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Effect of direct current pulse stimulating acupoints of JiaJi (T10-L3) and Ciliao (BL 32) with Han's Acupoint Nerve Stimulator on labour pain in women: a randomized controlled clinical study

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Journal of Traditional Chinese Medicine 2015年第6期35卷 620-625页

作者： Liu Ye Xu Mingjun Che Xiangming He Junqin Guo Dandan Zhao Guosheng Zhang Guogang Zhang Shuo Kang Kai Zhang Chunlei Wang Yinan Li Shan Zhang Qinglin Xu Li Zhang Ming Han Bin Jing Yumiao Zhang Ning Department of Anesthesiology Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University Department of Traditional Chinese Medicine Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University

OBJECTIVE: To assess the clinical effect and safety of direct current(DC) pulse produced by Han's Acupoint Nerve Stimulator in reduction(HANS) of labor pain.METHODS: Totally 120 participants were enrolled in this clinical trial, and were randomly divided into4 groups including: HANS group, patient controlled intravenous analgesia(PCIA) group, patient-controlled epidural analgesia(PCEA) group and control group. The HANS group was treated by stimulating the acupoints of Jia Ji(T10-L3) and Ciliao(BL 32)with DC pulse of 100 Hz and 15-30 m A produced by a portable battery-powered Han's Acupoint Nerve Stimulator for 30 min. The PCIA group was intravenously infused Ondansetron(8 mg) for 5 min,then tramadol injection(1.5 mg/kg) was slowly dripped by using Baxter APⅡ electronic pump with50 m L tramadol(0.70%) + ondansetron(8 mg),background infusion 2 m L/h, PCA dose of 2 m L,lockout interval of 10 min. In PCEA group, women received intrathecal injection ropivacaine(3 mg) in L2-3, and epidural catheter was connected to Baxter APⅡ electronic pump, with 100 m L Ropivacaine(0.1%) and Sufentanil(50 ug), background infusion5 m L, Patient controlled analgesia(PCA) dose of 5m L, lockout interval of 10 min. The control group was not received analgesia. The visual analogue scale(VAS), stage and manner of labor, Apgar score of newborn, neonatal weights, oxytocin dosage,postpartum hemorrhage and side effects were monitored in all groups.RESULTS: The vital signs were all stable in the four analgesic groups. After analgesia, there was statistical difference in VAS score between HANS group and control group, between PCEA group and the control group, between PCIA group and control group. The analgesic effect in the PCEA group was significantly better than that of other two groups.The second stage of labor in the PCEA group was longer than the other three groups, showing significant difference between them. The Apgar score of newborn 1min after birth in the PCIA group was slightly lower than that of the other two groups,showing significan

关键词： Analgesia, patient-controlled Analge-sia, epidural Anesthesia Combined spinal and epi-dural block The Han's Acupoint Nerve Stimulator Randomized controlled trial

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Combination of photodynamic therapy and Stimulator of interferon genes(STING)agonist inhibits colorectal tumor growth and recurrence

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Cancer Communications 2023年第4期43卷 513-518页

作者： Yang Hao Sen Ma Zili Gu Alireza Haghparast Timo Schomann Zhenfeng Yu Yuanyuan He Xiaoxv Dong Luis J Cruz Peter ten Dijke Translational Nanobiomaterials and Imaging(TNI)Group Department of RadiologyLeiden University Medical CenterZA Leidenthe Netherlands Department of Laboratory Animals College of Animal SciencesJilin UniversityChangchunChina Department of Ophthalmology Leiden University Medical Center(LUMC)ZA Leidenthe Netherlands Percuros B.V. CL Leidenthe Netherlands Immunology Section Department of PathobiologyFaculty of Veterinary MedicineFerdowsi University of Mashhad.MashhadIran School of Chinese Material Medica Beijing University of Chinese MedicineBeijingP.R.China Department of Cell and Chemical Biology and Oncode Institute Leiden University Medical CenterRC Leidenthe Netherlands

Dear Editor,Great progress has been made in the clinical use of photodynamic therapy(PDT)for the treatment of patients with superficial tumors[1].However,cancer recurrence and metastasis have limited the application of PDT in the treatment of solid tumors and advanced cancers.In this context,combining PDT with other complementary immunotherapy regimens may overcome these limitations of PDT[2].

