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艾沙康唑治疗儿童造血干细胞移植围手术期肺毛霉病一例

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临床药物治疗杂志 2024年第2期22卷 87-89页

作者：崔颖钟旭丽刘碧晴张益志郭茂文林爱华张建民首都儿科研究所附属儿童医院药学部北京100020

本文报道1例急性淋巴细胞白血病患儿在造血干细胞移植围手术期使用艾沙康唑治疗肺毛霉病的案例。临床药师参与会诊,根据患儿病情选择艾沙康唑治疗,并确定儿童用药剂量。治疗期间监测安全性和有效性,治疗后患儿肺内病变改善。艾沙康唑作... 详细信息

本文报道1例急性淋巴细胞白血病患儿在造血干细胞移植围手术期使用艾沙康唑治疗肺毛霉病的案例。临床药师参与会诊,根据患儿病情选择艾沙康唑治疗,并确定儿童用药剂量。治疗期间监测安全性和有效性,治疗后患儿肺内病变改善。艾沙康唑作为新药,儿童使用经验有限,临床药师查阅文献,制订用药方案,实施药学监护,保障儿童用药合理与安全。

关键词：艾沙康唑儿童肺毛霉病造血干细胞移植

Recent progress in carbene-catalyzed fluoroalkylation

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Science China Chemistry 2024年第8期67卷 2448-2460页

作者： Bei zhang Xuan zhang jian Wang jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China

The fluoroalkyl fragment plays a vital role in various fields such as pharmaceuticals and materials science, and has a significant impact on human life not only on the present but also in the future. The insertion of fluoroalkyl groups into the chemical skeletons can cause considerable alternations in the chemical, physical and biological properties of molecules, which has attracted numerous scientists from different fields. This review focuses on N-heterocyclic carbene(NHC)-catalyzed fluoroalkylation reactions, providing a detailed analysis and summary of the achievements in the past two decades. Many successful examples clearly indicate that NHCs can catalyze the tranformation of fluoroalkylation reagents with various electronic characteristics, whether electrophilic, nucleophilic, or radical precursors. Herein, the fluoroalkylation reactions are classified based on different catalytic modes of NHCs: Lewis base catalysis, Umploung catalysis, radical catalysis and others. Meanwhile, by refining and systematically studying the contribution of NHC catalysis in fluoroalkylation reactions, this review is expected to provide valuable insights and enlightenment for related fields.

关键词： N-heterocyclic carbene fluoroalkylation radical catalysis

Nanophononic metamaterials induced proximity effect in heat flux regulation

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Frontiers of physics 2024年第2期19卷 149-156页

作者： jian zhang Haochun zhang Gang zhang School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Institute of High Performance Computing Agency for ScienceTechnology and Research(A*STAR)Singapore 138632Singapore

Recent studies have shown that the construction of nanophononic metamaterials can reduce thermal conductivity without affecting electrical properties,making them promising in many fields of application,such as energy conversion and thermal ***,although extensive studies have been carried out on thermal conductivity reduction in nanophononic metamaterials,the local heat flux characteristic is still *** this work,we construct a heat flux regulator which includes a silicon nanofilm with silicon *** regulator has remarkable heat flux regulation ability,and various impacts on the regulation ability are ***,even in the region without nanopillars,the local heat current is still lower than that in pristine silicon nanofilms,reduced by the neighboring nanopillars through the thermal proximity *** combine the analysis of the phonon participation ratio with the intensity of localized phonon modes to provide a clear *** findings not only provide insights into the mechanisms of heat flux regulation by nanophononic metamaterials,but also will open up new research directions to control local heat flux for a broad range of applications,including heat management,thermoelectric energy conversion,thermal cloak,and thermal concentrator.

关键词： nanophononic metamaterials proximity effect

土与结构接触面弹塑性损伤模型用于单桩与地基相互作用分析

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工程力学 2006年第2期23卷 72-77页

作者：张嘎张建民清华大学岩土工程研究所北京100084

基于粗粒土与结构接触面弹塑性损伤静动力统一模型(称作EPDI模型)建立了可用于有限元分析的弹塑性损伤接触面单元。对接触面试验进行了模拟,采用不同的接触面本构模型及参数对单调和循环荷载作用下的单桩基础的侧摩阻力和桩顶位移进行... 详细信息

基于粗粒土与结构接触面弹塑性损伤静动力统一模型(称作EPDI模型)建立了可用于有限元分析的弹塑性损伤接触面单元。对接触面试验进行了模拟,采用不同的接触面本构模型及参数对单调和循环荷载作用下的单桩基础的侧摩阻力和桩顶位移进行了有限元分析。结果表明:包括剪应力应变关系和剪胀特性在内的接触面力学特性对桩土相互作用分析有重要影响,需要合理地加以描述。基于试验结果建立的弹塑性损伤接触面单元能够有效地用于土体与结构物相互作用分析,并能够合理地反映土与结构接触面的包括体应变及其与剪应变耦合特性在内的接触面主要静动力学特性。

关键词：岩土工程接触面有限元法本构模型单桩相互作用

From molecule to cell:the expanding frontiers of plant immunity

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Journal of Genetics and Genomics 2024年第7期51卷 680-690页

作者： Lei Li Jing Liu jian-min Zhou Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Hainan Yazhou Bay Seed Laboratory SanyaHainan 572025China

In recent years,the field of plant immunity has witnessed remarkable *** the co-evolution between plants and pathogens,plants have developed a wealth of intricate defense mechanisms to safeguard their *** identified immune receptors have added unexpected complexity to the surface and intracellular sensor networks,enriching our understanding of the ongoing plant–pathogen *** the molecular mechanisms of resistosome shapes our understanding of these mysterious molecules in plant ***,technological innovations are expanding the horizon of the plant–pathogen battlefield into spatial and temporal *** the development provides new opportunities for untangling the complex realm of plant immunity,challenges remain in uncovering plant immunity across spatiotemporal dimensions from both molecular and cellular levels.

