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Analysis and experimental study on resistance-increasing behavior of composite high efficiency autonomous inflow control device

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Petroleum Science 2024年第2期21卷 1290-1304页

作者： liang-liang Dong yu-Lin zhang School of Mechatronic Engineering Southwest Petroleum UniversityChengdu610500SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina Oil and Gas Equipment Technology Sharing and Service Platform of Sichuan ProvinceChengdu610500SichuanChina

Bottom water coning is the main reason to reduce the recovery of horizontal bottom water reservoir. By water coning, we mean the oil-water interface changes from a horizontal state to a mound-shaped cone and breaks through to the wellbore. Autonomous inflow control device(AICD) is an important instrument maintain normal production after bottom water coning, however, the resistance increasing ability of the swirl type AICD is insufficient at present, which seriously affects the water control effect. Aiming this problem, this paper designs a multi-stage resistance-increasing and composite type AICD. The separation mechanism of oil-water two phases in this structure, the resistance form of oil-water single phase and the resistance-increasing principle of water phase are analyzed. Establishing the dual-phase multi-stage separation and resistance-increasing model, and verified by measuring the throttling pressure drop and oil-water volume fraction of the AICD, it is found that the composite type AICD has the effect of ICD and AICD at the same time, which can balance the production rate of each well section at the initial stage of production, delay the occurrence of bottom water coning. In the middle and later stages of production, water-blocking can be effectively increased to achieve water control and stable *** structural sensitivity analysis, the influence law of various structural parameters on the water control performance of composite AICD was obtained. The simulation calculation results show that,compared with the existing swirl type AICD, composite AICD has higher sensitivity to moisture content,the water phase throttling pressure drop is increased by 4.5 times on average. The composite AICD is suitable for the entire stage of horizontal well production.

关键词： Water control Flow separation Flow resistance-increasing AICD device Simulation and experiment

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马流产沙门氏菌研究进展

动物医学进展 2024年第4期45卷 102-106页

作者：齐佳欣邵明杰崔平张玉良张鹤平肖跃强河北工程大学生命科学与食品工程学院河北邯郸056021 山东省滨州畜牧兽医研究院山东滨州256600 滨州市畜牧兽医管理服务中心山东滨州256600 无棣县畜牧兽医管理服务中心山东无棣251900

马流产沙门氏菌(Salmonella abortus equi)是以引起母马流产、种马睾丸炎和小马驹败血症及多发性关节炎为主要症状的病原菌。近年来,由于马属动物集约化养殖,该病在我国山东、新疆、内蒙等马属动物养殖地区陆续发生,造成了严重的经济损... 详细信息

马流产沙门氏菌(Salmonella abortus equi)是以引起母马流产、种马睾丸炎和小马驹败血症及多发性关节炎为主要症状的病原菌。近年来,由于马属动物集约化养殖,该病在我国山东、新疆、内蒙等马属动物养殖地区陆续发生,造成了严重的经济损失。论文通过对马流产沙门氏菌引起的临床症状、致病机制、疫苗研制等方面的研究进展进行论述或回顾,并对其研究趋势进行展望,旨在为更好地开展该菌引起的疾病的预防、控制和净化等提供参考。

关键词：马流产沙门氏菌临床症状致病机制疫苗

冠心康调控FTO的m^(6)A甲基化抑制炎症和凋亡抗动脉粥样硬化的研究

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时珍国医国药 2024年第6期35卷 1281-1284页

作者：吴奇东陶丽陈冉丁利建张余梁张少恒邱秀秀章怡祎上海中医药大学附属龙华医院上海200032

目的观察冠心康对脂多糖诱导的人脐静脉内皮细胞(HUVEC)中去甲基化酶FTO甲基化水平、炎症和凋亡的影响。方法将体外培养的HUVEC细胞随机分为空白对照(NC)组、脂多糖(LPS)组和冠心康(GXK)组。采用CCK8法检测不同浓度LPS和冠心康对HUVEC... 详细信息

