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Effects of elevated CO_2 on sensitivity of six species of algae and interspecific competition of three species of algae

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Journal of Environmental Sciences 2006年第2期18卷 353-358页

作者： yu Juan TANG Xue-xi TIAN Ji-yuan zhang pei-yu DONG Shuang-lin Division of Life Science and Technology Ocean University of China Qingdao 266003 China Department of Environmental Science and Engineering Qingdao University Qingdao 266071 China

Effects of elevated CO, （5000 μl/L） on sensitivity comparison of six species of algae and interspecific competition of three species of algae were investigated. The results showed that, the cell densities of six species of algae grown in elevated CO2 significantly increased compared to those in ambient CO2 （360 μl/L）, and with the time prolonged, the increasing extent increased. Therefore, elevated CO2 can promote the growth of six species of algae. However, there were differences in sensitivity between six species of algae. Based on the effects of elevated CO2 on biomass, the sensitive order （from high to low） was Platymanas sp., Platymanas subcordiformis, Nitzschia closterium, Isochrysis golbana Parke 8701, Dunoliella salina, Chlorella sp., on the condition of solitary cultivation. Compared to ambient CO2, elevated CO2 promoted the growth of three species of algae, Platymanas subcordiformis, Nitzschia closterium and Isochrysis galbana Parke 8701 under the condition of mixed cultivation. The sensitivity of the three species to elevated CO2 in mixed cultivation changed a lot compared to the condition of solitary cultivation. When grown in elevated CO2 under the condition of mixed cultivation, the sensitive order from high to low were Nitzschia clostertium, Platymonas subcordiformis; and Isochrysis galbana Parke 8701. However, under the condition of solitary cultivation, the sensitive order in elevated CO2 was Isochrysis galbana Parke 8701, Nitzschia clostertium, Platymonas subcordiformis, from sensitive to less sensitive. On the day 21, the dominant algae, the sub-dominant algae and inferior algae grown in elevated CO2 did not change. However, the population increasing dynamic and composition proportion of three algal species have significantly changed.

关键词： elevated CO2 microalgae sensitivity interspecific competition

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Exact Quantum-Scattering Study of the D(2S)+DS(2Ⅱ) Reaction

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Chinese Physics Letters 2012年第7期29卷 91-94页

作者： LV Shuang-Jiang zhang pei-yu HE Guo-Zhong State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023

The quantum scattering dynamics calculations are carried out for the exchange and abstraction processes in the D(2S)+DS(2Ⅱ) reaction by the time-dependent wave-packet (TDWP) *** calculations are based on the high-quality ab initio potential energy surface of the reacting *** reaction probabilities and integral cross sections are obtained in the collision energy (Ecol) range of 0.0-2.0eV for the reactant DS initially in the ground state and the first vibrationally excited *** take the Coriolis coupling (CC) effect into account and present the comparison between the CC and the centrifugal sudden (CS) approximation *** dynamics results show that the initial vibrational excitation of DS enhances both abstraction and exchange processes except that it has little effect on the abstraction cross section in the high energy region.

关键词： calculation vibrational exchange

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Effect of Soothing Gan(Liver) and Invigorating Pi(Spleen) Recipes on TLR4-p38 MAPK Pathway in Kupffer Cells of Non-alcoholic Steatohepatitis Rats

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Chinese Journal of Integrative Medicine 2019年第3期25卷 216-224页

作者： GONG Xiang-wen XU Yong-jian YANG Qin-he LIANG Yin-ji zhang yu-pei WANG Guan-long LI yuan-yuan School of Chinese Medicine Jinan University

