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Prevalence and risk factors of diabetes mellitus among elderly patients in the Lugu community

World Journal of Diabetes 2024年第4期15卷 638-644页

作者： Li-Zhen zhao wei-min Li Ying Ma Lugu Community Health Service Center West Campus Beijing Chao-yang Hospital Affiliated to Capital Medical UniversityBeijing 100043China

BACKGROUND Age is a significant risk factor of diabetes mellitus(DM).With the develop of population aging,the incidence of DM remains increasing.Understanding the epidemiology of DM among elderly individuals in a certain area contributes to the DM interventions for the local elderly individuals with high risk of DM.AIM To explore the prevalence of DM among elderly individuals in the Lugu community and analyze the related risk factors to provide a valid scientific basis for the health management of elderly individuals.METHODS A total of 4816 elderly people who came to the community for physical examination were retrospectively analyzed.The prevalence of DM among the elderly was calculated.The individuals were divided into a DM group and a non-DM group according to the diagnosis of DM to compare the differences in diastolic blood pressure(DBP)and systolic blood pressure(SBP),fasting blood glucose,body mass index(BMI),waist-to-hip ratio(WHR)and incidence of hypertension(HT),coronary heart disease(CHD),and chronic kidney disease(CKD).RESULTS DM was diagnosed in 32.70%of the 4816 elderly people.The BMI of the DM group(25.16±3.35)was greater than that of the non-DM group(24.61±3.78).The WHR was 0.90±0.04 in the non-DM group and 0.90±0.03 in the DM group,with no significant difference.The left SBP and SBP in the DM group were 137.9 mmHg±11.92 mmHg and 69.95 mmHg±7.75 mmHg,respectively,while they were 126.6 mmHg±12.44 mmHg and 71.15 mmHg±12.55 mmHg,respectively,in the non-DM group.These findings indicate higher SBP and lower DBP in DM patients than in those without DM.In the DM group,1274 patients were diagnosed with HT,accounting for 80.89%.Among the 3241 non-DM patients,1743(53.78%)were hypertensive and 1498(46.22%)were nonhypertensive.The DM group had more cases of HT than did the non-DM group.There were more patients with CHD or CKD in the DM group than in the non-DM group.There were more patients who drank alcohol more frequently(≥3 times)in the DM group than in the non-DM group.CONCLUSION Older adults in the Lugu c

关键词： Diabetes mellitus Type 2 diabetes mellitus Elderly Risk factors

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Research on a TOPSIS energy efficiency evaluation system for crude oil gathering and transportation systems based on a GA-BP neural network

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Petroleum Science 2024年第1期21卷 621-640页

作者： Xue-Qiang Zhang Qing-Lin Cheng wei Sun Yi zhao Zhi-min Li Key Lab of ministry of Education for Enhancing the Oil and Gas Recovery Ratio Northeast Petroleum UniversityDaqing163318HeilongjiangChina China Petroleum Pipeline Material and Equipment Co. LtdLangfang065000HebeiChina Research Institute of Petroleum Engineering and Technology Sinopec Northwest Oilfield CompanyUrumqi830011XinjiangChina

As the main link of ground engineering,crude oil gathering and transportation systems require huge energy consumption and complex structures.It is necessary to establish an energy efficiency evaluation system for crude oil gathering and transportation systems and identify the energy efficiency gaps.In this paper,the energy efficiency evaluation system of the crude oil gathering and transportation system in an oilfield in western China is established.Combined with the big data analysis method,the GA-BP neural network is used to establish the energy efficiency index prediction model for crude oil gathering and transportation systems.The comprehensive energy consumption,gas consumption,power consumption,energy utilization rate,heat utilization rate,and power utilization rate of crude oil gathering and transportation systems are predicted.Considering the efficiency and unit consumption index of the crude oil gathering and transportation system,the energy efficiency evaluation system of the crude oil gathering and transportation system is established based on a game theory combined weighting method and TOPSIS evaluation method,and the subjective weight is determined by the triangular fuzzy analytic hierarchy process.The entropy weight method determines the objective weight,and the combined weight of game theory combines subjectivity with objectivity to comprehensively evaluate the comprehensive energy efficiency of crude oil gathering and transportation systems and their subsystems.Finally,the weak links in energy utilization are identified,and energy conservation and consumption reduction are improved.The above research provides technical support for the green,efficient and intelligent development of crude oil gathering and transportation systems.

