Increased circulating level of interleukin-6 and CD8+T cell exhaustion are associated with progression of COVID-19

作     者：Peng-Hui Yang Yi-Bo Ding Zhe Xu Rui Pu Ping U Jin Yan Ji-Luo Liu Fan-Ping Meng Lei Huang Lei Shi Tian-Jun Jiang En-Qiang Qin Min Zhao Da-Wei Zhang Peng Zhao Ling-Xiang Yu Zhao-Hai Wang Zhi-Xian Hong Zhao-Hui Xiao Qing Xi De-Xi Zhao Peng Yu Cai-Zhong Zhu Zhu Chen Shao-Geng Zhang Jun-Sheng Ji Fu-Sheng Wang Guang-Wen Cao Peng-Hui Yang;Yi-Bo Ding;Zhe Xu;Rui Pu;Ping Li;Jin Yan;Ji-Luo Liu;Fan-Ping Meng;Lei Huang;Lei Shi;Tian-Jun Jiang;En-Qiang Qin;Min Zhao;Da-Wei Zhang;Peng Zhao;Ling-Xiang Yu;Zhao-Hai Wang;Zhi-Xian Hong;Zhao-Hui Xiao;Qing Xi;De-Xi Zhao;Peng Yu;Cai-Zhong Zhu;Zhu Chen;Shao-Geng Zhang;Jun-Sheng Ji;Fu-Sheng Wang;Guang-Wen Cao

作者机构：Department of HepatobiliaryThe Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing100039China Treatment and Research Center for Infectious DiseasesThe Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing100039China Department of EpidemiologySecond Military Medical UniversityShanghai200433China 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2020年第9卷第6期

页      面：42-50页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：This study was partly supported by National Natural Science Foundation of China(82041022 to:G Cao) Science and Technology Commission Shanghai Municipality(20JC1410200,20431900404 to:G Cao) Ministry of Science and Technology of the People’s Republic of China(2018ZX10101003-001-003 to:G Cao) 

主　　题：COVID-19 Progression Interleukin-6 CD8+T cell exhaustion Prospective case series 

摘      要：Background: Coronavirus disease 2019(COVID-19)is *** is critical to identify COVID-19 patients who are most likely to develop a severe *** study was designed to determine the clinical and epidemiological features of COVID-19 patients associated with the development of pneumonia and factors associated with disease ***:: Seventy consecutive patients with etiologically confirmed COVID-19 admitted to PLA General Hospital in Beijing,China from December 27,2019 to March 12,2020 were enrolled in this study and followed-up to March 16,*** in clinical and laboratory findings between COVID-19 patients with pneumonia and those without were determined by theχ2 test or the Fisher exact test(categorical variables)and independent group t test or Mann–Whitney U test(continuous variables).The Cox proportional hazard model and Generalized Estimating Equations were applied to evaluate factors that predicted the progression of ***: The mean incubation was 8.67(95%confidence interval,6.78–10.56)*** duration from the first test severe acute respiratory syndrome coronavirus 2-positive to conversion was 11.38(9.86–12.90)*** to pneumonia-free patients,pneumonia patients were 16.5 years older and had higher frequencies of having hypertension,fever,and cough and higher circulating levels of neutrophil proportion,interleukin-6,low count(190/µl)of CD8+T cells,and neutrophil/lymphocyte *** patients deteriorated during *** regression analysis indicated that older age and higher serum levels of interleukin-6,C-reactive protein,procalcitonin,and lactate at admission significantly predicted the progression of *** hospitalization,circulating counts of T lymphocytes,CD4+T cells,and CD8+T cells were lower,whereas neutrophil proportion,neutrophil/lymphocyte ratio,and the circulating levels of interleukin-6,C-reactive protein,and procalcitonin were higher,in pneumonia patients than in pneumo