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Detection of atherosclerotic plaque progression in the abdominal aorta of rabbits with 3T magnetic resonance imaging

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Chinese Medical Journal 2012年第15期125卷 2714-2718页

作者： MA Xiao-hai zhao Lei zhao quan-ming FENG Ting-ting SHANG Jian-feng ZHANG zhao-qi Department of Radiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Pathology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background With features of high tissue contrast, MRI can be used for the qualitative and quantitative evaluation of atherosclerosis plaques. In this study we investigated the development of atherosclerosis plaque with high resolution 3T MRI in a rabbit model and compared the findings with the histopathological results. Method Twenty male New Zealand white rabbits were randomly allocated into an experimental group （n=16） and a control group （n=4）. Atherosclerotic lesions were induced in the abdominal aorta by balloon injury and cholesterol feeding. Multiple sequences MRI examination （ToF, TIWI, T2WI, and CE T1WI） were performed at the 2nd, 3rd, and 4th months after aortic denudation. Vessel wall thickness, total vessel area, lumen area, and vessel wall area were recorded. Plaque components were analyzed using histological results as a standard reference. Results Seventeen rabbits （14 in the experimental group and 3 in the control group） received all three MR examinations. Gradually, from 2 months to 4 months, vessel wall thickness and area in the experimental group increased significantly compared with the control group （P 〈0.01）. In the lumen area progressive stenosis was not found, even a slight dilation had developed in the experimental group. Lipid, fibrotic and calcified plaques can be differentiated by MR image. According to histological results, MRI had good performance in detection of lipid plaque. Conclusion MRI can be used to monitor progression of atherosclerosis and differentiate plaque components.

关键词： magnetic resonance imaging, atherosclerosis progression abdominal aorta

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Magnetic resonance imaging features of vulnerable plaques in an atherosclerotic rabbit model

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Chinese Medical Journal 2013年第11期126卷 2163-2167页

作者： zhao Xue-cheng zhao quan-ming MA Xiao-hai ZENG Cong-he FENG Ting-ting zhao Xin ZHANG zhao-qi ZHANG ming-duo ZHUANG Xu-cui Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Radiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background Noninvasive detection of vulnerable plaque has a significant implication for prevention and treatment of atherosclerotic disea±ses. The aim of this study is to investigate the difference between vulnerable plaques and stable plaques in magnetic resonance （MR） images. Methods Atherosclerosis was induced in twenty male New Zealand white rabbits by high cholesterol diet and balloon injury of the abdominal aorta. After baseline （pre-triggering） MR imaging （MRI） scan, the rabbits underwent pharmaceutical triggering with Russell＇s viper venom and histamine to induce atherothrombosis, followed by another MRI scan 48 hours later （post-triggering）. Rabbits were euthanized to obtain pathological and histological data. The results of MRI were compared with those of pathology and histology. Results MRI showed that abdominal aorta of the rabbits had pathological change of atherosclerosis in different degrees. Seventy-five plaques were analysed, among which 14 had vulnerable thrombi and 61 stable. Thrombosis was identified in 7 of 11 rabbits by post-triggering MRI, the sensitivity and K value of MR in detection of vulnerable plaque was 71% and 0.803 （P 〈0.05）. MRI data significantly correlated with the histopathological data in fibrous cap thickness （t=0.749） plaque area （t=0.853）, lipid core area （r=0.900）. Compared with stable plaques, vulnerable plaques had a significantly thinner fibrous cap （（0.58±0.27） mm vs. （0.95±0.22） mm）, larger lipid core area （（7.56±2.78） mm2 vs. （3.29±1.75） mm2）, and a higher ratio of lipid core area/plaque area （（55±16）% vs. （27±17）%）, but plaque area was comparable in two groups on MRI. The ratio of lipid core area/plaque area was a strong predictor of vulnerable plaques. Conclusion MRI could distinguish vulnerable plaques from stable plaques in a rabbit model of atherothrombosis and may thus be useful as a noninvasive modality for detection of vulnerable plaques in humans.

