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Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Acta Pharmaceutica Sinica B 2020年第9期10卷 1709-1718页

作者： Kena Zhao Tao Guo Caifen Wang Yong Zhou Ting Xiong Li Wub Xue Li Priyanka Mittal Senlin Shi Ruxandra Gref jiwen zhang College of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 311402China Center for Drug Delivery System Shanghai Institute of Materia MedicaState Key Laboratory of Drug ResearchChinese Academy of SciencesShanghai 201203China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China Key Laboratory of Modern Chinese Medicine Preparations Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchang 330004China Universite´Paris-Saclay CNRS 8214Institut des Sciences Mole´culaires d’OrsayOrsay 91405France University of Chinese Academy of Sciences Beijing 100049China

It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related *** the inhalable micron-sized crystals ofγ-cyclodextrin metal-organic framework(CD-MOF)was utilized as dry powder inhalers(DPIs)carrier with high fine particle fraction(FPF),it was found in this research that the encapsulation of a glycoside compound,namely,scutellarin(SCU)in CD-MOF could significantly enhance its laryngeal ***,SCU loading into CD-MOF was optimized by ***,a series of characterizations were carried out to elucidate the mechanisms of drug ***,the laryngeal deposition rate of CD-MOF was 57.72±2.19%improved by SCU,about two times higher than that of CD-MOF,when it was determined by Next Generation Impactor(NGI)at 65 L/*** a proof of concept,pharyngolaryngitis therapeutic agent dexamethasone(DEX)had improved laryngeal deposition after being co-encapsulated with SCU in *** molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF,which defined the enhanced laryngeal *** conclusion,the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases.

关键词： Laryngeal delivery g-Cyclodextrin metalorganic framework Scutellarin Dexamethasone Molecular simulation

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Bio-mimetic drug delivery systems designed to help the senior population reconstruct melatonin plasma profiles similar to those of the healthy younger population

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Acta Pharmaceutica Sinica B 2014年第1期4卷 60-66页

作者： Ying Li Liuyi Wang Li Wu Xueju zhang Xue Li Zhen Guo Haiyan Li Peter York Shuangying Gui jiwen zhang Anhui University of Chinese Medicine Hefei 230038China Center for Drug Delivery Systems Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Hainan Weikang Pharmaceutical(Qianshan)Co. LtdAnqing 246000China College of Life Sciences Jilin UniversityChangchun 130012China

The secretion of melatonin(MT)is obviously different in the younger and the senior sectors of the population,and the maximum plasma concentration of seniors is only half of that in the younger population *** exogenous MT can be supplied to senior citizens based on the secretion rate and amount of endogenous MT in the younger population by a bio-mimetic drug delivery system(DDS),an improved therapeutic effect and reduced side effects can be *** upon this hypothesis,the pharmacokinetic parameters of MT,namely,the absorption rate constant(ka),the elimination rate constant(ke),and the ratio of absorption rate(F)to the apparent volume of distribution(V)were obtained by a residual method depending on the plasma concentration curve of immediate release preparations in the healthy younger *** dose-division method was applied to calculate the cumulative release profiles of MT achieved by oral administration of a controlled release drug delivery system(DDS)to generate plasma MT profiles similar to the physiological level-time *** in vivo release of MT deduced from the healthy younger population physiological MT profiles as the pharmacokinetic output of the bio-mimetic DDS showed a two-phase profile with two different zero order release rates,namely,4.919μg/h during 0-4 h(r=0.9992),and 11.097μg/h during 4-12 h(r=0.9886),*** the osmotic pump type of DDS generally exhibits a good correlation between in vivo and in vitro release behaviors,an osmotic pump controlled delivery system was designed in combination with dry coating technology targeting on the cumulative release characteristics to mimic the physiological MT profiles in the healthy younger *** high similarity between the experimental drug release profiles and the theoretical profiles(similarity factor f_(2)>50)and the high correlation between the predicted plasma concentration profiles and the theoretical plasma concentration profiles(r=0.9366,0.9163,0.9264)ind

