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Onset and Recurrence Characteristics of Chinese Patients with Noncardiogenic Ischemic Stroke in Chinese Medicine Hospitals

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Chinese Journal of Integrative Medicine 2022年第6期28卷 492-500页

作者： GAO Yang xiE Yan-ming WANG Gui-qian CAI Ye-feng SHEN xiao-ming zhao de-xi xiE Ying-zhen ZHANG Yin MENG Fan-xing YU Hai-qing JIANG Jun-jie WEI Rui-Li Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing100078China department of Emergency Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China department of Neurology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China department of Neurology the Affiliated Hospital of Changchun University of Chinese MedicineChangchun130017China department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China department of Neurology Taiyuan Hospital of Traditional Chinese MedicineTaiyuan140107China

Objective:To delineate the onset and recurrence characteristics of noncardiogenic ischemic stroke patients in ***:A prospective,multicenter and registry study was carried out in 2,558 patients at 7 representative clinical sub-centers during November 3,2016 to February 17,2019.A questionnaire was used to collect information of patients regarding CM syndromes and constitutions and associated risk ***,stroke recurrence was defined as a primary outcome ***:A total of 327(12.78%)patients endured recurrence events,1,681(65.72%)patients were men,and the average age was 63.33±9.45 *** 1,741(68.06%)patients suffered first-ever ischemic stroke,1,772(69.27%)patients reported to have hypertension,and1,640(64.11%)of them reported dyslipidemia,1,595(62.35%)patients exhibited small-artery occlusion by The Trial of Org 10172 in Acute Stroke Treatment(TOAST)***,1,271(49.69%)patients were considered as qi-deficient constitution,and 1,227(47.97%)patients were determined as stagnant blood *** were 1,303(50.94%)patients diagnosed as blood stasis syndrome,1,280(50.04%)patients exhibited phlegm and dampness syndrome and 1,012(39.56%)patients demonstrated qi deficiency *** 1,033(40.38%)patients declared intracranial artery stenosis,and 478(18.69%)patients reported carotid artery *** plaque in 1,508(41.36%)patients were of ***,41.09%of them demonstrated abnormal levels of glycated hemoglobin(HbA1 c)***:Recurrence in minor and small-artery stroke cannot be ***,dyslipidemia,abnormal HbA1 c,intracranial artery stenosis and carotid plaque were more common in stroke ***,phlegm-dampness and blood stasis syndromes,as well as qi deficiency and blood stasis constitutions,were still the main manifestations of stroke.(Trial registration at ***,***03174535)

关键词： noncardiogenic ischemic stroke Chinese medicine hospital onset characteristics recurrence

Relationship between Various Chinese Medicine Types and T-cell Subsets in Patients with Ulcerative Colitis

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Chinese Journal of Integrative Medicine 2009年第3期15卷 220-223页

作者：常廷民李秀敏赵习德 department of Internal Digestive Medicine First Affiliated Hospital of xinxiang Medical College Wuhan Union Hospital Tongji Medical College of Huazhong University of Science and Technology department of Integrative Chinese and Western Medicine First Affiliated Hospital of xinxiang Medical College

Objective:To investigate the relationship between various Chinese medicine(CM) types and T-cell subsets(CD4^+ and CD8^+) in the colonic mucous membranes of patients with ulcerative colitis(UC).Methods: Fifty UC patients were enrolled,after differentiation into four types by CM syndromes,i.e.,the internal heat-damp accumulation type(IHDA),the qi-stagnancy with blood stasis type(QSBS),the Pi(脾)-Shen(肾) yang-deficiency type(PSYD) and the yin-blood deficiency type(YBD).From every patient,3-5 pieces of intestina...

关键词： ulcerative colitis Chinese medicine typing T cell subset

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从少阳病论治失眠

中华中医药杂志 2017年第5期32卷 2040-2042页

作者：赵鸿飞高阳赵德喜长春中医药大学长春130117 长春中医药大学附属医院长春130021

中西医基于不同的理论,对失眠的病因病机有不同的认识。赵德喜教授从中医经典《伤寒论》出发,在"定位、定性、定方证三步辨证法"指导下,重新审视本病的中医证候特点,结合多年临床经验,认为失眠与少阳病是高度契合的,因此,提出"从少阳病... 详细信息

中西医基于不同的理论,对失眠的病因病机有不同的认识。赵德喜教授从中医经典《伤寒论》出发,在"定位、定性、定方证三步辨证法"指导下,重新审视本病的中医证候特点,结合多年临床经验,认为失眠与少阳病是高度契合的,因此,提出"从少阳病论治失眠"的学术观点,依据"方证对应"的经方辨证理念,采用《伤寒论》柴胡类方化裁治疗失眠,疗效显著。

关键词：失眠少阳病方证对应伤寒论

桂枝茯苓汤对非ST段抬高急性冠脉综合征患者YKL-40及hs-CRP的影响

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中国中西医结合杂志 2013年第2期33卷 186-190页

