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Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator

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Nuclear Science and Techniques 2024年第4期35卷 136-143页

作者： yang Zhang Sheng-quan yan Ming He qing-Zhang zhao Wen-Hui Zhang Chao-Xin Kan Jian-Ming Zhou Kang-Ning li Xiao-Fei Wang Jian-Cheng liu zhao-Hua Peng Zhuo liang Ai-ling li Jian Zheng Qi-Wen Fan Yun-Ju li You-Bao Wang Zhi-Hong li yang-ping Shen Ding nan wei nan Yu-Qiang Zhang Jia-Ying-Hao li Jun-Wen Tian Jiang-lin Hou Chang-Xin Guo Zhi-Cheng Zhang Ming-Hao Zhu Yu-Wen Chen Yu-Chen Jiang Tao Tian Jin-Long Ma Yi-Hui liu Jing-Yu Dong Run-Long liu Mei-Yue-nan Ma Yong-Shou Chen wei-ping liu Bing Guo China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China College of Science Southern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China

The Moon provides a unique environment for investigating nearby astrophysical events such as *** samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)*** this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy *** particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the ***,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS *** results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)*** sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated.

关键词： Accelerator mass spectrometry Wien filter Isobar separation Supernovae Chang'e-5 lunar samples

Formation Mechanism and Binding Energy for Body-Centred Regular Icosahedral Structure of li_(13) Cluster

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Communications in Theoretical Physics 2008年第11期50卷 1225-1228页

作者： liu wei-na li ping gou qing-quan zhao yan-ping Institute of Atomic and Molecular Physics Sichuan University Chengdu 610065 China

The formation mechanism for the body-centred regular icosahedral structure of li13 cluster is proposed. The curve of the total energy versus the separation R between the nucleus at the centre and nuclei at the apexes for this structure of li13 has been calculated by using the method of gou＇s modified arrangement channel quantum mechanics （MACQM）. The result shows that the curve has a minimal energy of-96.951 39 a.u. at R = 5.46ao. When R approaches to infinity, the total energy of thirteen lithium atoms has the value of-96.564 38 a.u. So the binding energy of lii3 with respect to thirteen lithium atoms is 0.387 01 a.u. Therefore the binding energy per atom for lii3 is 0.029 77 a.u. or 0.810 eV, which is greater than the binding energy per atom of 0.453 eV for li2, 0.494 eV for li3, 0.7878 eV for li4. 0.632 eV for lis, and 0.674 eV for liv calculated by us previously. This means that the li13 cluster may be formed stably in a body-centred regular icosahedral structure with a greater binding energy.

关键词： li13 cluster formation mechanism binding energy

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-Hong Zhou wei-Hong Jiang yan Jiang Jing-Wu Sun Qin-Tai yang Xue-Zhong li Ya-nan Sun li Shi Min Wang Xi-Cheng Song Fu-quan Chen Xiao-Shu Zhang Hong-quan wei Shao-qing Yu Dong-Dong Zhu Luo Ba Zhi-wei Cao Xu-ping Xiao Xin wei Zhi-Hong lin Feng-Hong Chen Chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong Qu Chang-qing zhao Zhen-lin Wang Hua-Bin li Feng liu Xiao-Bo Cui Sheng-nan Ye Zheng liu Yu Xu Xiao Cai wei Huang Ru-Xin Zhang Yu-lin zhao Guo-Dong Yu Guang-Gang Shi Mei-ping Lu yang Shen Yu-Tong zhao Jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai liu Shao-wei Gu Yu-Cheng yang Lei Cheng Jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Clinical features of 162 fatal cases of COVID-19:a multi-center retrospective study

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Emergency and Critical Care Medicine 2022年第3期2卷 109-115页

