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Prevalence of Helicobacter pylori infection in China from 2014-2023:A systematic review and meta-analysis

World Journal of Gastroenterology 2024年第43期30卷 4636-4656页

作者： Lu Xie Guang-Wei Liu ya-Nan Liu Peng-Yu Li Xin-Ning Hu Xin-Yi He Rui-Bo Huan Tai-Long zhao Hui-Jun Guo Department of Acquired Immune Deficiency Syndrome Treatment and Research Center The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina The First Clinical Medical School Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Department of Spleen StomachLiver and GallbladderThe First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina Henan Key Laboratory of Viral Diseases Prevention and Treatment of Chinese Medicine Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina

BACKGROUND Helicobacter pylori(***)stands as the predominant infectious agent linked to the onset of gastritis,peptic ulcer diseases,and gastric cancer(GC).Identified as the exclusive bacterial factor associated with the onset of GC,it is classified as a group 1 carcinogen by the World Health *** elimination of *** plays a crucial role in the primary prevention of *** the prevalence has declined in recent decades,*** infection is still highly prevalent in China,accounting for a significant part of the disease burden of ***,updated prevalence information for *** infection,especially regional and demographic variations in China,is an important basis for the design of targeted strategies that will be effective for the prevention of GC and application of policies for *** *** To methodically evaluate the occurrence of *** infection throughout China and establish a reference point for subsequent *** A systematic review and meta-analysis was conducted following established guidelines,as detailed in our methodology *** Our review synthesized data from 152 studies,covering a sample of 763827 individuals,314423 of whom were infected with *** evaluated infection rates in China's Mainland and the combined prevalence of *** was 42.8%(95%CI:40.7-44.9).Subgroup analysis indicated the highest prevalence in Northwest China at 51.3%(95%CI:45.6-56.9),and in Qinghai Province,the prevalence reached 60.2%(95%CI:46.5-73.9).The urea breath test,which recorded the highest infection rate,showed a prevalence of 43.7%(95%CI:41.4-46.0).No notable differences in infection rates were observed between ***,the prevalence among the elderly was significantly higher at 44.5%(95%CI:41.9-47.1),compared to children,who showed a prevalence of 27.5%(95%CI:19.58-34.7).CONCLUSION Between 2014 and 2023,the prevalence of *** infection in China decreased to 42.8%,down from the previous d

关键词： Helicobacter pylori Meta-analysis Prevalence Epidemiology China

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Effect of TSH Suppression Therapy on Sex Hormone Levels after Thyroid Cancer Surgery

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Proceedings of Anticancer Research 2024年第1期8卷 82-85页

作者： Shenglin He ya Su Bo zhao Xudong Gao Department of Endocrinology Shaanxi Provincial People’s HospitalXi’an 710068China Department of Otorhinolaryngology Head and Neck SurgeryShaanxi Provincial People’s HospitalXi’an 710068China

Objective:To analyze the effect of thyroid-stimulating hormone(TSH)suppression therapy on sex hormone levels in patients undergoing postoperative treatment for thyroid ***:A total of 40 patients undergoing postoperative thyroid cancer treatment were selected for data *** suppression therapy was implemented during the postoperative *** were grouped according to the TSH level:TSH0.05).For female patients,testosterone levels at different dosing times showed no significant differences under the same circumstances(P>0.05).The comparison of testosterone levels at different TSH levels over 5 years of TSH suppression therapy did not yield significant differences(P>0.05).However,the comparison of testosterone levels within 5 years of TSH suppression therapy yielded significant differences(P<0.05),with the lowest levels observed at 0.1≤TSH<***:The use of TSH suppression therapy in postoperative thyroid cancer treatment minimally affects sex hormone levels in male ***,it has a significant impact on female ***,preoperative sex hormone testing is recommended,and postoperative monitoring should include regular sex hormone testing.

