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质子泵抑制剂联合维生素C预防PCI术后双联抗血小板药物致消化道非活动性出血

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微循环学杂志 2024年第2期34卷 59-63页

作者：王海霞赵自冰牛燕运河北省邯郸市中医院心血管内科邯郸056001

目的:探讨质子泵抑制剂(PPI)联合维生素C预防经皮冠状动脉介入(PCI)术后双联抗血小板药物致消化道非活动性出血的效果。方法:采用前瞻性研究,通过随机数字表法将88例PCI术后接受双联抗血小板药物治疗且具有出血风险的患者分为对照组和... 详细信息

目的:探讨质子泵抑制剂(PPI)联合维生素C预防经皮冠状动脉介入(PCI)术后双联抗血小板药物致消化道非活动性出血的效果。方法:采用前瞻性研究,通过随机数字表法将88例PCI术后接受双联抗血小板药物治疗且具有出血风险的患者分为对照组和观察组,各44例。对照组患者给予口服泮托拉唑钠肠溶片,观察组在对照组的治疗基础上加用维生素C注射液静滴。比较两组患者术后3天残余血小板高反应性发生率、术后1个月消化道非活动性出血发生率、治疗前及术后3天应激反应及凝血功能指标的差异。结果:观察组患者术后3天残余血小板高反应性发生率及术后1个月内消化道非活动性出血发生率均低于对照组(均P0.05)。结论:维生素C联合PPI治疗能有效降低PCI后接受双重抗血小板疗法患者的消化道非活动性出血风险。

关键词：经皮冠状动脉介入双联抗血小板治疗出血

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封丘县典型农田土壤质量与时空变化特征

生态与农村环境学报 2024年第3期40卷 408-417页

作者：谢越马东豪王擎运赵炳梓朱安宁张丛志张佳宝李晓鹏安徽农业大学资源与环境学院安徽合肥230036 土壤与农业可持续发展国家重点实验室(中国科学院南京土壤研究所) 江苏南京210008

黄淮海平原作为我国重要的粮食产区,系统全面地评价该区域典型潮土的质量变化,对指导农业生产具有重要意义。以典型潮土分布的封丘县作为研究区,选取1984、2003和2011年的17项土壤指标,基于土壤参与生态过程中作物生产、碳固存、持水净... 详细信息

黄淮海平原作为我国重要的粮食产区,系统全面地评价该区域典型潮土的质量变化,对指导农业生产具有重要意义。以典型潮土分布的封丘县作为研究区,选取1984、2003和2011年的17项土壤指标,基于土壤参与生态过程中作物生产、碳固存、持水净化和养分运移等功能,构建土壤综合质量评价系统,采用主成分分析结合逼近理想点排序法(TOPSIS)计算各功能得分及土壤质量综合指数,通过GIS空间插值描述封丘县27年内潮土耕作区土壤质量和功能的时空变化特征。结果表明:(1)封丘县土壤全氮、全磷、碱解氮、有效磷、速效钾和有机质含量及阳离子交换量、饱和导水率和孔隙度均呈现不同程度的提升趋势;全钾含量、pH、容重、田间持水量和有效含水量则呈逐年降低趋势;(2)封丘县土壤作物生产、碳固存和养分运移功能得分均有所提升,增长率分别为9.29%、9.68%和7.36%,持水净化功能得分则降低4.17%;(3)封丘县土壤质量综合指数提升较为明显,1984年全县耕地土壤质量综合指数均≤2.0,2003年综合指数>2.0的耕地面积占全县总面积的8.44%,2011年提升至24.05%。整体而言,封丘县该时期的耕地保护和利用模式基本是有效的,封丘县耕地整体质量不断向好的方向发展,相关结果可以为黄淮海地区耕地资源可持续利用提供参考。

关键词：土壤质量评价体系土壤功能黄淮海平原 TOPSIS法 GIS

Turning point of organoid transplantation:first-in-human trial of iPSC-derived retinal organoid grafting in patients with retinitis pigmentosa

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Science China(Life Sciences) 2024年第5期67卷 1082-1084页

作者： Chang-Jun Zhang zi-bing Jin Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

The discovery of induced pluripotent stem cells(iPSCs)has revolutionized the field of disease research,providing a promising platform for studying various *** the last decade,significant progress has been made in combining iPSCs with other cutting-edge technologies to investigate disease mechanisms and develop potential treatments.