作者： Xianlong Zhou Guoyong Ding qing Fang Jun Guo Luyu yang ping Wang Shou-Zhi Fu Ang li Jian Xia Jiangtao Yu Jianyou Xia Min Ma Zhuanzhuan Hu Lei Huang Ruining liu Cheng Jiang Shaoping li Mingxia Yu Xizhu Xu yan zhao quan Hu weijia Xing Zhigang zhao Emergency Center Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina School of Public Health Shandong First Medical University and Shandong Academy of Medical SciencesTai’anShandongChina Emergency Department General Hospital of Central Theater Command of PLAWuhanHubeiChina Intensive Care Unit Huazhong University of Science and Technology Union Jiangbei HospitalWuhanHubeiChina Intensive Care Unit Wuhan Third HospitalWuhanHubeiChina Department of Urology General Hospital of Central Theater Command of PLAWuhanHubeiChina Department of Clinical Laboratory Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Hubei Clinical Research Center for Emergency and Resuscitation Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Intensive Care Unit The First People’s Hospital of Jiangxia DistrictWuhanHubeiChina

Background:The coronavirus disease 2019(COVID-19)has affected approximately 2 million individuals worldwide;however,data regarding fatal cases have been ***:To report the clinical features of 162 fatal cases of COVID-19 from 5 hospitals in Wuhan between December 30,2019 and March 12,***:The demographic data,signs and symptoms,clinical course,comorbidities,laboratory findings,computed tomographic(CT)scans,treatments,and complications of the patients with fatal cases were retrieved from electronic medical ***:The median patient age was 69.5(interquartile range:63.0–77.25)years,and 80%of the patients were over 61 years.A total of 112(69.1%)patients were ***(45.1%)was the most common comorbidity,while 59(36.4%)patients had no *** admission,131(81.9%)patients had severe or critical COVID-19,whereas 39(18.1%)patients with hypertension or chronic lung disease had moderate *** total,126(77.8%)patients received antiviral treatment,while 132(81.5%)patients received glucocorticoid treatment.A total of 116(71.6%)patients were admitted to the intensive care unit(ICU),and 137(85.1%)patients received mechanical *** patients received mechanical ventilation before ICU *** 93.2%of the patients developed respiratory failure or acute respiratory distress *** were no significant differences in the inhospital survival time among the hospitals(P=0.14).Conclusion:Young patients with moderate COVID-19 without comorbidity at admission could also develop fatal *** in-hospital survival time of the fatal cases was similar among the hospitals of different levels in Wuhan.

关键词： Clinical features Coronavirus disease 2019 Fatal cases Survival time

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)

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Research in Astronomy and Astrophysics 2012年第9期12卷 1197-1242页

作者： Xiang-Qun Cui Yong-Heng zhao Yao-quan Chu Guo-ping li Qi li li-ping Zhang Hong-Jun Su Zheng-Qiu Yao Ya-nan Wang Xiao-Zheng Xing Xin-nan li Yong-Tian Zhu Gang Wang Bo-Zhong Gu A-li Luo Xin-Qi Xu Zhen-Chao Zhang Gen-Rong liu Hao-Tong Zhang De-Hua yang Shu-Yun Cao Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Ying Chen Jia-Ru Chu Lei Feng Xue-Fei Gong Yong-Hui Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua li yan li Ye-ping li Guan-Qunliu Zhi-Gang liu Huo-Ming Shi Zheng-Hong Tang qing-Sheng Tao Xiang-yan Yuan Chao Zhai Jing Zhang yan-Xia Zhang Yong Zhang Ming zhao Fang Zhou Guo-Hua Zhou Jie Zhu Si-Cheng Zou national Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China yzhao @ *** nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Tecfinologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST’s special design allows both a large aperture (effective aperture of 3.6 m–4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror’s surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects.