关键词： Bio-mimetic DDS Melatonin Dose-division method Osmotic pump Residual method

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Optimization of taste-masking on ibuprofen microspheres with selected structure features

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Asian Journal of Pharmaceutical Sciences 2019年第2期14卷 174-182页

作者： Wei Qin Yuanzhi He Zhen Guo Liu zhang Li Wu Xianzhen Yin Shailendra Shakya Abi Maharjan Yan Tang Weifeng Zhu jiwen zhang Ministry of Education Jiangxi University of Traditional Chinese Medicine Shanghai Institute of Materia Medica Chinese Academy of Sciences School of Pharmacy Shenyang Pharmaceutical University School of Pharmacy University of Chinese Academy of Sciences

The microsphere was a primary particulate system for taste-masking with unique structural features defined by production process. In this article, ibuprofen lipid microspheres of octadecanol and glycerin monostearate were prepared to mask the undesirable taste of ibuprofen via three kinds of spray congealing processes, namely, air-cooling, water-cooling and citric acid solution-cooling. The stereoscopic and internal structures of ibuprofen microspheres were quantitatively analyzed by synchrotron radiation X-ray micro-computed tomography(SR-μCT) to establish the relationship between the preparation process and microsphere architectures. It was found that the microstructure and morphology of the microspheres were significantly influenced by preparation processes as the primary factors to determine the release profiles and taste-masking effects. The sphericity of ibuprofen microspheres congealed in citric acid solution was higher than that of other two and its morphology was more regular than that being congealed in air or distilled water, and the contact angles between congealing media and melted ibuprofen in octadecanol and glycerin monostearate well demonstrated the structure differences among microspheres of three processes which controlled the release characteristics of the microspheres. The structure parameters like porosity, sphericity, and radius ratio from quantitative analysis were correlated well with drug release behaviors. The results demonstrated that the exterior morphology and internal structure of microspheres had considerable influences on the drug release behaviors as well as taste-masking effects.

关键词： Ibuprofen microsphere Spray congealing Internal structure Synchrotron radiation X-ray micro-computed tomography

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惯量对称非合作目标参数的单目估计方法

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清华大学学报（自然科学版） 2022年第9期62卷 1492-1499页

作者：迟昊刘宇陈恳冯渭春张继文清华大学机械工程系北京100084 北京跟踪与通信技术研究所北京100094

针对失效卫星等空间非合作目标缺少信息交互,无法直接获取旋转运动参数与动力学参数的问题,提出一种惯量对称非合作目标参数的单目估计方法。首先建立动力学参数化模型,并推出模型几何参数与目标星参数的解析关系;然后在此基础上以单目... 详细信息

针对失效卫星等空间非合作目标缺少信息交互,无法直接获取旋转运动参数与动力学参数的问题,提出一种惯量对称非合作目标参数的单目估计方法。首先建立动力学参数化模型,并推出模型几何参数与目标星参数的解析关系;然后在此基础上以单目相机图像作为输入,通过对实时定位与建图(simultaneous localization and mapping,SLAM)算法前端的含噪位姿结果进行多阶滤波,对角速度向量进行双锥体拟合的方法;最后实现目标星旋转运动学参数和动力学参数的全局最优估计。仿真结果表明,该方法能够快速、高精度地实现参数估计,相对误差小于0.9%。

关键词：非合作目标参数估计单目视觉数据滤波

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Metal-organic frameworks for advanced drug delivery

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2362-2395页

作者： Siyu He Li Wu Xue Li Hongyu Sun Ting Xiong Jie Liu Chengxi Huang Huipeng Xu Huimin Sun Weidong Chen Ruxandra Gref jiwen zhang Center for Drug Delivery Systems Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Institut de Sciences Moléculaires D'Orsay UniversitéParis-SaclayOrsay Cedex 91400France Key Laboratory of Modern Chinese Medicine Preparations Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchang 330004China School of Pharmaceutical Sciences Anhui University of Chinese MedicineHefei 230012China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China

Metal-organic frameworks(MOFs),comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous,crystalline *** tunable porosity,chemical composition,size and shape,and easy surface functionalization make this large family more and more popular for drug *** is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical *** article presents an overall review and perspectives of MOFs-based drug delivery systems(DDSs),starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ***,the synthesis and characterization of MOFs for DDSs are developed,followed by the drug loading strategies,applications,biopharmaceutics and quality ***,a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics,diseases therapy and advanced *** particular,the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be ***,challenges in MOFs development for DDSs are discussed,such as biostability,biosafety,biopharmaceutics and nomenclature.

