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Process Control for Structure of Martensite/Austenite Islands of 15.3 mm X100 Pipeline Steel in BX Steel

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Journal of Iron and Steel Research International 2011年第S1期18卷 487-491页

作者： XU Xue-li,zhao ke,zhao Di,WANG Wen-fei (Technical Center of BX Steel,Benxi 117000,liaoning,China) Tech Ctr BX Steel Benxi 117000 Liaoning Peoples R China

This paper mainly studies the influence of deformation amount and cooling rate,which existed in X100 pipeline steel rolled at 2300mm rolling mill in BX STEEL,on morphology,size relations and distribution of M/A islands of steel plate *** results show that structures of M/A islands are homogenized and refined under the conditions of appropriately increasing the deformation amount in non-recrystallization region on basis of rational deformation amount in recrystallization region and cooling rate after deformation,***,according to the actual situation of 2300mm hot rolling mill,this paper gives rational deformation amount and cooling rate used to obtain ideal structure of M/A islands.

关键词： X100 pipeline steel martensite/austenite (M/A) islands deformation amount cooling rate

Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou ke Yajing zhao Xin Min Yanghong li Ruiyu Mi Yangai liu Xiaowen Wu Minghao Fang zhaohui Huang Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

Screening disease-associated proteins from sera of patients with rheumatoid arthritis： a comparative proteomic study

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Chinese Medical Journal 2010年第5期123卷 537-543页

作者： li Tian-wang ZHENG Ben-rong HUANG Zhi-xiang liN Qu zhao li-ke liAO Ze-tao zhao Ji-jun liN Zhi-ming GU Jie-ruo Department of Rheumatology Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510630 China Department of Rheumatology Beijing Hospital Beijing 100730 China

Background Rheumatoid arthritis （RA） is an autoimmune disease characterized by chronic inflammation at the synovial membrane. Although great progress has been made recently in exploring the etiology and pathogenesis of RA, its molecular pathological mechanism remains to be further defined and it is still a great challenge in determining the diagnosis and in choosing the appropriate therapy in early patients. This study was performed to screen candidate RA-associated serum proteins by comparative proteomics to provide research clues to early diagnosis and treatment of RA. Methods Sera isolated from 6 RA patients and 6 healthy volunteers were pooled respectively and high-abundance proteins were depleted by Plasma 7 Multiple Affinity Removal System. The protein expression profiles between the two groups were then compared by two-dimensional gel electrophoresis （2-DE） and the proteins over/under-expressed by more than 3-fold were identified by mass spectrometry analysis. To validate the differential expression levels of the identified proteins between the two groups, EliSA was performed in two of the identified proteins in individual sera from 32 RA patients and 32 volunteers. Results Eight proteins which over/under-expressed in sera of RA patients were identified. Among them, chain A of transthyretin （TTR） was under-expressed, while serum amyloid A protein, apolipoprotein A （ApoA）-IV, ApoA-IV precursor, haptoglobin 2, ceruloplasmin （Cp）, immunoglobulin superfamily 22 and HT016 were over-expressed. EliSA test confirmed that Cp expressed remarkably higher while TTR obviously lower in RA group compared with volunteer group. Conclusion There were 8 identified proteins differentially expressed between RA group and volunteer group, which might be candidate RA-associated proteins and might be promising diagnostic indicators or therapeutic targets for RA.

关键词： rheumatoid arthritis serum proteomics gel electrophoresis, two-dimensional

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi li Jing Xue Yuejia Ma ke Ye Xue zhao Fangliang Ge Feifei Zheng Lulu liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Sedimentary environments controlled by tectonics and induced differential subsidence:A perspective in the Permian liangshan and Qixia Formations,northwestern Sichuan Basin,China

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Journal of Central South University 2020年第11期27卷 3398-3416页

作者： ZHONG Yuan YANG Yue-ming WEN Long LUO Bing XIAO Di TAN Xiu-cheng zhao li-ke li Ming-long PetroChina Southwest Oil and Gas field Company Exploration and Development Research Institute Chengdu 610041China Division of key Laboratory of Carbonate Reservoirs CNPCSouthwest Petroleum UniversityChengdu 610500China PetroChina Southwest Oil and Gas field Company Chengdu 610051China School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China

Based on field observation,core description and well logging analysis,the tectonic-sedimentary framework of the liangshan and Qixia Formations in the northwestern Sichuan Basin,China is deeply *** long-term sequence cycles were identified,denoted as LSC1 and LSC2,*** sequence stratigraphic framework was established,suggesting the liangshan Formation to be not isochronously *** before deposition of LSC1 was reconstructed by the impression ***1 was featured by thin,low-energy shoal deposits in the high topography,and thick inter-shoal sea and open sea deposits in the low ***,paleogeomorphy before deposition of LSC2 was reconstructed using the residual thickness method,which was demonstrated to have primary high-energy,thick shoal deposits in the high topography,and thin inter-shoal and open sea deposits in the low *** results show that differential tectonic subsidence has already taken place during the Qixia Period,and thus the Dongwu Movement should occur earlier than previously ***,pre-depositional paleogeomorphy has obvious controlling effects on the sequence stratigraphic filling and sedimentary facies *** of this study were expected to provide practical guidance to fine characterization of the sedimentary evolution process and prediction of high-quality reservoir distribution.

