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沉默MR-1.血管紧张素Ⅱ诱导小鼠心肌肥厚基因表达谱的影响

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生物化学与生物物理进展 2011年第7期38卷 633-641页

作者：戴文建张曼陈金晶王以光孔维佳王真中国医学科学院北京协和医学院医药生物技术研究所北京100050 湖南环境生物职业技术学院衡阳421005

肌纤基因调节因子(myofibrillogenesis regulator1.MR1.是首次从人体骨骼肌cDNA文库中分离得到的基因.以前的研究证明MR1.够介导血管紧张素Ⅱ(AngⅡ)诱导的体内外心肌肥厚效应,但相关分子机制有待进一步阐明.利用腺病毒载体在小鼠中沉... 详细信息

肌纤基因调节因子(myofibrillogenesis regulator1.MR1.是首次从人体骨骼肌cDNA文库中分离得到的基因.以前的研究证明MR1.够介导血管紧张素Ⅱ(AngⅡ)诱导的体内外心肌肥厚效应,但相关分子机制有待进一步阐明.利用腺病毒载体在小鼠中沉默MR1.达,利用基因芯片对比检查了小鼠心肌基因表达谱的变化.结果发现,在AngⅡ诱导心肌肥厚的小鼠,沉默MR1.后出现明显的信号通路方面的变化和基因表达差异,其中沉默MR1.表达降低90%以上的基因有39个,而表达升高1.倍以上的基因有5个.在这些基因中,对与心肌肥厚密切相关的基因进行了定量RT-PCR检测,以进一步验证基因芯片的结果,发现沉默MR1.HSP72.硫氧还蛋白1.Trx1.均表达升高,而钙调神经磷酸酶β(CnAβ)和β肌球蛋白(β-myosin)的基因表达则受抑制.这些信号通路和基因均与AngⅡ诱导的心肌肥厚有一定的关系,为揭示MR1.AngⅡ所致心肌肥厚中的作用和分子机制提供了新的证据.

关键词：肌纤基因调节因子血管紧张素Ⅱ 心肌肥厚基因芯片基因表达谱

A NEW CALCULATION METHOD FOR GAS-WELL LIQUID LOADING CAPACITY

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Journal of Hydrodynamics 2010年第6期22卷 823-828页

作者： WANG Yi-wei zhang Shi-{1.g YAN Jin {1. wen-bin Ministry of Education Key Laboratory of Petroleum Engineering China University of Petroleum Beijing 102249 Petroleum Exploration and Production Research institute S1NOPEC Beijing 100083 China Sinochem Petroleum Exploitation and Production Co. Ltd Beijing 100031 china

This article proposes a new model for calculating the gas-well liquid loading capacity, which is critical to an accurate prediction of gas well production. Based on analysis of flow regime during the gas well production with water, which is regarded as many single particles in the model, with the shape of particles being assumed as disk-like ellipsoid instead of traditional sphere and changing according to the forces exerted on them, the influences of non-Darcy flow, compressibility, and non-sphere shape on friction factor are analyzed. The differences between the new model and other models are discussed and a new formula for calculating the critical flow rate is obtained. The calculation results and a comparison with other two models show that the new model is more consistent with the actual situation and is practical.

关键词： gas well accumulated liquid drag factor critical flow rate

国内外典型富氦气藏稀有气体地球化学特征及对氦气成藏过程的示踪意义

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天然气地球科学 2024年第6期35卷 1099-1112页

作者：张文陈文李玉宏周俊林中国地质科学院地质研究所北京100037 中国地质调查局西安地质调查中心陕西西安710119

氦气是重要的战略性资源,在航空航天、医疗成像和高新制造业发挥着不可替代的作用。稀有气体具有壳源、幔源和大气源三大来源,且在不同储集库中同位素特征差别大,可有效揭示壳—幔演化以及各圈层相互作用,也为示踪弱源氦气成藏过程提供... 详细信息