关键词： Stimulator superficial clinical

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Design, synthesis and systematic evaluation of all possible cyclic dinucleotides (CDNs) that activate human Stimulator of interferon genes (STING) variants

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Science China Chemistry 2020年第4期63卷 534-545页

作者： Zheng-Hua Wang Can-Can Zhao Qiang-Zhe Zhang Chuan-Lin Wang Hang Zhang De-Jun Ma Da-Wei Wang Xin Wen Lu-Yuan Li Zhen Xi State Key Laboratory of Elemento-organic Chemistry Department of Chemical BiologyCollege of ChemistryNankai UniversityTianjin 300071China State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300071China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300071China National Pesticide Engineering Research Center(Tianjin) Tianjin 300071China

Cyclic dinucleotides(CDNs) are known to activate Stimulator of interferon genes(STING) and induce type I interferon responses, therefor possess great potentials to be of immunotherapeutic value for cancers and infectious diseases. However, the existence of different single nucleotide polymorphism(SNP) of human STING(hSTING) gene poses an obstacle to achieve broad-spectrum activation by CDNs. We reported here the design and synthesis of a total of 36 CDNs, representing all structural variations, that contain four bases(A, G, C, U) and two linkage directions(2′-5′-linked and 3′-5′-linked phosphodiester).Through systematic evaluation of IFN-β induction with a dual-luciferase reporter assay, we discovered that wild type hSTING and two isoforms(HAQ and AQ) showed strong response while hSTING-R232 H and R293 Q exhibited the relatively weak response to CDNs stimulation. For the first time, we found that the c[G(2′,5′)U(2′,5′)] showed excellent activity against all five hSTING variants even equivalent to the endogenous ligand c[G(2′,5′)A(3′,5′)]. Furthermore, we have also demonstrated that 3′-3′CDNs with two 3′-5′ phosphodiesters showed higher serum and hydrolase stability than 2′-2′ CDNs with two 2′-5′ phosphodiesters and 2′-3′ CDNs with one 2′-5′ and one 3′-5′ phosphodiester. It is very interesting to note that 2′-2′ CDNs has been found for the first time to show strong activity. These findings will stimulate our exploration for the new functional role of CDNs, and provide guidelines to design CDNs based hSTING targeted drugs.

关键词： cyclic dinucleotides(CDNs) Stimulator of interferon genes(STING) pyrimidine CDNs interferonβ ecto-nucleotide pyrophosphatase/phosphodiesterase 1(ENPP1)

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Effect of nerve Stimulator-guided nerve block on the pain mediator secretion and stress degree after lower extremity operation

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Journal of Hainan Medical University 2018年第7期24卷 16-19页

作者： Xin-Rui Du Pei-Yan Yang Zhan Chen Department of Anesthesiology Mianyang Orthopaedic Hospital in Sichuan ProvinceMianyangSichuan Province621000 Department of Laboratory Mianyang Orthopaedic Hospital in Sichuan ProvinceMianyangSichuan Province621000

Objective: To study the effect of nerve Stimulator-guided nerve block on the pain mediator secretion and stress degree after lower extremity operation. Methods: Patients who received lower extremity operation in Mianyang Orthopaedic Hospital between March 2015 and August 2017 were selected, and the analgesia methods within the medical records were reviewed and used to divide the patients into nerve block group, spinal analgesia group and intravenous analgesia group. The secretion of pain mediators, stress hormones, stress products and inflammatory factors in serum was measured 24 h after surgery. Results: CGRP, β-EP, 5-HT, HA, ACTH, Cor, PRL, GH, TSH, sTNFR-1, IL-2, IL-10 and TGF-β1 secretion as well as CRP, MPO, MDA and ROS generation in serum of nerve block group were significantly lower than those of spinal analgesia group and intravenous analgesia group, and the differences in serum pain mediators, stress hormones, stress products and inflammatory factors were statistically significant between nerve block group and spinal analgesia group as well as between nerve block group and intravenous analgesia group. Conclusion: The nerve Stimulator-guided nerve block can be more effective than spinal analgesia and intravenous analgesia to reduce the secretion of pain mediators and relieve the degree of stress after lower extremity operation.

