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Journal of Integrative Agriculture 2020年第11期19卷 2829-2838页

作者： LI Fu-hua ZHENG Shao-jie zhao ji-chun LIAO Xia WU Su-rui MING jian College of Food Science Southwest UniversityChongqing 400715P.R.China Research Center of Food Storage&Logistics Southwest UniversityChongqing 400715P.R.China Kunming Edible Fungi Institute All China Federation of Supply and Marketing CooperativesKunming 650223P.R.China

Morchella angusticeps Peck,one of the most popular edible mushrooms,has attracted great attention due to its delicious taste and healthy ***,both its biological effects and the possible mechanism of action have not yet been *** investigated the anti-proliferative activity of the phenolic extract derived from Morchella angusticeps Peck(MPE)against HepG2 human hepatocellular carcinoma *** showed that MPE at non-cytotoxicity doses significantly inhibited the proliferation of HepG2 cells in a dose-dependent manner with inhibitory rates ranging from 18 to 90%(P<0.01).The possible mechanism might be that MPE induced apoptosis through initiating the mitochondrial death pathway by regulating Bax,Bcl-2 and cleaved *** the other hand,MPE might trigger cell cycle arrest at G0/G1/S phases by managing p21,Cyclin D1,cyclin-dependent kinases-4(CDK4)and proliferating cell nuclear antigen(PCNA).Additionally,MPE downregulated TRAF-2 and p-p53,while upregulated p-ASK1 and ***,it could be inferred that MPE might induce the anti-proliferative function to HepG2 cells through the p38/MAPK signal transduction pathway.

关键词： Morchella angusticeps Peck phenolic extract cell cycle apoptosis anti-proliferation

Changes in phenolic content,composition,and antioxidant activity of blood oranges during cold and on-tree storage

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Journal of Integrative Agriculture 2022年第12期21卷 3669-3683页

作者： zhao ji-chun AO Miao HE Xiao-qin LI Wei-zhou DENG Li-li ZENG Kai-fang MING jian College of Food Science Southwest UniversityChongqing 400715P.R.China Research Center of Food Storage&Logistics Southwest UniversityChongqing 400715P.R.China

Citrus fruits are rich in phenolic compounds that possess several health ***,few studies have focused on the changes in phenolic compounds in citrus fruits during postharvest *** study dynamically monitored the phenolic content,components and antioxidant activity of‘Tarocco’blood oranges during a period of 12-week cold storage and on-tree storage,*** investigated the alteration mechanism of phenolic compounds in blood oranges by evaluating phenylpropanoid pathway-related enzyme activities and gene *** showed that flavanones were the main phenolic compounds in blood *** storage methods mainly stimulated the accumulation of phenolic acids to improve total phenolic content,which reached the maximum at week ***,blood oranges had a higher phenolic content and antioxidant activity under on-tree storage than cold ***,the enzyme activities and gene expression of the phenylpropanoid pathway demonstrated that the accumulation of phenolics in blood oranges during storage was highly related to the activation of the phenylpropanoid *** results demonstrate that on-tree storage is a potential approach for extending the supply period of blood orange from the perspective of phenolic compounds.

关键词： ‘Tarocco’blood orange polyphenol components antioxidant ability phenylpropanoid pathway on-tree storage

Potential etiopathogenesis of seventh day syndrome following living donor liver transplantation:ischemia of the graft?

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Hepatobiliary & Pancreatic Diseases International 2010年第1期9卷 22-26页

作者： Lan, Xiang Li, Bo Wang, Xiao-Fei Wei, Yong-Gang Yan, Lu-Nan zhao, ji-chun Sichuan Univ W China Hosp Div Liver Transplantat Chengdu 610041 Peoples R China Sichuan Univ W China Hosp Div Vasc Surg Chengdu 610041 Peoples R China

