strongly coupled dual interfacial engineering in heterogeneous bimetallic sulfides with densified carbon matrix

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SusMat 2024年第3期4卷 175-191页

作者： Wenxi Zhao Xiaoqing Ma Guangzhao Wang Linglin Tan Xinqin Wang Xun He Yan Wang Yongsong Luo dongdong zheng Shengjun Sun Qian Liu Luming Li Wei Chu Xuping Sun School of Electronic Information Engineering Yangtze Normal UniversityFulingChongqingChina Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengduSichuanChina School of Electronic Engineering Lanzhou City UniversityLanzhouGansuChina College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinanShandongChina Institute for Advanced Study Chengdu UniversityChengduSichuanChina

The development of highly efficient sodium-ion batteries depends critically on the successful exploitation of advanced anode hosts that is capable of overcoming sluggish reaction kinetics while also withstanding severe structural deformation triggered by the large radius of Na^(+)-***,a hierarchically hybrid material with hetero-Co_(3)S_(4)/NiS hollow nanosphere packaged into a densified N-doped carbonmatrix(Co_(3)S_(4)/NiS@N-C)was designed and fabricated utilizing CoNi-glycerate as the self-sacrifice template,making the utmost of the synergistic effect of hetero-Co_(3)S_(4)/NiS with strong electric field and rich reaction active-sites together with the densified outer-carbon scaffolds with remarkable electronic conductivity and robust mechanical *** anticipated,as-fabricated Co_(3)S_(4)/NiS@N-C anode affords remarkable specific capacity,prolonged cycle lifespan up to 2400 cycles with an only 0.05%fading each cycle at 20.0 A g^(−1),and excellent rate feature(354.9 mAh g^(−1)at 30.0 A g^(−1)),one of the best performances for most existing Co_(3)S_(4)/NiS-based *** situ structural characterizations in tandem with theoretical analysis demonstrate the reversible insertion-conversion mechanism of initially proceeding with Na^(+)de-/intercalation and superior heterogeneous interfacial reaction behavior with strong Na^(+)-adsorption ***,sodium-ion full cell and hybrid capacitor based on Co_(3)S_(4)/NiS@N-C anode exhibit impressive electrochemical characteristics on cycling performance and rate capability,showcasing its outstanding feasibility toward practical use.

关键词： anode materials bimetallic metal sulfides heterogeneous interface outer-carbon skeleton sodium ion battery

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