检索结果-南通市图书馆

A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression

在线全文

学校读者我要写书评

暂无评论

Science China(life sciences) 2024年第4期67卷 765-777页

作者： Hui Zhao lin-lin liu {3. Sun lian Jin Hai-Bing Xie {3.-bo li Hui Xu dong-dong Wu Xiao-lin Zhuang Min-sheng Peng ya-Jun Guo Wei-Zhu {13.an Newton OOtecko Wei-Jie Sun liang-Hu Qu Jie He Zhao-li Chen rong liu Ce-Shi Chen ya-Ping zhang State Key Laboratory for Conservation and Utilization of Bio-resource School of Life SciencesSchool of Ecology and Environmental ScienceYunnan UniversityKunming 650091China School of Forensic Medicine Kunming Medical UniversityKunming 650500China Academy of Biomedical Engineering Kunming Medical UniversityKunming 650500China The Third Affiliated Hospital Kunming Medical UniversityKunming 650118China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China State Key Laboratory of Genetic resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China The Key Laboratory of Gene Engineering of the Ministry of Education State Key Laboratory for BiocontrolSun Yat-sen UniversityGuangzhou 510275China National Engineering Research Center for Antibody Medicine and Shanghai Key Laboratory of Cell Engineering and Antibody Shanghai 201203China Department of Thoracic Surgery Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Human-specific insertions play important roles in human phenotypes and *** we reported a 446-bp insertion(Insert-446)in intron 11 of the TBC1D8B gene,located on chromosome X,and traced its origin to a portion of intron 6 of the EBF1 gene on chromosome ***,Insert-446 was present in the human Neanderthal and Denisovans genomes,and was fixed in humans after human-chimpanzee *** have demonstrated that Insert-446 acts as an enhancer through binding transcript factors that promotes a higher expression of human TBC1D8B gene as compared with orthologs in *** addition,over-expression TBC1D8B promoted cell proliferation and migration through“a dual finger”catalytic mechanism(Arg53. and Gln573.in the TBC domain in vitro and knockdown of TBC1D8B attenuated tumorigenesis in *** of Insert-446 prevented cell proliferation and migration in cancer and normal *** results reveal that the human-specific Insert-446 promotes cell proliferation and migration by upregulating the expression of TBC1D8B *** findings provide a significant insight into the effects of human-specific insertions on evolution.

关键词： human-specific insertion enhancer gene expression cell proliferation and migration

N Accumulation and Translocation in Four Japonica Rice Cultivars at Different N Rates

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2007年第6期17卷 792-800页

作者： zhang yao-Hong fan jian-bo {3. wang dong-sheng HUANG qi-Wei shen qi-rong college of resources and environmental {3. Nanjing Agricultural University Nanjing 210095 （China）

Developing high-yielding rice(Oryza sativa L.)cultivars depends on having a better understanding of nitrogen(N) accumulation and translocation to the ear during the reproductive *** experiments were carried out to evaluate the genetic variation for N accumulation and translocation in different Japonica rice cultivars at different N rates and to identify any relationship to grain yield in southeast *** Japonica cultivars with similar agronomic characteristics were grown at two experimental sites in 2004 with three N rates of 0,60,and 180 kg N ha^(-1).Dry weights and N contents of rice plants were measured at tillering,initiation,anthesis,and *** yields exhibited significant differences (Plication *** N rates improved N uptake at anthesis and maturity in all four cultivars(P3.% to 68%. Grain yield was linear to N uptake at anthesis(r^2=0.78^(**))and N translocation(r^2=0.67^(**)).Thus,cultivars with a high N uptake at anthesis,low residual N in the straw at maturity,and appropriate low N fertilizer supply in southeast China should efficiently increase N-recovery rate while maintaining grain yield and soil fertility.

