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Chinese Journal of Natural Medicines 2022年第11期20卷 846-853页

作者： GAO Juanjuan zhao mengling SHAN Shujun LI Yongyi LUO Jun LI Yi School of Food Science and Pharmaceutical Engineering Testing&Analysis CenterNanjing Normal UniversityNanjing 210023China Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

Steroid saponins are secondary metabolites with multiple medicinal values that are found in large quantities in natural medicines,especially Vernonia amygdalina,a famous nature medicine for the treatment of tonsillitis,diabetes,pneumonia.The current study was designed to combine molecular networking(MN)with diagnostic ions for rapid identification ofΔ^(7,9(11))stigmastane-type saponins which were theα-glucosidase inhibitory active substances in V.amygdalina.First,theα-glucosidase inhibitory activities of fiveΔ^(7,9(11))stigmastane-type steroid saponins that were previously isolated were screened,which indicated that theΔ^(7,9(11))stigmastane-type steroid saponin was one of the active constituents responsible for ameliorating diabetes.Furthermore,a strategy was proposed to identify stigmastane-type steroid saponins and verify the plausibility of derived fragmentation pathways by applying MN,MolNetEnhancer and unsupervised substructure annotation(MS2LDA).Based on this strategy,other sevenΔ^(7,9(11))stigmastane-type steroid saponins were identified from this plant.Our research provide scientific evidence for the antidiabetic potential of the steroid saponin-rich extract of V.amygdalina leaf.

关键词： Δ^(7,9(11))Stigmastane-type steroid saponins α-Glucosidase inhibitory activity Fragmentation pathways Diagnostic ions Molecular networking

Identification of new cotton fiber-quality QTL by multiple genomic analyses and development of markers for genomic breeding

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The Crop Journal 2024年第3期12卷 866-879页

作者： Haozhe Tan Binghui Tang mengling Sun Qiulu Yin Yizan Ma Jianying Li Pengcheng Wang Zhonghua Li Guannan zhao Maojun Wang Xianlong Zhang Chunyuan You Lili Tu National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070HubeiChina Cotton Research Institute Shihezi Academy of Agriculture ScienceShihezi 832000XinjiangChina

Cotton fiber is one of the main raw materials for the textile industry.In recent years,many cotton fiber quality QTL have been identified,but few were applied in breeding.In this study,a genome wide association study(GWAS)of fiber-quality traits in 265 upland cotton breeding intermediate lines(GhBreeding),combined with genome-wide selective sweep analysis(GSSA)and genomic selection(GS),revealed 25 QTL.Most of these QTL were ignored by only using GWAS.The CRISPR/Cas9 mutants of GhMYB_D13 had shorter fiber,which indicates the credibility of QTL to a certain extent.Then these QTL were verified in other cotton natural populations,5 stable QTL were found having broad potential for application in breeding.Additionally,among these 5 stable QTL,superior genotypes of 4 showed an enrichment in most improved new varieties widely cultivated currently.These findings provide insights for how to identify more QTL through combined multiple genomic analysis to apply in breeding.

关键词： Cotton fiber quality breeding GWAS Genome-wide selective sweep analysis Genomic selection InDel markers

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基于TCPSO的三维无线传感器网络覆盖

河南科技大学学报（自然科学版） 2024年第4期45卷 40-48,M0004,M0005页

作者：赵梦玲赵昊男西安科技大学理学院陕西西安710054

针对三维无线传感器网络(3D WSNs)的节点部署问题,提出了一种基于双层混沌粒子群优化(TCPSO)算法的解决方案。利用TCPSO算法对节点进行优化部署,以提高网络的空间覆盖率。TCPSO算法通过非线性分类系数将种群分为精英种群和普通种群,分... 详细信息

针对三维无线传感器网络(3D WSNs)的节点部署问题,提出了一种基于双层混沌粒子群优化(TCPSO)算法的解决方案。利用TCPSO算法对节点进行优化部署,以提高网络的空间覆盖率。TCPSO算法通过非线性分类系数将种群分为精英种群和普通种群,分别采取不同的速度、位置更新公式进行迭代优化。TCPSO提出了基于Logistic混沌映射的递减惯性权重,用来控制算法在局部的开发,并且为了避免算法早熟,引入了Levy飞行策略增强算法的全局搜索能力。通过在1个三维网格空间中进行仿真实验,验证TCPSO以及粒子群优化(PSO)算法解决3D WSNs的节点部署问题的能力。分别在不同数量的节点数、不同的通信半径以及不同的种群规模上进行了3组实验,实验采用控制变量法,观察在不同条件下TCPSO的性能。TCPSO在全部的实验中提出的节点部署方案均明显优于PSO的部署方案。