关键词： Plant immunity Calcium Spatiotemporal Biomolecular condensate Immune receptor Resistosome

粗粒土与结构接触面的可逆性与不可逆性剪胀规律

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岩土力学 2005年第5期26卷 699-704页

作者：张嘎张建民清华大学岩土工程研究所北京100084

进行了粗粒土与结构接触面的单调和往返剪切试验,研究了接触面的剪胀特性。试验结果表明,接触面的剪胀体应变是由一个完全可逆性的体应变分量和一个不可逆性的体应变分量构成的。不可逆性剪胀体应变反映了接触面内的土颗粒破碎和剪切压... 详细信息

进行了粗粒土与结构接触面的单调和往返剪切试验,研究了接触面的剪胀特性。试验结果表明,接触面的剪胀体应变是由一个完全可逆性的体应变分量和一个不可逆性的体应变分量构成的。不可逆性剪胀体应变反映了接触面内的土颗粒破碎和剪切压密两种物态变化,其变化规律与接触面的应力相对位移关系的演化规律具有相似性,是接触面力学特性演化的一个重要量度。可逆性剪胀体应变存在相变点,并表现出明显的剪切异向性,该异向性的主要内因是由于剪切引起的结构面附近土的结构异向性。基于接触面受力变形机理分析,引入有效剪应变等概念,建立了剪胀方程。

关键词：接触面可逆性剪胀不可逆性剪胀剪胀方程

Quality Control of 1-Alkyl-3-methylimidazolium Ionic Liquid Precursors with HPLC

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过程工程学报 2007年第6期7卷 1094-1098页

作者：张延强张建敏陈玉涣张锁江 State Key Laboratory of Multi-phase Complex System Institute of Process EngineeringChinese Academy of Sciences

A high performance liquid chromatography(HPLC) method was proposed to monitor the synthesis and purification of the 1-alkyl-3-methylimidazolium ionic liquid precursors from alkylation of 1-methylimidazole with alkyl halides and determine the purity of final *** results showed that separation of 1-methylimidazole from the precursors could be obtained under the HPLC performance conditions such as cation exchange column,acetonitrile/KH2PO4 aqueous solution and 209 nm *** content of unreacted 1-methylimidazole in the precursors could be easily calculated from their corresponding HPLC peak areas with the calibration curve of *** retention times of the 1-alkyl-3-methylimidazolium ionic liquid precursors decreased with their increasing alkyls,and the ionic liquids with the same cation and different anions had almost the same retention times.

关键词：质量控制 1-烃基-3-甲基咪唑液相色谱离子性液体前体纯度 1-甲基咪唑

Modulating Co-Co bonds average length in Co_(0.85)Se_(1-x)S_(x) to enhance conversion reaction for potassium storage

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Journal of Energy Chemistry 2024年第4期91卷 111-121页

作者： Daming Chen Yuchun Liu Pan Feng Xiao Tao Zhiquan Huang Xiyu zhang min Zhou jian Chen jiangsu Key Laboratory of Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189JiangsuChina Hefei National Laboratory for Physical Sciences at the Microscale School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026AnhuiChina

While alloying transition metal chalcogenides(TMCs)with other chalcogen elements can effectively improve their conductivity and electrochemical properties,the optimal alloying content is still *** this study,we study the influence of dopant concentration on the chemical bonds in TMC and reveal the associated stepwise conversion reaction mechanism for potassium ion *** to density function theory calculations,appropriate S-doping in Co0.85Se(Co_(0.85)Se_(1-x)S_(x))can reduce the average length of Co-Co bonds because of the electronegativity variation,which is thermodynamically favourable to the phase transition *** optimal Se/S ratio(x=0.12)for the conductivity has been obtained from experimental *** assembled as an anode in potassium-ion batteries(PIBs),the sample with optimized Se/S ratio exhibits extraordinary electrochemical *** rate performance(229.2 mA h g^(-1)at 10 A g^(-1))is superior to the state-of-the-art *** assembled with Prussian blue(PB)as a cathode,the pouch cell exhibits excellent performance,demonstrating its great potential for ***,the stepwise K+storage mechanism caused by the coexistence of S and Se is revealed by in-situ X-ray diffraction and ex-situ transmission electron microscopy ***,this work not only provides an effective strategy to enhance the electrochemical performance of transition metal chalcogenides but also reveals the underlying mechanism for the construction of advanced electrode materials.

关键词： Co_(0.85)Se_(1-x)S_(x) Co-Co bonds Phase transition reactions Optimal Se/s Potassium ion batteries

Virtual and physical address translation mechanism of interconnect network

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Journal of Beijing Institute of Technology 2016年第3期25卷 365-374页

作者： LI Tie-jun zhang jian-min MA Ke-fan XIAO Li-quan LI Si-kun School of Computer National University of Defense Technology Changsha 410073 China

Most of users are accustomed to utilizing virtual address in their parallel programs running at the scalable high-performance parallel computing *** a virtual and physical address translation mechanism is necessary and crucial to bridge the hardware interface and software *** this paper,a new virtual and physical translation mechanism is proposed,which includes an address validity checker,an address translation cache（ATC）,a complete refresh scheme and many reliability *** ATC employs a large capacity embedded dynamic random access memory（eDRAM）to meet the high hit ratio *** also can switch the cache and buffer mode to avoid the high latency of accessing the main memory *** tests have been conducted on the real chip,which implements the address translation *** results show that the ATC has a high hit ratio while running the well-known benchmarks,and additionally demonstrates that the new high-performance mechanism is well designed.

关键词： interconnect network virtual address physical address cache