关键词： rain yield Japonica rice cultivar N accumulation N application rate N translocation

Correlation between Combined Urinary Metal Exposure and Grip Strength under Three Statistical Models:A Cross-sectional Study in Rural Guangxi

在线全文

学校读者我要写书评

暂无评论

Biomedical and environmental sciences 2024年第1期37卷 3-18页

作者： liANG Yu jian rong Jia Hui {3. Xue Xiu CAI jian sheng qiN li dong liU qiu Mei TANG Xu MO Xiao Ting WEI yan Fei liN Yin Xia HUANG {13. Xiang LUO Ting Yu GOU Ruo Yu CAO Jie Jing HUANG Chu Wu LU Yu Fu qiN jian zhang Zhi Yong Department of environmental and Occupational Health School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Tumor Immunology and Microenvironmental Regulation Guilin Medical UniversityGuilin 541199GuangxiChina Department of environmental Health and Occupational Medicine School of Public HealthGuilin Medical UniversityGuilin 541199GuangxiChina Guangxi colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Key Laboratory of Environment and Health Research Guangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Health Commission Key Laboratory of Entire lifecycle Health and Care Guilin Medical UniversityGuilin 541199GuangxiChina

Objective This study aimed to investigate the potential relationship between urinary metals copper(Cu),arsenic(As),strontium(Sr),barium(Ba),iron(Fe),lead(Pb)and manganese(Mn)and grip *** We used linear regression models,quantile g-computation and Bayesian kernel machine regression(BKMR)to assess the relationship between metals and grip *** In the multimetal linear regression,Cu(β=−2.119),As(β=−1.3.8),Sr(β=−2.480),Ba(β=0.781),Fe(β=1.13.)and Mn(β=−0.404)were significantly correlated with grip strength(P3.2,−0.652;P3.and 0.018,respectively).Conclusion In summary,this study suggests that combined exposure to metal mixtures is negatively associated with grip ***,Sr and As were negatively correlated with grip strength levels,and there were potential interactions between As and Mn and between Cu and Mn.

关键词： Urinary metals Handgrip strength Quantile g-computation Bayesian kernel machine regression

Root Physiological and Morphological Characteristics of Two Rice Cultivars with Different Nitrogen-Use Efficiency

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2010年第4期20卷 446-455页

作者： fan jian-bo {3. D. TURNER DUAN Yin-Hua wang dong-sheng shen qi-rong jiangsu Provincial Key Laboratory for Solid Organic Waste Utilization Nanjing Agricultural University Nanjing 210095(China) college of resources and environmental {3. Nanjing Agricultural University Nanjing 210095 (China) Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 (China) School of Resource Management The University of MelbourneVictoria 3010 (Australia)

The variation in nitrogen （N） uptake by rice has been widely studied but differences in rice root morphology that may contribute to this variation are not completely understood. Field and greenhouse experiments were carried out to study N accumulation, root dry weights, total root lengths, root surface areas, and root bleeding rates of two rice cultivars, Elio with low N-use efficiency and Nanguang with high N-use efficiency. Low （1 mmol N L^-1） and high （5 mmol N L^-1） N applications were established in the greenhouse experiment, and the N rates were 0, 120, and 240 kg ha^-1 in the field experiments at {3.gning and {3.gpu farms, nanjing, China. The results showed that the N accumulation, root dry weight, total root length, and root surface area increased with an increase in N application. At the heading stage, N accumulation in the shoots and roots of Nanguang was greater than that of Elio in the field experiments and that of Elio at 5 mmol N L^-1 in the greenhouse experiment. After the heading stage, N accumulation was higher for Nanguang at both 1 and 5 mmol N L^-1 in the greenhouse experiment. The total root length and root surface area were significantly different between the two cultivars. Over the range of the fertilizer application rates, the root lengths of Nanguang at {3.gning Farm were 49%-6170 greater at booting and 26%-3.% greater at heading than those of Elio, and at {3.gpu Farm they were 22%-42% and 26%-3.% greater, respectively. Nanguang had a greater root bleeding rate than Elio. It was concluded that the N-use efficiency of the two rice cultivars studied depended to a great extent on the root morphological parameters and root physiological characteristics at different growth stages.