关键词：无线传感器网络节点部署空间覆盖率粒子群优化算法

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脱细胞真皮基质微粒移植的应用研究进展

中华整形外科杂志 2024年第6期40卷 698-701页

作者：袁梦聆赵欢欢刘毅兰州大学第二医院烧伤整形与创面修复外科兰州730000

随着生物材料在临床中的广泛应用,脱细胞真皮基质作为组织工程中的佼佼者,近年来发展势头迅猛,具备良好的临床应用优势。尤其是在整形美容领域的注射美容中,微粒化脱细胞真皮基质(mADM)以其独特的形态学特征受到瞩目,具有安全、微创、... 详细信息

随着生物材料在临床中的广泛应用,脱细胞真皮基质作为组织工程中的佼佼者,近年来发展势头迅猛,具备良好的临床应用优势。尤其是在整形美容领域的注射美容中,微粒化脱细胞真皮基质(mADM)以其独特的形态学特征受到瞩目,具有安全、微创、可持续性等优点。对于mADM在注射时选择的介质、介质与mADM适宜的混合比例等问题,还有待于进一步实践验证。该文就相关研究成果进行了综述。

关键词：生物相容性材料微粒化脱细胞真皮基质介质美容注射

面向可调谐微波应用的Ba_(x)Sr_(1-x)TiO_(3)铁电薄膜材料与器件研究进展

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硅酸盐学报 2024年第1期52卷 229-239页

作者：沈德坤杨淄涵郭沛源赵梦玲葛健邓功勋王爱记北京师范大学多尺度自旋物理教育部重点实验室北京师范大学物理学系北京100875 中国科学院物理研究所北京100190

可调谐微波器件是相控阵雷达和现代移动通信技术的重要技术核心,具有广阔的应用前景和市场需求。Ba_(x)Sr_(1-x)TiO_(3)铁电薄膜材料因其高介电可调性和快速的场响应而被认为是可调谐微波器件最有前途的材料之一。目前,人们对该材料降... 详细信息

可调谐微波器件是相控阵雷达和现代移动通信技术的重要技术核心,具有广阔的应用前景和市场需求。Ba_(x)Sr_(1-x)TiO_(3)铁电薄膜材料因其高介电可调性和快速的场响应而被认为是可调谐微波器件最有前途的材料之一。目前,人们对该材料降低介质损耗和提升介电可调性方面的研究取得了众多进展。综述了近年来国内外有关Ba_(x)Sr_(1-x)TiO_(3)铁电薄膜的介电性能研究以及其在可调谐微波器件的发展现状,并探讨了其研究中所存在的主要问题及未来研究重点。

关键词：钛酸锶钡薄膜介电性能可调谐微波器件

患病异育银鲫中嗜冷黄杆菌的分离鉴定及组织病理学观察

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水产学报 2024年第5期48卷 94-106页

作者：姜虎成李润波赵彦华徐晓雁孙梦玲夏爱军薛晖江苏省淡水水产研究所上海海洋大学农业农村部淡水水产种质资源重点实验室

为确定越冬期内江苏多地异育银鲫暴发性死亡的原因，本研究利用高通量测序比较了健康样品和患病样品的微生物群落多样性和结构组成的差异，分析了异育银鲫病害暴发过程中的细菌类型及特性。结果显示，在属水平上，患病样品中黄杆菌属丰... 详细信息

为确定越冬期内江苏多地异育银鲫暴发性死亡的原因，本研究利用高通量测序比较了健康样品和患病样品的微生物群落多样性和结构组成的差异，分析了异育银鲫病害暴发过程中的细菌类型及特性。结果显示，在属水平上，患病样品中黄杆菌属丰度最高。在种水平上，患病样品中嗜冷黄杆菌的丰度最高，分别达到63.01%和61.31%，显著高于健康组的1.55%。根据微生物群落特征分析结果，从患病样品体表的病灶处分离出优势病原菌NJ01，通过细菌形态学、生理生化分析、16S rDNA序列比对确定NJ01菌株为嗜冷黄杆菌。人工感染NJ01菌株14 d后，1.7×10～6和1.7×10～7 CFU/mL两组的死亡率达到100%，感染症状和自然发病症状一致。组织病理学观察发现，病鱼的肌细胞坏死，间质中充满了淋巴细胞；肝脏中细胞溶解坏死，细胞核消融；在脾脏中发现脾细胞散在坏死，伴随着充血的症状；肾小管上皮脱落，肾间质存在大量淋巴细胞。药物敏感实验结果显示，NJ01菌株对头孢西叮、头孢哌酮、庆大霉素和克拉霉素等敏感。研究表明，优势菌NJ01是致病菌，可通过扰乱机体正常的免疫和代谢功能导致疾病的发生。本研究首次报道了嗜冷黄杆菌在异育银鲫中的致病性，这将为大宗淡水鱼“越冬综合征”的药物防治及其致病机理研究提供参考依据。

