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Losartan reduced connexin43 expression in left ventricular myocardium of spontaneously hypertensive rats

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 448-454页

作者： li-li zhao Hong-juan CHEN Jun-zhu CHEN Min YU Yun-lan NI Wei-fang ZHANG Department of Cardiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective:To assess the effect of angiotensin II type 1(AT1)receptor antagonist losartan on myocardium con- nexin43(Cx43)gap junction(GJ)expression in spontaneously hypertensive rats(SHRs)and investigate possible mechanisms. Methods:Sixteen 9-week-old male SHRs and 8 age-matched male Wistar-Kyoto(WKY)rats were included in this *** were randomly divided into two groups to receive losartan at 30 mg/(kg·d)by oral gavage once daily for 8 weeks(SHR-L)or vehicle(0.9%saline)to act as controls(SHR-V);WKY rats receiving vehicle for 8 weeks served as normotensive *** the end of the experiment,rats were sacrificed and the hearts were *** of Cx43 and nuclear factor-kappaB p65 (NF-κB p65)proteins in all three groups were observed and further investigations on the effect of angiotensin II type 1 receptor antagonist losartan(30 mg/(kg·d),8 weeks)on Cx43 expression were conducted with Western blot and immunohistochemistry. NF-κB p65 protein in nuclear extracts was determined by Western ***:Left ventricular(LV)hypertrophy was prominent in SHRs,Cx43 and NF-κB p65 protein expressions were obviously upregulated and Cx43 distribution was dispersed over the cell *** with losarton reduced the over-expressions of Cx43 and NF-κB p65 in LV *** distribution of Cx43 gap junction also became much regular and confined to intercalated disk after losartan ***- sion:Cx43 level was upregulated in LV myocardium of SHR during early stage of *** II type 1 receptor antagonist losartan prevented Cx43 gap junction remodeling in hypertrophied left ventricles,possibly through the NF-κB pathway.

关键词： Connexin43 (Cx43) Left ventricular (LV) hypertrophy Angiotensin II Nuclear factor-kappaB p65 (NF-κB p65) Gap junction (GJ)

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Enzymatic activity and chlorophyll fluorescence imaging of maize seedlings (Zea mays L.) after exposure to low doses of chlorsulfuron and cadmium

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Journal of Integrative Agriculture 2018年第4期17卷 826-836页

作者： zhao-li-juan XIE Jing-fang ZHANG Hong WANG Zhen-tao JIANG Hong-jin GAO Shao-long College of Environment and Resource Shanxi University Taiyuan 030006 P.R. China Department of Biology Xinzhou Teachers University Xinzhou 034000. P.R.China Shanxi Academy of Analytical Science Taiyuan 030006 P.R.China

The aim of this research was to study the influence of chlorsulfuron residue and cadmium on the enzymatic activity and photosynthetic apparatus of maize(Zea mays L.) plants. Chlorsulfuron and cadmium at 0.001 and 5.0 mg kg–1, respectively, were mixed and applied to soil prior to planting. The levels of chlorsulfuron-and cadmium-induced stress to plants were estimated by growth, chlorophyll content, lipid peroxide content, enzyme activities, and major fluorescence parameters of chlorophyll(revealed by the fluorescence imaging system Fluor Cam). Chlorsulfuron negatively affected the chlorophyll content, photochemical efficiency of photosystem II in the dark-adapted state, the maximum efficiency of photosystem II, photochemical quenching coefficient, and steady-state fluorescence decline ratio in the leaves of maize seedlings. However, cadmium did not produce noticeable changes. Plants that were exposed to both chlorsulfuron and cadmium showed an obvious increase in the steady-state fluorescence decline ratio. These results implied that the seedlings possessed more resistance to cadmium than to chlorsulfuron and their resistance to chlorsulfuron toxicity was enhanced by the presence of cadmium. The results also suggested that chlorophyll fluorescence imaging reveals overall alterations within the leaves but may not reflect small-scale effects on tissues, as numeric values of specific parameters are averages of the data collected from the whole leaf.

关键词： major parameters of Chl fluorescence imaging germination growth metals sulfonylurea herbicides

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Enhancement of Er^(3+) Luminescence in liNbO_(3):Mg Crystals

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Chinese Physics Letters 2001年第9期18卷 1205-1207页

作者： zhao li-juan YANG Jian XU Jing-Jun HUANG Hui ZHANG Guang-Yin Photonics Research Center College of Physical ScienceNankai UniversityTianjin 300071 State Key Laboratory of Rare Earth Materials Chemistry and Applications Beijing UniversityBeijing 100871

The luminescent properties of Er^(3+) ions in liNbO_(3):Er and liNbO_(3):Mg, Er crystals at room temperature have been investigated by the emission spectra and the selective excitation spectra. The energy transition processes of Er3+ luminescence have been analysed. It has been found that the luminescent intensity of Er^(3+) ions in the liNbO_(3):Mg, Er crystal increased up to 7.8 times compared with that in the liNbO_(3):Er crystal. The decrease of the defect centre (Nbli) concentration due to doping with Mg^(2+) ions plays a key role in this phenomenon.