关键词： N accumulation root bleeding rate root dry weight root surface area total root length

在线全文

学校读者我要写书评

暂无评论

外源富氢水对盐胁迫下绿豆幼苗生长的影响

土壤通报 2024年第4期55卷 1014-1021页

作者：武泉栋姚玲崔健张丁郭锋申慧芳王新妤王晋山西农业大学资源环境学院山西太谷030801 山西农业大学农学院山西太谷030801 山西农业大学基础部山西太谷030801

【目的】盐胁迫是制约绿豆生长最严重的非生物胁迫之一,如何缓解绿豆盐胁迫已成为植物抗逆研究方面的重要课题。富氢水作为一种新型外源添加物质在提高植物抗逆性方面发挥着重要作用,本文旨在探究外源富氢水缓解绿豆盐胁迫的可行性。【... 详细信息

【目的】盐胁迫是制约绿豆生长最严重的非生物胁迫之一,如何缓解绿豆盐胁迫已成为植物抗逆研究方面的重要课题。富氢水作为一种新型外源添加物质在提高植物抗逆性方面发挥着重要作用,本文旨在探究外源富氢水缓解绿豆盐胁迫的可行性。【方法】以绿豆幼苗为试验材料,采用沙培方式,从幼苗生长指标、光合色素含量和抗逆性指标三方面,研究根灌不同浓度富氢水(25%、50%和100%)对盐含量1.5 g kg^(-1)盐胁迫下绿豆幼苗的缓解效应。【结果】与非盐胁迫对照相比,在1.5 g kg^(-1)盐胁迫处理下,绿豆幼苗生长和叶片光合色素含量受到明显抑制,丙二醛、可溶性糖和可溶性蛋白的含量明显增加。与1.5 g kg^(-1)盐胁迫、非富氢水处理相比,施加不同浓度富氢水(25%、50%、100%)处理均有效促进绿豆幼苗根系和地上部生长,丙二醛的含量显著降低,叶绿素、可溶性糖含量显著增加(P<0.05)。【结论】外源不同浓度富氢水处理均能缓解绿豆幼苗盐胁迫,其中50%富氢水处理的缓解效果最佳。利用外源富氢水缓解盐胁迫的成本较低、操作简单、不会对环境造成污染,研究结果对外源富氢水缓解绿豆幼苗盐胁迫方面的应用具有一定的指导意义。

关键词：绿豆富氢水盐胁迫幼苗

基于非参数统计方法估算青藏高原臭氧背景浓度

在线全文

学校读者我要写书评

暂无评论

中国环境科学 2024年第8期44卷 4274-4281页

作者：谢民生吉东生殷秀峰辛金元万欣李健军张强弓布多丛志远西藏大学生态环境学院青藏高原生物多样性与生态环境保护教育部重点实验室西藏拉萨850000 中国科学院大气物理研究所北京100029 中国科学院西北生态环境资源研究院甘肃兰州730000 中国科学院青藏高原研究所北京100101 中国环境监测总站北京100012

基于Kolmogorov-Zurbenko(KZ)滤波和Robust Extraction of Baseline Signal(REBS)方法处理了青藏高原纳木错站和珠峰站多年连续的近地面臭氧原始观测数据.通过合理选择KZ滤波器和REBS滤波窗口与带宽,成功去除了臭氧时间序列中的短期变动... 详细信息