关键词： conditions patients retinitis

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Flotation separation of feldspar from quartz using sodium fluosilicate as a selective depressant

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Rare Metals 2024年第3期43卷 1288-1300页

作者： Xin Hu Xian-Ping Luo zi-Shuai Liu Yong-bing Zhang He-Peng Zhou Zhi-zhao Yang Xue-Kun Tang Faculty of Resource and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou341000China Yichun Lithium New Energy Industry Research Institute Jiangxi University of Science and TechnologyYichun336000China

The physical and chemical properties of feldspar and quartz are highly similar,thus they cannot be easily separated *** this work,the flotation separation of feldspar from quartz using sodium fluosilicate(Na_(2)SiF_(6);SF)as a selective depressant was ***,the influence mechanism of SF on the selective flotation separation of feldspar and quartz was investigated via flotation tests,chemical analysis of flotation solution,Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and contact angle *** results of the flotation tests show that feld spar and quartz without SF treatment have good *** SF treatment,feldspar still has good floatability,whereas quartz has significantly reduced *** solution chemical analysis shows that the functional group plays an important role in depressing the quartz is[SiF_(6)]^(2-).FTIR,XPS and contact angle analysis results show that[SiF_(6)]^(2-)is adsorbed only on the surface of ***,a thin hydrophilic SiOF layer is generated on the surface,which interferes with the adsorption of the collector on the surface of the *** phenomenon leads to a significant reduction in quartz's ***,SF has a good ability to separate feldspar from quartz by flotation.

关键词： Flotation separation Depressants Sodium fluorosilicate Quartz Feldspar

Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential

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World Journal of Stem Cells 2024年第5期16卷 512-524页

作者： Hang Zhang Ling-zi Wu Zhen-Yu Liu zi-bing Jin Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND Human induced pluripotent stem cell(hiPSC)technology is a valuable tool for generating patient-specific stem cells,facilitating disease modeling,and invest-igating disease ***,iPSCs carrying specific mutations may limit their clinical applications due to certain inherent *** To investigate the impact of MERTK mutations on hiPSCs and determine whether hiPSC-derived extracellular vesicles(EVs)influence anomalous cell junction and differentiation *** We employed a non-integrating reprogramming technique to generate peripheral blood-derived hiPSCs with and hiPSCs without a MERTK ***-somal karyotype analysis,flow cytometry,and immunofluorescent staining were utilized for hiPSC *** and proteomics were employed to elucidate the expression patterns associated with cell junction abnormalities and cellular differentiation ***,EVs were isolated from the supernatant,and their RNA and protein cargos were examined to investigate the involvement of hiPSC-derived EVs in stem cell junction and *** The generated hiPSCs,both with and without a MERTK mutation,exhibited normal karyotype and expressed pluripotency markers;however,hiPSCs with a MERTK mutation demonstrated anomalous adhesion capability and differentiation potential,as confirmed by transcriptomic and proteomic ***,hiPSC-derived EVs were involved in various biological processes,including cell junction and *** HiPSCs with a MERTK mutation displayed altered junction characteristics and aberrant differentiation ***,hiPSC-derived EVs played a regulatory role in various biological processes,including cell junction and differentiation.

关键词： Cell junction Cellular differentiation Extracellular vesicle Human induced pluripotent stem cells Transcriptomics Proteomics

Random Raman Fiber Laser as a Liquid Refractive Index Sensor

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Photonic Sensors 2024年第1期14卷 13-22页

作者： bing HAN Yuxi MA Han WU Yong zhao College of Information Science and Engineering Northeastern UniversityShenyang 110819China Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology Qinhuangdao 066004China College of Electronics and Information Engineering Sichuan UniversityChengdu 610064China

