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工程力学 2024年第10期41卷 I0003-I0003页

作者：郑晓静中国科学院中国力学学会

关键词：

Numerical investigation on dynamic response of the screen mesh in vibrating screening through DEM-FEM co-simulation

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Particuology 2024年第4期87卷 205-217页

作者： Huan Zhang xiao zheng Weimin jing Key Laboratory of MetallurgicalEquipment and Control Technology Ministry of EducationWuhan University of Science and TechnologyWuhan430081 China Hubei Key Laboratory of Mechanical Transmssion and Manufacturing Engineering Wuhan University of Science and TechnologyWuhan430081China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400044China

Dynamic response of the screen mesh is of great significance in the optimum vibrating screen *** this paper,based on the DEM-FEM co-simulation method,the effect of screening parameters on the dynamic response of the screen mesh is explored and the mechanism is revealed on the particle ***,a virtual experiment on a linear vibrating screen was carried out to analyze the screening pa-rameters'effect with both impact load and sustained stress inflicted on the screen ***,the time-domain evolution regularity of the screen mesh LVA(Local Vibration Amplitude)under different particle plugging conditions was investigated based on the ***,the influence of screening parameters on LVA and its distribution was *** results show that the screening parameters can greatly affect the screen mesh LVA and its distribution by changing the movement of the granular material and the particle penetration probability,which provides an important basis for the optimal design of the screen mesh and its supporting structure.

关键词： Vibrating screen Dynamic response DEM-FEM Screening parameters Local vibration amplitude

Local environment regulation of transition metal dichalcogenide-based single-atom catalysts

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Rare Metals 2024年第9期43卷 4019-4037页

作者： Ming-Hui Li jing Li xiao-Yu zheng Yao Zhou Advanced Research Institute of Multidisciplinary Science and School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China Laser Micro/Nano Fabrication Laboratory School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China

Single-atom catalysts have risen significant attention in the realm of green electrocatalytic energy conversion to address energy and environmental sustainability *** metal dichalcogenide(TMD)-based single-atom catalysts are considered highly effective in electrocatalysis due to the TMDs'notable specific surface area,tunable elemental species and efficient utilization of single *** order to enhance electrocatalytic performance,it is imperative to elaborately engineer the local environment surrounding the active sites of single atoms within *** this review,we initially explore the effects of synthesis methods on single-atom active sites and the influence of loading of single atoms on catalytic performance for *** modulation strategies of the local environment surrounding single-atom sites in TMDs are elaborated,including substitution engineering,surface adsorption,vacancies,spatial confinement and dual-atom site *** each modulation strategy,the effects of diverse local environments on various electrocatalytic applications are presented,such as the oxygen evolution reaction,oxygen reduction reaction,nitrogen reduction reaction,CO_(2)reduction reaction and CO ***,this study presents a comprehensive overview of the challenges encountered and the potential directions for the advancement of single-atom catalysts based on TMDs in the realm of electrocatalysis.

关键词： Single-atom catalysts Transition metal dichalcogenide Local environment Electrocatalysis

H-FABP与BNP在快速心房纤颤诊断与评估中的应用

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心血管病防治知识（学术版） 2024年第1期14卷 42-45页

作者：高翔李伟真于立涛刘艳郑晓静山东省潍坊市坊子区人民医院山东潍坊261200 潍坊医学院附属医院山东潍坊261031

目的旨在研究心脏型脂肪酸结合蛋白(H-FABP)与前体B型钠尿肽(pro-BNP)在快速心房纤颤(简称房颤)中的诊断和评估价值。方法应用双抗夹心酶联免疫吸附试验(ELISA)对2021年1月至2022年12月间,潍坊市坊子区人民医院急诊收治的79例快速房颤... 详细信息

目的旨在研究心脏型脂肪酸结合蛋白(H-FABP)与前体B型钠尿肽(pro-BNP)在快速心房纤颤(简称房颤)中的诊断和评估价值。方法应用双抗夹心酶联免疫吸附试验(ELISA)对2021年1月至2022年12月间,潍坊市坊子区人民医院急诊收治的79例快速房颤患者的血浆中H-FABP和pro-BNP进行检测。进一步结合患者的临床表现、心功能检测进行综合分析。结果在阵发性、持续性和永久性房颤患者中,血浆H-FABP的平均含量分别为(7.0±1.7)ng/mL、(8.3±2.2)ng/mL和(9.5±3.0)ng/mL,而pro-BNP的平均含量则分别为(819±125)pg/mL、(1630±215)pg/mL和(2189±165)pg/mL。阵发性房颤患者经过胺碘酮转复心律后,H-FABP和pro-BNP水平均显著下降至(6.2±1.1)ng/mL和(561±117)pg/mL。根据NYHA心功能分级,Ⅲ级和Ⅳ级患者的H-FABP和pro-BNP含量显著高于心功能较好的患者。结论H-FABP和pro-BNP的血浆水平与快速房颤患者的心功能状态显著关联,因此有潜力作为房颤诊断和心功能评估的生物标志物。

