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系统性红斑狼疮初诊患者骨密度与疾病活动性的关系

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中华医学杂志 2012年第33期92卷 2331-2334页

作者：张方泽苏美华李萍吉林大学白求恩医学院临床医学系长春130033 吉林大学白求恩医学院第三医院风湿免疫科

目的探讨系统性红斑狼疮（SLE）疾病活动性及相关指标与骨密度的关系。方法采用双能X线骨密度吸收仪（DEXA）测定120例2010至2012年在吉林大学白求恩医学院第三医院风湿免疫科就诊的SLE绝经前女性患者及50例健康对照的腰椎及双髋各部位... 详细信息

目的探讨系统性红斑狼疮（SLE）疾病活动性及相关指标与骨密度的关系。方法采用双能X线骨密度吸收仪（DEXA）测定120例2010至2012年在吉林大学白求恩医学院第三医院风湿免疫科就诊的SLE绝经前女性患者及50例健康对照的腰椎及双髋各部位骨密度。选择未经糖皮质激素及免疫抑制剂治疗的SLE初诊患者作为研究对象，与SLE治疗组进行比较，采用简单线性回归分析及多重线性回归分析探讨导致SLE患者骨密度改变的相关危险因素。结果与健康对照组比较，SLE初诊组及SLE治疗组患者双侧股骨颈、双侧股骨大转子、双侧全髋骨密度均明显降低（P〈0．01）。与SLE初诊组比，治疗组双侧股骨大转子骨密度明显降低（前者左、右股骨颈骨密度均为－0．06，后者分别为－0．11和－0．12，P〈0．05）。回归分析显示，病程长、SLEDAI评分高是导致初诊组SLE患者发生双侧股骨大转子、双侧全髋骨密度降低的相关危险因素（P〈0．05），其中SLEDAI评分的影响更为显著。结论SEE疾病本身可引起患者骨密度降低，多发生在双髋关节；病程长、SLEDAI评分高与初诊SLE患者骨密度降低有密切关系。

关键词：红斑狼疮系统性骨密度疾病活动性

二氧化硅-共聚物杂化荧光纳米材料用于动物活体成像

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无机化学学报 2018年第11期34卷 1943-1949页

作者：张泽芳袁薇徐明易韬张善端李富友复旦大学先进照明技术教育部工程研究中心上海200433 复旦大学化学系上海200433 复旦大学附属华山医院中西医结合科上海200040

以氧化硅(SiO_2)前驱体与三嵌段共聚物F108合成较小粒径的SiO_2-共聚物杂化纳米体系(SNP),并与高效近红外发射的疏水染料M507自组装,构建了近红外发光纳米探针M507@SNP。同时,研究了M507@SNP的光物理性能和细胞毒性。动物成像实验证明... 详细信息

以氧化硅(SiO_2)前驱体与三嵌段共聚物F108合成较小粒径的SiO_2-共聚物杂化纳米体系(SNP),并与高效近红外发射的疏水染料M507自组装,构建了近红外发光纳米探针M507@SNP。同时,研究了M507@SNP的光物理性能和细胞毒性。动物成像实验证明该纳米成像探针可实现活体层次高信噪比的小动物全身成像和前哨淋巴结的指示。

关键词：杂化复合材料荧光成像空心二氧化硅粒子近红外荧光染料

单晶菱形CeOHCO_3片状物的制备及其向CeO_2的热转换(英文)

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无机化学学报 2011年第4期27卷 759-763页

作者：张泽芳俞磊刘卫丽宋志棠中国科学院上海微系统与信息技术研究所信息功能材料国家重点实验室纳米技术研究室上海200050 中国科学院研究生院北京100049

以硝酸铈铵和尿素为反应物,γ-氨丙基三乙氧基硅烷(KH550)为助剂,通过沉淀反应制得了单晶菱形CeOHCO3片状物。然后将CeOHCO3在600℃空气气氛中灼烧获得了菱形CeO2。通过XRD和SEM对反应物中是否含有KH550助剂所得的产物进行了分析,结果... 详细信息