关键词： Thyroid cancer Postoperative TSH suppression therapy Sex hormone levels

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Preoperative application of combination of portal venous injection of donor spleen cells and intraperitoneal injection of rapamycin prolongs the survival of cardiac allografts in mice

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Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 433-439页

作者： Wen-lin Gong Chuang Sha Gang Du Zhong-gui Shan Zhong-quan Qi Su-fang zhou Nuo yang Yong-xiang zhao National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy ResearchCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical University Department of Cardiac Surgery Zhongshan HospitalXiamen University Organ Transplantation Institute Xiamen University Department of Cardio-Thoracic Surgery The First Affiliated Hospital of Guang Xi Medical University

Objective:To investigate the effects of preoperative portal venous injection of donor spleen cells(PVIDSC) and intraperitoneal injection of rapamycin in the acute rejection of cardiac allograft in mice and the underlying mechanisms. Methods:Homogenous female B6 mice and BALB/c mice were used as recipients and donors of heart transplantation. These mice were randomly divided into different groups and received PVIDSC alone,rapamycin alone,or PVIDSC and rapamycin combined therapy. In addition,the underlying mechanism was studied by measuring a number of cytokines. Results:Preoperative combination of PVIDSC and intraperitoneal injection of rapamycin significantly prolonged the survival of heterotopic cardiac allograft in mice,but had no effects on the survival time of cardiac allografts in mice pre-sensitized by skin grafting. Preoperative combination of PVIDSC and intraperitoneal injection of rapamycin increased the expression of IL-10 and Foxp3 and reduced the expression of INF-γ. Short-term preoperative administration of rapamycin promotes the expression of CD4^+CD25^+Foxp3^+ regulator T cells. However,preoperative using alone of rapamycin,or combination of PVIDSC and rapamycin had no effects on the inhibition of proliferation of memory T cells. Conclusions:Preoperative application of combination of PVIDSC and rapamycin significantly prolonged the survival time of cardiac allografts in mice but not in mice pre-sensitized by skin grafting. This may be explained by the fact that combination of PVIDSC and rapamycin inhibited the cellular immune response and induced the expression of IL-10 from Tr1 cells and CD4^+CD25^+FoxP3^+ regulatory T cells.

关键词： Heart transplantation tolerance Portal venous injection of donor spleen cells Rapamycin

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薄壁箱梁纵向剪滞翘曲函数精度选择的研究

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工程力学 2008年第6期25卷 100-106页

作者：甘亚南周广春哈尔滨工业大学土木工程学院黑龙江哈尔滨150090

根据箱形结构纵向翘曲位移函数设置的基本原理,选择一系列符合箱梁基本翘曲模式的翘曲位移函数,然后以最小势能原理为基础,综合考虑剪力滞后效应、剪切变形和转动惯量的影响,推导出相应翘曲位移函数箱形截面梁的振动控制微分方程和边界... 详细信息

根据箱形结构纵向翘曲位移函数设置的基本原理,选择一系列符合箱梁基本翘曲模式的翘曲位移函数,然后以最小势能原理为基础,综合考虑剪力滞后效应、剪切变形和转动惯量的影响,推导出相应翘曲位移函数箱形截面梁的振动控制微分方程和边界条件,据此得出箱形结构的固有频率方程。依据固有频率方程求出特定边界条件下相应翘曲位移函数箱形结构的自振频率,然后借助自振频率的大小对所设置翘曲位移函数的精确度做出评判。静力分析算例结果证明了翘曲位移函数精度选择的必要性,该文将解析解与数值解结果进行了比较,证明了方法的有效性。

关键词：桥梁工程剪力滞后效应能量变分原理薄壁箱梁翘曲位移函数固有频率

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Characterizations of Stress and Strain Variation in Three-Dimensional Forming of Laser Micro-Manufacturing

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Chinese Physics Letters 2010年第2期27卷 86-89页

作者：周明赵国欢黄涛丁华蔡兰 Photonic Manufacturing and Science Technology Center Jiangsu University Zhenjiang 212013