BACKGROUND: Seventh-day syndrome (7DS) is an early serious complication following liver transplantation with a high mortality because of its unknown etiopathogenesis. This study aimed to analyze the potential etiopathogenesis of 7DS. METHODS: A retrospective analysis of 98 consecutive living donor liver transplants performed from 2001 to 2007 at our center revealed that 5 patients had suffered from 7DS; their age, MELD score, portal vein inflow and other parameters were compared with those of the other recipients. RESULTS: The 5 patients showed common features: (a) initial uneventful recovery, and a dramatic rise of serum liver enzyme levels I to 2 weeks later; (b) decreased inflow in the portal vein accompanied by augmentation of serum creatinine and urea nitrogen level; and (c) serial liver biopsy findings of apoptosis and ischemic necrosis of hepatocytes. Four of the 5 patients died. Age, waiting time to transplantation, MELD score, operation time, cold ischemic time, portal interceptive time and diameter of the portal vein were not significantly different between the 2 groups, but a difference was found in the flow rate of the portal vein (t=3.234, P<0.001). CONCLUSIONS: The 5 patients suffered from a decreased portal vein inflow, ischemic liver necrosis, and renal failure. Hence, hypoperfusion of the liver graft was considered to be the etiopathogenesis of 7DS, for which, however sufficient evidence is lacking. More studies of 7DS are needed.

关键词： seventh-day syndrome living donor liver transplantation ischemic hepatitis etiopathogenesis hepatocellular necrosis

A successful pregnancy following liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 98-100页

作者： Pan, Guang-Dong Yan, Lu-Nan Li, Bo Zeng, Yong Wen, Tian-Fu zhao, ji-chun Wang, Wen-Tao Yang, jia-Yin Sichuan Univ W China Hosp Ctr Liver Transplantat Dept Gen Surg Chengdu 610041 Peoples R China Guangxi Med Sci Univ Affiliated Hosp 5 Dept Gen Surg Liuzhou 545051 Peoples R China

BACKGROUND: The safety and possibility of pregnancy following liver transplantation has been the hot topic in transplant. A case is reported with a review the of literature. METHOD: The data of a 22-year-old pregnant patient with end-stage liver disease who had undergone orthotopic liver transplantation in September 28, 2000 were analyzed retrospectively. RESULTS: After surgery, the patient was uneventfully recovered and was pregnant at the time of the 33rd month postoperation. The patient experienced a rejection on the 8th week of pregnancy and was successfully treated at this hospital. The patient was closely monitored throughout her pregnancy, and received routine antenatal care with respect to sonographic screening. Caesarean section was performed in March 18, 2004, and a health live-born infant weighing 2000 g was delivered at full-term. After the delivery, the patient was satisfactory with, her health and the baby was healthy. CONCLUSION: Under close monitoring, successful pregnancy following liver transplantation is possible and safe in women with end-stage liver diseases.

关键词： pregnancy liver transplantation

Microsurgical reconstruction of hepatic artery in A-A LDLT:124 consecutive cases without HAT

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World Journal of Gastroenterology 2010年第21期16卷 2682-2688页

作者： Yang, Yi Yan, Lu-Nan zhao, ji-chun Ma, Yu-Kui Huang, Bin Li, Bo Wen, Tian-Fu Wang, Wen-Tao Xu, Ming-Qing Yang, jia-Yin Sichuan Univ W China Hosp Dept Liver & Vasc Surg Chengdu 610041 Sichuan Prov Peoples R China

AIM:To retrospectively investigate microsurgical hepatic artery(HA) reconstruction and management of hepatic thrombosis in adult-to-adult living donor liver transplantation(A-A LDLT).METHODS:From January 2001 to September 2009,182 recipients with end-stage liver disease underwent A-A *** of these patients received dual *** 157 men and 25 women had an age range of 18 to 68 years(mean age,42 years).Microsurgical techniques and running sutures with back-wall first techniques were performed in all arterial reconstructions under surgical loupes(3.5 ×) by a group of vascular *** dissections were resolved by interposition of the great saphenous vein(GSV) between the donor right hepatic artery(RHA) and recipient common HA(3 cases) or abdominal aorta(AA)(2 cases),by interposition of cryopreserved iliac vessels between the donor RHA and recipient AA(2 cases).RESULTS:In the 58 incipient patients in this series,hepatic arterial thrombosis(HAT) was encountered in 4 patients,and was not observed in 124 consecutive cases(total 192 grafts,major incidence,2.08%).All cases of HAT were suspected by routine color Doppler ultrasonographic examination and confirmed by contrast-enhanced ultrasound and hepatic *** these cases of HAT,two occurred on the 1st and 7th d,respectively,following A-A LDLT,and were immediately revascularized with GSV between the graft and recipient *** in one patient occurred on the 46th postoperative day with no symptoms,and the remaining case of HAT occurred on the 3rd d following A-A LDLT,and was cured by thrombolytic therapy combined with an anticoagulant but died of multiorgan failure on the 36th d after A-A *** deaths were related to ***:Applying microsurgical techniques and selecting an appropriate anastomotic artery for HA reconstruction are crucial in reducing the high risk of HAT during A-A LDLT.

