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MoS2 synaptic transistor with one-step manufacture

Science China(Information Sciences) 2025年第1期68卷 357-365页

作者： Yihao GUO yang WANG Wenjie DENG Yi WU Jingtao LI Kexin LI Yuehui zhao Songlin YU Xiaoting WANG Yongzhe ZHANG Hui yan Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of Education Faculty of Materials and ManufacturingBeijing University of Technology The 11th Research Institute of Electronics Technology Group Corporation

The synaptic transistor,which is a neuromorphic device with brain-like functions,has garnered significant attention due to characteristics such as low energy consumption,high integration,multiple functions,and high computational ***,the current synaptic transistor possesses a complicated structure and involves complex manufacturing steps,which is not conducive to low-cost,large-scale bionic ***,we introduce a simple MoS2synaptic transistor exhibiting robust synaptic *** transistor utilizes magnetron sputtering manufacture to combine the process of device metal electrode deposition and the introduction of defect states,which helps streamline the manufacturing process into a single *** long-term potentiation and long-term depression in photoelectric coordination are initially ***,biological functions,such as double pulse facilitation and the transformation behavior of short-term memory to long-term memory,are thoroughly evaluated,along with learning-forgetting-relearning ***,the device exhibits robust synaptic plasticity until incident light angles down to 30° to imitate the multi-to-one axon-cellular ***,a classical simulation of Pavlov's dog conditioned reflex is demonstrated along with the multiview extraction *** experimental results demonstrate a promising synaptic transistor with a simple structure,manufacturing technique,and excellent *** further indicates the potential for large-scale integration of bionic neuromorphic systems.

关键词： process optimization artificial synaptic device one-stepmanufacture synaptic plasticity bionic simulation

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen yan Han Li yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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美国高校创新创业课程体系构建及其启示

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职业教育研究 2017年第8期 82-86页

作者：孙婷赵晏鹤沈阳师范大学辽宁沈阳110034

美国高校的创新创业课程体系构建在国际处于领先地位,尤其在学位制度、实践学习、竞争机制、环境建设等方面均有较高的代表性与针对性;美国不同地区的大学或社区学院也根据自身特色与区域发展特点制定了一系列创新创业课程体系建设措施... 详细信息

美国高校的创新创业课程体系构建在国际处于领先地位,尤其在学位制度、实践学习、竞争机制、环境建设等方面均有较高的代表性与针对性;美国不同地区的大学或社区学院也根据自身特色与区域发展特点制定了一系列创新创业课程体系建设措施。美国的先进经验可使我国高职院校在创新创业课程体系构建中获得借鉴。

关键词：美国高校创新创业课程体系高职院校

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Epigenetics in the modern era of crop improvements

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Science China Life Sciences 2025年

作者： yan Xue Xiaofeng Cao Xiangsong Chen Xian Deng Xingwang Deng Yong Ding Aiwu Dong Chengguo Duan Xiaofeng Fang Lei Gong Zhizhong Gong Xiaofeng Gu Chongsheng he Hang he Shengbo he Xinjian he yan he Yuehui he Guifang Jia Danhua Jiang Jianjun Jiang Jinsheng Lai zhaobo Lang Chenlong Li Qing Li Xingwang Li Bao Liu Bing Liu Xiao Luo Yijun Qi Weiqiang Qian Guodong Ren Qingxin Song Xianwei Song Zhixi Tian Jiawei Wang Yuan Wang Liang Wu Zhe Wu Rui Xia Jun Xiao Lin Xu Zhengyi Xu Wenhao yan Hongchun yang Jixian Zhai Yijing Zhang Yusheng zhao Xuehua Zhong Daoxiu Zhou Ming Zhou Yue Zhou Bo Zhu Jiankang Zhu Qikun Liu College of Life Sciences Institute of Life Science and Green Development Hebei University Biotechnology Research Institute Chinese Academy of Agricultural Sciences College of Biology Hunan Key Laboratory of Plant Functional Genomics and Developmental Regulation Hunan Engineering and Technology Research Center of Hybrid Rapeseed Hunan University Institute of Advanced Agricultural Sciences School of Advanced Agricultural Sciences Peking University State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural University National Institute of Biological Sciences Key Laboratory of Seed Innovation Institute of Genetics and Developmental Biology Chinese Academy of Sciences School of Advanced Agricultural Sciences Peking-Tsinghua Center for Life Sciences Peking University Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry and Molecular Engineering Peking University Key Laboratory of Seed Innovation State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences State Key Laboratory of Wheat Improvement Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in Weifang State Key Laboratory of Crop Stress Adaptation and Improvement School of Life Sciences Henan University State Key Laboratory of Maize Bio-breeding National Maize Improvement Center Department of Plant Genetics and Breeding China Agricultural University Frontiers Science Center for Molecular Design Breeding China Agricultural University Center for Crop Functional Genomics and Molecular Breeding China Agricultural University Sanya Institute of China Agricultural University Hainan Yazhou Bay Seed Laboratory Institute of Advan