关键词： magnetic resonance imaging vulnerable plaques rabbits thrombus

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对比主成分分析的近红外光谱测量及其在水果农药残留识别中的应用

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光谱学与光谱分析 2020年第3期40卷 917-921页

作者：陈淑一赵全明董大明河北工业大学电子信息工程学院天津300401 北京农业智能装备技术研究中心北京市农林科学院北京100097

近红外光谱(NIR)分析具有测试方便、不破坏样本、响应快速等优势,但是,由于在谱带分布和结构分析中存在着许多复杂因素,使得在提取特征光谱信息时存在许多困难。现阶段,虽然已经有多种光谱数据降维方式被广泛使用,但是这些传统的数据降... 详细信息

近红外光谱(NIR)分析具有测试方便、不破坏样本、响应快速等优势,但是,由于在谱带分布和结构分析中存在着许多复杂因素,使得在提取特征光谱信息时存在许多困难。现阶段,虽然已经有多种光谱数据降维方式被广泛使用,但是这些传统的数据降维方式都有一个局限性,就是数据的降维仅仅针对于一个数据集,当数据集中有多个关键因素形成干扰时,数据降维和分类的结果往往不是很理想,得不到想要分析的信息。这一问题造成了在分析近红外光谱时建立的数据降维模型极差,无法正确的对样品进行预测分类。对比主成分分析(contrastive principle component analysis, cPCA)是一种基于主成分分析(PCA)的改进算法,起源于对比学习,并应用于基因组信息解析。cPCA算法的优势就是能够将一个数据集中的降维推广到两个相关联数据集之间的降维,从而能够得到数据集中的关键信息。将cPCA算法应用于近红外光谱处理中,建立了准确的近红外光谱数据降维模型。在实验验证中,使用cPCA算法对不同类型水果(苹果和梨)表面农药残留进行分析。结果表明,在对不同类型的水果进行农药残留分析时,使用PCA算法进行数据降维只能区分出不同的水果类型,而水果表面是否喷洒农药这一关键的特征信息并不能分析出来;而使用cPCA算法进行数据降维分析时,由于对背景光谱的约束作用,能够清晰的将有无喷洒农药的样本分类。这说明了, cPCA在近红外光谱数据降维中有着明显的优势,解决了近红外光谱数据降维模型中数据集受限和特征信息的提取问题,进而建立准确的近红外光谱数据降维模型。

关键词：近红外 cPCA 数据降维模型建立

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Procedural results and 30-day clinical events analysis following Edwards transcatheter aortic valve implantation in 48 consecutive patients： initial experience

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Chinese Medical Journal 2012年第16期125卷 2807-2810页

作者： zhao quan-ming Therese Lognone Calin Ivascau Remi Sabatier Vincent Roule Ziad Dahdouh Massimo Massetti Gilles Grollier Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background Transcatheter aortic valve implantation （TAVI） is a rapidly evolving strategy for therapy of aortic stenosis. We presented the procedural results and analyzed the death causes of 30-day mortality and clinical events in patients who underwent TAVI with Edwards prosthetic valves in University Hospital of Caen, France. Methods The patients with severe aortic stenosis but at high surgical risk or inoperable were considered as candidates for TAVI. Forty-eight patients undergoing TAVI from July 2010 to September 2011 were enrolled in this registry. The Edwards prosthetic valves were solely used in this clinical trial. Results Overall 48 patients underwent TAVI, 28 of which accepted TAVI by trans-femoral （TF） approaches, 20 by trans-apical approaches （TA）. The aortic valve area （AVA） was （0.70±0.23） cm2, left ventricular ejection fraction （LVEF） was （57.4±17.6）%, Log EuroSCORE was （19.2±15.8）%, mean gradient was （47.0±16.6） mmHg. There were no significant differences between TF and TA groups in all these baseline parameters. Device success rate was 95.8%, and procedural success rate was 93.7% in total. Procedural mortality was 6.7% （3/48）： two deaths in TA group （10%）, and one death in TF group （3.6%）. Forty-six Edwards valves were implanted： 10 Edwards Sapien and 36 Edwards XT. Procedure-related complications included cardiac tamponade in 2 cases （4.2%）, acute myocardial infarction （AMI） in 1 case （2.1%）, permanent pacemaker implantation in 1 case （2.1%）, life-threatening and major bleeding in 3 cases; access site related major complication in 1 case, AKI stage 3 in 3 cases （6.3%）, minor stroke in 1 case （2.1%）. Thirty-day survival rate was 89.6%. There were 5 deaths in total （10.4%）： 4 in TA group （20%） and 1 in TF group （3.6%）. Conclusion The procedural success rate and 30-day mortality were acceptable in these high risk patients withpatients withEdwards prosthetic valves in the first 48 TAVI.