Objective: To investigate the mechanism of inflammatory-mediated toll-like receptor 4(TLR4)-p38 mitogen-activated protein kinase(p38 MAPK) pathway in Kupffer cells(KCs) of non-alcoholic steatohepatitis(NASH) rats and the intervention effect of soothing Gan(Liver) and invigorating Pi(Spleen) recipes on this pathway. Methods: After 1 week of acclimatization, 120 Sprague-Dawley male rats were randomly divided into 8 groups using a random number table(n=15 per group): normal group, model group, low-dose Chaihu Shugan Powder(柴胡疏肝散, CHSG) group(3.2 g/kg), high-dose CHSG group(9.6 g/kg), low-dose Shenling Baizhu Powder(参苓白术散, SLBZ) group(10 g/kg), high-dose SLBZ(30 g/kg) group, and low-and highdose integrated recipe(L-IR, H-IR) groups. All rats in the model and treatment groups were fed with a high-fat diet(HFD). The treatments were administrated by gastrogavage once daily and lasted for 26 weeks. The liver tissues were detected with hematoxylin-eosin(HE) and oil red O staining. Levels of liver lipids, serum lipids and transaminases were measured. KCs were isolated from the livers of rats to evaluate the mRNA expressions of TLR4 and p38 MAPK by real-time fluorescence quantitative polymerase chain reaction, and proteins expressions of TLR4, p-p38 MAPK and p38 MAPK by Western blot. Levels of inflammatory cytokines including tumor necrosis factor α(TNF-α), interleukin(IL)-1 and IL-6 in KCs were measured by enzyme-linked immunosorbent assay. Results: After 26 weeks of HFD feeding, HE and oil red O staining showed that the NASH model rats successfully reproduced typical pathogenesis and histopathological features. Compared with the normal group, the model group exhibited significant increases in body weight, liver weight, liver index, serum levels of total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol, and aspartate aminotransferase as well as TC and TG levels in liver tissues, and significant decrease in serum level of high-density lipoprotein choleste

关键词： non-alcoholic steatohepatitis soothing Gan (Liver)and invigorating Pi (Spleen)recipes Kupffer cel toll-like receptor 4-p38 mitogen-activated protein kinase signaling pathway inflammation,Chinese medicine

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Attenuation of myocardial apoptosis by alpha-lipoic acid through suppression of mitochondrial oxidative stress to reduce diabetic cardiomyopathy

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Chinese Medical Journal 2009年第21期122卷 2580-2586页

作者： LI Chun-jun zhang Qiu-mei LI Ming-zhen zhang Jing-yun yu pei yu De-min The Ministry of Health Key Laboratory of Hormone and Development Department of Endocrinology Metabolic Disease Hospital of Tianjin Medical University Tianjin 300070 China

Background Cardiac failure is a leading cause of the mortality of diabetic patients. In part this is due to a specific cardiomyopathy, referred to as diabetic cardiomyopathy. Oxidative stress is widely considered to be one of the major factors underlying the pathogenesis of the disease. This study aimed to test whether the antioxidant α-lipoic acid （α-LA） could attenuate mitochondrion-dependent myocardial apoptosis through suppression of mitochondrial oxidative stress to reduce diabetic cardiomyopathy. Methods A rat model of diabetes was induced by a single tail intravenous injection of streptozotocin （STZ） 45 mg/kg. Experimental animals were randomly assigned to 3 groups： normal control （NC）, diabetes （DM） and DM treated with α-LA （α-LA）. The latter group was administered with a-LA （100 mg/kg ip per day）, the remainder received the same volume vehicle. At weeks 4, 8, and 12 after the onset of diabetes, cardiac apoptosis was examined by TUNEL assay. Cardiomyopathy was evaluated by assessment of cardiac structure and function. Oxidative damage was evaluated by the content of malondialdehyde （MDA）, reduced glutathione （GSH） and the activity of manganese superoxide diamutase （Mn-SOD） in the myocardial mitochondria. Expression of caspase-9 and caspase-3 proteins was determined by immunohistochemistry and mitochondrial cytochrome c release was detected by Western blotting Results At 4, 8, and 12 weeks after the onset of diabetes, significant reductions in TUNEL-positive cells, caspase-9,-3 expression, and mitochondrial cytochrome c release were observed in the α-LA group compared to the DM group. In the DM group, the content of MDA in the myocardial mitochondria was significantly increased, and there was a decrease in both the mitochondrial GSH content and the activities of Mn-SOD. They were significantly improved by α-LA treatment. HE staining displayed structural abnormalities in diabetic hearts, while α-LA reversed this structural derangement. The index of cardiac fun

关键词： alpha-lipoic acid myocardial apoptosis mitochondrial oxidative stress diabetic cardiomyopathy

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Separation mechanism of chiral compounds in chiral stationary phase liquid chromatography

