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Women's activisim in Africa

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Serum tissue inhibitor metalloproteinase-1 levels and prognosis of acute ischemic stroke

作者： Badri Balghis Tripp aili Mari

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中国循环杂志 2018年第S1期 115-116页

作者： Chongke Zhong aili Wang Yonghong Zhang Jiang He School of Public Health Medical College of Soochow University School of Public Health and Tropical Medicine Tulane University

Background and objective Tissue inhibitor metalloproteinase-1(TIMP-1),thenaturalendogenousinhibitorofmatrix metalloproteinases-9 (MMP-9), is implicated in dysfunction of the extracellular matrix and results in blood-b...

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Inhibiting octahedral tilting for stable CsPbI_(2)Br solar cells

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InfoMat 2022年第1期4卷 155-162页

作者： aili Wang Jianwei Wang Xiaobin Niu Chuantian Zuo Feng Hao Liming Ding School of Materials and Energy University of Electronic Science and Technology of ChinaChengduChina Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijingChina

The intrinsic phase instability of CsPbI_(2)Br perovskite hinders its development and application in solar ***,we adopt 1-butyl-3-methylimidazolium hexafluorophosphate(BMIMPF6),a hydrophobic ionic liquid(IL),to improve the phase stability of CsPbI_(2)*** functional theory calculation reveals that the formation energy of CsPbI_(2)Br with BMIMPF6 is reduced,thereby restraining the[PbX_(6)]^(4-) octahedral *** reduced structural distortion and relaxed lattice strain result in improved phase stability of CsPbI_(2)*** addition,the interfacial dipole moment increases after introducing BMIMPF6,which facilitates the charge ***,the CsPbI_(2)Br solar cells with BMIMPF6 deliver a power conversion efficiency(PCE)of 16.2%along with excellent *** unencapsulated devices with BMIMPF6 maintain 98.9%,88.6%,and 99.5%of the initial PCEs after 1200 h storage in N_(2),1000 h storage in air(30%relative humidity),and 200 thermal cycles(25–100℃),respectively.

关键词： CsPbI_(2)Br perovskite octahedral tilting phase stability solar cells thermal cycle

山东蓬莱大赵家地区金矿蚀变带地球物理特征及找矿方向

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山东国土资源 2025年第2期41卷 14-21页

作者：于爱丽赵晶赵瑞峰栾翔宇张珂毓烟台市土地储备和利用中心山东烟台264003 烟台市国有资产运营保障中心山东烟台264003 山发海岳环境科技(山东)股份有限公司山东烟台264006

综合地球物理方法对隐伏金属矿产勘查具有良好的指示作用,研究区位于胶东半岛北部、栖霞-蓬莱成矿带西侧大赵家地区,金矿成矿地质条件优越。本文针对蓬莱大赵家地区,利用岩矿石之间的物性差异,通过综合地球物理勘探圈定物探异常,发现多... 详细信息

综合地球物理方法对隐伏金属矿产勘查具有良好的指示作用,研究区位于胶东半岛北部、栖霞-蓬莱成矿带西侧大赵家地区,金矿成矿地质条件优越。本文针对蓬莱大赵家地区,利用岩矿石之间的物性差异,通过综合地球物理勘探圈定物探异常,发现多条矿化蚀变带,其中Ⅰ号、Ⅲ号蚀变带规模相对较大,并在平面和垂向上反应蚀变带的赋存特征,基本了解了该区蚀变带的分布及深部特征;根据区域地质、地球物理特征结合物探工作成果,分析了蓬莱大赵家地区金矿找矿前景,认为Ⅰ号、Ⅲ号蚀变带成矿潜力较好,为下一步该区金矿找矿工作指明了方向,对指导该区地质找矿具有重要意义。

关键词：地球物理特征蚀变带金矿蓬莱大赵家

血栓弹力图与凝血四项精准指导肝硬化患者输血治疗的价值差异

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国际医药卫生导报 2025年第6期31卷 940-944页

作者：杜旭利白艳丽樊艳婷侯爱丽西安国际医学中心医院输血科西安710010 西北大学附属西安国际医学中心医院输血科西安710010 渭南市华州区人民医院检验科渭南714100

目的比较血栓弹力图(TEG)和凝血四项精准指导肝硬化患者输血治疗的价值差异。方法采用前瞻性研究,选取2022年4月至2024年3月在西安国际医学中心医院行输血治疗的157例肝硬化患者作为研究对象,通过随机数字表法分为对照组(78例)和观察组... 详细信息

