Separation mechanism of chiral compounds in chiral stationary phase liquid chromatography
Separation mechanism of chiral compounds in chiral stationary phase liquid chromatography作者机构：Dalian Chromatographic R & D Center of China Dalian Institute of Chemical Physics Academia Sinica Dalian 116011
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：1991年第9卷第3期
页 面：231-236页
核心收录：
基 金：This work was supported by the National Natural Science Foundation of China
主 题：Separation mechanism of chiral compounds in chiral stationary phase liquid chromatography
摘 要：In this paper,the concept of reversed-or normal-phase chiral stationary phase liquid chromatography has been put forward according to the polar strength of mobile and stationary phases. The statistical model developed in HPLC has been used to investigate the separation mechanism of D-and L-enantiomer in chiral stationary phase liquid *** has been observed that the variation of capacity factor of enantiomers with mobile phase composition in both reversed-phase and normal-phase chiral stationary phase liquid chromatography can be described by the fundamental elution equation lnk =a+blnC_b+cC_*** effect of mobile phase composition on the selec- tivity of enantiomers D and L in normal-phase chiral stationary phase liquid chromatography cam be described by the equation lnα=⊿a+⊿blnC_b,but in reversed-phase chiral stationary phase liquid chromatography the selectivity is almost independant of the mobile phase composition.
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