关键词： aortic stenosis transcatheter aortic valve implantation, registry

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Imaging of atherosclerotic aorta of rabbit model by detection of plaque inflammation with fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography

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Chinese Medical Journal 2011年第6期124卷 911-917页

作者： zhao quan-ming FENG Ting-ting zhao Xin XU Zhan-min LIU Yu LI De-peng LI Li-qin SU Gong ZHANG Xiao-xia Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Institute of Basic Medicine Capital Medical University Beijing 100069 China Center for PET/CT General Hospital of Second Artillery of People's Liberation Army Beijing 100088 China

Abstract：Background Atherosclerotic plaque rupture is the primary mechanism of thrombosis which plays a key role in the onset of acute coronary syndromes. Detection of these plaques prone to rupture （vulnerable plaque） could be clinically significant for prevention of cardiac events. It has been shown that high metabolism cells have a high uptake of fluorine-18 fluorodeoxyglucose （18F-FDG）. The objective of this study was to investigate the correlation of FDG uptake and the immuno-histochemistry parameters of plaques, and the effect of atorvastatin on vulnerable atherosclerotic plaque in a rabbit *** Ten male New Zealand White rabbits were divided into three groups as follows：（1） normal control group （n=2,C group）： the animals were fed a standard diet at 120 g/d and were given water ad labium; （2） atherosclerosis group （n=4,As group）： animals were fed with high fat diet for 5 months after aortic endothelia damage; （3） treatment group （atherosclerosis ＋ atorvastatin, n=4, Statin group）： animals were fed with high fat diet for 5 months and then changed into normal chow plus atorvastatin （2.5 mg·d-1·kg-1） treatment for another 4 months. Then these four rabbits were imaged with fluorine-18 fluorodexyglucose positron emission tomography/computed tomography （PET/CT） and sacrificed for pathohistologic studies. FDG uptake by the aorta was expressed as target-to-background ratio （TBR）. Maximal standardized uptake value （SUV） was measured over the thoracic and abdominal aortas. The aortic smooth muscle cell （SMC） number, CD-14 antibody positive cell （macrophage） number and the ratio of the thickness of fibrous cap to the thickness of lipid core （cap-to-core ratio） in atherosclerotic plaques were *** As group showed significantly higher uptake of FDG than C group （SUVs： 0.746±0.172 vs. 0.286±0.073, P 〈0.001）. After 4 months of atorvastatin treatment and the modification of diet, SUVs decreased significantly （Statin group：0.550±0.134, compared to As grou

关键词： fluorine-18 fluorodeoxyglucose positron emission tomography angiography vulnerable plaque inflammation

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核素成像检测易损斑块的进展

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中国医学影像技术 2008年第2期24卷 301-305页

作者：杜慧锋赵全明首都医科大学附属北京安贞医院心内科北京100029

一个事实已得到公认:引发大多数危及生命的临床实践的易损斑块的主要特点为炎症细胞和炎症蛋白介质的大量聚集。这就更强调了对粥样硬化斑块内的炎症定性定量分析的合适影像技术的迫切需要。在这方面,正电子发射断层扫描术(PET)和单光... 详细信息

一个事实已得到公认:引发大多数危及生命的临床实践的易损斑块的主要特点为炎症细胞和炎症蛋白介质的大量聚集。这就更强调了对粥样硬化斑块内的炎症定性定量分析的合适影像技术的迫切需要。在这方面,正电子发射断层扫描术(PET)和单光子发射计算机体层摄影(SPECT)前景较好。标记物可评价巨噬细胞募集,泡沫细胞产生,基质金属蛋白酶(MMP)产物,巨噬细胞凋亡和巨噬细胞代谢。这些标记物均正在被研究并已在颈动脉和外周动脉上进行了实验。然而,冠脉内易损斑块的识别仍难以如愿,主要的原因有:斑块过小,心跳和呼吸运动的干扰,以及缺乏合适且特异的核标记物。

关键词：核素易损斑块

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基于动态递归模糊神经网络的自适应电液位置跟踪系统

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控制理论与应用 2005年第4期22卷 551-556页

作者：张友旺桂卫华赵泉明中南大学信息科学与工程学院湖南大学机械与汽车工程学院湖南长沙410082

提出了动态递归模糊神经网络(DRFNN)以在线估计电液位置跟踪系统中包括非线性、参数不确定性、负载干扰等在内的未知动态非线性函数,基于lyapunov稳定性理论推导出DRFNN可调参数和估计误差的界的自适应律,并构造出稳定的自适应控制器.... 详细信息

提出了动态递归模糊神经网络(DRFNN)以在线估计电液位置跟踪系统中包括非线性、参数不确定性、负载干扰等在内的未知动态非线性函数,基于lyapunov稳定性理论推导出DRFNN可调参数和估计误差的界的自适应律,并构造出稳定的自适应控制器.实验结果表明:基于DRFNN的自适应控制器可使电液位置跟踪系统具有较强的鲁棒性和满意的跟踪性能.

