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重组人干扰素的研究进展

中国生物制品学杂志 2010年第12期23卷 1384-1388页

作者：赵广荣教育部系统生物工程重点实验室生物与制药工程天津市重点实验室天津大学化工学院制药工程系天津300072

重组人干扰素(Recombinant human interferon,rhuIFN)是一类抗病毒、抗肿瘤和多发性硬化调节免疫的重要生物制品。自1957年发现干扰素以来,人们不断采用新技术对干扰素分子结构进行改造,先后研发了原型干扰素、保守干扰素、聚乙二醇修... 详细信息

重组人干扰素(Recombinant human interferon,rhuIFN)是一类抗病毒、抗肿瘤和多发性硬化调节免疫的重要生物制品。自1957年发现干扰素以来,人们不断采用新技术对干扰素分子结构进行改造,先后研发了原型干扰素、保守干扰素、聚乙二醇修饰干扰素等几十个品种,目前已批准十余个一类新药干扰素上市。本文在回顾干扰素药物历史的基础上,对化学修饰改型干扰素、融合干扰素、杂合干扰素等的研究进展作一综述。

关键词：重组人干扰素干扰素α 化学修饰改型干扰素融合干扰素杂合干扰素

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综合物探法在老窑采空区探测中的应用

煤矿安全 2009年第11期40卷 43-44,47页

作者：赵光荣鄂尔多斯市煤炭局内蒙古鄂尔多斯017000

各种物探方法的应用都有一定的前提条件,所以单一方法很难解决一些较为复杂的问题,综合物探技术发挥了不同探测方法的优点,提高了物探成果的解译精度。针对某地方煤矿存在老窑采空区问题,采用了高密度电阻率法和瞬变电磁法为主的综合探... 详细信息

各种物探方法的应用都有一定的前提条件,所以单一方法很难解决一些较为复杂的问题,综合物探技术发挥了不同探测方法的优点,提高了物探成果的解译精度。针对某地方煤矿存在老窑采空区问题,采用了高密度电阻率法和瞬变电磁法为主的综合探测技术,基本查明了采空区的位置、范围和分布情况,为煤矿安全生产提供了保障。

关键词：采空区综合物探法瞬变电磁法高密度电阻率法

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匹马菌素的生物合成研究进展

中国抗生素杂志 2012年第10期37卷 728-732页

作者：王宗瑞赵广荣天津大学化工学院制药工程系系统生物工程教育部重点实验室天津300072

匹马菌素是纳塔链霉菌产生的一种安全、高效的多烯大环类真菌抑制剂,广泛应用于医药领域与食品工业。作为26元环的糖基化多烯大环聚酮,其生物合成基因簇长度约110kb,包含19个基因,编码5个聚酮合酶、10个修饰和转运蛋白及4个调控因子。... 详细信息

匹马菌素是纳塔链霉菌产生的一种安全、高效的多烯大环类真菌抑制剂,广泛应用于医药领域与食品工业。作为26元环的糖基化多烯大环聚酮,其生物合成基因簇长度约110kb,包含19个基因,编码5个聚酮合酶、10个修饰和转运蛋白及4个调控因子。本文分析了匹马菌素生物合成的基因基础、多烯聚酮合成过程、氧化和糖基化修饰与调控机理等最新研究进展,展望了利用组合生物合成进行基因簇改造的方案与应用前景。

关键词：匹马菌素纳塔链霉菌生物合成基因簇聚酮合成基因修饰基因转运基因调控基因

Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges

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Nano-Micro Letters 2025年第3期17卷 168-216页

作者： Shuai Zhong Lirou Su Mingkun Xu Desmond Loke Bin Yu Yishu Zhang rong zhao guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China College of Integrated Circuits Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Precision Instruments Tsinghua UniversityBeijing 100084People’s Republic of China Center for Brain‑Inspired Computing Research Tsinghua UniversityBeijing 100084People’s Republic of China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power *** fully leverage its advantages,convertingthe external analog signals to spikes is an essential *** including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area *** efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory *** can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory *** review summarizesand benchmarks the recent progress of artificial sensory *** starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial ***,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also ***,we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

General Automatic Solution Generation for Social Problems

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Machine Intelligence Research 2025年第1期22卷 145-159页