A micro-manufacturing technology is presented to form three-dimensional metallic micro-structures directly. Micro grid array structures are replicated on a metallic foil surface, with high spatial resolution in micron levels. The numerical simulation results indicate that the material deformation process is characterized by an ultrahigh strain rate. With increasing pulse duration, the sample absorption strain energy increases, and the sample deformation degree enlarges. The stress state of the central point fluctuates between tensile stress and compression stress. The stress state of the angular point is altered from compressive stress to tensile stress due to geometry and loading conditions. The duration length of pulse stress has an effect on the stress state, as with the increase of pulse duration, fluctuation in the stress state decreases. Therefore, laser micro-manufacturing technology will be a potential laser micro forming method which is characterized by low cost and high efficiency.

关键词： Chinese climate network complex systems small world community

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Phenotypic research on senile osteoporosis caused by SIRT6 deficiency

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International Journal of Oral Science 2016年第2期8卷 84-92页

作者： De-Mao Zhang Di-Xin Cui Ruo-Shi Xu ya-Chuan zhou Li-Wei Zheng Peng Liu Xue-Dong zhou State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University

Osteoporosis is a serious public bone metabolic disease. However, the mechanisms underlying bone loss combined with ageing, which is known as senile osteoporosis, remains unknown. Here we show the detailed phenotype of this disease caused by SIRT6 knock out （KO） in mice. To the best of our knowledge, this is the first study to reveal that SIRT6 is expressed in both bone marrow stroma cells and bone-related cells in both mouse and human models, which suggests that SIRT6 is an important regulator in bone metabolism. SIRT6-KO mice exhibit a significant decrease in body weight and remarkable dwarfism. The skeleton of the SIRT6-KO mouse is deficient in cartilage and mineralized bone tissue. Moreover, the osteocalcin concentration in blood is lower, which suggests that bone mass is markedly lost. Besides, the tartrate-resistant acid phosphatase 5b （TRAP5b） concentration is much higher, which suggests that bone resorption is overactive. Both trabecular and cortical bones exhibit severe osteopenia, and the bone mineral density is decreased. Moreover, double-labelling analysis shows that bone formation is much slower. To determine whether SIRT6 directly regulates bone metabolism, we cultured primary bone marrow stromal cells for osteogenesis and osteoclastogenesis separately to avoid indirect interference in vivo responses such as inflammation. Taken together, these results show that SIRT6 can directly regulate osteoblast proliferation and differentiation, resulting in attenuation in mineralization. Furthermore, SIRT6 can directly regulate osteoclast differentiation and results in a higher number of small osteoclasts, which may be related to overactive bone resorption.

关键词： ageing osteoclastogenesis osteogenesis osteoporosis

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Mechanism of Burn Resistance of Alloy Ti40

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Journal of Materials Science & Technology 2001年第6期17卷 677-678页

作者： Yongqing zhao, Lian zhou,Kanging ZHU,Henglei QU and Huan WU Northwest Institute for Nonferrous Metal Research, Xi’an 710016, China [Manuscript received June 5, 2000] NW Inst Nonferrous Met Res Xian 710016 Peoples R China

The Ti fire found in high performance engines promotes the development of burn resistant Ti alloys. The burn resistant mechanism of Ti40 alloy is investigated. Ti40 alloy reveals good burn resistance. Its interfacial products between burning products and the matrix are tenacious, which retard the diffusion of oxygen into the matrix. Two burn resistant mechanisms, that is, fast scatter dispersion of heat and suppression of oxygen diffusion, are proposed.