关键词： techniques: wide field telescope - active optics - multi fiber - spectroscopy survey - data reduction

Efficacy and Safety of All-oral,12-week Ravidasvir Plus Ritonavir-boosted Danoprevir and Ribavirin in Treatment-naive Noncirrhotic HCV Genotype 1 Patients:Results from a Phase 2/3 Clinical Trial in China

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Journal of Clinical and Translational Hepatology 2019年第3期7卷 213-220页

作者： Xiaoyuan Xu Bo Feng Yujuan Guan Sujun Zheng Jifang Sheng Xingxiang yang Yuanji Ma yan Huang Yi Kang Xiaofeng Wen Jun li Youwen Tan qing He qing Xie Maorong Wang ping An Guozhong Gong Huimin liu Qin Ning Rui Hua Bo Ning Wen Xie Jiming Zhang Wenxiang Huang Yongfeng yang Minghua lin Yingren zhao yanhong Yu Jidong Jia Dongliang yang liang Chen Yinong Ye Yuemin nan Zuojiong Gong quan Zhang Peng Hu Fusheng Wang Yongguo li Dongliang li Zhansheng Jia Jinlin Hou Chengwei Chen Jinzi JWu Lai wei Peking University First Hospital BeijingChina Peking University People's Hospital BeijingChina Guangzhou Eighth People's Hospital GuangzhouChina Beijing YouAn Hospital Capital Medical UniversityBeijingChina The First Affiliated Hospital of Medical School of Zhejiang University HangzhouChina Sichuan Provincial People's Hospital ChengduChina West China Hospital Sichuan UniversityChengduChina Xiangya Hospital Central South UniversityChangshaChina Henan Provincial People's Hospital ZhengzhouChina liuzhou People's Hospital LiuzhouChina Jiangsu Province Hospital NanjingChina Zhenjiang No.3 People's Hospital ZhenjiangChina The Third People's Hospital of Shenzhen ShenzhenChina Ruijin Hospital Shanghai Jiaotong University School of MedicineShanghaiChina People's liberation Army Bayi Hospital NanjingChina Shenyang Sixth People's Hospital ShenyangChina The 2nd Xiangya Hospital of Central South University ChangshaChina Xixi Hospital of Hangzhou HangzhouChina Tongji Medical College of Huazhong University of Science&Technology WuhanChina The First Hospital of Jilin University ChangchunChina Baoji Center Hospital BaojiChina Beijing Ditan Hospital BeijingChina Huashan Hospital Affiliated to Fudan University ShanghaiChina Chongqing Medical University No.1 Affiliated Hospital ChongqingChina The Second Hospital of nanjing NanjingChina Fujian Fuzhou Municipal Infectious Disease Hospital FuzhouChina No.1 Affiliated Hospital of Xi'an Jiaotong University Xi'anChina The First Affiliated Hospital of Guangxi Medical University NanningChina Beijing Friendship Hospital Capital Medical UniversityBeijingChina Wuhan Union Hospital WuhanChina Shanghai Public Health Clinical Center ShanghaiChina Foshan No.1 People's Hospital FoshanChina The Third Hospital of Hebei Medical University ShijiazhuangChina Wuhan University Renmin Hospital WuhanChina The Affiliated Hospital of Guizhou Medical University GuiyangChina The Second Affiliated Hospital of Chongqing Medical University ChongqingChina PLA 302 Hospital Be

Background and Aims:Ravidasvir(RDV)is a new generation pangenotypic hepatitis C virus(HCV)NS5A inhibitor,with high barrier to baseline resistance-associated *** is the first phase 2/3 study conducted in China's Mainland confirming the efficacy and safety of RDV+ritonavir-boosted danoprevir+ribavirin for 12 weeks in treatment-naive noncirrhotic patients with genotype 1 infection in a large ***:In this multicenter,randomized,doubleblinded,placebo-controlled phase 2/3 trial(NCT03362814),we enrolled 424 treatment-nafve,noncirrhotic adult HCV genotype 1 *** patients were randomized at 3∶1 ratio to receive a combination of RDV 200mg once daily plus ritonavir-boosted danoprevir 100mg/100mg twice daily and oral ribavirin 1000/1200mg/day(body weightline NS5A resistance-associated species in the treatment group(76/76,per protocol set)achieved sustained virological response at 12 weeks after *** treatment-related serious adverse events were *** abnormalities showed mild or moderate severity(grade 1 and grade 2)in liver function ***:In treatment-na(i)ve,noncirrhotic HCV Chinese patients infected with HCV genotype 1,all-oral regimen of RDV+ritonavir-boosted danoprevir+ribavirin for 12 weeks was highly efficacious,safe,and well tolerated.