Epigenetic mechanisms are integral to plant growth, development, and adaptation to environmental stimuli. Over the past two decades,our comprehension of these complex regulatory processes has expanded remarkably, producing a substantial body of knowledge on both locus-specific mechanisms and genome-wide regulatory patterns. Studies initially grounded in the model plant Arabidopsis have been broadened to encompass a diverse array of crop species, revealing the multifaceted roles of epigenetics in physiological and agronomic traits. With recent technological advancements, epigenetic regulations at the single-cell level and at the large-scale population level are emerging as new focuses. This review offers an in-depth synthesis of the diverse epigenetic regulations, detailing the catalytic machinery and regulatory functions. It delves into the intricate interplay among various epigenetic elements and their collective influence on the modulation of crop traits. Furthermore, it examines recent breakthroughs in technologies for epigenetic modifications and their integration into strategies for crop improvement. The review underscores the transformative potential of epigenetic strategies in bolstering crop performance, advocating for the development of efficient tools to fully exploit the agricultural benefits of epigenetic insights.

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Liquid refractive index measurement method based on orthogonal polarization laser self-mixing interference

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Optoelectronics Letters 2025年

作者： zhao yan WANG Haipeng DU Shengzhi TONG Jigang KANG Jun School of Electrical Engineering and Automation， Tianjin University of Technology Tianjin Key Laboratory for Control Theory and Applications in Complicated Systems Department of Electrical Engineering， Tshwane University of Technology

In this paper， a novel method combining orthogonal polarization laser self-mixing interference is proposed. The method utilizes a rotating cuvette to measure the refractive index of liquids at different concentrations. The cuvette is filled with the liquid to be measured and rotated by a certain angle. The change in the number of interference fringes， caused by comparing an empty cuvette with a liquid-filled cuvette， is used to calculate the refractive index of the liquid. A four-fold logic subdivision algorithm is then used to improve measurement resolution. The experimental results show that for pure water and different NaCl and glucose solutions concentrations， the average relative errors are 0.47%， 0.59%， and 2.17%， respectively， with the maximum relative error within ±2.54%. The standard deviation of all solutions is less than 3.4%.

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亨廷顿相关蛋白1在丙戊酸钠诱导神经干细胞分化过程中的表达和作用

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解剖学报 2021年第2期52卷 182-188页

作者：王珊珊李雯何辉秦建兵田美玲赵荷艳成翔金国华南通大学医学院人体解剖学系江苏省神经再生重点实验室神经再生协同创新中心江苏南通226001

目的探讨丙戊酸钠(VPA)诱导神经干细胞(NSCs)向神经元分化过程中亨廷顿相关蛋白1(HAP-1)的表达及其作用。方法分离培养SD大鼠海马NSCs,应用Real-time PCR和Western blotting检测VPA诱导NSCs向神经元分化过程中0、1、3和5d时HAP-1 mRNA... 详细信息

目的探讨丙戊酸钠(VPA)诱导神经干细胞(NSCs)向神经元分化过程中亨廷顿相关蛋白1(HAP-1)的表达及其作用。方法分离培养SD大鼠海马NSCs,应用Real-time PCR和Western blotting检测VPA诱导NSCs向神经元分化过程中0、1、3和5d时HAP-1 mRNA和蛋白的表达变化;Real-time PCR检测成年SD大鼠多组织及NSCs、神经元和星形胶质细胞中HAP-1 mRNA的表达;应用小干扰RNA技术下调NSCs中HAP-1的表达后,Real-time PCR和Western blotting分别检测神经元特异分子微管解聚蛋白2(Stmn-2)、神经元分化因子1(Neurod-1)、微管相关蛋白2(Map-2)和突触蛋白1(Syn-1)基因和神经元特异性标志物β-微管蛋白Ⅲ(Tuj-1)的表达水平,应用免疫荧光检测NSCs向Tuj-1阳性神经元分化的比例,并观察神经元发育情况。结果与对照组相比,VPA组NSCs向神经元分化过程中HAP-1 mRNA和蛋白在VPA处理后1 d和3 d表达明显上调;HAP-1 mRNA在中枢神经系统的海马中呈优势表达,在神经元中表达较高,NSCs中表达较低,星形胶质细胞中表达最低;干扰HAP-1表达后,VPA诱导NSCs向神经元分化的比例减少,神经元发育变差。结论VPA可能通过上调HAP-1的表达促进NSCs向神经元分化。

关键词：亨廷顿相关蛋白1 丙戊酸钠神经干细胞神经元分化实时定量聚合酶链反应大鼠

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质子泵抑制剂对非甾体类抗炎药相关小肠黏膜损伤的影响

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胃肠病学和肝病学杂志 2018年第5期27卷 585-587页