关键词： Metal-organic frameworks Drug loading Drug delivery systems Synthesis and characterization Diseases therapy Pharmaceutics Biopharmaceutics Biosafety

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Synchrotron radiation-based Fourier-transform infrared spectromicroscopy for characterization of the protein/peptide distribution in single microspheres

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Acta Pharmaceutica Sinica B 2015年第3期5卷 270-276页

作者： Manli Wang Xiaolong Lu Xianzhen Yin Yajun Tong Weiwei Peng Li Wu Haiyan Li Yan Yang Jingkai Gu Tiqiao Xiao Min Chen jiwen zhang School of Pharmaceutical Sciences Anhui University of Chinese Medicine Center for Pharmaceutical Preparations Shanghai Institute of Materia MedicaChinese Academy of Sciences School of Mechanical Engineering Shanghai Institute of Technology Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied PhysicsChinese Academy of Sciences College of Life Sciences Jilin University

The present study establishes a visualization method for the measurement of the distribution and localization of protein/peptide constituents within a single poly-lactide-co-glycolide(PLGA) microsphere using synchrotron radiation–based Fourier-transform infrared spectromicroscopy(SR-FTIR).The representative infrared wavenumbers specific for protein/peptide(Exenatide) and excipient(PLGA) were identified and chemical maps at the single microsphere level were generated by measuring and plotting the intensity of these specific *** quantitative analysis of the distribution within microspheres,Matlab software was used to transform the map file into a 3D matrix and the matrix values specific for the drug and excipient were *** of the normalized SR-FTIR maps of PLGA and Exenatide indicated that PLGA was uniformly distributed,while Exenatide was relatively non-uniformly distributed in the *** conclusion,SR-FTIR is a rapid,nondestructive and sensitive detection technology to provide the distribution of chemical constituents and functional groups in microparticles and microspheres.

关键词： Fourier-transform infrared spectromicroscopy Protein distribution Microsphere Exenatide PLGA

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Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography

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Asian Journal of Pharmaceutical Sciences 2017年第4期12卷 326-334页

作者： Li Wu Manli Wang Vikramjeet Singh Haiyan Li Zhen Guo Shuangying Gui Peter York Tiqiao Xiao Xianzhen Yin jiwen zhang Center for Drug Delivery Systems Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201210China School of Pharmaceutical Sciences Anhui University of Chinese MedicineHefei 230038China Institute of Pharmaceutical Innovation University of BradfordBradfordWest Yorkshire BD7 1DPUnited Kingdom Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201204China

This study investigated the formulation mechanism of microspheres via internal surfactant distribution. Eudragit L100 based microspheres loaded with bovine serum albumin were prepared by solid in oil in oil emulsion solvent evaporation method using acetone and liquid paraffin system containing sucrose stearate as a surfactant. The fabricated microspheres were evaluated for encapsulation efficiency, particle size, production yield, and in vitro release characteristics. The internal structures of microspheres were characterized using synchrotron radiation X-ray microcomputed tomography(SR-μCT). The enhanced contrast made the sucrose stearate distinguished from Eudragit to have its three dimensional(3D) distribution. Results indicated that the content and concentration determined the state of sucrose stearate and had significant influences on the release kinetics of protein. The dispersity of sucrose stearate was the primary factor that controlled the structure of the microspheres and further affected the encapsulation efficiency, effective drug loading, as well as in vitro release behavior. In conclusion, the 3D internal distribution of surfactant in microspheres and its effects on protein release behaviors have been revealed for the first time. The highly resolved 3D architecture provides new evidence for the deep understanding of the microsphere formation mechanism.