关键词： Crude oil gathering and transportation system GA-BP neural network Energy efficiency evaluation TOPSIS evaluation method Energy saving and consumption reduction

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From Liquid to Solid‑State Lithium Metal Batteries:Fundamental Issues and Recent Developments

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Nano-Micro Letters 2024年第2期16卷 68-125页

作者： zhao Zhang wei‑Qiang Han School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China

The widespread adoption of lithium-ion batteries has been driven by the proliferation of portable electronic devices and electric vehicles,which have increasingly stringent energy density requirements.Lithium metal batteries(LMBs),with their ultralow reduction potential and high theoretical capacity,are widely regarded as the most promising technical pathway for achieving high energy density batteries.In this review,we provide a comprehensive overview of fundamental issues related to high reactivity and migrated interfaces in LMBs.Furthermore,we propose improved strategies involving interface engineering,3D current collector design,electrolyte optimization,separator modification,application of alloyed anodes,and external field regulation to address these challenges.The utilization of solid-state electrolytes can significantly enhance the safety of LMBs and represents the only viable approach for advancing them.This review also encompasses the variation in fundamental issues and design strategies for the transition from liquid to solid electrolytes.Particularly noteworthy is that the introduction of SSEs will exacerbate differences in electrochemical and mechanical properties at the interface,leading to increased interface inhomogeneity—a critical factor contributing to failure in all-solidstate lithium metal batteries.Based on recent research works,this perspective highlights the current status of research on developing high-performance LMBs.

关键词： Lithium metal batteries All-solid-state lithium metal battery Li dendrite Solid electrolyte Interface

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Biological factors driving colorectal cancer metastasis

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 259-272页

作者： Shuai-Xing An zhao-Jin Yu Chen Fu min-Jie wei Long-Hai Shen Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122Liaoning ProvinceChina Liaoning Key Laboratory of Molecular Targeted Antitumor Drug Development and Evaluation Liaoning Cancer Immune Peptide Drug Engineering Technology Research CenterKey Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors(China Medical University)Ministry of EducationShenyang 110122Liaoning ProvinceChina BD Department Greenpine Pharma Group Co.LtdTianjin 300020China Center of Oncology Genertec Liaoyou Gem Flower HospitalPanJin 124010Liaoning ProvinceChina

Approximately 20%of colorectal cancer(CRC)patients present with metastasis at diagnosis.Among Stage I-III CRC patients who undergo surgical resection,18%typically suffer from distal metastasis within the first three years following initial treatment.The median survival duration after the diagnosis of metastatic CRC(mCRC)is only 9 mo.mCRC is traditionally considered to be an advanced stage malignancy or is thought to be caused by incomplete resection of tumor tissue,allowing cancer cells to spread from primary to distant organs;however,increa-sing evidence suggests that the mCRC process can begin early in tumor development.CRC patients present with high heterogeneity and diverse cancer phenotypes that are classified on the basis of molecular and morphological alterations.Different genomic and nongenomic events can induce subclone diversity,which leads to cancer and metastasis.Throughout the course of mCRC,metastatic cascades are associated with invasive cancer cell migration through the circulatory system,extravasation,distal seeding,dormancy,and reactivation,with each step requiring specific molecular functions.However,cancer cells presenting neoantigens can be recognized and eliminated by the immune system.In this review,we explain the biological factors that drive CRC metastasis,namely,genomic instability,epigenetic instability,the metastatic cascade,the cancer-immunity cycle,and external lifestyle factors.Despite remarkable progress in CRC research,the role of molecular classification in therapeutic intervention remains unclear.This review shows the driving factors of mCRC which may help in identifying potential candidate biomarkers that can improve the diagnosis and early detection of mCRC cases.