关键词： Ti Mechanism of Burn Resistance of Alloy Ti40

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Short-term application of low-dose growth hormone in surgical patients: Effects on nitrogen balance and blood glucose

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World Journal of Gastroenterology 2007年第3期13卷 452-456页

作者： Ming-Ming Zhang Xiao-Ting Wu Yong zhou Kun Qian ya-Min Zheng Department of General Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of General Surgery Xuanwu Hospital Capital University of Me.dical Sciences Beijing 100053 China

AIM： To investigate the effectiveness and safety of recombinant human growth hormone （rhGH） in postoperative patients. METHODS： A total of 48 consecutive patients undergoing abdominal operations were randomized to receive either subcutaneous rhGH （0.15 IU/kg） or placebo （menstruum） injections daily for 7 d after surgery. The two groups had similar nutritional intake. Blood samples for serum fibronecUn, albumin, prealbumin, transferrin and the total lymphocyte count, as well as glucose levels were collected to study the rhGH effect. Basal laboratory evaluation, and nutritional status were estimated on d 1 before as baseline and d 3 and 10 after operation using standard laboratory techniques. Nitrogen balance was measured from d 3 to 9 after operation. RESULTS： The cumulative nitrogen balance was significantly improved in rhGH group compared with the placebo group （11.37 ± 16.82 vs -9.11 ± 17.52, P = 0.0003）. Serum fibronectin was also significantly higher in the rhGH group than in the placebo group （104.77 ± 19.94 vs 93.03 ± 16.03, P 〈 0.05）, whereas changes in serum albumin, prealbumin, transferrin and total lymphocyte counts were not statistically significant. Mean blood glucose levels were significantly higher in the rhGH group from d 3 to 6 after operation. CONCLUSION： If blood glucose can be controlled, lowdose growth hormone together with hypocaloric nutrition is effective on improving positive nitrogen balance and protein conservation and safe is in postoperative patients.

关键词： Growth hormone Nutritional support Abdominal surgery Hyperglycemia Nitrogen balance

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Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3298-3312页

作者： Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian yang ya-Ping Wang Li-Bin Pan Hang Yu Chi-Yu He Hai-Bin Luo Zhen-Xiong zhao Xin-Bo zhou Yu-Li Wang Jie Fu Pei Han Yu-Hui Dong Gang Wang Song Li yan Wang Jian-Dong Jiang Wu Zhong State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China Beijing Institute of Pharmacology and Toxicology Beijing 100000China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China School of Pharmaceutical Sciences Hainan UniversityHainan 570228China National Engineering Research Center for the Emergence Drugs Beijing 100000China

Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota.

关键词： Depression Morinda oficinalis oligosaccharides Gut microbiota Tryptophan hydroxylase 5-Hydroxytryptophan decarboxylase 5-Hydroxytryptophan Serotonin Drug metabolism

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Clinical significance of HOTAIR expression in colon cancer

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World Journal of Gastroenterology 2016年第22期22卷 5254-5259页

作者： Zhi-Fen Luo Dan zhao Xi-Qing Li Yong-Xia Cui Ning Ma Chuang-Xin Lu Ming-Yue Liu Yun zhou Department of Oncology Henan Provincial People’s Hospital Department of Oncology Zhengzhou Third People’s Hospital

AIM: To detect the expression of the long noncoding RNA HOTAIR in colon cancer and analyze its relationship with clinicopathological parameters of colon cancer. METHODS: Total RNA was extracted from 80 colon cancer tissues and matched tumor-adjacent normal colon tissues and reverse transcribed. Quantitative polymerase chain reaction was used to detect the expression of HOTAIR. The relationship between the expression of HOTAIR and clinicopathological parameters of colon cancer was analyzed. RESULTS: The expression of HOTAIR was significantly higher in colon cancer tissues than in matched tumoradjacent normal colon tissues(P < 0.05). HOTAIR expression was significantly higher in cases with lymph node metastasis than in those without metastasis; in lowly differentiated and undifferentiated cases than in highly and moderately differentiated cases; and in stages Ⅲ + Ⅳ cases than in stages?Ⅰ?+ Ⅱ cases(P < 0.05).CONCLUSION: HOTAIR expression is upregulated in colon cancer, suggesting that HOTAIR plays an important role in the tumorigenesis, development and metastasis of colon cancer. HOTAIR may act as an oncogene and represents a new molecular target for the treatment of colon cancer.

关键词： HOTAIR Long non-coding RNA Oncogene Colon tumor

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