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Chinese Journal of Chemistry 1991年第3期9卷 231-236页

作者： ZOU,Han-Fa zhang,yu-Kui LU,pei-Chang Dalian Chromatographic R & D Center of China Dalian Institute of Chemical Physics,Academia Sinica,Dalian 116011 Dalian Chromatographic R & D Center of China Dalian Institute of Chemical Physics Academia Sinica Dalian 116011

In this paper,the concept of reversed-or normal-phase chiral stationary phase liquid chromatography has been put forward according to the polar strength of mobile and stationary phases. The statistical model developed in HPLC has been used to investigate the separation mechanism of D-and L-enantiomer in chiral stationary phase liquid *** has been observed that the variation of capacity factor of enantiomers with mobile phase composition in both reversed-phase and normal-phase chiral stationary phase liquid chromatography can be described by the fundamental elution equation lnk'=a+blnC_b+cC_*** effect of mobile phase composition on the selec- tivity of enantiomers D and L in normal-phase chiral stationary phase liquid chromatography cam be described by the equation lnα=⊿a+⊿blnC_b,but in reversed-phase chiral stationary phase liquid chromatography the selectivity is almost independant of the mobile phase composition.

关键词： Separation mechanism of chiral compounds in chiral stationary phase liquid chromatography

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Advances in early diagnosis and therapy of pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2011年第2期10卷 128-135页

作者： Qiang Xu, Tai-Ping zhang and yu-pei ZhaoDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medial Sciences, Beijing 100730, China Department of General Surgery Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medial Sciences Beijing 100730 China

BACKGROUND: Pancreatic cancer remains a devastating disease with a 5-year survival rate of less than 5%. Recent advances in diagnostic methods and therapeutic approaches have increased the possibility of improving the existing poor prognosis. DATA SOURCES: English-language articles reporting early diagnosis and therapy of pancreatic cancer were searched from the MEDLINE and PubMed databases, Chinese-language articles were from CHKD (China Hospital Knowledge Database) RESULT: The current literature about pancreatic cancer was reviewed from three aspects: statistics, screening and early detection, and therapy. CONCLUSIONS: Early detection and screening of pancreatic cancer currently should be limited to high risk patients Surgical resection is the only curative approach available, with some recent improvement in outcomes. Gemcitabine has been a standard treatment during the last decade. Gemcitabine based combination treatment, especially combined with newer molecular targeted agents, is promising. The rationale for radiotherapy is controversial, but with the recent development of modern radiation delivery techniques, radiotherapy should be intensified. Patients with borderline pancreatic cancer could benefit from neoadjuvant therapy but more evidence is needed and the best neoadjuvant regimen is still to be determined.

关键词： pancreatic neoplasm early diagnosis biomarkers surgery adjuvant therapy neoadjuvant therapy borderline resectable tumor

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Associations between gene polymorphisms of thymidylate synthase with its protein expression and chemosensitivity to 5-fluorouracil in pancreatic carcinoma cells

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Chinese Medical Journal 2011年第2期124卷 262-267页

作者： zhang Qiang ZHAO yu-pei LIAO Quan HU Ya XU Qiang ZHOU Li SHU Hong Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background Thymidylate synthase （TS） is a key regulatory enzyme for de novo DNA *** activity is also an important determinant of the response to chemotherapy with fluoropyrimidine prodrugs,and its expression may be affected by gene *** this study,we investigated the associations between polymorphisms of the TS gene and its protein expression,and the implications on the efficacy of 5-fluorouracil （5-FU） in pancreatic cancer *** Genotypes based on the 28-bp TS tandem repeat for pancreatic cell lines were determined by electrophoretic analysis of PCR products.A single nucleotide polymorphism （SNP） at nucleotide 12 of the second 28-bp repeat of the 3R allele was determined by nucleotide *** chemosensitivity of pancreatic carcinoma cells to 5-FU in vitro was evaluated using Cell Counting Kit-8 （CCK-8）.TS protein expression was analyzed by Western *** Seven pancreatic carcinoma cell lines had different genotypes in terms of the 28-bp TS tandem repeat,as follows：homozygous 2R/2R （T3M4 and BxPC-3 cells）,heterozygous 2R/3R （AsPC-1,Capan-1,and SU86.86）,and homozygous 3R/3R （PANC-1 and COLO357）.The optical density ratio of genotypes 3R/3R,2R/2R and 2R/3R was 1.393±0.374,0.568±0.032 and 0.561±0.056,*** with the 2R/3R or 3R/3R genotypes were further analyzed for the G to C SNP at nucleotide 12 of the second 28-bp repeat of the 3R allele,yielding heterozygous 2R/3Rc （AsPC-1,Capan-1,and SU86.86）,homozygous 3Rg/3Rg （COLO357） and homozygous 3Rc/3Rc （PANC-1）.The optical density ratio of homozygous 3Rg/3Rg cells and homozygous 3Rc/3Rc cells was 1.723±0.062 and 1.063±0.134,respectively,and this difference was statistically significant （P 〈0.05）.Cells with the 2R/2R and 2R/3R genotypes of TS were hypersensitive to 5-FU in vitro as compared with those with the 3R/3R *** Polymorphisms in the TS gene influenced its protein expression and affected sensitivity of 5-FU in seven pancreatic cancer cell ***