氦气是重要的战略性资源,在航空航天、医疗成像和高新制造业发挥着不可替代的作用。稀有气体具有壳源、幔源和大气源三大来源,且在不同储集库中同位素特征差别大,可有效揭示壳—幔演化以及各圈层相互作用,也为示踪弱源氦气成藏过程提供重要手段。研究统计了中国各大盆地的含氦特征,并进一步对美国Hugoton-Panhandle气田、国内柴北缘地区油气田、坦桑尼亚裂谷带温泉区和国内渭河盆地地热田等典型富氦气藏中稀有气体同位素特征进行了归纳性研究。结果表明,国内多个含油气盆地均发现有富氦气藏,国内外目前具有工业开采价值的氦气藏中3He/4He值基本显示壳源特征,即由铀、钍等氦源元素通过α放射性衰变生成。不同气藏中2.Ne/36Ar值及2.Ne和36Ar等同位素含量特征差异较大,代表不同富氦气藏形成时所经历的油—气—水等多相平衡过程不尽相同,氦气的富集与地下水及气藏主要气体组分的运移密切相关。壳源氦气藏中4He与2.Ne之间常呈正相关关系,表明这些气藏中4He富集可能与地下水密切相关,氦气应先溶于地下水再脱溶进入油气藏。幔源CO_(2.富氦气藏通常规模较小,氦气富集过程可能是因为CO_(2.易溶解于地下水或矿化形成碳酸盐矿物,使得气藏中CO_(2.减少,氦气相对丰度增加。进一步提出氦气成藏的四大有利条件:古老克拉通及富铀钍花岗岩提供充足的氦气来源、发育新构造活动、存在地下水系统和游离气相以及气藏中主要气体组分相对于氦气补给量适中。

关键词：氦气稀有气体同位素典型氦气藏油气藏地热温泉气

A novel strategy for partial functional recovery of completely transected lower thoracic spinal cord of adult rats

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A novel strategy for partial functional recovery of complete...

A study on the haplotype of the solute carrier family 1. member 1.(SLC1.A1. gene of pulmonary tuberculosis (PTB) patients in chinese Tibetans

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ting-Bao ZHAO~(1,2.#),Shi-De LIN~(2.#),Xiao-Jun zhang~(1,2.#),Shu-Guang yang~(1,#),Fan-{2. KONG~(1,#),Zheng YONG~3, Fang-Jin chen~1,Zhao-Qing LIU~1,Hai-Ping QUE~1,Guo-Hua WANG~1,Jian-Quan ZHENG~3,Dong-Hua TIAN~(1,4),San-Jun HU~5,Shu-Qian JING~(1,4),Shao-Jun LIU~(1,2.4,*) 1 Department of Neurobiology and State Key Laboratory of Proteomics,institute of Basic Medical sciences,2. Taiping Road,beijing 100850,china 2.Department of Spinal Cord Repair,Jinan General Hospital,2. Shifan Road,Jinan 2.0031,china 3 beijing institute of Pharmacology and Toxicology,2. Taiping Road,beijing 100850,china 4 School of Social Development and Public Policy,beijing Normal University,19 Xinjiekou Wai St.beijing 100875, china 5 institute of Neuroscience,The Fourth Military Medical University,Xian 710032.china

＜正＞Completely transected rat lower thoracic spinal cord was bridged either immediately or lingeringly by microsurgically linking T7 intercostal nerves to L3 dorsal root stumps to establish a bridged *** surgical sites were treated locally with a neurotrophin/growth factor *** the surgery,partial hind limb locomotion and visceral function were gradually *** nerve fibers were then traced to pass through linking sites,grow into L3 dorsal root stumps,enter the spinal cord and eventually contact with neurons in the gray matter of the spinal cord between L2.and *** bridged nerves could trigger evoked potentials in sciatic nerve, bladder,and colon,and induce hind limb *** the bridged nerves transected,the evoked potentials and hind limb locomotion disappeared,urinary retention and feces incontinence occurred *** observations demonstrate that physical and functional linkages between the segments of injured spinal cords have been established by bridging *** is first evidence that the peripheral nerves grow into the central nerve *** importantly,this innovative strategy is potentially applicable for clinic.

关键词： spinal cord injury novel strategy functional recovery neurotrophin/growth factor cocktail

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A study on the haplotype of the solute carrier family 11 mem...