关键词： sequence stratigraphy paleogeomorphy sedimentary facies Qixia Formation Permian northwest Sichuan Basin

Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao li zhao Yajun Zhang Zhe Yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

Gradient maturation experiment on hairs implies taphonomic changes in fossil hairs

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Science China Earth Sciences 2025年第1期68卷 62-73页

作者： Xin li Yibo ZHOU Tao zhao Xingjian HE Yanhong PAN State key Laboratory for Mineral Deposits Research Center for Critical Earth Material Cycling Centre for Research and Education on Biological Evolution and Environment and Frontiers Science School of Earth Sciences and Engineering Nanjing University Institute of Palaeontology Yunnan Key Laboratory of Earth System Science Yunnan Key Laboratory for PalaeobiologyYunnan University

Mammalian hair, as a key feature related to endothermy, physical protection, and camouflage, has a long geohistorical record that dates back even to the Mesozoic. However, the limited information on the taphonomy of hair hinders the understanding of its evolutionary significance in deep time. To address this, we conducted taphonomic experiments to simulate the transformation process of black hair. The changes in the morphological structure, microscopic characteristics, and chemical composition of hair during the simulated fossilization process were documented by scanning electron microscopy, Fourier transform infrared(FTIR) spectroscopy, and Raman spectroscopy. Our results revealed that damage to the morphology of hair began at a mild temperature(150–175°C), and hair transformed into a fluid-like mass at a relatively high temperature(200°C). In addition, the morphological structure of melanosomes had relatively greater preservation potential than keratins did, and the microscopic features of melanosomes were persistently stable. The Raman and FTIR spectra indicated that the characteristic melanin and keratin peaks changed as the temperature increased. Although the chemical signals were not lost completely, the variations in the characteristic amide bands in the FTIR spectra indicate that the keratins severely degraded at high temperatures(>200°C), whereas the characteristic melanin bands in the Raman spectra suggested that melanin signals were still recognizable, even at high temperatures(>200°C). These results were confirmed by principal component analysis(PCA) and principal component analysis linear discriminant analysis(PCA–LDA). In addition, the Raman signals of all the samples in the simulated experiments were distinguished from the signals of common geological carbonaceous materials(humic acid), which suggested that Raman spectroscopy can be used to detect melanin in fossils.

关键词： Mammalian hair Melanin keratin Fossilization Experimental taphonomy

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基于质谱技术的糖链结构解析研究进展

生物化学与生物物理进展 2017年第10期44卷 848-856页

作者：赵克力黄纯翠武红梅李岩中国科学院生物物理研究所北京100101 中国科学院大学北京100049 广东中科康仪生物技术有限公司佛山528000

糖组学是继基因组学、蛋白质组学之后,又一门新兴的学科,其主要是研究糖分子的结构与功能.糖是一类比核酸、蛋白质更加独特的生物分子,它们不仅是生物体储存能量和释放能量的主要物质,更是生物体内的信息传递分子,并且在生理和病理过程... 详细信息

糖组学是继基因组学、蛋白质组学之后,又一门新兴的学科,其主要是研究糖分子的结构与功能.糖是一类比核酸、蛋白质更加独特的生物分子,它们不仅是生物体储存能量和释放能量的主要物质,更是生物体内的信息传递分子,并且在生理和病理过程中扮演着重要的角色,如细胞间的识别作用、炎症以及自身免疫疾病等.在结构上,糖类物质更为复杂,具有宏观不均一性(蛋白质上有多个糖基化位点)和微观不均一性(同一结合位点上可以连接不同的多糖),所以糖链的结构解析一直是糖组学研究的难题.相较于传统的分析方法,质谱法具有高灵敏度、高精度、高通量等优势,被认为是在糖链结构解析过程中重要的分析方法.本文综述了质谱、多级质谱、液相色谱-质谱、毛细管电泳-质谱等方法在糖组学中糖链结构解析的研究进展.

关键词：糖组学聚糖质谱多级质谱结构分析

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基于主动控制面的大跨悬索桥颤振控制

中国公路学报 2017年第2期30卷 57-68页

作者：郭增伟葛耀君赵林李柯重庆交通大学山区桥梁结构与材料教育部工程研究中心重庆400074 同济大学土木工程防灾国家重点实验室上海200092

针对目前主动控制面研究中存在的不足,通过风洞试验探讨了控制面扭转运动对主梁周围流场的干扰效应,按照现代控制理论对动态系统的描述方式,建立了主动控制面颤振控制的状态空间模型,并以一座主跨3 000m的悬索桥为工程背景,采用二次型... 详细信息

针对目前主动控制面研究中存在的不足,通过风洞试验探讨了控制面扭转运动对主梁周围流场的干扰效应,按照现代控制理论对动态系统的描述方式,建立了主动控制面颤振控制的状态空间模型,并以一座主跨3 000m的悬索桥为工程背景,采用二次型最优控制算法对主动控制面系统的颤振控制效果进行了数值仿真分析,讨论了控制面颤振控制参与模态的选择方法,分析了控制面布置长度和作动器数量对其颤振控制效果的影响。研究结果表明:在控制面宽度为1/20梁宽,距离主梁3.0倍梁高时控制面扭转运动会对主梁周围流场特别是前部区域的压力脉动产生影响,但控制面振动所造成的那部分卓越脉动压力在总脉动压力中的比例不足10%,在控制面气动力模型中可以忽略干扰效应产生的气动力;相比于模态幅值比,依据模态能量比选择参与模态进行颤振分析更为有效;安装主动控制面后主跨3 000 m的悬索桥颤振临界风速提高了近1倍,且在0~80m·s-1风速范围内可能发生的颤振形态均得到了有效控制,控制面的颤振控制效果随其布置长度和作动器数量的增加而逐步提高;作动器超过2组以后,作动器数量虽不会进一步提高悬索桥颤振临界风速,但控制面可以被划分为更多独立的部分,控制系统的可靠性将得到进一步增强。

关键词：桥梁工程颤振控制仿真分析主动控制面振动控制