作者：马文慧赵艳和水祥西安交通大学第一附属医院消化内科陕西西安710061

非甾体类抗炎药(non-steroidal anti-inflammatory drugs,NSAIDs)的主要不良反应是对食管、胃、十二指肠等消化道黏膜的损伤。随着胶囊内镜及小肠镜的日益普及,NSAIDs对小肠黏膜的损伤也开始受到大家的关注。目前,质子泵抑制剂(proton p... 详细信息

非甾体类抗炎药(non-steroidal anti-inflammatory drugs,NSAIDs)的主要不良反应是对食管、胃、十二指肠等消化道黏膜的损伤。随着胶囊内镜及小肠镜的日益普及,NSAIDs对小肠黏膜的损伤也开始受到大家的关注。目前,质子泵抑制剂(proton pump inhibitor,PPI)因对上消化黏膜有保护作用而被广泛应用,但其对NSAIDs相关小肠黏膜损伤的作用存在争议。本文系统回顾分析了PPI对服用NSAIDs的实验动物、健康志愿者及服用NSAIDs的患者小肠黏膜损伤的作用,发现PPI对服用NSAIDs的实验动物小肠黏膜损伤的作用与对健康志愿者或患者小肠黏膜损伤的作用不同。

关键词：小肠黏膜损伤质子泵抑制剂非甾体类抗炎药

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Weak feedback self-mixing interference fringe slope discrimination method based on deep learning

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Optoelectronics Letters 2025年

作者： zhao yan LIN Maohua DU Shengzhi TONG Jigang LIU Bin HAN Fangfang School of Electrical Engineering and Automation， Tianjin University of Technology Tianjin Key Laboratory for Control Theory and Applications in Complicated Systems Department of Electrical Engineering， Tshwane University of Technology

In order to identify the tilt direction of the self-mixing interference (SMI) signals under weak feedback regime interfered by noise， a deep learning method is proposed. The one-dimensional U-Net (1D U-Net) neural network can discriminate the direction of self-mixing fringes accurately and quickly. For experimental SMI signals， the 1D U-Net can be used for discriminant direction after a one-step normalization. Simulation and experimental results show that the proposed method is suitable for SMI signals with noise within the whole weak feedback regime， and can maintain a high discrimination accuracy for signals interfered by 5dB noise. Combined with fringe counting method， accurate and rapid SMI signal displacement reconstruction can be realized.

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普通高校继续教育信息化建设研究

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河北大学成人教育学院学报 2017年第1期19卷 18-22页

作者：赵彦彬何学剑河北大学继续教育学院河北保定071002

继续教育信息化是教育信息化的重要组成部分,普通高校承担着继续教育信息化建设的重要使命。通过对继续教育信息化内涵和特征的诠释,分析普通高校继续教育信息化建设的意义以及出现的问题,提出以继续教育信息化理念为指引,以基础设施和... 详细信息

继续教育信息化是教育信息化的重要组成部分,普通高校承担着继续教育信息化建设的重要使命。通过对继续教育信息化内涵和特征的诠释,分析普通高校继续教育信息化建设的意义以及出现的问题,提出以继续教育信息化理念为指引,以基础设施和网络平台的建设为基础,以适宜的法规和政策为依据,以信息化人才队伍的培养为重点,以信息资源的开发和信息技术的应用为手段的策略,进而推动终身教育体系和学习型社会的建设,使普通高校更好地为社会经济发展服务。

关键词：普通高校继续教育教育信息化

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盐酸帕罗西汀治疗对合并焦虑、抑郁的冠心病患者左室心功能的影响

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中国继续医学教育 2017年第9期9卷 182-184页

作者：李春燕赵艳何艳琼云南省大理州第二人民医院电生理科云南大理671000

目的探讨盐酸帕罗西汀对冠心病伴焦虑、抑郁患者左室心功能的影响。方法以我院焦虑、抑郁的冠心病患者为研究对象,随机分为:研究组和对照组,两组基础冠心病治疗均相同,研究组加用盐酸帕罗西汀治疗。对比(1)两组治疗前后汉密尔顿焦虑量... 详细信息

目的探讨盐酸帕罗西汀对冠心病伴焦虑、抑郁患者左室心功能的影响。方法以我院焦虑、抑郁的冠心病患者为研究对象,随机分为:研究组和对照组,两组基础冠心病治疗均相同,研究组加用盐酸帕罗西汀治疗。对比(1)两组治疗前后汉密尔顿焦虑量表评分及汉密尔顿抑郁量表评分。(2)两组治疗前后左室射血分数。结果两组治疗前汉密尔顿焦虑量表评分、汉密尔顿抑郁量表评分、左室射血分数比较差异无统计学意义(P>0.05);两组治疗后汉密尔顿焦虑量表评分、汉密尔顿抑郁量表评分、左室射血分数比较差异有统计学意义(P<0.05)。结论盐酸帕罗西汀不仅可以改善冠心病伴焦虑、抑郁患者左室心功能,还能改善情绪。

关键词：盐酸帕罗西汀焦虑抑郁冠心病

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