关键词： Nerve block Nerve Stimulator Pain mediator Stress response

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Improvement of gait of freezing in patients with Parkinson’s disease by electrical stimulation to common peroneal nerve delivered by wearable Stimulator

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China Medical Abstracts(Internal Medicine) 2019年第4期36卷 233-234页

作者：李娟 Dept of Neurol 1st Affil HospAnhui Med UnivHefei 230022

Objective To explore whether the proprioceptive sensory cueing delivered by electrical Stimulator to common peroneal nerve can improve the freezing of gait of parkinsonian patients.Methods Thirty patients with Parkinson’s disease experiencing freezing of gait(FOG)admitted to the First Affiliated Hospital of Anhui Medical University from January to December 2018 were included in the trial.

关键词： Improvement Parkinson’s Stimulator

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Change in Impedance with Change in Posture during Spinal Cord Stimulator Placement

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Pain Studies and Treatment 2014年第2期2卷 70-72页

作者： Samer Abdel-Aziz Ahmed Ghaleb Department of Anesthesiology and Pain Medicine University of Arkansas for Medical Sciences Little Rock USA

In this article we discuss the effect of posture on impedance during the placement of a spinal cord Stimulator. Although, according to several studies, there appears not to be a specific and consistent change in impedance with change in posture, we noticed on multiple occasions that if the impedance remains very high during spinal cord Stimulator (SCS) lead placement, asking the patient to sit up from the prone position may drop the impedance down. This could be explained by having air around the lead, from using loss of resistance to air technique in finding the epidural space, which moves up when sitting the patient up, or having the lead immersed in epidural fat. Sitting the patient up from the prone position should be tried if the impedance remains very high before aborting the procedure and taking the lead out.

关键词： Impedance Spinal Cord Stimulator Change in Posture

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Live birth following an innovative artificial oocyte activation protocol using double calcium Stimulators

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Chinese Medical Journal 2023年第17期136卷 2101-2103页

作者： Yingzhuo Gao Dalei Yang Yuanyuan Fang Xiuxia Wang Da Li Center of Reproductive Medicine Shengjing Hospital of China Medical UniversityShenyangLiaoning 110004China

Intracytoplasmic sperm injection(ICSI)is an effective method for human-assisted reproductive technology,especially for male-factor infertility.However,the average fertilization rate of ICSI is 70%,and total fertilizat... 详细信息

关键词： Stimulator injection activation

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Partial isolation and identification of hepatic Stimulator substance mRNA extracted from human fetal liver

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World Journal of Gastroenterology 1998年第2期4卷 8-10页

ＰａｒｔｉａｌｉｓｏｌａｔｉｏｎａｎｄｉｄｅｎｔｉｆｉｃａｔｉｏｎｏｆｈｅｐａｔｉｃｓｔｉｍｕｌａｔｏｒｓｕｂｓｔａｎｃｅｍＲＮＡｅｘｔｒａｃｔｅｄｆｒｏｍｈｕｍａｎｆｅｔａｌｌｉｖｅｒＹＡＮＧＸｉａｏＭｉｎｇ，... 详细信息

ＰａｒｔｉａｌｉｓｏｌａｔｉｏｎａｎｄｉｄｅｎｔｉｆｉｃａｔｉｏｎｏｆｈｅｐａｔｉｃｓｔｉｍｕｌａｔｏｒｓｕｂｓｔａｎｃｅｍＲＮＡｅｘｔｒａｃｔｅｄｆｒｏｍｈｕｍａｎｆｅｔａｌｌｉｖｅｒＹＡＮＧＸｉａｏＭｉｎｇ，ＸＩＥＬｉｎｇ，ＸＩＮＧＧｕｉＣ...