基于Kolmogorov-Zurbenko(KZ)滤波和Robust Extraction of Baseline Signal(REBS)方法处理了青藏高原纳木错站和珠峰站多年连续的近地面臭氧原始观测数据.通过合理选择KZ滤波器和REBS滤波窗口与带宽,成功去除了臭氧时间序列中的短期变动,提取了代表两站近地面臭氧背景浓度信号.结果表明,KZ滤波法得到的纳木错站和珠峰站臭氧年平均背景浓度分别为89.71μg/m^(3.和88.98μg/m^(3.;REBS方法得到的分别为89.62μg/m^(3.和88.52μg/m^(3..两种方法得到的背景臭氧浓度一致性较好,都呈现出相似的季节变化规律.4~5月臭氧浓度较高,而季风期间则较低.KZ滤波更侧重反映长期趋势和季节周期性变化,而REBS在局部污染时段的表现更好.两种非参数统计方法均可有效应用于背景区域臭氧时间序列分析,为监测和防治臭氧污染提供重要依据.

关键词：臭氧背景浓度 KZ滤波 REBS 青藏高原

在线全文

学校读者我要写书评

暂无评论

改性菠萝皮对水中亚甲基蓝的吸附性能研究

当代化工 2024年第1期53卷 25-31页

作者：李芹张婉剑李逢雨何东升武汉工程大学化学与环境工程学院湖北武汉430205 武汉工程大学资源与安全工程学院湖北武汉430205

以农业废弃物菠萝皮为原料,使用柠檬酸对菠萝皮粉末分别进行超声波改性和热改性,探究了改性菠萝皮对亚甲基蓝的去除效果。通过扫描电子显微镜(SEM)和傅里叶变换红外光谱(FTIR)对改性前后菠萝皮孔隙和表面结构进行表征,同时考察了改性前... 详细信息

以农业废弃物菠萝皮为原料,使用柠檬酸对菠萝皮粉末分别进行超声波改性和热改性,探究了改性菠萝皮对亚甲基蓝的去除效果。通过扫描电子显微镜(SEM)和傅里叶变换红外光谱(FTIR)对改性前后菠萝皮孔隙和表面结构进行表征,同时考察了改性前后菠萝皮的投加量、pH值、反应时间和染料质量浓度对吸附亚甲基蓝的影响。结果表明:经过柠檬酸改性后的菠萝皮表面引入了羧基官能团,对亚甲基蓝的吸附效果显著增加。在吸附剂用量为1.2 g·L^(-1)、起始p H为6.52、改性时间90 min、起始质量浓度为100 mg·L^(-1)的条件下,柠檬酸超声波改性菠萝皮(PA-US)和柠檬酸热改性菠萝皮(PA-TM)对亚甲基蓝的去除率分别可以达到65%、98%。吸附等温线的研究表明,PA-US和PA-TM吸附过程均符合Langmuir等温模型,说明该吸附过程为单分子层吸附,且对亚甲基蓝的最大吸附量分别为56.05 mg·g^(-1)和3.3.3. mg·g^(-1),与未改性菠萝皮(PA)的最大吸附量相比,分别提高了1.3.、8.08倍。吸附动力学研究表明,PA-US和PA-TM对亚甲基蓝的吸附均符合准二级动力学方程模型。由吸附等温线和动力学模型结果可以推断该吸附过程属于化学吸附。

关键词：菠萝皮柠檬酸亚甲基蓝热改性超声改性

Breeding against mycorrhizal symbiosis:Modern cotton (Gossypium hirsutum L.) varieties perform more poorly than older varieties except at very high phosphorus supply levels

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2023年第3期22卷 701-715页

作者： wang Xin-xin zhang Min sheng {3.-dong FENG Gu Thomas W.KUYPER college of resources and environmental {3. China Agricultural UniversityBeijing 100193P.R.China State Key Laboratory of North China Crop Improvement and Regulation/Mountain Area Research Institute Hebei Agricultural UniversityBaoding 071001P.R.China college of Resource and environmental sciences Xinjiang Agricultural UniversityUrumqi 830052P.R.China Soil Biology Group Wageningen University&ResearchWageningen 6700AAThe Netherlands