关键词： spectra crystal luminescent

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Cooperative Quantum Cutting in Er^(3+)/Yb^(3+)Codoped Oxyfluoride Glass Ceramics

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Chinese Physics Letters 2011年第3期28卷 97-99页

作者： LUO Shi-Qiang zhao li-juan HU Nan ZHANG Ming ZHANG Pan WANG Ya-Zhou YU Hua Key Laboratory for Weak light Nonlinear Photonics(Ministry of Education) Nankai UniversityTianjin 300457 College of Physics Nankai UniversityTianjin 300071

Oxvfluoride glass ceramic doped with doped with Er^(3+)/Yb^(3+)was *** earth ions are doped into fluoride nanocrystals according to x-ray diffractive *** enhanced red emission of Er^(3+)/Yb^(3+)in the fluoride nanocrystals,excited by xenon lamp ta 449nm,is investigated and analyzed by cooperative quantum cutting *** cross relaxation appears from^(4)F_(5/2)→^(4)F_(9/2)to^(4)I_(15/2)→^(4)I_(13/2)because of the nearer distance of rare earth ions and the larger absorption section of^(4)F_(5/2)→^(4)I_(13/2)in the quantum *** results in two emissions of^(4)F_(9/2)→^(4)I_(15/2)and^(4)I_(13/2)→^(4)I_(15/2).This implies that a 449nm photon could dissolve into two emiswith wavelength 665nm and *** could be an effective way to obtain 1530nm emission for optical communication.

关键词： ceramic fluoride earth

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环境温度宽范围变化对光纤布里渊频移的影响

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物理学报 2010年第9期59卷 6219-6223页

作者：赵丽娟华北电力大学生物质发电成套设备国家工程实验室保定071003

搭建了光纤布里渊频移测量系统,实现了色散位移光纤20℃到820℃布里渊频移的测量,并对测量数据进行拟合.在环境温度大范围变化时,目前采用的布里渊频移-温度一阶线性关系式对测量数据分析误差较大,针对这个问题,本文从纯石英光纤的结构... 详细信息

搭建了光纤布里渊频移测量系统,实现了色散位移光纤20℃到820℃布里渊频移的测量,并对测量数据进行拟合.在环境温度大范围变化时,目前采用的布里渊频移-温度一阶线性关系式对测量数据分析误差较大,针对这个问题,本文从纯石英光纤的结构特点和材料的物性系数出发,在分析光纤的热膨胀系数、光纤密度、折射率、弹性模量和泊松比与宽范围温度关系的基础上,根据布里渊频移与各物性参数的关系式理论推导了宽范围温度变化与布里渊频移之间的二次项关系式.理论推导结果与实验数据基本符合,验证了理论分析的正确性,从而为光纤宽范围布里渊温度传感奠定了基础.

关键词：光纤高温传感布里渊散射布里渊频移

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Proteomic analysis for detecting serum biomarkers related to smoking in humans

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Chinese Medical Journal 2012年第17期125卷 3027-3032页

作者： XIAO Dan zhao li-juan CHU Shui-lian JING Hang WANG Chen Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing Institute of Respiratory Medicine WHO Collaborating Center for Tobacco or Health Beijing 100020China Department of Respiratory Diseases Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Respiratory Epidemiology Research Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Beijing Hospital Ministry of Health Beijing 100730 China

Background Smoking is the leading cause of death in the world. This study focused on the difference of the serum proteomic profiling between healthy smokers and nonsmokers in order to find smoking-specific serum biomarkers. Methods Pattern-based proteomic profiling of 100 serum samples （from 50 Chinese male smokers and 50 matched nonsmokers） was performed through magnetic bead fractionation coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis （MALDI-TOF-MS） and resulting data were statistically analyzed by Ciphergen ProteinChip software 3.0.2. Results We found 72 serum peaks were significantly different between smokers and nonsmokers （P 〈0.05）. Marker peaks of mass-to-charge ratio （m/z） 3159.13, 7561.03 and 9407.32 were smoking-specific. Conclusion The preliminary data suggested that smoking-specific serum biomarkers could be detected in humans.

关键词： smoking serum biological markers proteomics

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超声波作用对改善煤储层渗透性的实验分析

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天然气地球科学 2014年第5期25卷 747-752页

作者：赵丽娟秦勇中国矿业大学资源学院江苏徐州221116 大同煤矿集团有限责任公司同大科技研究院山西大同037003

为揭示超声波作用对煤岩渗透率的影响规律,基于煤岩渗透率性原理,开展超声波作用下煤样渗透率测试实验。对比分析未加超声波与不同功率超声波作用下的实测数据;与此同时,超声波的加载促进了CH4气体在煤岩中的渗流,增大了煤样的渗透率;... 详细信息