关键词： fetal liver tissue RNA, messenger hepatic Stimulator substance hepatocyte proliferation

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Transmembrane domain-mediated Lck association underlies bystander and coStimulatory ICOS signaling

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Cellular & Molecular Immunology 2020年第2期17卷 143-152页

作者： Zurong Wan Xingxing Shao Xingyu Ji Lihui Dong Jiacheng Wei Zhuqing Xiong Wanli Liu Hai Qi Tsinghua-Peking Center for Life Sciences Tsinghua University100084 BeijingChina Laboratory of Dynamic Immunobiology Institute for Immunology100084 BeijingChina Department of Basic Medical Sciences School of Medicine100084 BeijingChina School of Life Sciences 100084 BeijingChina Beijing Key Lab for Immunological Research on Chronic Diseases 100084 BeijingChina MOE Key Laboratory of Protein Sciences Tsinghua University100084 BeijingChina

The B7-family inducible coStimulator(ICOS)activates phosphoinositide-3 kinase(PI3K)and augments calcium mobilization triggered by the T-cell receptor(TCR).We surprisingly found that the entire cytoplasmic domain of ICOS is dispensable for its costimulation of calcium mobilization.This coStimulatory function relies on the unique transmembrane domain(TMD)of ICOS,which promotes association with the tyrosine kinase Lck.TMD-enabled Lck association is also required for p85 recruitment to ICOS and subsequent PI3K activation,and Lck underlies both the bystander and coStimulatory signaling activity of ICOS.TMD-replaced ICOS,even with an intact cytoplasmic domain,fails to support T FH development or GC formation in vivo.When transplanted onto a chimeric antigen receptor(CAR),the ICOS TMD enhances interactions between T cells and antigen-presenting target cells.Therefore,by revealing an unexpected function of the ICOS TMD,our study offers a new perspective for the understanding and potential application of costimulation biology.

关键词： ICOS stimulation Stimulator

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Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects

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Chronic Diseases and Translational Medicine 2020年第1期6卷 6-17页

作者： Li Ke-Yu Yuan Jia-Long Trafton Diego Wang Jian-Xin Niu Nan Yuan Chun-Hui Liu Xu-Bao Zheng Lei Department of Pancreatic Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Oncology Sidney Kimmel Cancer Center at Johns Hopkins University School of MedicineBaltimoreMD21231USA School of Basic Medical Science Capital Medical UniversityBeijing 100069China Department of Hepatic-biliary-pancreatic Surgery First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiang 310000China Department of Gastrointestinal and Pancreatic Surgery Zhejiang Provincial People's HospitalHangzhouZhejiang 310014China Department of General Surgery Peking University Third HospitalBeijing 100191China

The tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is non-immunogenic, which consists of the stellate cells, fibroblasts, immune cells, extracellular matrix, and some other immune suppressive molecules. This low tumor perfusion microenvironment with physical dense fibrotic stroma shields PDAC from traditional antitumor therapies like chemotherapy and various strategies that have been proven successful in other types of cancer. Immunotherapy has the potential to treat minimal and residual diseases and prevent recurrence with minimal toxicity, and studies in patients with metastatic and nonresectable disease have shown some efficacy. In this review, we highlighted the main components of the pancreatic tumor microenvironment, and meanwhile, summarized the advances of some promising immunotherapies for PDAC, including checkpoint inhibitors, chimeric antigen receptors T cells, and cancer vaccines. Based on our previous researches, we specifically discussed how granulocyte-macrophage colony stimulating factor based pancreatic cancer vaccine prime the pancreatic tumor microenvironment, and introduced some novel immunoadjuvants, like the Stimulator of interferon genes.

关键词： Pancreatic ductal adenocarcinoma Tumor microenvironment Immunotherapy Cancer vaccine Stimulator of interferon genes

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