Cotton (Gossypium hirsutum L.) is an importantfiber cash crop,but its root traits related to phosphorus (P) acquisition,including mycorrhizal root traits,are poorly *** cotton varieties bred in northwestern China that were released between 1950 and 2013.were grown in pots with or without one arbuscular mycorrhizal fungal (AMF) species(Funneliformis mosseae) at three P supply levels (0,50 and 3.0 mg P as KH_(2)PO_(4)kg^(-1)).Eleven root traits were measured and calculated after 7 wk of *** more recent accessions had smaller root diameters,acquired less P and produced less biomass,indicating an (inadvertent) varietal selection for thinner roots that provided less cortical space for AMF,which then increased the need for a high P fertilizer *** the two lower P levels,the mycorrhizal plants acquired more P and produced more biomass than non-mycorrhizal plants (3.2 vs.0.9 mg P per plant;1.8 vs.0.9 g biomass per plant at P_(0);14.5 vs.1.7 mg P per plant;and 4.7 vs.1.6 g biomass per plant at P_(50)).At the highest P level,the mycorrhizal plants acquired more P than non-mycorrhizal plants (18.8 vs.13.4 mg per P plant),but there was no difference in biomass (6.2 vs.6.3.g per plant).At the intermediate P level,root diameter was significantly positively correlated with shoot biomass,P concentration and the P content of mycorrhizal *** results of our study support the importance of the outsourcing model of P acquisition in the root economics space *** varietal selection in the last decades,resulting in thinner roots and a lower benefit from AMF,has led to a lower productivity of cotton varieties at moderate P supply (i.e.,when mycorrhizal,the average biomass of older varieties 5.0 g per plant *** of newer varieties 4.4 g per plant),indicating the need to rethink cotton breeding efforts in order to achieve high yields without very high P *** feasible way to solve the problem of inadvertent varietal selection for cotto

关键词： cotton varieties plant breeding arbuscular mycorrhizal fungi root economics space outsourcing phosphorus acquisition

Intra-continental deformation and tectonic evolution of the West Junggar Orogenic Belt,Central Asia:Evidence from remote sensing and structural geological analyses

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2020年第2期11卷 651-663页

作者： Wei-Cui Ding Ting-dong li Xuan-Hua Chen jian-Ping Chen {3.-lin Xu Yi-Ping zhang Bing li qiang yang School of Earth sciences and resources China University of GeosciencesBeijing 100083China SinoProbe Center Chinese Academy of Geological Sciences and China Geological SurveyBeijing 100037China Center for Hydrogeology and environmental Geology CGSBaodingHebei 071051China

The West Junggar Orogenic Belt(WJOB)in northwestern Xinjiang,China,is located in the core of the western part of the Central Asian Orogenic Belt(CAOB).It has suffered two stage tectonic evolutions in Phanerozoic,before and after the ocean–continental conversion in Late *** later on intracontinental deformation,characterized by the development of the NE-trending West Junggar sinistral strike-slip fault system(WJFS)since Late Carboniferous and Early Permian,and the NW-trending Chingiz-Junggar dextral strike-slip fault(CJF)in Mesozoic and Cenozoic,has an important significance for the tectonic evolution of the WJOB and the *** this paper,we conduct geometric and kinematic analyses of the WJOB,based on field geological survey and structural interpretation of remote sensing image *** some piercing points such as truncated plutons and anticlines,an average magnitude of^73.km for the left-lateral strike-slip is calculated for the Darabut Fault,a major fault of the *** partial of the displacement should be accommodated by strike-slip fault-related folds developed during the strike-slip *** and curved faults,asymmetrical folds,and irregular contribution of ultramafic bodies,implies potential opposite vertical rotation of the Miao’ergou and the Akebasitao batholiths,resulted from the sinistral strike-slipping along the Darabut *** to conjugate shearing set of the sinistral WJFS and the dextral CJF since Early Mesozoic,superimposed folds formed with N–S convergence in southwestern part of the WJOB.

关键词： Remote sensing Structural analysis Strike-slip fault system Darabut fault West Junggar Central Asian orogenic belt