南阿尔金陆块科克萨依新元古代花岗岩成因及地质意义

第二届国际防痨和肺部疾病联合会亚太区学术大会暨2.09年中国防痨协会学术会议

作者： chen Xue-rong~(1.),FENG Yu-lin~1.MA Yu~2. {1. Zong-de~2.LI Chuan-you~2.wen Fu-qiang~1.TANG Xiao-yan~1.SU Zhi-guang~1.1. Department of Respiratory Diseases, West china Hospital,Sichuan University, chengdu,china 61.041.2.beijing Tuberculosis & Thoracic Tumor Research institute, beijing,china 1.1.49 Corresponding auther Feng Yulin * Department of Respiratory Diseases,West china Hospital,Sichuan University, chengdu,china 61.041

Objective To investigate the association of the haplotype of the solute carrier family 1. member 1.SLC1.A1. gene with susceptibility to pulmonary tuberculosis in chinese Tibetans. Methods Four polymorphisms of the SLC1.A1.gene(5’(GT),INT4,D53N,3’UTR) were investigated by the denaturalization high performance liquid chromatography(DHPLC) and the polymerase chain reaction-restriction

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地球科学 2018年第4期43卷 1278-1292页

作者：陈红杰吴才来雷敏郭文峰张昕郑坤高栋吴迪中国地质科学院地质研究所中国地质调查局大陆动力学研究中心北京100037 中国地质大学北京100083

南阿尔金陆块是阿尔金造山带的重要组成部分.大量新元古代花岗岩出露于南阿尔金亚干布阳-帕夏拉依裆-科克萨依一带.这些花岗岩记录了与Rodinia超大陆汇聚有关的动力学信息,因此对其进行研究有利于对阿尔金造山带演化历史的认识和理解.... 详细信息

南阿尔金陆块是阿尔金造山带的重要组成部分.大量新元古代花岗岩出露于南阿尔金亚干布阳-帕夏拉依裆-科克萨依一带.这些花岗岩记录了与Rodinia超大陆汇聚有关的动力学信息,因此对其进行研究有利于对阿尔金造山带演化历史的认识和理解.选取了科克萨依花岗岩岩体进行了岩相学、地球化学、锆石U-Pb年代学和Hf同位素组成的研究.研究结果表明:(1.科克萨依二长花岗岩的主要矿物有:石英、钾长石、斜长石、黑云母和白云母;花岗岩的锆石U-Pb年龄为947~945Ma.(2.地球化学特征显示,岩石具有高SiO2.71.54%~74.69%)、高Na2.+K2.(6.33%~7.40%),低CaO(1.59%~2.00%),低MgO(0.43%~0.61.)和TiO2.0.2.%~0.37%)的特征,相对富钾,K2./Na2.比值为1.02.1.71.A/CNK在1.1.~1.1.之间,属高钾钙碱性系列的过铝质花岗岩.富集Rb、Th、K、La等元素,亏损Nb、Ta、P、Ti等元素;轻稀土富集而重稀土亏损,具有明显的负Eu异常.(3)锆石εHf(t)为-4.09^+3.87之间,二阶段模式年龄tDM2.1.6~2.0Ga.这些特征表明科克萨依二长花岗岩是古老地壳富长石贫黏土的(变)杂砂岩部分熔融形成的S型花岗岩.结合相邻地区新元古代花岗岩类的地球化学、同位素特征及阿尔金区域构造资料,认为科克萨依二长花岗岩形成于新元古代时期,是碰撞造山环境下的产物,是Rodinia超大陆汇聚碰撞过程的响应.