关键词：心房纤颤 H-FABP pro-BNP 心功能状态

A remote control training system for rat navigation in complicated environment

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 323-330页

作者： FENG Zhou-yan CHEN Wei-dong YE Xue-song ZHANG Shao-min zheng xiao-jing WANG Peng JIANG Jun JIN Lin XU Zhi-jian LIU Chun-qing LIU Fu-xin LUO Jian-hong ZHUANG Yue-ting zheng xiao-xiang Qiushi Academy for Advanced Studies Zhejiang University Hangzhou 310027 China College of Biomedical Engineering and instrument Science Zhejiang University Hangzhou 310027 China College of Computer Science and Technology Zhefiang University Hangzhou 310027 China School of Medicine Zhejiang University Hangzhou 310006 China

A remote control system has been developed to deliver stimuli into the rat brain through a wireless micro-stimulator for animal behavior training. The system consists of the following main components： an integrated PC control program, a transmitter and a receiver based on Bluetooth （BT） modules, a stimulator controlled by C8051 microprocessor, as well as an operant chamber and an eight-arm radial maze. The micro-stimulator is featured with its changeable amplitude of pulse output for both constant-voltage and constant-current mode, which provides an easy way to set the proper suitable stimulation intensity for different training. The system has been used in behavior experiments for monitoring and recording bar-pressing in the operant chamber, controlling rat roaming in the eight-arm maze, as well as navigating rats through a 3D obstacle route. The results indicated that the system worked stably and that the stimulation was effective for different types of rat behavior controls. In addition, the results showed that stimulation in the whisker barrel region of rat primary somatosensory cortex （SI） acted like a cue. The animals can be trained to take different desired turns upon the association between the SI cue stimulation and the reward stimulation in the medial forehrain bundle （MFB）.

关键词： Remote control Brain Navigation Stimulator Reward stimulation Whisker

方氏头针联合择时耳穴贴压治疗维持性血液透析失眠患者的临床观察

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广州中医药大学学报 2024年第3期41卷 671-677页

作者：路金华任媛媛郑晓静张少梅胡曦月黄伟西安市中医医院陕西西安710021

【目的】观察方氏头针联合择时耳穴贴压治疗维持性血液透析失眠患者的临床疗效。【方法】将70例维持性血液透析失眠患者随机分为观察组和对照组,每组各35例。2组均给予常规治疗,对照组在常规治疗的基础上给予艾司唑仑片口服,观察组给予... 详细信息

【目的】观察方氏头针联合择时耳穴贴压治疗维持性血液透析失眠患者的临床疗效。【方法】将70例维持性血液透析失眠患者随机分为观察组和对照组,每组各35例。2组均给予常规治疗,对照组在常规治疗的基础上给予艾司唑仑片口服,观察组给予方氏头针联合择时耳穴贴压治疗,共治疗4周。治疗1个月后,评价2组临床疗效,观察2组患者治疗前后匹兹堡睡眠质量指数量表(PSQI)评分与肾脏疾病生活质量简表(KDQOL-SF)评分的变化情况,以及汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评分的情况。比较2组患者治疗前后血红蛋白(Hb)、血肌酐(Scr)、血尿素氮(BUN)水平的变化情况。并评价2组的安全性。【结果】(1)治疗后,2组患者的PSQI、KDQOL-SF评分均明显改善(P0.05)。【结论】方氏头针联合择时耳穴贴压治疗维持性血液透析失眠,能够有效改善患者的睡眠质量,缓解焦虑抑郁情绪,从而提高患者的生活质量,疗效显著。

关键词：方氏头针择时耳穴贴压维持性血液透析失眠焦虑抑郁临床观察

Impact of baseline hepatitis B virus viral load on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2504-2519页

作者： Di Pan Hao-Nan Liu Zhi-Yuan Yao xiao-xiao Chen Yu-Qi Li jing-jing Zhu zheng-Xiang Han xiao-Bing Qin Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Although the combination of lenvatinib and PD-1 inhibitors has become the standard regimen for the treatment of advanced hepatocellular carcinoma(HCC),real data on the impact of baseline hepatitis B virus(HBV)-DNA levels on the clinical efficacy of this regimen is still *** To evaluate the effectiveness of camrelizumab combined with lenvatinib in patients with HCC at varying levels of *** One hundred and twenty patients with HCC who received camrelizumab and lenvatinib treatment were categorized into two cohorts:HBV-DNA≤2000(n=66)and HBV-DNA>2000(n=54).The main outcomes measured were overall survival(OS)and progression-free survival(PFS),while additional outcomes included the rate of objective response rate(ORR),disease control rate(DCR),and any negative *** proportional hazards regression analysis revealed independent predictors of OS,leading to the creation of a nomogram incorporating these *** The median PFS was 8.32 months for the HBV-DNA≤2000 group,which was similar to the 7.80 months observed for the HBV DNA>2000 group(P=0.88).Likewise,there was no notable variation in the median OS between the two groups,with durations of 13.30 and 14.20 months respectively(P=0.14).The ORR and DCR were compared between the two groups,showing ORR of 19.70%vs 33.33%(P=0.09)and DCR of 72.73%vs 74.07%(P=0.87).The nomogram emphasized the importance of antiviral treatment as the main predictor of patient results,with portal vein tumor thrombus and Barcelona Clinic Liver Cancer staging following closely *** The clinical outcomes of patients with HBV-associated HCC treated with camrelizumab in combination with lenvatinib are not significantly affected by HBV viral load.