关键词： Three dimensional Synchrotron radiation X-ray microcomputed tomography Distribution Microsphere Sucrose stearate

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A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs

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Science China(Life Sciences) 2020年第5期63卷 623-634页

作者： Weiye Chen Dongming Zhao Xijun He Renqiang Liu Zilong Wang Xianfeng zhang Fang Li Dan Shan Hefeng Chen jiwen zhang Lulu Wang Zhiyuan Wen Xijun Wang Yuntao Guan Jinxiong Liu Zhigao Bu State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150001China National High Containment Laboratory for Animal Diseases Control and Prevention Harbin 150069China

African swine fever(ASF)is a devastating infectious disease in swine that is severely threatening the global pig *** efficacious vaccine is urgently ***,we used the Chinese ASFV HLJ/18 as a backbone and generated a series of genedeleted *** virulence,immunogenicity,safety,and protective efficacy evaluation in specific-pathogen-free pigs,commercial pigs,and pregnant sows indicated that one virus,namely HLJ/18-7GD,which has seven genes deleted,is fully attenuated in pigs,cannot convert to the virulent strain,and provides complete protection of pigs against lethal ASFV *** study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV,and as such is expected to play an important role in controlling the spread of ASFV.

关键词： African swine fever vaccine safety protective efficacy pig

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“关”和“闺”:王昌龄诗的两种情结——兼论王昌龄的家国守望情怀

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岭南师范学院学报 2022年第1期43卷 88-94页

作者：章继文安徽启蒙狗文化传播有限公司安徽池州247000

“关”和“闺”或者与二者相关的物象、意象大量而密集地直接或间接地出现在王昌龄的边塞诗、闺怨诗甚至羁旅赠别诗中,两类意象不仅体现了王昌龄诗的风格,更成了王昌龄诗的两种情结。两种情结也并非互相孤立无关,而是在矛盾中紧密伴随的... 详细信息

“关”和“闺”或者与二者相关的物象、意象大量而密集地直接或间接地出现在王昌龄的边塞诗、闺怨诗甚至羁旅赠别诗中,两类意象不仅体现了王昌龄诗的风格,更成了王昌龄诗的两种情结。两种情结也并非互相孤立无关,而是在矛盾中紧密伴随的,共同凝结了王昌龄的守望情怀,前者守望国家、民族,后者守望家园、情爱。

关键词：王昌龄关闺情结家国守望

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一种基于复合材料剩余强度的衍生疲劳损伤模型

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复合材料学报 2020年第10期37卷 2473-2481页

作者：赵晟张继文东南大学土木工程学院南京210096

为了研究纤维增强树脂复合材料在疲劳载荷作用下的损伤发展规律,提出了一种基于复合材料剩余强度的归一化衍生疲劳损伤模型。在该模型中,假定累积损伤与应力水平呈线性关系,可以由拉-拉疲劳试验的应力水平的损伤曲线衍生出未试验的应力... 详细信息

为了研究纤维增强树脂复合材料在疲劳载荷作用下的损伤发展规律,提出了一种基于复合材料剩余强度的归一化衍生疲劳损伤模型。在该模型中,假定累积损伤与应力水平呈线性关系,可以由拉-拉疲劳试验的应力水平的损伤曲线衍生出未试验的应力水平的损伤曲线。对直径为8 mm的碳纤维增强树脂复合材料(CFRP)索材进行了不同应力幅的疲劳试验,并同时采用了文献中玻璃纤维增强树脂复合材料(GFRP)层合板的试验数据验证模型的可靠性,试验结果表明:损伤模型能较好地反映出三阶段的发展规律,衍生的损伤曲线与试验数据拟合出来的损伤曲线偏离度较小。此外,本文还研究了应力水平对复合材料损伤演化的影响,结果表明随着应力水平的增大,损伤曲线相邻阶段的边界变得不明显。

关键词：复合材料剩余强度衍生损伤曲线疲劳寿命等幅疲劳试验

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