关键词： thymidylate synthase gene polymorphisms pancreatic carcinoma

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The prediction of the peak width at half height in HPLC

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Chinese Journal of Chemistry 1991年第3期9卷 237-244页

作者： ZOU,Han-Fa zhang,yu-Kui LU,pei-Chang Dalian Chromatographic R.& D.Center of China Dalian Institute of Chemical Physics,Academia Sinica,Dalian 116011 Dalian Chromatographic R. & D. Center of China Dalian Institute of Chemical Physics Academia Sinica Dalian 116011

The prediction of the peak width at half height is an important aspect in the optimization of the chromatographic operating *** this paper,a linear relationship,between the peak widths at half height and the retention values with various isocratic elution is *** gradient elution,however,the relationship between the peak widths at half height and the so-called invented retention values that correspond to the mobile phase composition by eluting the solute from the column end is *** believe that there is almost the same band width at half height inside the column (in unit of length)for different *** peak width at half height in the chromatogram(in unit of time)is mainly determined by the capacity factor of the solute when it is eluted front the column *** larger the capacity factor of a solute eluted from the column end,the more slowly will be the solute eluted from the column end and the wider will be the peak width at half *** is possible to predict the peak width at half height in various isocratic and gradient elutions by using this linear relationship.

关键词： The prediction of the peak width at half height in HPLC

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我国民族自治地方变通立法权的法理属性探析

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贵州民族研究 2018年第2期39卷 28-32页

作者：张佩钰武汉大学中国中部发展研究院湖北武汉430000 贵州师范大学法学院贵州贵阳550001

在对比和评析学界几种主流学说的基础上,通过引入法学方法论中的几组基本概念作为分析工具,对我国民族自治地方变通立法权的法理属性进行探究。法律实质化、利益法学以及功能主义等概念作为分析工具,能更为清晰、深刻地对我国民族自治... 详细信息

在对比和评析学界几种主流学说的基础上,通过引入法学方法论中的几组基本概念作为分析工具,对我国民族自治地方变通立法权的法理属性进行探究。法律实质化、利益法学以及功能主义等概念作为分析工具,能更为清晰、深刻地对我国民族自治地方变通立法权的法理属性从不同视角予以透析。我国民族自治地方变通立法权法理属性是立体型的,其性质上属于授权立法,兼具权力和权利两种属性,更多地体现为变通性立法。

关键词：民族自治变通立法法理属性

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The Application and Prospect of Stabilization/Solidification Technology for Hazardous Waste in China

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科技信息 2011年第27期 I0018-I0019页

作者： WANG Ji-wei zhang pei-yu CHEN Shu ZHENG Meng Environmental Science and Engineering Department of Qingdao University Qingdao Shandong 266071

The number of hazardous waste in our country increased dramatically in recent years,stabilization/solidification technology begins to attract a wide spread attention by domestic *** on the domestic related literature,this paper discussed the present situation about the treatment of the solid waste using stabilization/solidification technology;meanwhile we have a variety of outlooks on the future of the stabilization/solidification technology.

关键词：学位论文研究生青岛大学凝固工艺

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