关键词：异育银鲫嗜冷黄杆菌扩增子分析分离鉴定致病性耐药性

Hydroxyl-and-carboxyl ligand concatenating multi-lanthanide substituted tellurotungstates and electrochemical detection of noradrenaline

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Journal of Rare Earths 2022年第11期40卷 1785-1793,I0005页

作者： mengling Liu Yan Zhang Jun Jiang Dan Wang Yanzhou Li Junwei zhao Lijuan Chen Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Chemical EngineeringHenan UniversityKaifeng 475004China

Developing and exploring organic-inorganic hybrid multi-lanthanide(Ln)implanted heteropolyoxometalates(HPOMs)has bloomed into an emerging research fieId.In this article,two neoteric Dgluconic acids(H_(6)GA)concatenating multi-Ln^(Ⅲ) implanted heteropoly tungstates K_(14)H_(10)[Ln_(4)(H_(2)O)_(4)W_(6)(H_(2)-GA)_(4) O_(12)(B-α-TeW_(9)O_(33))_(4)]·60 H_(2)O(Ln=La^(3+)(1),Pr^(3+)(2))were obtained in acidic aqueous system.Attractively,in the polyanion structure of 1 and 2,six WⅥand four LnⅢcenters are connected by four flexible H_(2)GA^(4-) ligands via carboxyl and hydroxyl groups,resulting in the heterometallic[Ln_(4)(H_(2)O)_(4)W_(6)H_(2)GA)_(4)O_(12)]^(8+)cluster and then the heterometallic cluster is surrounded by four[B-α-TeW_(9)O_(33)]^(8-)segments.Electrochemical measurements for the 1@CFMCN/GCE sensor(CFMCN=carboxylfunctionalized multiwalled carbon nanotube;GCE=glass carbon electrode)demonstrate that 1@CFMCN/GCE shows benign recognition response to detecting noradrenaline(NDA).This research expands the structural diversity of Ln-implanted HPOMs and presents an electrochemical platform of recognizing NDA in the field of biosensors.

关键词： Polyoxometalate Tellurotungstate Lanthanide Gluconic acid Electrochemical sensing Rare earths

Effects of different calcium salts on the physicochemical properties of sliver carp myosin

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Food Bioscience 2022年第3期47卷 298-306页

作者： Yang Hu mengling Zhang Yu zhao Xia Gao Juan You Tao Yin Shanbai Xiong Ru Liu College of Food Science and Technology Huazhong Agricultural UniversityWuhanHubei430070China Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt Ministry of EducationWuhan430070China National R & D Branch Center for Conventional Freshwater Fish Processing WuhanHubei430070China

To investigate the effects of different calcium salts on the physicochemical properties of myosin,the intermolecular interactions,particle size,surface hydrophobicity,reactive sulfhydryl group content and rheological properties of sliver carp myosin with the addition of four different kinds of calcium salts (CaCl_(2),calcium citrate (CC),nano-hydroxyapatite (HAP),tricalcium phosphate (TCP)) during gel processing were measured.The results showed that the addition of CaCl_(2) promoted the unwinding of α-helix,the increase in hydrophobic interactions,the formation of disulfide bonds of myosin,and increased the viscoelasticity of myosin.While,the addition of calcium citrate (CC) enhanced the hydrophobic interaction between myosin molecules,and the viscoelasticity of CC-added myosin was second only to the CaCl_(2)-added myosin.On the contrary,the addition of HAP and TCP interfered with the hydrophobic interaction between myosin molecules,and greatly reduced the viscoelasticity of myosin.In summary,calcium with high calcium release rate can improve the physicochemical properties of myosin,HAP and TCP with a very low calcium release rate interfered with the formation of myosin gelation.And it could be concluded that the calcium ions played a leading role in the physicochemical properties of myosin,the more calcium ion that the calcium salt can release,the better physicochemical properties the myosin were.Our work may provide an insight into the phenomenon why different kinds of calcium salts differ from each other on affecting the physicochemical properties of myosin during gel processing.

