Plasma HGF and OPN as Potential Biomarkers of Pulmonary Arterial Hypertension in Congenital Heart Disease

作     者：Dongdong Zheng Chi Shen Wenshi Liu Wenjing Lv Xiaofei Li 

作者机构：Department of Cardiovascular Internal MedicineAffiliated Hospital of Nantong UniversityNantong226001China Department of Cardiovascular Internal MedicineTongzhou People’s Hospital Affiliated to Nantong UniversityNantong226300China 

出 版 物：《Congenital Heart Disease》 (先天性心脏病（英文）)

年 卷 期：2021年第16卷第4期

页      面：373-381页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the Nantong Municipal Science and Technology Plan(JCZ19107) 

主　　题：Congenital heart disease pulmonary hypertension hepatocyte growth factor osteopontin suppression of tumorigenicity 2 biomarker 

摘      要：Objectives:Pulmonary arterial hypertension in congenital heart disease(PAH-CHD)is the most common type of PAH and increases morbidity and mortality in patients with *** heart catheterization(RHC)is the standard method to diagnose ***,RHC is an invasive and complicated method with relatively high ***,feasible,and cost-efficient methods are urgently *** objective of this study was to evaluate three potential biomarkers of PAH-CHD:Hepatocyte growth factor(HGF),osteopontin(OPN),and suppression of tumorigenicity 2(ST2).Methods:Plasma samples were collected from patients with CHD(n=46)and healthy individuals(n=22)and divided into four groups according to the severity of *** levels of HGF,OPN,and ST2 were then analyzed using an enzyme-linked immunosorbent *** between HGF,OPN,ST2,and clinical parameters of PAH-CHD were ***:The plasma HGF levels in the moderate to the severe group were significantly higher than those in the mild group,nonPAH group,and healthy control group(p0.05).Derived from a receiver operating characteristic(ROC)curve analysis,a cut-off value of 356.75 ng/ml for the HGF concentration was able to predict PAH-CHD with 53%sensitivity and 89%*** HGF level was positively related to pulmonary arterial systolic pressure(PASP)(r=0.36,p0.05)and pulmonary vascular resistance(PVR)(r=0.36,p0.05).Plasma OPN levels in the mild group were significantly higher than other groups and positively correlated with the pulmonary-systemic shunt ratio(Qp/Qs)(r=0.33,p0.05).There was no statistically significant between-group difference in plasma soluble ST2(sST2)***:The plasma HGF level was elevated in PAH-CHD patients and can be used as a potential *** plasma OPN level was positively correlated with the Qp/Qs.