A remote control training system for rat navigation in complicated environment

作     者：FENG Zhou-yan CHEN Wei-dong YE Xue-song ZHANG Shao-min ZHENG Xiao-jing WANG Peng JIANG Jun JIN Lin XU Zhi-jian LIU Chun-qing LIU Fu-xin LUO Jian-hong ZHUANG Yue-ting ZHENG Xiao-xiang 

作者机构：Qiushi Academy for Advanced Studies Zhejiang University Hangzhou 310027 China College of Biomedical Engineering and instrument Science Zhejiang University Hangzhou 310027 China College of Computer Science and Technology Zhefiang University Hangzhou 310027 China School of Medicine Zhejiang University Hangzhou 310006 China 

出 版 物：《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 (浙江大学学报（英文版）A辑（应用物理与工程）)

年 卷 期：2007年第8卷第2期

页      面：323-330页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 08[工学] 071006[理学-神经生物学] 081101[工学-控制理论与控制工程] 0811[工学-控制科学与工程] 

基　　金：Project supported by the Zhejiang University Grant for Multiple Discipline Associated Research  Zhejiang University  China 

主　　题：Remote control Brain Navigation Stimulator Reward stimulation Whisker 

摘      要：A remote control system has been developed to deliver stimuli into the rat brain through a wireless micro-stimulator for animal behavior training. The system consists of the following main components： an integrated PC control program, a transmitter and a receiver based on Bluetooth （BT） modules, a stimulator controlled by C8051 microprocessor, as well as an operant chamber and an eight-arm radial maze. The micro-stimulator is featured with its changeable amplitude of pulse output for both constant-voltage and constant-current mode, which provides an easy way to set the proper suitable stimulation intensity for different training. The system has been used in behavior experiments for monitoring and recording bar-pressing in the operant chamber, controlling rat roaming in the eight-arm maze, as well as navigating rats through a 3D obstacle route. The results indicated that the system worked stably and that the stimulation was effective for different types of rat behavior controls. In addition, the results showed that stimulation in the whisker barrel region of rat primary somatosensory cortex （SI） acted like a cue. The animals can be trained to take different desired turns upon the association between the SI cue stimulation and the reward stimulation in the medial forehrain bundle （MFB）.