关键词： Adult-to-adult living donor liver transplantation Hepatic arterial thrombosis Microsurgical reconstruction

加强多学科协作团队建设,提高糖尿病周围血管病变与足病的诊治水平

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四川大学学报（医学版） 2012年第5期43卷 728-733页

作者：冉兴无赵纪春四川大学华西医院糖尿病足诊治中心成都610041 四川大学华西医院内分泌代谢科成都610041 四川大学华西医院血管外科和腔内治疗中心成都610041

糖尿病下肢血管病变与糖尿病足溃疡是糖尿病患者住院的主要原因,也是糖尿病患者截肢的主要原因之一,并且增加心血管死亡和全因死亡率,在临床上呈增加趋势。与既往的标准治疗或单一的专科医师治疗方法相比,多学科协作能较好的治疗糖尿病... 详细信息

糖尿病下肢血管病变与糖尿病足溃疡是糖尿病患者住院的主要原因,也是糖尿病患者截肢的主要原因之一,并且增加心血管死亡和全因死亡率,在临床上呈增加趋势。与既往的标准治疗或单一的专科医师治疗方法相比,多学科协作能较好的治疗糖尿病下肢血管病变与足病。多学科协作团队应该包括糖尿病专科医师、糖尿病教育护士、血管外科医师、骨科医师、矫形外科医师、普通外科医师、创面外科医师、足踝外科医师、血管影像医师及感染科医师、心理学科医师、社会教育工作者、糖尿病足治疗鞋定做者和康复治疗小组。通过糖尿病教育、适当的足部护理、早期发现导致足病的危险因素以及早期干预可以预防足病的发生和防止截肢;对于糖尿病下肢血管病变及足病患者,及时且积极的多学科协作治疗方案如控制代谢异常、感染控制、溃疡清创、下肢血循重建、创面覆盖等能够防止病情恶化甚至截肢的发生。因此,应该加强多学科协作团队建设,对于糖尿病下肢动脉病变和足病患者,提供更好的综合治疗,从而改善患者的生存和预后。

关键词：糖尿病糖尿病下肢血管病变糖尿病足溃疡多学科协作团队治疗截肢

Efficacy of middle hepatic vein reconstruction in adult right-lobe living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2010年第2期9卷 135-138页

作者： Peng, Ci-Jun Wang, Xiao-Fei Li, Bo Wei, Yong-Gang Yan, Lu-Nan Wen, Tian-Fu Yang, jia-Yin Wang, Wen-Tao zhao, ji-chun Sichuan Univ Dept Liver & Vasc Surg Chengdu 610041 Peoples R China Sichuan Univ W China Hosp Vasc Surg & Liver Transplantat Ctr Chengdu 610041 Peoples R China

BACKGROUND: Congestion of the right anterior segment may lead to graft dysfunction in right-lobe living donor liver transplantation (LDLT) without a middle hepatic vein (MHV) trunk. Selective reconstruction of MHV tributaries with the interposition of vascular grafts has been introduced to overcome this problem. However, there is still no consensus on the definite criteria of MHV reconstruction. METHODS: LDLT patients were reviewed to evaluate the effects of MHV reconstruction. From March 2005 to September 2008 in our transplantation center, 120 consecutive LDLTs were performed using a right-lobe graft without a MHV. Excluding 11 patients, among the remainder, 73 (67%) had reconstructed MHV tributaries, and the others 36 (33%) did not. The values of liver functional index and liver graft regeneration ratio were compared between the two groups. RESULTS: There was a prolonged period of liver functional recovery in patients with small-for-size grafts and a graft-recipient weight ratio (GRWR) <1.0%, and without MHV reconstruction. The ratio of liver regeneration 1 month postoperatively in reconstruction cases was 81%, versus 78% in patients without reconstruction (P=0.352), but among small-for-size grafts, there was a significant difference between the two groups (95% vs. 80%). CONCLUSION: Our study shows that reconstruction of MHV tributaries is not necessary in all patients, but is beneficial for patients with GRWR <1.0%. (Hepatobiliary Pancrent Dis Int 2010; 9: 135-138)

关键词： middle hepatic vein reconstruction living donor liver transplantation interposition vascular conduits