关键词： Calcium Myosin Gel properties Silver carp

Rumen microbiome structure and metabolites activity in dairy cows with clinical and subclinical mastitis

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1148-1168页

作者： Yue Wang Xuemei Nan Yiguang zhao Linshu Jiang mengling Wang Hui Wang Fan Zhang Fuguang Xue Dengke Hua Jun Liu Junhu Yao Benhai Xiong State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Beijing Key Laboratory for Dairy Cow Nutrition Beijing University of AgricultureBeijing 102206China Engineering Research Center of Feed Development Jiangxi Province Key Laboratory of Animal NutritionJiangxi Agricultural UniversityNanchang 330045China Langfang Academy of Agriculture and Forestry Langfang 065000China

Background:Due to the high prevalence and complex etiology,bovine mastitis(BM)is one of the most important diseases to compromise dairy cow health and milk quality.The shift in milk compositions has been widely investigated during mastitis,but recent studies suggested that gastrointestinal microorganism also has a crucial effect on the inflammation of other peripheral tissues and organs,including the mammary gland.However,research focused on the variation of rumen inner-environment during mastitis is still limited.Therefore,the ruminal microbial profiles,metabolites,and milk compositions in cows with different udder health conditions were compared in the present study.Furthermore,the correlations between udder health status and ruminal conditions were investigated.Based on the somatic cell counts(SCC),California mastitis test(CMT)parameters and clinical symptoms of mastitis,60 lactating Holstein dairy cows with similar body conditions(excepted for the udder health condition)were randomly divided into 3 groups(n=20 per group)including the healthy(H)group,the subclinical mastitis(SM)group and the clinical mastitis(CM)group.Lactation performance and rumen fermentation parameters were recorded.And rumen microbiota and metabolites were also analyzed via 16S rRNA amplicon sequencing and untargeted metabolomics,respectively.Results:As the degree of mastitis increased,rumen lactic acid(LA)(P<0.01),acetate,propionate,butyrate,valerate(P<0.001),and total volatile fatty acids(TVFAs)(P<0.01)concentrations were significantly decreased.In the rumen of CM cows,the significantly increased bacteria related to intestinal and oral inflammation,such as Lachnospiraceae(FDR-adjusted P=0.039),Moraxella(FDR-adjusted P=0.011)and Neisseriaceae(FDR-adjusted P=0.036),etc.,were accompanied by a significant increase in 12-oxo-20-dihydroxy-leukotriene B4(FDR-adjusted P=5.97×10^(−9))and 10beta-hydroxy-6beta-isobutyrylfuranoeremophilane(FDR-adjusted P=3.88×10^(−10)).Meanwhile,in the rumen of SM cows,the Ruminiclostridium_9(FDR-adjusted P=0.042)a

关键词： Dairy cows Lactation performance Mastitis Rumen fermentation Ruminal metabolisms Ruminal microbiota

Organic–inorganic hybrid perovskite scintillators for mixed field radiation detection

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InfoMat 2022年第9期4卷 97-108页

作者： mengling Xia Guangda Niu Linyue Liu Runlong Gao Tong Jin Pengying Wan Weicheng Pan Xianpeng Zhang Zuoxiang Xie Sam Teale Zenghua Cai Jiajun Luo Shan zhao Haodi Wu Shiyou Chen Zhiping Zheng Qingguo Xie Xiaoping Ouyang Edward HSargent Jiang Tang Wuhan National Laboratory for Optoelectronics(WNLO) WuhanChina School of Optical and Electronic Information Huazhong University of Science and Technology(HUST)WuhanChina State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi'anChina School of Nuclear Science and Technology Xi'an Jiaotong UniversityXi'anChina Department of Electrical and Computer Engineering University of TorontoTorontoOntarioCanada School of Microelectronics Fudan UniversityShanghaiChina College of Life Science and Technology Huazhong University of Science and TechnologyWuhanChina

Sensitive and fast detection of neutrons and gamma rays is vital for homeland security,high-energy physics,and proton therapy.Fast-neutron detectors rely on light organic scintillators,andγ-ray detectors use heavy inorganic scintillators and semiconductors.Efficient mixed-field detection using a single material is highly challenging due to their contradictory requirements.Here we report hybrid perovskites(C_(8)H_(12)N)_(2)Pb(Br_(0.95)Cl_(0.05))_(4)that combine light organic cations and heavy inorganic skeletons at a molecular level to achieve unprecedented performance for mixed-field radiation detection.High neutron absorption due to a high density of hydrogen,strong radiative recombination within the highly confined[PbX_(6)]^(4-)layer,and sub-nanometer distance between absorption sites and radiative centers,enable a light yield of 41000 photons/MeV,detection pulse width of 2.97 ns and extraordinary linearity response toward both fast neutrons andγ-rays,outperforming commonly used fast-neutron scintillators.Neutron energy spectrum,time-of-flight based fast-neutron/γ-ray discrimination and neutron yield monitoring were all successfully achieved using(C_(8)H_(12)N)_(2)Pb(Br_(0.95)Cl_(0.05))_(4)detectors.We further demonstrate the monitoring of reaction kinetics and total power of a nuclear fusion reaction.We envision that molecular hybridized scintillators open a new avenue for mixed-field radiation detection and imaging.

关键词： fast neutron mixed-field radiation detection organic-inorganic hybrid perovskite