In this paper,a new concept of forward-pumped random Raman fiber laser(RRFL)-based liquid refractive index sensing is proposed for the first *** liquid refractive index sensing,the flat fiber end immersed in the liquid can act as the point reflector for generating random fiber lasing and also as the sensing *** to the high sensitivity of the output power of the RRFL to the reflectivity provided by the point reflector in the ultralow reflectivity regime,the proposed RRFL is capable of achieving liquid refractive index sensing by measuring the random lasing output *** theoretically investigate the effects of the operating pump power and fiber length on the refractive index sensitivity for the proposed *** a proof-of-concept demonstration,we experimentally realize high-sensitivity half-open short-cavity RRFL-based liquid refractive index sensing with the maximum sensitivity and the sensing resolution of-39.88W/RIU and 2.5075×10^(-5) RIU,*** also experimentally verify that the refractive index sensitivity can be enhanced with the shorter fiber length of the *** work extends the application of the random fiber laser as a new platform for highly-sensitive refractive index sensing in chemical,biomedical,and environmental monitoring applications,etc.

关键词： Fiber optic sensors refractive index measurements fiber lasers Rayleigh scattering stimulated Raman scattering

Use of curcumin and its nanopreparations in the treatment of inflammatory bowel disease

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World Journal of Gastroenterology 2024年第3期30卷 280-282页

作者： zi-Wen Meng bing Chang Li-Xuan Sang Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Department of Gastroenterology the First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

Inflammatory bowel disease(IBD)is a nonspecific inflammatory disease of the intestine that includes Crohn’s disease and ulcerative *** IBD is difficult to heal and easily relapses,it could worsen patient quality of life and increase economic ***(CUR)is a bioactive component derived from the rhizome of turmeric(Curcuma longa).Many basic and clinical studies have shown that CUR can efficiently treat IBD by decreasing the activity of proinflammatory cytokines by communicating with transcription factors and signaling ***,due to the limitations of being almost insoluble in aqueous solutions and having low oral bioavailability,it is important to select appropriate pharmaceutical preparations.

关键词： Curcumin Inflammatory bowel disease Bioavailability Nanotherapeutics

Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： zi-bing Qian Jun-Feng Li Wan-Yuan Xiong Xiao-Rong Mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic *** forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver *** general,more than one form of cell death pathways is responsible for the disease ***,it is particularly important to study the regulation and interaction of various cell death forms in liver *** sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver *** also used terms such as signal path,inducer,and inhibitor to supplement the query ***:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver ***:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

Copper-Free Click Chemistry-Mediated Assembly of Single Quantum Dot Nanosensor for Accurately Monitoring Locus-Specific m^(6)A in Cancer Cells

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Chinese Journal of Chemistry 2024年第5期42卷 499-504页

作者： Yue-Ying Li Ning-Ning zhao Yi-Xuan Geng Qian Han Jian-Ge Qiu bing-Hua Jiang zi-Yue Wang Chun-Yang Zhang Translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityThe Academy of Medical SciencesHenan Institute of Medical and Pharmaceutical Sciences BGI CollegeZhengzhou UniversityZhengzhouHenan450052 China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinanShandong250014 China School of Chemistry and Chemical Engineering Southeast UniversityNanjingJiangsu211189 China

N6-methyladenosine(m^(6)A)plays an important role in embryogenesis,nuclear export,transcription splicing,and protein translation ***,we demonstrate a copper-free click chemistry-mediated assembly of single quantum dot(QD)nanosensor for accurately monitoring locus-specific m^(6)A in cancer *** m^(6)A-sensitive endoribonuclease MazF can digest the unmethylated A-RNA,and the intact m^(6)A-RNA then hybridizes with DNA probes a and b to produce a sandwich hybrid,initiating the click chemistry to generate probe a–b ligation product via first tandem ligation detection reaction(LDR)***,DNA probes c and d can hybridize with the probe a–b ligation product to generate the probe c–d ligation product via second LDR *** LDR cycles can be repeated through denaturation and annealing reaction to generate abundant biotin-/fluorophore-modified probe c–d ligation products that can easily assemble on the QD surface to induce distinct fluorescence resonance energy transfer(FRET)between QD and *** assay can be homogenously performed without the involvement of copper catalyst,m^(6)A-specific antibody,radioactive labeling,ligase enzyme,enzymatic reverse transcription,and next-generation ***,it can discriminate even 0.01% m^(6)A level in complex samples and accurately measure cellular m^(6)A-RNA expression,providing a promising avenue for clinical diagnostics and biomedical research.

关键词： RNA methylation Click chemistry Förster resonance energy transfer Biosensor Cancer