作者：裴强桑文凤赵习德新乡医学院第一附属医院中西医结合科河南卫辉453100 新乡医学院内科教研室河南新乡453000

目的探讨非ST段抬高急性冠脉综合征(acute coronary syndrome,ACS)患者血清几丁质酶-3样蛋白-1(chitinase-3-like-1protein,YKL-40)、高敏C-反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平变化及其与疾病严重程度的关系;观察桂枝茯苓汤对其血脂、YKL-40和hs-CRP水平的影响。方法选择新乡医学院第一附属医院中西医结合科2010年8月—2011年6月就诊的不稳定型心绞痛(un-stable angina,UA)或非ST段抬高型心肌梗死(non-ST segment elevation myocardial infarction,NSTE-MI)患者72例,随机分为治疗组(36例)和对照组(36例)。两组均给予常规治疗,治疗组加用桂枝茯苓汤口服,共4周。所有患者入院时按病情严重程度UA分为低危、中危、高危及NSTEMI4个等级。分析YKL-40、hs-CRP水平及病情严重程度间相关性。检测两组治疗前后甘油三酯(triglyceride,TG)、总胆固醇(to-tal cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)。检测两组治疗前、治疗2周及治疗后血清YKL-40和hs-CRP水平。结果 YKL-40及hs-CRP与病情严重程度间存在显著正相关(r=0.729,P0.05)。与本组治疗前比较,两组治疗2周后YKL-40、hs-CRP均降低,治疗后TG、TC、LDL-C、YKL-40、hs-CRP均降低(P<0.05),HDL-C均升高(P<0.05)。与对照组同期比较,治疗组治疗后HDL-C升高(P<0.05),YKL-40、hs-CRP降低(P<0.05)。结论桂枝茯苓汤能在西药抗炎、改善血脂的基础上进一步降低ACS患者血清hs-CRP和YKL-40,升高HDL-C,起到抗动脉粥样硬化(atherosclerosis,AS)的作用。

关键词：非ST段抬高急性冠脉综合征桂枝茯苓汤几丁质酶-3样蛋白-1 高敏 C反应蛋白

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《伤寒论》六经病内涵与复杂方剂再认识

中华中医药杂志 2016年第5期31卷 1559-1562页

作者：赵鸿飞高阳赵德喜长春中医药大学研究生学院长春130117 长春中医药大学附属医院脑病科长春130021

张仲景在《伤寒论》中创立了独特的辨证论治体系,即以表、里、半表半里定病位,再以阴阳定病性,表里与阴阳相配即成后世归纳的六经辨证体系。《伤寒论》中针对复杂方证所制的方剂都是以三阳三阴为基本构件,在合病、并病的思想指导下完成... 详细信息

张仲景在《伤寒论》中创立了独特的辨证论治体系,即以表、里、半表半里定病位,再以阴阳定病性,表里与阴阳相配即成后世归纳的六经辨证体系。《伤寒论》中针对复杂方证所制的方剂都是以三阳三阴为基本构件,在合病、并病的思想指导下完成的。通过对寒热错杂、攻补兼施方剂的分析说明,只要掌握三阳三阴病各自的特征,采用定位、定性、定方证三步法,就可以掌握张仲景的学术思想,并能自由运用《伤寒论》和《金匮要略》中的方剂,使中医人能够早日成才。

关键词：伤寒论六经八纲定位定性方证

Increased circulating level of interleukin-6 and CD8+T cell exhaustion are associated with progression of COVID-19

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Infectious Diseases of Poverty 2020年第6期9卷 42-50页

作者： Peng-Hui Yang Yi-Bo Ding Zhe Xu Rui Pu Ping U Jin Yan Ji-Luo Liu Fan-Ping Meng Lei Huang Lei Shi Tian-Jun Jiang En-Qiang Qin Min zhao Da-Wei Zhang Peng zhao Ling-xiang Yu zhao-Hai Wang Zhi-xian Hong zhao-Hui xiao Qing xi de-xi zhao Peng Yu Cai-Zhong Zhu Zhu Chen Shao-Geng Zhang Jun-Sheng Ji Fu-Sheng Wang Guang-Wen Cao department of Hepatobiliary The Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing100039China Treatment and Research Center for Infectious Diseases The Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing100039China department of Epidemiology Second Military Medical UniversityShanghai200433China

Background: Coronavirus disease 2019(COVID-19)is *** is critical to identify COVID-19 patients who are most likely to develop a severe *** study was designed to determine the clinical and epidemiological features of COVID-19 patients associated with the development of pneumonia and factors associated with disease ***:: Seventy consecutive patients with etiologically confirmed COVID-19 admitted to PLA General Hospital in Beijing,China from december 27,2019 to March 12,2020 were enrolled in this study and followed-up to March 16,*** in clinical and laboratory findings between COVID-19 patients with pneumonia and those without were determined by theχ2 test or the Fisher exact test(categorical variables)and independent group t test or Mann–Whitney U test(continuous variables).The Cox proportional hazard model and Generalized Estimating Equations were applied to evaluate factors that predicted the progression of ***: The mean incubation was 8.67(95%confidence interval,6.78–10.56)*** duration from the first test severe acute respiratory syndrome coronavirus 2-positive to conversion was 11.38(9.86–12.90)*** to pneumonia-free patients,pneumonia patients were 16.5 years older and had higher frequencies of having hypertension,fever,and cough and higher circulating levels of neutrophil proportion,interleukin-6,low count(deteriorated during *** regression analysis indicated that older age and higher serum levels of interleukin-6,C-reactive protein,procalcitonin,and lactate at admission significantly predicted the progression of *** hospitalization,circulating counts of T lymphocytes,CD4+T cells,and CD8+T cells were lower,whereas neutrophil proportion,neutrophil/lymphocyte ratio,and the circulating levels of interleukin-6,C-reactive protein,and procalcitonin were higher,in pneumonia patients than in pneumo