作者： Tong Niu Haoyu Huang Yu Du Weihao Zhang Luping Shi rong zhao Center for Brain-Inspired Computing Research(CBICR) Optical Memory National Engineering Research Centerand Department of Precision InstrumentTsinghua UniversityBeijing100084China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing100084China THU-CET HIK Joint Research Center for Brain-Inspired Computing Beijing100084China

Given the escalating intricacy and multifaceted nature of contemporary social systems,manually generating solutions to address pertinent social issues has become a formidable *** response to this challenge,the rapid development of artificial intelligence has spurred the exploration of computational methodologies aimed at automatically generating ***,current methods for the auto-generation of solutions mainly concentrate on local social regulations that pertain to specific ***,we report an automatic social operating system(ASOS)designed for general social solution generation built upon agent-based models that enables both global and local analyses and regulations of social problems across spatial and temporal *** adopts a hypergraph with extensible social semantics for a comprehensive and structured representation of social *** also incorporates a generalized protocol for standardized hypergraph operations and a symbolic hybrid framework that delivers interpretable solutions,yielding a balance between regulatory efficacy and functional *** demonstrate the effectiveness of the ASOS,we apply it to the domain of averting extreme events within international oil futures *** generating a new trading role supplemented by new mechanisms,ASOS can adeptly discern precarious market conditions and make front-running interventions for nonprofit *** study demonstrated that ASOS provides an efficient and systematic approach for generating solutions for enhancing our society.

关键词： General automatic generation global-local regulation hypergraph social representation symbolic hybrid scheme generalized operation protocol

Recent advancements in noble-metal electrocatalysts for alkaline hydrogen evolution reaction

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Chinese Chemical Letters 2025年第1期36卷 176-200页

作者： Guoliang Gao guangzhen zhao guang Zhu Bowen Sun Zixu Sun Shunli Li Ya-Qian Lan Key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes Suzhou UniversitySuzhou 234000China Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and EngineeringHenan UniversityKaifeng 475004China School of Chemistry South China Normal UniversityGuangzhou 510006China

Available online Alkaline water electrolysis(AWE)is a prominent technique for obtaining a sustainable hydrogen source and effectively managing the energy *** metal-based electrocatalysts,owing to their exceptional hydrogen binding energy,exhibit remarkable catalytic activity and long-term stability in the hydrogen evolution reaction(HER).However,the restricted accessibility and exorbitant cost of noble-metal materials pose obstacles to their extensive adoption in industrial *** review investigates strategies aimed at reducing the dependence on noble-metal electrocatalysts and developing a cost-effective alkaline HER catalyst,while considering the principles of sustainable *** initial discussion covers the fundamental principle of HER,followed by an overview of prevalent techniques for synthesizing catalysts based on noble metals,along with a thorough examination of recent *** subsequent discussion focuses on the strategies employed to improve noble metalbased catalysts,including enhancing the intrinsic activity at active sites and increasing the quantity of active ***,this investigation concludes by examining the present state and future direction of research in the field of electrocatalysis for the HER.

关键词： Hydrogen evolution reaction Alkaline water electrolysis Electrocatalysts Noble metal-based Synthesis method Modification strategy

苯甘氨酸氨基转移酶基因hpgt的原核优化表达与酶动力学特性研究

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中国生物工程杂志 2012年第5期32卷 51-57页

作者：王宗瑞赵广荣天津大学化工学院制药工程系天津300072

苯甘氨酸氨基转移酶(4-Hydroxyphenylglycine aminotransferase)是假单胞菌所产生的一种能够合成D-苯甘氨酸的重要转氨酶。利用密码子优化技术,合成苯甘氨酸转移酶基因。构建原核重组质粒pCDF-hpgt,转入感受态细胞*** BL21(DE3),优化表... 详细信息

苯甘氨酸氨基转移酶(4-Hydroxyphenylglycine aminotransferase)是假单胞菌所产生的一种能够合成D-苯甘氨酸的重要转氨酶。利用密码子优化技术,合成苯甘氨酸转移酶基因。构建原核重组质粒pCDF-hpgt,转入感受态细胞*** BL21(DE3),优化表达His-HpgT蛋白。利用Ni-NTA柱纯化技术获得高纯度的His-HpgT融合蛋白。分别测定融合蛋白在正反向反应中的酶活力单位及最佳的反应温度、pH值及其他动力学参数,并对该酶特性作相关的机理分析。测定结果表明,正向反应和反向反应的酶比活力分别为749mU/mg、2 257mU/mg,此酶分解苯甘氨酸的能力要强于合成苯甘氨酸;正向反应的最适温度与pH分别是35℃和8.0;由米氏方程得出该酶对苯甘氨酸的亲和力远大于谷氨酸;较低浓度的苯乙醛酸即可抑制反应的进行。