关键词： cancer Metastasis cascade Cancer immunity Genomic variation Epigenetic instability Lifestyle factor

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Communication efficiency optimization of federated learning for computing and network convergence of 6G networks

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Frontiers of Information Technology & Electronic Engineering 2024年第5期25卷 713-727页

作者： Yizhuo CAI Bo LEI Qianying zhao Jing PENG min wei Yushun ZHANG Xing ZHANG Wireless Signal Processing and Network Laboratory Beijing University of Posts and TelecommunicationsBeijing 100876China Research Institute of China Telecom Co. Ltd.Beijing 102209China Beijing Telecom Beijing 100011China

Federated learning effectively addresses issues such as data privacy by collaborating across participating devices to train global models.However,factors such as network topology and computing power of devices can affect its training or communication process in complex network environments.Computing and network convergence(CNC)of sixth-generation(6G)networks,a new network architecture and paradigm with computing-measurable,perceptible,distributable,dispatchable,and manageable capabilities,can effectively support federated learning training and improve its communication efficiency.By guiding the participating devices'training in federated learning based on business requirements,resource load,network conditions,and computing power of devices,CNC can reach this goal.In this paper,to improve the communication eficiency of federated learning in complex networks,we study the communication eficiency optimization methods of federated learning for CNC of 6G networks that give decisions on the training process for different network conditions and computing power of participating devices.The simulations address two architectures that exist for devices in federated learning and arrange devices to participate in training based on arithmetic power while achieving optimization of communication efficiency in the process of transferring model parameters.The results show that the methods we proposed can cope well with complex network situations,effectively balance the delay distribution of participating devices for local training,improve the communication eficiency during the transfer of model parameters,and improve the resource utilization in the network.

关键词： Computing and network convergence Communication efficiency Federated learning Two architectures

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Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

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Food Science and Human Wellness 2024年第2期13卷 982-992页

作者： Guangsu Zhu min Guo Jianxin zhao Hao Zhang Gang Wang wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China National Engineering Center of Functional Food Jiangnan UniversityWuxi 214122China

The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive impairment.However,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive improvements.Here,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)training.In this study,we found that compared with EE or B.breve treatment alone,B.breve intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic function.Moreover,using microbiome and metabolome profiling,we found that the combination of B.breve and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite changes.Finally,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain interactions.Collectively,combined B.breve intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut microbiome.Our findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.

关键词： Alzheimer’s disease Bifidobacterium breve Environmental enrichment Glutamine metabolism Microbiota-gut-brain axis

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RebL1 is required for macronuclear structure stability and gametogenesis in Tetrahymena thermophila

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Marine Life Science & Technology 2024年第2期6卷 183-197页

作者： Huijuan Hao Yinjie Lian Chenhui Ren Sitong Yang min zhao Tao Bo Jing Xu wei Wang Key Laboratory of Chemical Biology and Molecular Engineering of ministry of Education Institute of BiotechnologyShanxi UniversityTaiyuan 030006China School of Life Science Shanxi UniversityTaiyuan 030006China Shanxi Key Laboratory of Biotechnology Taiyuan 030006China

Histone modification and nucleosome assembly play important roles in chromatin-related processes.Histone chaperones form different complexes and coordinate histone transportation and assembly.Various histone chaperone complexes have been identified in different organisms.The ciliate protozoa(ciliates)have various chromatin structures and different nuclear morphology.However,histone chaperone components and functions of different subunits remain unclear in ciliates.Tet-rahymema thermophila contains a transcriptionally active macronucleus(MAC)and a transcriptionally inactive micronu-cleus(MIC)which exhibit multiple replication and various chromatin remodeling progresses during vegetative growth and sexual developmental stages.Here,we found histone chaperone RebL1 not only localized evenly in the transcriptionally active MAC but also dynamically changed in the MIC during vegetative growth and sexual developmental stages.REBL1 knockdown inhibited cellular proliferation.The macronuclear morphology became bigger in growing mutants.The abnormal macronuclear structure also occurred in the starvation stage.Furthermore,micronuclear meiosis was disturbed during sexual development,leading to a failure to generate new gametic nuclei.RebL1 potentially interacted with various factors involved in histone-modifying complexes and chromatin remodeling complexes in different developmental stages.REBL1 knockdown affected expression levels of the genes involved in chromatin organization and transcription.Taken together,RebL1 plays a vital role in maintaining macronuclear structure stability and gametogenesis in T.thermophila.