目的观察冠心康对脂多糖诱导的人脐静脉内皮细胞(HUVEC)中去甲基化酶FTO甲基化水平、炎症和凋亡的影响。方法将体外培养的HUVEC细胞随机分为空白对照(NC)组、脂多糖(LPS)组和冠心康(GXK)组。采用CCK8法检测不同浓度LPS和冠心康对HUVEC细胞增殖活性的影响,筛选出造模和冠心康干预的最佳浓度;造模及冠心康治疗24h后,利用m^(6)A RNA定量试剂盒(比色法)检测m^(6)A RNA甲基化水平,实时荧光定量PCR(RT-qPCR)及蛋白质印迹法(Western blotting)法检测FTO mRNA及蛋白的表达量,ELISA法检测IL-1β、IL-6、TNF-α炎症因子变化,流式细胞术检测各种细胞凋亡水平。结果(1)分别选择1μg/mL和6μg/mL作为脂多糖和冠心康的最佳浓度;(2)与NC组比较,LPS组m^(6)A RNA甲基化水平升高(P<0.05),与LPS组比较,冠心康组m^(6)A RNA甲基化水平降低(P<0.05);(3)与NC组比较,LPS组FTO mRNA及蛋白表达量降低(P<0.05),与LPS组比较,冠心康干预后FTO mRNA及蛋白表达量升高(P<0.05);(4)与NC组比较,LPS组细胞上清液中IL-1β、IL-6、TNF-α炎症因子水平升高(P<0.05),与LPS组比较,冠心康组IL-1β、IL-6、TNF-α炎症因子水平下降(P<0.05);(5)与NC组比较,LPS组细胞凋亡率增加(P<0.05),与LPS组比较,冠心康组细胞凋亡率下降(P<0.05)。结论冠心康可能通过调控去甲基化酶FTO抑制LPS诱导的炎症和凋亡抗动脉粥样硬化。

关键词：冠心康 FTO 炎症凋亡动脉粥样硬化

Heat Transfer Characteristics of a Microchannel Heat Sink with Highly-Dense Micro-Jet Arrays

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Journal of Thermal Science 2024年第3期33卷 1148-1160页

作者： zhang yu CHEN Xiaoyan MIAO Lin CHEN liang HOU yu State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China Beijing Aerospace Technology Institute Beijing100083China

This paper proposed a new structure of highly-dense micro-jet arrays for hybrid jet-impingement/microchannel heat sinks(~120 jet per cm^(2) with jet width of 0.35 mm).Parametric study is performed to investigate the influence of structure and flow parameters on the convective heat transfer of water jet cooling in confined *** simulation results show that the optimal jet width,jet spacing and impingement distance are around 0.2 mm,0.2 mm and 0.3 mm,respectively,which can achieve a low thermal resistance as well as a relatively low pressure *** analysis of the heat transfer pathways shows that the micro-fin jet structures can extend the impinging heat transfer area and conduct a considerable proportion of heat,which can reach up to 38.9%with the Reynolds number ranging from 797.1 to *** heat transfer characteristics in the heat sink will shift from impingement dominated heat transfer to the channel-convection dominated heat transfer as the jet impingement distance increases.A correlation is proposed to predict the average Nusselt number on the stagnation area for the heat sink with different structure parameters,and the deviations of predictions from the numerical results are less than 10%.

关键词： hybrid heat sink impingement microchannel thermal management high heat flux

Practice of Fighting Fire and Suppressing Explosion for a Super-Large and Highly Gassy Mine

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Journal of China University of Mining and Technology 2007年第4期17卷 459-463页

作者： ZHOU Fu-bao WANG De-ming zhang Yong-jiu zhang yu-liang LI Xiang School of Mining and Safety Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China Ningxia Mining Industry Group Yinchuan Ningxia 750004 China

The Baijigou Mine fire in Ningxia Province,which broke out on October 24,2003,affected more than 108 m3 of the mine and was probably the largest underground fire in China in recent years. In addition to its size,the fire was also characterized by excessive air leakage and the potential for violent methane explosions. A series of new measures were taken to fight the fire,including sealing intake tunnels with water,injecting three-phase foam through boreholes,and flushing with a large volume of nitrogen. The fire was successfully extinguished and production re-sumed soon afterwards; not one single methane explosion occurred during fire-fighting and afterwards.