关键词：基因hpgt D-苯甘氨酸原核优化表达酶动力学特性

Airborne Investigation of Riming:Cloud and Precipitation Microphysics within a Weak Convective System in North China

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Advances in Atmospheric Sciences 2025年第3期42卷 515-526页

作者： Xiangfeng HU Hao HUANG Shaoyu HOU Kun zhao Chuanfeng zhao Yinghui LU Jiefang YANG rong ZHANG Delong zhao Weiguo LIU Dan ZHANG Haixia XIAO Key Laboratory of Radar Meteorology and State Key Laboratory of Severe Weather China Meteorology AdministrationBeijing 100044China China Meteorological Administration Xiong'an Atmospheric Boundary Layer Key Laboratory Xiong'an New AreaHebei 071703China Hebei Provincial Weather Modification Center ShijiazhuangHebei 051430China School of Atmospheric Sciences Key Laboratory of Mesoscale Severe Weather/MOEand Frontiers Science Center for Critical Earth Material CyclingNanjing UniversityJiangsu 210023China Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Laboratory of Cloud-Precipitation Physics and Severe Storms Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Cloud-Precipitation Physics and Weather Modification Key Laboratory China Meteorology AdministrationBeijing 100044China Beijing Weather Modification Center Beijing 100089China Nanjing Joint Institute for Atmospheric Sciences NanjingJiangsu 210000China

The process of riming significantly impacts the microphysical characteristics of *** study uses aircraft and radar observation data in stratiform clouds with convection embedded that occurred in the central and southern regions of North China on 22 May *** microphysical structural characteristics and processes near the embedded convection core and in the stratiform cloud are analyzed *** attention is given to the effect of riming on the microphysical properties near the upper boundary of the melting layer and to the factors influencing riming *** collaborative observations reveal that the particle size distributions observed near the convection core and in the stratiform region are close,while the particle properties like habit and riming degree are quite *** the melting layer,larger plate-like ice particles and supercooled water droplets(D>50μm)are more abundant near the convective core,leading to higher collision efficiencies between ice particles and supercooled water *** fluctuation amplitudes of vertical airflow near the convective core also contribute to the increased riming activity and the formation of more heavily rimed particles,such as ***,in situ measurements from airborne probes also revealed that above the melting layer,the riming process involves two stages:the mass of snow crystals grows as supercooled droplets merge internally without changing size,followed by external freezing that significantly enlarges the crystals.

关键词： riming collision efficiency airflow fluctuation particle habit aircraft measurement

过氧亚硝基阴离子对重组人干扰素α2b的氧化硝化修饰特征

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化学学报 2010年第19期68卷 2024-2028页

作者：赵广荣田莉莉马琼乔斌天津大学化工学院制药工程系系统生物工程教育部重点实验室天津300072

在体外模拟研究体内氧化硝化应激状态下产生的过氧亚硝基阴离子(ONOO-)对重组人干扰素α2b(rhIFNα2b)造成的氧化硝化修饰特征,并利用HPLC-MS/MS分析方法鉴定了ONOO-对重组人干扰素α2b氨基酸序列中的氧化硝化位点.结果表明ONOO-对重组... 详细信息

在体外模拟研究体内氧化硝化应激状态下产生的过氧亚硝基阴离子(ONOO-)对重组人干扰素α2b(rhIFNα2b)造成的氧化硝化修饰特征,并利用HPLC-MS/MS分析方法鉴定了ONOO-对重组人干扰素α2b氨基酸序列中的氧化硝化位点.结果表明ONOO-对重组人干扰素α2b的修饰位点主要在A螺旋的Met16被氧化,DE颈环的Tyr135被硝化,以及E螺旋的Trp140被硝化修饰.

关键词：重组人干扰素α2b 过氧亚硝基阴离子氧化硝化氨基酸修饰