关键词：花岗岩地球化学 U-Pb年代学 Hf同位素特征南阿尔金陆块

"Three-Component" Digital Prospecting Method: A New Approach for Mineral Resources Quantitative Prediction and Assessment

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Journal of Earth Science 2004年第3期 6-13页

作者： Zhao Pengda Chioa University of Geosciences, Wuhan 430074, china chen Jianping School of the Earth sciences and Resources, china University of Geosciences, beijing 100083, china chen Jianguo institute of Mathematical Geology, china University of Geosciences, Wuhan 430074, china zhang Shouting School of the Earth sciences and Resources, china University of Geosciences, beijing 100083, china chen Yongqing china geological Survey, beijing 100073, china

Three-component" method consists of three close-connected aspects: geological anomaly, diversity of mineralization and mineral deposit spectrum. All these three concepts are not new separately, but it is a new approach to combine these three aspects in one single concept for quantitative mineral resources prediction and assessment and it is also the first time to conduct a more detailed study in each aspect. Investigation and clarification of geological anomalies, diversity of mineralization and spectrum of mineral deposits are realized by digitization and quantification of ore forming controlling factors, ore-existing symbols or marks, characteristics of mineralization and regulation of ore-genesis and laws of distribution. These procedures lead to construction of a "digital model" for mineral resources prediction and assessment.

关键词： three-component" method geological anomaly diversity of mineralization spectrum of mineral deposits.

Stable photocurrent-voltage characteristics of perovskite single crystal detectors obtained by pulsed bias

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chinese Physics B 2024年第4期33卷 209-214页

作者：刘新陈之龙王虎张雯清董昊王鹏祥邵宇川 Laboratory of Thin Film Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Materials for High-Power Laser Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Key Laboratory for Ultrafine Materials of Ministry of Education Shanghai Engineering Research Center of Hierarchical NanomaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China School of Microelectronics Shanghai UniversityShanghai 201899China Hangzhou institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China

Photocurrent-voltage characterization is a crucial method for assessing key parameters in x-ray or y-ray semiconductor detectors,especially the carrier mobility lifetime ***,the high biases during photocurrent measurements tend to cause severe ion migration,which can lead to the instability and inaccuracy of the test *** the mixed electronic-ionic charac teristics,it is imperative to devise novel methods capable of precisely measuring photocurrentvoltage characteristics under high bias conditions,free from interference caused by ion *** this paper,pulsed bias is employed to explore the photocurrent-voltage characteristics of MAPbBr_(3) single *** method yields stable photocurrent-voltage characteristics at a pulsed bias of up to 30 V,proving to be effective in mitigating ion *** fitting the modified Hecht equation,we determined the mobility lifetime products of 1.0×1.^(2. cm^(2.·V^(-1.for hole and 2.78×1.~(-3)cm^(2.·V^(-1.for *** approach offers a promising solution for accurately measuring the transport properties of carriers in perovskite.

关键词： perovskites ion migration pulsed bias mobility lifetime product

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库车坳陷晚白垩世隆升过程及其地质响应

石油学报 2003年第3期24卷 1-5,15页

作者：贾承造陈汉林杨树锋卢华复周宇章中国石油勘探开发研究院北京100083 浙江大学理学院地球科学系浙江杭州310027 南京大学地球科学系江苏南京210093

利用裂变径迹分析技术 ,并结合地质学研究方法 ,对库车坳陷晚白垩世隆升过程进行了研究。库车坳陷晚白垩世隆升约发生在 89Ma前 ,平均隆升速率为 3 7 8～ 45 3m/Ma ,是一个较缓慢的隆升过程。这一隆升过程不仅造成了库车坳陷全区缺失... 详细信息

利用裂变径迹分析技术 ,并结合地质学研究方法 ,对库车坳陷晚白垩世隆升过程进行了研究。库车坳陷晚白垩世隆升约发生在 89Ma前 ,平均隆升速率为 3 7 8～ 45 3m/Ma ,是一个较缓慢的隆升过程。这一隆升过程不仅造成了库车坳陷全区缺失晚白垩世地层 ,而且也导致了库车坳陷构造变形雏形的发育。晚白垩世的隆升事件局限在库车坳陷内部 ,没有影响到天山造山带。隆升事件的北部界限位于库车坳陷的前陆逆冲断层带中 ,界线南北的隆升差异明显 ,南部的隆升发生在晚白垩世时期 ,而北部的隆升事件发生在中新世时期。这一隆升过程在特提斯北缘的盆地群中都有表现 ,而隆升的形成是青藏高原地区Kohistan_Dras岛弧与拉萨地体在晚白垩世时期的碰撞事件远距离效应的结果。

关键词：库车坳陷晚白垩世裂变径迹分析隆升过程地质响应