为揭示超声波作用对煤岩渗透率的影响规律,基于煤岩渗透率性原理,开展超声波作用下煤样渗透率测试实验。对比分析未加超声波与不同功率超声波作用下的实测数据;与此同时,超声波的加载促进了CH4气体在煤岩中的渗流,增大了煤样的渗透率;且超声波的功率越大,煤样渗透率的提高率越大。在此基础上,通过超声波功率与气体流量比的关系,推算拟合出不同围压、不同功率下煤岩的渗透率关系模型。通过实验结果分析,详细论述了超声波提高煤层气渗透性的原理。

关键词：煤层气超声波渗透率

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多模光纤不同模式布里渊散射参数

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光子学报 2015年第3期44卷 21-27页

作者：李永倩赵旭赵丽娟马立李晓娟安琪华北电力大学电子与通信工程系河北保定071003

基于射线光学和波动光学理论分析了多模光纤的布里渊散射特性,提出了确定布里渊散射角取值范围的方法;推导了阶跃型和渐变型多模光纤不同模式群布里渊频移、线宽、散射谱和散射功率的表达式.结果表明,阶跃型和渐变型多模光纤布里渊散射... 详细信息

基于射线光学和波动光学理论分析了多模光纤的布里渊散射特性,提出了确定布里渊散射角取值范围的方法;推导了阶跃型和渐变型多模光纤不同模式群布里渊频移、线宽、散射谱和散射功率的表达式.结果表明,阶跃型和渐变型多模光纤布里渊散射角的最大取值范围为全反射临界角的2倍到π;阶跃型光纤的布里渊频移、线宽、归一化峰值增益和散射功率随模式群的变化比渐变型光纤缓慢,且随着模式群编号的增加,阶跃型光纤的上述参量分别在11.084～10.932GHz、21.760～21.168 MHz、1～0.933和1.990×10-9～1.857×10-9 W范围内呈曲线下降;渐变型光纤的上述参量分别在11.064～10.969GHz、21.683～21.314MHz、1～0.957和2.052×10-9～1.965×10-9 W范围内呈直线下降.

关键词：非线性光学布里渊散射射线光学波动光学多模光纤布里渊散射角不同模式

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薄煤层采煤机振动特性研究

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振动与冲击 2015年第1期34卷 195-199页

作者：赵丽娟田震辽宁工程技术大学机械工程学院辽宁阜新123000

为研究复杂煤层赋存条件下薄煤层采煤机的振动特性,根据多体拓扑结构建立采煤机刚柔耦合模型,通过仿真得到采煤机在截割含夹矸韧性煤工况下前后滚筒受到冲击载荷作用时的动态特性。基于子结构模态综合方式(CMS)的振动疲劳分析方法,进行... 详细信息

为研究复杂煤层赋存条件下薄煤层采煤机的振动特性,根据多体拓扑结构建立采煤机刚柔耦合模型,通过仿真得到采煤机在截割含夹矸韧性煤工况下前后滚筒受到冲击载荷作用时的动态特性。基于子结构模态综合方式(CMS)的振动疲劳分析方法,进行危险点动应力与模态振动的相关性分析,发现牵引部壳体在实际工作过程中产生具有3阶垂向弯曲模态特征的弹性振动;以不同测试点加速度频域响应为依据,分析采煤机振动对其电控系统以及液压系统的影响,判断测试点加速度与模态振动的相关性,同时确定出牵引部柔性壳体的高动应力区域及其结构疲劳性质。分析结果为薄煤层采煤机的优化设计、后续测试、安全性评价提供了重要的参考。

关键词：薄煤层采煤机动态特性振动模态疲劳

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Mechanism of aluminum corrosion in liFSI-based electrolyte at elevated temperatures

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Transactions of Nonferrous Metals Society of China 2021年第5期31卷 1439-1451页

作者： Chun-lei li Shuang-wei ZENG Peng WANG zhao-juan li li YANG Dong-ni zhao Jie WANG Hai-ning liU Shi-you li College of Petrochemical Technology Lanzhou University of TechnologyLanzhou 730050China CAS Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt LakeChinese Academy of SciencesXining 810008China

lithium bis(fluorosulfonyl)imide(liFSI) is a promising replacement for lithium hexafluorosphate due to its excellent properties. A solution to the corrosion of aluminum(Al) current collectors by liFSI at elevated temperatures is essential. The mechanisms of Al corrosion in liFSI-based electrolyte at 45 ℃ were studied with density functional theory calculations and spectroscopic investigations. It is found that the irregular, loose and unprotected AlF3 materials caused by the dissolution of co-generated Al(FSI)3 can exacerbate Al corrosion with the increase of temperature. lithium bis(oxalate)borate(liBOB) can effectively inhibit the Al corrosion with a robust and protective interphase;this can be attributed to the interfacial interactions between the Al foil and electrolyte. Boron-containing compounds promote the change from AlF3 to liF, which further reinforces interfacial stability. This work allows the design of an interface to Al foil using liFSI salt in lithium-ion batteries.

关键词： lithium-ion batteries liFSI-based electrolyte lithium bis(oxalate)borate(liBOB) corrosion inhibition elevated temperatures interfacial film

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