关键词：动态递归模糊神经网络电液位置跟踪系统变结构控制鲁棒性

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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星形胶质细胞条件培养液对体外模拟脑缺血再灌注损伤神经元的作用

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解剖学杂志 2006年第4期29卷 468-472页

作者：赵全明宋岳涛山西医科大学解剖学教研室太原030001 中国人民解放军总医院神经信息中心北京100853

目的：探讨星形胶质细胞(Ast)条件培养液(ACM)对体外模拟脑缺血再灌注损伤神经元的影响。方法：分离纯化培养大鼠大脑皮质Ast和神经元,体外模拟脑缺血再灌注损伤模型,用ACM培养损伤后的神经元,测定其神经元的活性、存活率、死亡率、培... 详细信息

目的：探讨星形胶质细胞(Ast)条件培养液(ACM)对体外模拟脑缺血再灌注损伤神经元的影响。方法：分离纯化培养大鼠大脑皮质Ast和神经元,体外模拟脑缺血再灌注损伤模型,用ACM培养损伤后的神经元,测定其神经元的活性、存活率、死亡率、培养液乳酸脱氢酶(LDH)的漏出率和NOS强阳性细胞的表达量。结果：ACM能使脑缺血再灌注损伤神经元的活性和存活率明显提高,使死亡率、LDH的漏出率和NOS强阳性细胞的表达量显著降低。结论：(1)体外模拟脑缺血再灌注损伤神经元的变化具有一定的规律性；(2)ACM对受损的神经元具有重要的保护和修复作用；(3)Ast在脑缺血预适应中发挥重要的作用。

关键词：星形胶质细胞脑缺血再灌注损伤神经元

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受体酪氨酸蛋白激酶Tyro3在大鼠脑的表达及定位分析(英文)

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北京大学学报（医学版） 2012年第6期44卷 905-910页

作者：赵全明李灵敏张策郭睿山西医科大学基础医学院解剖学教研室太原030001 山西医科大学基础医学院病理学教研室太原030001 山西医科大学细胞生理学省部共建教育部重点实验室太原030001

目的:分析受体酪氨酸蛋白激酶(receptor tyrosine kinases,RTKs)亚家族TAM(Tyro3、Axl和Mer)在大鼠脑中的表达模式及细胞定位,并进一步探讨TAM在脑中表达的意义。方法:分别提取出生后3、9、15、30及52 d龄SD大鼠脑组织总RNA和总蛋白,实... 详细信息

目的:分析受体酪氨酸蛋白激酶(receptor tyrosine kinases,RTKs)亚家族TAM(Tyro3、Axl和Mer)在大鼠脑中的表达模式及细胞定位,并进一步探讨TAM在脑中表达的意义。方法:分别提取出生后3、9、15、30及52 d龄SD大鼠脑组织总RNA和总蛋白,实时定量PCR(real time quantitative PCR)检测TAM mRNA水平的表达,Westernblotting检测TAM蛋白水平的表达,免疫组织化学染色检测Tyro3蛋白在大鼠脑中的定位。结果:Tyro3 mRNA在脑的表达水平显著高于Axl及Mer,从生后15 d龄开始有明显表达,随后呈现明显上调趋势,至生后52 d龄Tyro3mRNA的表达量达到15 d的3.2倍。Tyro3蛋白的表达水平也呈明显上调趋势,从生后15 d龄开始到52 d龄,Ty-ro3蛋白的表达量显著增高,生后52 d龄Tyro3蛋白的表达量是15 d龄的1.3倍;免疫组织化学染色结果显示Ty-ro3蛋白主要分布于皮层细胞,梨状皮层和海马区细胞内有Tyro3蛋白的强阳性着色;在亚细胞水平,Tyro3蛋白存在于锥体神经元的胞质和树突部分。结论:TAM受体酪氨酸蛋白激酶家族Tyro3基因及其编码产物在大鼠脑组织发育过程中呈阶段性上调表达,并且Tyro3蛋白在海马神经元胞体及轴突有显著高表达,提示Tyro3蛋白可能通过受体酪氨酸蛋白激酶信号转导途径参与了脑突触功能的调控。

关键词：受体酪氨酸蛋白激酶脑实时定量聚合酶链反应大鼠,SpragueDawley

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