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下肢动脉硬化闭塞症腔内治疗

中国实用外科杂志 2016年第12期36卷 1263-1268页

作者：赵纪春杨轶四川大学华西医院血管外科四川成都610041

下肢动脉硬化闭塞症(ASO)是一种主要由动脉粥样硬化引起的疾病,发病率、病死率较高,严重影响病人生活质量。根据下肢ASO病人病情严重度及病变部位而制定的Fontain、Rutherford分期及TASCⅡ分级标准在临床治疗方案决策及预后估计中起到... 详细信息

下肢动脉硬化闭塞症(ASO)是一种主要由动脉粥样硬化引起的疾病,发病率、病死率较高,严重影响病人生活质量。根据下肢ASO病人病情严重度及病变部位而制定的Fontain、Rutherford分期及TASCⅡ分级标准在临床治疗方案决策及预后估计中起到重要作用。下肢ASO病人的治疗方案根据病变解剖位置的不同而有所不同,同时也受到病人合并症以及手术医师水平的限制。目前下肢ASO的手术治疗以血管重建为主,其中腔内手术为大多数病人首选治疗方案。

关键词：动脉硬化闭塞症血管重建腔内治疗

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血管创伤术后并发症的处理

中国实用外科杂志 2014年第12期34卷 1160-1162页

作者：黄斌赵纪春四川大学华西医院血管外科四川成都610041

血管创伤,尤其是肢体血管创伤在外伤病人并不少见。血管创伤机制主要包括钝性损伤、穿通伤、爆炸冲击伤及医源性损伤。手术过程对于病人的救治十分重要,但术后并发症的处理对于手术效果的维持和病人的康复同样重要。保守治疗、手术治疗... 详细信息

血管创伤,尤其是肢体血管创伤在外伤病人并不少见。血管创伤机制主要包括钝性损伤、穿通伤、爆炸冲击伤及医源性损伤。手术过程对于病人的救治十分重要,但术后并发症的处理对于手术效果的维持和病人的康复同样重要。保守治疗、手术治疗或者血管腔内介入治疗的选择及应用对于术后并发症的处理意义重大。医生对术后并发症认识的不断深入有助于病人的进一步康复。

关键词：血管创伤并发症术后处理

Measures for increasing the safety of donors in living donor liver transplantation using right lobe grafts

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Hepatobiliary & Pancreatic Diseases International 2007年第6期6卷 590-595页

作者： Wen, Tian-Fu Chen, Zhe-Yu Yan, Lu-Nan Li, Bo Zeng, Yong zhao, ji-chun Wang, Wen-Tho Yang, jia-Yin Ma, Yu-Kui Xu, Ming-Qing Liu, jiang-Wen Deng, Zhi-Gang Wu, Hong Sichuan Univ W China Hosp Div Liver Transplantat Chengdu 610041 Peoples R China

BACKGROUND: The safety of donors in living donor liver transplantation (LDLT) should be the primary consideration. The aim of this study was to report our experience in increasing the safety of donors in LDLTs using right lobe grafts. METHODS: We retrospectively studied 37 living donors of right lobe grafts from January 2002 to March 2006. The measures for increasing the safety of donors in LDLT included carefully selected donors, preoperative evaluation by ultrasonography, angiography and computed tomography; and necessary intraoperative cholangiography and ultrasonography. Right lobe grafts were obtained using an ultrasonic dissector without inflow vascular occlusion on the right side of the middle hepatic vein. The standard liver volume and the ratio of left lobe volume to standard liver volume were calculated. RESULTS: There was no donor mortality in our group. Postoperative complications only included bile leakage (I donor), biliary stricture (1) and portal vein thrombosis (1). All donors recovered well and resumed their previous occupations. In recipients, complications included acute rejection (2 patients), hepatic artery thrombosis (1), bile leakage (1), intestinal bleeding (1), left subphrenic abscess (1) and pulmonary infection (1). The mortality rate of recipients was 5.4% (2/37); one recipient with pulmonary infection died from multiple organ failure and another from occurrence of primary disease. CONCLUSIONS: The first consideration in adult-to-adult LDLT is the safety of donors. The donation of a right lobe graft is safe for adults if the remnant hepatic vasculature and bile duct are ensured, and the volume-of the remnant liver exceeds 35% of the total liver volume.

关键词： living donor liver transplantation hepatectomy right lobe graft safety