关键词： mine fire gas explosion fire-fighting explosion-suppression three-phase foam

Elastic buckling analysis and optimization of thin-walled bamboo-like pipe beam subjected to pure bending

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Chinese Journal of Aeronautics 2024年第3期37卷 133-152页

作者： Yayun yu Dongli MA liang zhang Xiaopeng YANG Hao GUAN School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China

In this paper,a stiffening design imitating the bamboo node is proposed for weight reduction of the long composite pipe beam subjected to bending *** distribution of bamboo nodes can efficiently suppress the ovalization of the section,thus significantly improving the bending resistance of the *** on this principle,ring stiffeners are proposed to be fixed to the pipe beam,making the long beam equivalent to the combination of a series of short pipes that suffered less section ovalization.A database of the optimal laminate orientations for different normalized lengths is obtained through optimizations,where the discreteness of the ply count is *** on this database,weight optimizations are conducted,and the optimal designs of beams with and without stiffeners are obtained and *** comparison results show that the proposed bamboo-like stiffened beam not only regains a near-linear load–displacement relationship,but also reduces the weight by up to 16%under the same buckling *** addition,it is found that for the pipe beams with radius-to-thickness ratios of more than 18,increasing the radius leads to a decrease in elastic buckling resistance when the weight remains a constant,which is opposite to the design for strength and *** model and database developed in this paper can provide a reference for weight reduction design and weight estimation for composite pipe beams.

关键词： Composite beam Buckling Thin-walled structure Unmanned aerial vehicles Bamboo

Mechanisms of Compound Kushen Injection for the treatment of bladder cancer based on bioinformatics and network pharmacology with experimental validation

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Chinese Journal of Natural Medicines 2022年第1期20卷 43-53页

作者： zhang Li-Hui zhang Wan-Ying XIONG Jia-Ming DUAN Xiu-Mei HAI Li-Na zhang yu-liang zhang Miao-Miao QIN Gui-Fang zhang Guo-Wei College of Traditional Chinese Medicine Hebei UniversityBaoding 071002China Beijing Zhendong Guangming Pharmaceutical Research Institute Beijing 100085China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China

Bladder cancer is the most common malignancy of the urinary *** Kushen Injection(CKI)is a Chinese medicinal preparation that has been widely used in the treatment of various types of cancers in the past two ***,the pharmacological effect of CKI on bladder cancer is not still completely *** the current study,network pharmacology com-bined with bioinformatics was used to elucidate the therapeutic mechanism and potential targets of CKI in bladder *** mech-anism by which CKI was effective against bladder cancer was further verified in vitro using human bladder cancer cell line ***-work pharmacology analysis identified 35 active compounds and 268 target genes of *** data indicated 5500 differen-tially expressed genes associated with bladder *** genes of CKI and bladder cancer suggested that CKI exerted anti-blad-der cancer effects by regulating genes such as MMP-9,JUN,EGFR,and *** enrichment analysis indicated that CKI ex-erted therapeutic effects on bladder cancer by regulating certain biological processes,including cell proliferation,cell migration,and cell *** addition,Kyoto Encyclopedia of Genes and Genomes enrichment analysis implicated pathways related to cancer,bladder cancer,and the PI3K-Akt signaling ***,cell experiments indicated that CKI inhibited the proliferation and migration of T24 cells,and induced their ***,RT-qPCR and Western blot results demonstrated that CKI was likely to treat bladder cancer by down-regulating the gene and protein expression of MMP-9,JUN,EGFR,and *** inhibited the prolif-eration and migration,and induced the apoptosis of T24 bladder cancer cells through multiple biological pathways and *** also exhibited significant effects on the regulation of key genes and proteins associated with bladder ***,our findings provide solid evidence and deepen current understanding of the therapeutic effects

关键词： Compound Kushen Injection Bladder cancer Network pharmacology GEO Molecular mechanism

Investigating the elliptic anisotropy of identified particles in p-Pb collisions with a multi-phase transport model

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Nuclear Science and Techniques 2024年第2期35卷 160-169页

作者： Si-yu Tang liang Zheng Xiao-Ming zhang Ren-Zhuo Wan School of Mathematical and Physical Sciences Wuhan Textile UniversityWuhan 430200China School of Mathematics and Physics China University of Geosciences(Wuhan)Wuhan 430074China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China Hubei Key Laboratory of Digital Textile Equipment Wuhan Textile UniversityWuhan 430200China School of Electronic and Electrical Engineering Wuhan Textile UniversityWuhan 430200China