目的比较血栓弹力图(TEG)和凝血四项精准指导肝硬化患者输血治疗的价值差异。方法采用前瞻性研究,选取2022年4月至2024年3月在西安国际医学中心医院行输血治疗的157例肝硬化患者作为研究对象,通过随机数字表法分为对照组(78例)和观察组(79例)。对照组男42例、女36例,年龄(54.83±9.35)岁,依据凝血四项结果指导输血治疗;观察组男44例、女35例,年龄(56.25±10.48)岁,依据TEG指标指导输血治疗。采用Pearson相关性分析患者输血前TEG指标[凝血反应时间(R)、Angle角、最大血凝块强度(MA)]和凝血四项[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)]的相关性。对比两组患者血液成分输注量、治疗前后凝血指标、输血不良反应发生情况、住院时间和住院费用。统计学方法采用t检验、χ^(2)检验。结果Pearson相关性分析结果显示,R与APTT(r=0.473,P<0.001)呈正相关;Angle角与PT(r=-0.367,P<0.001)、APTT(r=-0.392,P<0.001)呈负相关,与FIB(r=0.571,P<0.001)呈正相关;MA与FIB(r=0.594,P<0.001)呈正相关。观察组新鲜冰冻血浆、冷沉淀、红细胞悬液、单采血小板输注量分别为(203.75±37.58)ml、(13.26±4.04)U、(3.43±1.29)U、(1.48±0.28)U,均少于对照组[(287.37±46.72)ml、(17.54±3.76)U、(4.87±1.54)U、(2.05±0.26)U],差异均有统计学意义(t=8.580、4.638、5.133、9.921,均P<0.05)。治疗后24 h,观察组PT、APTT、TT均短于对照组[(14.01±4.33)s比(17.26±3.26)s、(34.28±4.74)s比(39.32±4.18)s、(19.87±3.52)s比(23.71±3.74)s],FIB指标高于对照组[(1.81±0.24)g/L比(1.53±0.17)g/L],差异均有统计学意义(t=5.308、7.063、6.626、8.426,均P<0.05)。观察组输血不良反应发生率为1.27%(1/79),低于对照组的10.26%(8/78),差异有统计学意义(χ^(2)=4.325,P=0.038)。观察组住院时间短于对照组[(9.08±2.87)d比(11.23±3.27)d],住院费用低于对照组[(5.17±1.05)万元比(5.83±1.21)万元],差异均有统计学意义(t=4.380、3.652,均P<0.05)。结论TEG指标和凝血四项存在一定相关性,但基于TEG指标指导肝硬化患者输血可减少血液成分输注量及并发症,改善凝血功能,缩短住院时间,并节约医疗费用。

关键词：肝硬化输血治疗血栓弹力图凝血四项

Assessment of alternated cooling and heating treatment by US combined CEUS in the VX2 rabbit liver tumor model

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Chinese Science Bulletin 2014年第9期59卷 865-873页

作者： Cong Wei E.Shen Di Sun aili Zhang Jianqi Sun Bing Hu Department of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai Institute of Ultrasound in Medicine Department of Biomedical Engineering and Med-X Research Institute Shanghai Jiao Tong University

Inoperable liver tumors are often treated by thermal ablation that destroys the tumor in situ and spares the adjacent hepatic ***–physical treatment has many advantages,but treatment by freezing or heating alone has some *** taking the advantages and disadvantages of cryosurgery and thermotherapy into consideration,a new thermal technique that combines cryosurgery and radio frequency ablation has been proposed,thereby overcoming the disadvantages of each treatment strategy and improving therapeutic *** new approach remains to be systematically studied in the liver;therefore,this study was performed to estimate survival after alternated cooling and heating ablation therapy in a VX2 rabbit liver tumor *** days after VX2 carcinoma implantation into the rabbit liver,tumors were treated with alternated cooling and heating ablation *** were monitored for 6 months after treatment and assessed with ultrasound(US)and computed tomography at 1,7,14,and 30 days *** tumor-bearing animals served as the control *** results show that alternate freezing and heating ablation therapy resulted in a good recovery of VX2 *** with the control group,treated rabbits lived significantly longer(P\0.05),with 70%of treated animals surviving to 196 days posttreatment without metastasis or recurrence,while none of the controls did *** was no local recurrence in the treatment *** rabbits in the control group developed metastasis,while metastasis was only observed in 30% of treated *** results suggest that alternate cooling and heating ablation therapy can prolong the survival time of rabbits with VX2 liver tumors and is an effective method for tumor ***,we also showed in this model that contrast enhanced US is a valid follow-up approach to assess treatment effectiveness.