关键词： Hepatitis B virus Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy

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供应链复杂交互作用Agent的资源流分析

系统工程理论与实践 2007年第6期27卷 71-79,85页

作者：白世贞郑小京东南大学经济管理学院南京210096 哈尔滨商业大学物流学院哈尔滨150076

为了研究供应链复杂适应系统各Agent携带资源流在Agent交互作用过程中发生的涌现规律及内在诱因,首先定义Agent汲取的资源包括系统外部资源、系统资源、其他Agent携带资源以及Agent自身携带的动态资源,建立资源多Agent区室{y111,y112,…... 详细信息

为了研究供应链复杂适应系统各Agent携带资源流在Agent交互作用过程中发生的涌现规律及内在诱因,首先定义Agent汲取的资源包括系统外部资源、系统资源、其他Agent携带资源以及Agent自身携带的动态资源,建立资源多Agent区室{y111,y112,…,y118}{y121,y122,…,y128}…{y191,y192,…,y198}{y211,y212,…,y218}{y221,y222,…,y228}…{y291,y292,…,y298}{y311,y312,…,y318}{y321,y322,…,y328}…{y391,y392,…,y398},并通过8个随机数控制交互作用时Agent携带的8种主要资源流交互作用点,以匹配能力、匹配速度、匹配时间三层次依次表示Agent交互作用过程中资源流的方向与大小、速度及稳定性;然后以GEF和LEF两种规则进行Agent间的资源进化,建立供应链复杂系统资源流模型;最后,分别对该模型及资源简单相加而不考虑资源多Agent区室两种情况进行Swarm仿真,前者更能准确描述供应链系统资源变化规律,这说明8种相互影响、制约的资源流融为一体是供应链资源流复杂涌现的内在诱因.

关键词：供应链资源流 Agent 模拟仿真

A Trust Evaluation Mechanism Based on Autoencoder Clustering Algorithm for Edge Device Access of IoT

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Computers, Materials & Continua 2024年第2期78卷 1881-1895页

作者： xiao Feng zheng Yuan Cyber Security Academy Beijing University of Posts and TelecommunicationsBeijing100876China Department of Cyberspace Security Beijing Electronic Science and Technology InstituteBeijing100070China State Grid Info-Telecom Great Power Science and Technology Co. Ltd.Beijing102211China

First,we propose a cross-domain authentication architecture based on trust evaluation mechanism,including registration,certificate issuance,and cross-domain authentication processes.A direct trust evaluation mechanism based on the time decay factor is proposed,taking into account the influence of historical interaction *** weight the time attenuation factor to each historical interaction record for updating and got the new historical record *** refer to the beta distribution to enhance the flexibility and adaptability of the direct trust assessment model to better capture time trends in the historical *** we propose an autoencoder-based trust clustering *** perform feature extraction based on *** leibler(KL)divergence is used to calculate the reconstruction *** constructing a convolutional autoencoder,we introduce convolutional neural networks to improve training efficiency and introduce sparse constraints into the hidden layer of the *** sparse penalty term in the loss function measures the difference through the KL *** clustering is performed based on the density based spatial clustering of applications with noise(DBSCAN)clustering *** the clustering process,edge nodes have a variety of trustworthy attribute *** assign different attribute weights according to the relative importance of each attribute in the clustering process,and a larger weight means that the attribute occupies a greater weight in the calculation of ***,we introduced adaptive weights to calculate comprehensive trust *** experiments prove that our trust evaluation mechanism has excellent reliability and accuracy.

关键词： Cross-domain authentication trust evaluation autoencoder

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蝶阀在高温时受力与变形的仿真分析

阀门 2024年第5期 585-591页

作者：邵力亭柳相卿张希恒赵昕宇周军郑小静北泽阀门集团有限公司浙江温州325025 兰州理工大学甘肃兰州730050

高温蝶阀是目前在航空航天试验、现代化工等领域最需要的控制设备之一。本文介绍了一种DN500的高温蝶阀在高温816℃、压力为1 MPa、阀杆施加8978 N·m的关闭扭矩时受力与变形的仿真分析,通过对蝶阀建立三维模型并用有限元计算方法获得... 详细信息

高温蝶阀是目前在航空航天试验、现代化工等领域最需要的控制设备之一。本文介绍了一种DN500的高温蝶阀在高温816℃、压力为1 MPa、阀杆施加8978 N·m的关闭扭矩时受力与变形的仿真分析,通过对蝶阀建立三维模型并用有限元计算方法获得的仿真分析数据使得产品设计在高温条件下更加安全可靠。

关键词：高温蝶阀有限元仿真分析应力变形密封比压