关键词： Gametogenesis Histone chaperone Macronuclear structure RebL1 Tetrahymena thermophilaIntroduction

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Infrared microspectroscopy beamline BL06B at SSRF

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Nuclear Science and Techniques 2024年第1期35卷 10-17页

作者： Te Ji Hua-Chun Zhu wei-wei Peng Jie Wang Hong-wei zhao Ai-Guo Li min Chen Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

The infrared microspectroscopy beamline(BL06B) is a phase Ⅱ beamline project at the Shanghai Synchrotron Radiation Facility(SSRF). The construction and optical alignment of BL06B were completed by the end of 2020. By 2021, it became accessible to users. The synchrotron radiation infrared(SRIR) source included edge radiation(ER) and bending magnet radiation(BMR). The extracted angles in the horizontal and vertical directions were 40 and 20 mrad, respectively. The photon flux, spectral resolution, and focused spot size were measured at the BL06B endstation, and the experimental results were consistent with theoretical calculations. SRIR light has a small divergence angle, high brightness, and a wide wavelength range. As a source of IR microscopy, it can easily focus on a diffraction-limited spatial resolution with a high signal-to-noise ratio(SNR). The BL06B endstation can be applied in a wide range of research fields, including materials, chemistry, biology, geophysics, and pharmacology.

关键词： Synchrotron radiation Infrared beamline Infrared microspectroscopy

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Al-modified yolk-shell silica particle-supported NiMo catalysts for ultradeep hydrodesulfurization of dibenzothiophene and 4,6-dimethyldibenzothiophene:Efficient accessibility of active sites and suitable acidity

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Petroleum Science 2024年第1期21卷 654-666页

作者： Ke Yu wei-min Kong Zhen zhao Ai-Jun Duan Lian Kong Xi-Long Wang State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034LiaoningChina

Yolk-shell SiO2 particles(YP)with center-radial meso-channels were fabricated through a simple and effective method.Al-containing YP-supported NiMo catalysts with different Al amounts(NiMo/AYP-x,x=Si/Al molar proportion)were prepared and dibenzothiophene(DBT)and 4,6-dimethyl-dibenzothiophene(4,6-DMDBT)were employed as the probes to evaluate the hydrodesulfurization(HDS)catalytic performance.The as-prepared AYP-x carriers and corresponding catalysts were characterized by some advanced characterizations to obtain deeper correlations between physicochemical properties and the HDS performance.The average pore sizes of series AYP-x supports are above 6.0 nm,which favors the mass transfer of organic sulfides.The cavity between the yolk and the shell is beneficial for the enrichment of S-containing compounds and the accessibility between reactants and active metals.Aluminum embedded into the silica framework could facilitate the formation of Lewis(L)and Brønsted(B)acid sites and adjust the metal-support interaction(MSI).Among all the as-synthesized catalysts,NiMo/AYP-20 catalyst shows the highest HDS activities.The improved HDS activity of NiMo/AYP-20 catalyst is attributed to the perfect combination of excellent structural properties of the yolk-shell mesoporous silica,enhanced acidity,moderate MSI,and good accessibility/dispersion of active components.

关键词： Al-containing yolk-shell silica particles Accessibility Acidity Metal-support interaction Hydrodesulfurization

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Universal method for designing periodic orbits by homotopy classes in the elliptic restricted three-body problem

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Astrodynamics 2024年第1期8卷 175-188页

作者： Yue Zheng min zhao School of Electronic Engineering Xi’an Aeronautical InstituteXi’an710077China School of Aircraft Engineering Xi’an Aeronautical InstituteXi’an710077China School of Astronautics Northwestern Polytechnical UniversityXi’an710072China

The current methods for designing periodic orbits in the elliptic restricted three-body problem(ERTBP)have the disadvantages of targeting limited orbits and ergodic searches and considering only symmetric orbits.A universal method for designing periodic orbits is proposed in this paper.First,the homotopy classes of orbits are structured based on their topological structures.Second,a dynamic model based on homotopy classes,ranging from the circular restricted three-body problem(CRTBP)to the ERTBP,can be built using the homotopy method.Third,a multi-and a single-period orbit were selected based on the resonance ratios.Finally,the corresponding orbit in the ERTBP was computed by modifying the initial condition of the orbit in the CRTBP.This method,without an ergodic search,can extend to any orbit,including an asymmetric orbit in the CRTBP,to the ERTBP model,and the two orbits are of the same homotopy class.Examples of the Earth–Moon ERTBP are presented to verify the efficiency of this method.

关键词： periodic orbit elliptic restricted three-body problem(ERTBP) topology homotopy circular restricted three-body problem(CRTBP)

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