关键词：物理治疗肿瘤模型肝肿瘤后评估兔肝加热美国超声

WheatGene: A genomics database for common wheat and its related species

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The Crop Journal 2021年第6期9卷 1486-1491页

作者： Diego F.Garcia zhengyu Wang Jiantao Guan Lingjie Yin Shuaifeng Geng aili Li Long Mao Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China

Common wheat(Triticum aestivum) is a hexaploid plant(AABBDD) derived from genetically related tetraploid wheat T. turgidum(AABB) and a diploid goatgrass Aegilops tauschii(DD). Recent advances in sequencing technology and genome assembly strategies allow the acquisition of multiple wheat genomes, calling for a centralized database to store, manage and query the genomics information in a manner to reflect their evolutionary relationship and to perform effective comparative genome analysis. Here,we built WheatGene, a database that contains five wheat genomes of 318,102 genes and 945,900 transcripts and their expression information in 998 RNA-seq samples that can be searched and compared in an interactive manner. WheatGene was developed with Drupal, a popular content management system and the toolkit Tripal managed the biological information. The database was accessible through a web browser with species, search, gene expression, tools, and literature entries. Tools available were BLAST,synteny viewer, map viewer, JBrowse, data downloads, gene expression heatmap and bar chart, and homologs viewer. Moreover, the map viewer connected genomics data with genetic maps and QTL that can be searched for markers for molecular breeding. WheatGene was developed with open-source modules and libraries. WheatGene is available at http://***.

关键词： Wheat Genome Comparative genomics Database Genome browser

Design of Real-Time Temperature Monitoring and Control System for Multimodal Ablation

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Journal of Shanghai Jiaotong university(Science) 2022年第4期27卷 535-542页

作者： ZOU Ke ZOU Jincheng WANG Yifei ZHANG aili School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai200240China

By combining cryogenic cryotherapy and high-temperature radiofrequency therapy,multimodal ablation generates a rapidly changing temperature field in tissue by heating after *** method completely breaks tumour cells and releases a large amount of active *** with the traditional single modality,the thermal physical ablation method has been shown to have a greater therapeutic effect,but it presents challenges in terms of precise monitoring and rapid control of the temperature during the treatment *** solve this problem,we propose a temperature control system design utilizing aspects of probe sensing,real-time software and hardware signal interfaces,and dynamic compensation control strategies to accurately monitor the temperature changes during multimodal ablation *** results show that the design system has millisecond-level high-speed control capability,an accuracy of 0.5℃,and the dynamic response time is less than 0.1 ***,the temperature fluctuation in in vivo experiments is less than 0.5℃.

关键词： ablation temperature monitor system design

CRISPR/Cas9:A powerful tool for crop genome editing

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The Crop Journal 2016年第2期4卷 75-82页

作者： Gaoyuan Song Meiling Jia Kai Chen Xingchen Kong Bushra Khattak Chuanxiao Xie aili Li Long Mao National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop ScienceChinese Academy of Agricultural Sciences

The CRISPR/Cas9 technology is evolved from a type II bacterial immune system and represents a new generation of targeted genome editing technology that can be applied to nearly all organisms. Site-specific modification is achieved by a single guide RNA(usually about 20nucleotides) that is complementary to a target gene or locus and is anchored by a protospaceradjacent motif. Cas9 nuclease then cleaves the targeted DNA to generate double-strand breaks(DSBs), which are subsequently repaired by non-homologous end joining(NHEJ) or homology-directed repair(HDR) mechanisms. NHEJ may introduce indels that cause frame shift mutations and hence the disruption of gene functions. When combined with double or multiplex guide RNA design, NHEJ may also introduce targeted chromosome deletions,whereas HDR can be engineered for target gene correction, gene replacement, and gene knock-in. In this review, we briefly survey the history of the CRISPR/Cas9 system invention and its genome-editing mechanism. We also describe the most recent innovation of the CRISPR/Cas9 technology, particularly the broad applications of modified Cas9 variants, and discuss the potential of this system for targeted genome editing and modification for crop improvement.

关键词： CRISPR/Cas9 Double-strand break Genome editing TALENs ZFNs