关键词： COVID-19 Progression Interleukin-6 CD8+T cell exhaustion Prospective case series

桂枝茯苓胶囊联合鼠神经生长因子治疗糖尿病周围神经病变

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中成药 2013年第7期35卷 1396-1399页

作者：裴强桑文凤赵习德新乡医学院第一附属医院河南卫辉453100 新乡医学院河南新乡453000

目的观察桂枝茯苓胶囊联合鼠神经生长因子对糖尿病周围神经病变患者的临床疗效。方法糖尿病周围神经病变患者60例,随机分为治疗组和对照组各30例。两组均口服甲钴胺片;治疗组另外口服桂枝茯苓胶囊,肌肉注射鼠神经生长因子,共4周。观察... 详细信息

目的观察桂枝茯苓胶囊联合鼠神经生长因子对糖尿病周围神经病变患者的临床疗效。方法糖尿病周围神经病变患者60例,随机分为治疗组和对照组各30例。两组均口服甲钴胺片;治疗组另外口服桂枝茯苓胶囊,肌肉注射鼠神经生长因子,共4周。观察两组治疗前后神经传导速度、多伦多临床评分系统(TCSS)评分及血清高敏C-反应蛋白(hs-CRP)变化。结果与本组治疗前比较,两组治疗后神经传导速度均明显提高、TCSS评分均明显下降(P<0.05),治疗组hs-CRP水平降低(P<0.05);与对照组同期比较,治疗组治疗后神经传导速度提高、TCSS评分及hs-CRP水平降低(P<0.05);治疗组总有效率高于对照组。结论桂枝茯苓胶囊联合鼠神经生长因子对糖尿病周围神经病变有确切疗效。

关键词：桂枝茯苓胶囊鼠神经生长因子甲钴胺糖尿病周围神经病变

参附注射液与生脉注射液治疗慢性心力衰竭的对比研究

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中成药 2013年第3期35卷 471-475页

作者：裴强赵习德桑文凤新乡医学院第一附属医院河南卫辉453100 新乡医学院河南新乡453000

目的对比研究辨证与辨病条件下,参附注射液与生脉注射液对慢性心力衰竭患者临床疗效的差异。方法慢性心力衰竭患者108例,随机均分为3组。3组均给予常规治疗,其中A组加用参附注射液静脉输注,B组加用生脉注射液静脉输注,C组常规治疗组共2... 详细信息

目的对比研究辨证与辨病条件下,参附注射液与生脉注射液对慢性心力衰竭患者临床疗效的差异。方法慢性心力衰竭患者108例,随机均分为3组。3组均给予常规治疗,其中A组加用参附注射液静脉输注,B组加用生脉注射液静脉输注,C组常规治疗组共2周。观察3组治疗前后中医症候积分、生活质量、心衰疗效积分、6 min步行距离及血浆N末端B型利钠肽原(NT-proBNP)变化。结果 A组临床总有效率明显高于其他两组(P0.05)。治疗后3组患者在中医症候积分、生活质量积分、心衰疗效积分、血浆NT-proBNP水平均明显下降,6 min步行距离明显增加(P<0.05);A组在中医症候积分、生活质量积分、心衰疗效积分、6 min步行距离方面改善优于其他两组,在NT-proBNP水平方面改善优于C组(P<0.05);B组在6 min步行距离方面改善优于C组(P<0.05)。结论参附注射液对阳气虚型慢性心力衰竭有确切疗效。

关键词：参附注射液生脉注射液慢性心力衰竭辨证

稀土元素La对Ni_(75)B_(17)Si_8非晶合金形成能力和热稳定性的影响

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物理学报 1993年第3期42卷 465-469页

作者：邢力谦赵德乾陈希成陈熙琛杨根仓周尧和中国科学院物理研究所北京100080 西北工业大学西安710072

本文发现微量稀土元素在某些合金中可不呈均匀固溶态分布,而与母合金某些原子反应生成高熔点化合物,或吸附于合金中异质核心表面改变其异质形核的活性。当稀土元素以这种状态存在时,不但失去稳定非晶相的作用,而且促进异质形核,降低合... 详细信息

本文发现微量稀土元素在某些合金中可不呈均匀固溶态分布,而与母合金某些原子反应生成高熔点化合物,或吸附于合金中异质核心表面改变其异质形核的活性。当稀土元素以这种状态存在时,不但失去稳定非晶相的作用,而且促进异质形核,降低合金的非晶形成能力和热稳定性。

关键词：稀土族金属玻璃热稳定性形成