以硝酸铈铵和尿素为反应物,γ-氨丙基三乙氧基硅烷(KH550)为助剂,通过沉淀反应制得了单晶菱形CeOHCO3片状物。然后将CeOHCO3在600℃空气气氛中灼烧获得了菱形CeO2。通过XRD和SEM对反应物中是否含有KH550助剂所得的产物进行了分析,结果发现只有含有KH550才能获得菱形CeOHCO3片状物,并且在灼烧过程中产物的形貌仍保持菱形。然后采用TEM对菱形CeOHCO3和CeO2进行了表征,结果发现CeOHCO3为单晶产物而灼烧后所得的CeO2为多晶产物。

关键词： CeOHCO3 CeO2 KH550 菱形沉淀法

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan fang Yuyu Zhou Chuxia zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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氧化铝/聚甲基丙烯酸复合粒子的抛光性能

微细加工技术 2008年第1期 45-48页

作者：雷红张泽芳上海大学纳米中心上海200444

在化学机械抛光(CMP)中,为了提高氧化铝磨料的分散稳定性及减少抛光划痕,通过硅烷偶联剂在其表面接枝了聚甲基丙烯酸(PMAA)制得了一种新型的复合粒子(-αAl2O3-g-PMAA)。SEM结果表明,制得的复合粒子分散稳定性明显提高。进而用SPEEDFAM-... 详细信息

在化学机械抛光(CMP)中,为了提高氧化铝磨料的分散稳定性及减少抛光划痕,通过硅烷偶联剂在其表面接枝了聚甲基丙烯酸(PMAA)制得了一种新型的复合粒子(-αAl2O3-g-PMAA)。SEM结果表明,制得的复合粒子分散稳定性明显提高。进而用SPEEDFAM-16B-4M抛光机研究了其在玻璃基片中的抛光性能。抛光后玻璃基片表面的ZYGO表面形貌仪和AFM分析结果表明,在相同的抛光条件下,与纯Al2O3磨料相比,所制得的复合粒子表现出了低的表面粗糙度及划痕。该复合粒子可望用做新型CMP磨粒。

关键词：氧化铝/聚甲基丙烯酸复合粒子化学机械抛光玻璃基片

基于CMUT的超声波信号检测及放大电路设计

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仪表技术与传感器 2020年第2期 37-40页

作者：张泽芳任勇峰何常德中北大学仪器与电子学院山西太原030051

超声波信号检测及放大是搭建水下超声系统的基础,当微型电容式超声换能器(CMUT)处于接收状态时,电容值变化量为pF级,这对信号检测与放大电路设计提出了很高的要求。在进行了CMUT工作原理分析、C-V特性测试、电荷放大原理理论分析、仿真... 详细信息

超声波信号检测及放大是搭建水下超声系统的基础,当微型电容式超声换能器(CMUT)处于接收状态时,电容值变化量为pF级,这对信号检测与放大电路设计提出了很高的要求。在进行了CMUT工作原理分析、C-V特性测试、电荷放大原理理论分析、仿真及实验后,所设计的电路灵敏度可达到2.5 V/pF,该电路性能优良,可集成度高,可推动CMUT的广泛应用。

关键词： CMUT 超声波信号检测电荷放大原理

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing fang Liangming zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao fang Qiuxia Peng Wen Qin Xuebing Yan Kun zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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略谈国内外地下装载机自动化现状与发展趋势

有色设备 2020年第4期34卷 96-99页

作者：张方泽赵金元广西华锡集团股份有限公司广西大厂547207 中钢集团衡阳机械有限公司湖南衡阳421002

地下装载机是非煤地下矿无轨采矿的主要设备。由于地下矿经过长期和大规模开采,浅层矿产资源逐渐减少,正逐步转入深部开采。深部开采恶劣的工作环境对人体健康和设备安全的危害越来越严重,它促进了地下采矿设备技术发展,经过了人工控制... 详细信息

地下装载机是非煤地下矿无轨采矿的主要设备。由于地下矿经过长期和大规模开采,浅层矿产资源逐渐减少,正逐步转入深部开采。深部开采恶劣的工作环境对人体健康和设备安全的危害越来越严重,它促进了地下采矿设备技术发展,经过了人工控制、遥控控制、远距离控制、半自主控制、自主控制等发展阶段,国外有些矿山已经实现了或部分实现了自动化的目标,全自动化、智能化是地下采矿装备的一个重要发展方向。本文简略介绍了国内外地下装载机自动化发展现状与趋势。

关键词：地下装载机自动化智能化发展趋势