The elliptic azimuthal anisotropy coefficient(v_(2))of the identified particles at midrapidity(|η|<0.8)was investigated in p-Pb collisions at√s_(NN)=5.02 TeV using a multi-phase transport model(AMPT).The calculations of differential v_(2)based on the advanced flow extraction method of light flavor hadrons(pions,kaons,protons,andΛ)in small collision systems were extended to a wider transverse momentum(p_(T))range of up to 8 GeV/c for the first *** string-melting version of the AMPT model provides a good description of the measured p_(T)-differential v_(2)of the mesons but exhibits a slight deviation from the baryon v_(2).In addition,we observed the features of mass ordering at low p_(T)and the approximate number-of-constituentquark(NCQ)scaling at intermediate p_(T).Moreover,we demonstrate that hadronic rescattering does not have a significant impact on v_(2)in p-Pb collisions for different centrality selections,whereas partonic scattering dominates in generating the elliptic anisotropy of the final *** study provides further insight into the origin of collective-like behavior in small collision systems and has referential value for future measurements of azimuthal anisotropy.

关键词： Azimuthal anisotropy Small collision systems Transport model

侧深施控释氮肥运筹方式对水稻产量、NH_(3)挥发和温室气体排放的影响

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作物学报 2024年第6期50卷 1525-1539页

作者：郭松郭慧婷张裕梁钱紫慧王子君路佳明汪源赵灿王维领张洪程杨凤萍霍中洋扬州大学生物科学与技术学院行为生态学实验室江苏扬州225009 江苏省作物遗传生理国家重点实验室培育点江苏扬州225009

为建立机插稻高产低碳减排的控释氮肥施用技术,以迟熟中粳南粳9108、泰香粳1402为材料,选用控释期100 d、43%树脂包膜缓释氮肥与46%速效尿素为氮肥,分别设置基穗氮肥比例为100(NM1)∶、82(NM2)∶、73∶(NM3)与64(NM4)∶不同运筹方式处理... 详细信息

为建立机插稻高产低碳减排的控释氮肥施用技术,以迟熟中粳南粳9108、泰香粳1402为材料,选用控释期100 d、43%树脂包膜缓释氮肥与46%速效尿素为氮肥,分别设置基穗氮肥比例为100(NM1)∶、82(NM2)∶、73∶(NM3)与64(NM4)∶不同运筹方式处理,基肥采用侧深施肥方法,控释氮肥与速效尿素比例均为55,∶穗氮肥为尿素,并设置常规施肥(FFT)与不施氮肥(0N)对照处理,研究不同氮肥运筹方式对水稻产量、NH_(3)挥发和温室气体排放的影响。结果表明:与FFT处理相比,侧深施控释氮肥推迟NH_(3)挥发峰值出现,避免分蘖期NH_(3)挥发峰值产生,穗期追施尿素后的NH_(3)挥发通量和平均NH_(3)挥发通量显著降低,NH_(3)累积损失总量降低25.33%~48.76%,NH_(3)排放系数降低29.14%~60.81%,单位产量NH_(3)排放强度显著降低29.60%~56.01%。与FFT处理相比,侧深施控释氮肥分蘖期和抽穗后的CH_(4)排放通量显著降低,搁田期和穗期追施尿素后的N_(2)O排放通量显著降低,CH_(4)排放累积总量降低20.20%~55.04%,CH_(4)减排率随基穗氮肥比例变小而降低,N_(2)O排放累积总量降低25.56%~61.56%,N_(2)O减排率表现为NM1>NM3>NM2>NM4,GWP和GHGI分别降低20.96%~53.35%、25.91%~55.40%。品种间NH_(3)挥发和温室气体规律一致,减排效果均表现为NM1>NM3>NM2>NM4。综合考虑经济、生态效益,NM1处理氨挥发和温室气体减排效果最佳,且比NM3和FFT处理减少施肥次数1~2次,利于水稻绿色轻简规模化生产;NM3处理增产率最高且NH_(3)挥发和温室气体减排效果仅次NM1,实现丰产减排协同进行。综上,本文探索出一套适配迟熟中粳减排增产的控释氮肥施肥方式,重点发现“轻简+减排”型施肥方式NM1和“丰产+减排”型施肥方式NM3。

关键词：控释氮肥运筹方式 NH_(3)挥发 CH_(4) N_(2)O 减排

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