关键词： Ravidasvir Danoprevir HCV SVR Treatment-naive Noncirrhotic GT1

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng zhao Gang zhao li-Cai Deng Xiao-wei liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-quan Chu Guo-ping li Zhong-Rui Bai Yue Wu yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen li Chen Xue-Lei Chen Xiao-yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu yan-Xin Guo Zhan-Wen Han Bo-liang He Jin-liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-wei li Hai-Ning li Jian li Qi li Shuang li Sha-Sha li Xin-nan li yan li Yin-Bi li Ye-ping li Yuan liang Chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-ling Wang Jian-ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-qing Wang Xia Wang Ya-nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng wei Ming-Zhi wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu yan Xu Tai-Sheng yan De-Hua yang Hai-Feng yang Hui-Qin yang Ming yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan wei-Min Yuan Chao Zhai En-Peng Zhang Hua-wei Zhang Jian-nan Zhang li-Pin Zhang wei Zhang Yong Zhang yan-Xia Zhang Zheng-Chao Zhang Ming zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo national Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

Protocol on transcranial alternating current stimulation for the treatment of major depressive disorder:a randomized controlled trial

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Chinese Medical Journal 2020年第1期133卷 61-67页

作者： Hong-Xing Wang Kun Wang Wen-Rui Zhang Wen-Feng zhao Xiao-Tong yang li Wang Mao Peng Zhi-Chao Sun qing Xue Yu Jia Ning li Kai Dong Qian Zhang Shu-Qin Zhan Bao-quan Min Chun-Qiu Fan Ai-Hong Zhou Hai-qing Song Lu Yin Tian-Mei Si Jing Huang Jie Lu Hai-Xia Leng wei-Jun Ding Yuan liu Tian-Yi yan Yu-ping Wang Departm ent of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Key Laboratory of Neuromodulation Beijing 100053China Center of Epilepsy Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100053China Department of Neurology Beijing Puren HospitalBeijing 100062China Medical Research&Biometrics Centre National Centre for Cardiovascular DiseasesBeijing 102300China Peking University Sixth Hospital Beijing 100083China Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijing 100053China School of life Science Beijing Institute of TechnologyBeijing 100081China

Background:Transcranial alternating current stimulation(tACS)offers a new approach for adult patients with major depressive disorder(MDD).The study is to evaluate the efficacy and safety of tACS treating ***:This is an 8-week,double-blind,randomized,placebo-controlled ***-two drug-naive patients with MDD aged 18 to 65 years will receive 20 daily 40-min,77.5-Hz,15-mA sessions of active or sham tACS targeting the forehead and both mastoid areas on weekdays for 4 consecutive weeks(week 4),following a 4-week observation period(week 8).The primary outcome is the remission rate defined as the 17-item Hamilton depression rating scale(HDRS-17)score≤7 at week *** outcomes are the rates of response at weeks 4 and 8 and rate of remission at week 4 based on HDRS-17,the proportion of participants having improvement in the clinical global impression-improvement,the change in HDRS-17 score(range,0-52,with higher scores indicating more depression)over the study,and variations of brain imaging and neurocognition from baseline to week *** will be assessed by vital signs at weeks 4 and 8,and adverse events will be collected during the entire ***:The tACS applied in this trial may have treatment effects on MDD with minimal side *** registration:Chinese Clinical Trial Registry,ChiCTR1800016479;http://***/***?proj=22048.

关键词： Major depressive disorder Transcranial alternating current stimulation Treatment Trial