Peroxynitrite Scavenging Activities of Resveratrol and Piceid

作     者：ZHAO Guang-rong TIAN Li-li MA Qiong WANG Chang-song QIAO Bin ZHANG Jun-gang JI Xiang-wu 

作者机构：Key Laboratory of Systems Bioengineering Ministry of Education Department of Pharmaceutical Engineering School of Chemieal Engineering and Teehnology Tianjin University Tianjin 300072 P. R. China Department of Cardiology Weifang People's Hospital Weifang 261041 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2012年第28卷第6期

页      面：953-956页

核心收录：

学科分类：0710[理学-生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 071003[理学-生理学] 

基　　金：Supported by the National Basic Research Program of China(Nos.2012CB721105,2011CBA00802,2007CB714301) the National Natural Science Foundation of China(No.30873400) the Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20090032110015) 

主　　题：Resveratrol Piceid Peroxynitrite 3-Nitrotyrosine Antioxidant activity Nitration reaction Radical scavenging 

摘      要：In vitro antioxidant activities of resveratrol and piceid against peroxynitrite（ONOO-） were examined by the inhibition of 3-nitrotyrosine *** was used as a positive *** and piceid exhibited high ONOO--scavenging activities in a concentration dependent *** antioxidant activities（the concentration of test compound required to yield a 50% inhibition of tyrosine nitration,IC 50） of resveratrol and piceid against ONOO-were（48.34±0.97） and（74.69±1.49） μmol/L,*** with that of trolox[（105.40±1.16） μmol/L],their scavenging activities were 2.2-and 1.5-fold higher for resveratrol and *** of nitroresveratrol as shown by UV-Vis spectroscopy and liquid chromatography-tandom mass spectrometry（LC-MS/MS） analysis indicates that resveratrol could directly scavenge ONOO-via nitration *** results demonstrate that foods and medicinal herbs with resveratrol and piceid as stronger ONOO-scavengers are valuable ingredients and have healthy application in preventing humans from peroxynitrite-mediated oxidative damage by scavenging peroxynitrite efficiently.