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Dual Photo/Thermo-Responsive Polypeptoids

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Chinese Journal of Polymer Science 2023年第1期41卷 24-31页

作者： Yu-xuan zhang Jie Huang Jun zhang Ning Ren Gang-Sheng Tong Xin-Yuan Zhu School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesResearch Institute of Polymer MaterialsShanghai Jiao Tong UniversityShanghai200240China

A series of polypeptoids with dual photo/thermo-responsiveness were prepared by incorporating both azobenzene(Azo)group and oligo(ethylene glycol)(OEG)segment into the side ***,the N-substituted-N-carboxyanhydride(NNCA)monomers with different Azo and OEG groups were synthesized,and then a single NNCA ring-openning polymerization was performed to afford dual-responsive polypeptoids without any post-polymerization *** ultra-violet/visible(UV/Vis)photo-responsive behaviors of the polypeptoids were achieved by cis-trans photoisomerization of the Azo group and confirmed by both ^(1)H-NMR and UV/Vis *** thermo-responsive behaviors were realized by both OEG segment and Azo group and confirmed by UV/Vis spectroscopy and dynamic light *** work demonstrated the synthetic pathway for dual responsive polypeptoids using NNCA monomers with two responsive groups and revealed the potential of polypeptoids as smart materials that could respond to different environmental stimuli.

关键词： Dual-responsive polymer Polypeptoid Ring-opening polymerization

Efficient and green tetrahydropyranylation and deprotection of alcohols and phenols by using activated carbon supported sulfuric acid

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Chinese Chemical Letters 2008年第8期19卷 893-896页

作者： Jin Hui Yang xuan zhang Wan Yi Liu Key Laboratory of Energy Sources ＆ Engineering Ningxia University Yinchuan 750021 China School of Chemistry and Chemical Engineering Ningxia University Yinchuan 750021 China

A simple, green and efficient method for the DHP protection of various alcohols and phenols and the subsequent removal of the corresponding protective group in the presence of a catalytic amount of the activated carbo... 详细信息

关键词： Tetrahydropyranylation Deprotection THP ethers Activated carbon

过表达溶质载体家族1成员5和敲低慢病毒载体构建及稳定转染RAW264.7细胞株

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中国组织工程研究 2025年第7期29卷 1414-1421页

作者：郭大鑫范苏苏朱振东侯建红张旋云南省第三人民医院/大理大学第二附属医院云南省昆明市650011 昆明医科大学药学院暨云南省天然药物药理重点实验室/现代生物医药产业学院云南省昆明市650500

背景:溶质载体家族1成员5(solute carrier family 1 member 5,SLC1A5)在多种疾病中发挥了潜在作用,但确切作用机制尚不清楚。构建稳定的SLC1A5过表达和敲低细胞模型可为深入研究SLC1A5在疾病中的确切作用机制以及发现潜在治疗靶点提供... 详细信息

背景:溶质载体家族1成员5(solute carrier family 1 member 5,SLC1A5)在多种疾病中发挥了潜在作用,但确切作用机制尚不清楚。构建稳定的SLC1A5过表达和敲低细胞模型可为深入研究SLC1A5在疾病中的确切作用机制以及发现潜在治疗靶点提供有力的实验工具。目的:构建小鼠SLC1A5过表达和敲低的慢病毒载体,以建立稳定转染的RAW264.7细胞株,为深入探讨SLC1A5在炎症中的作用提供实验基础。方法:根据SLC1A5基因序列设计合成引物并使用聚合酶链反应扩增该基因片段。将目的基因定向接入经Age I/Nhe I酶切的载体质粒GV492中构建重组慢病毒质粒,对阳性克隆进一步筛选后测序比对结果;pHelper1.0质粒载体、pHelper2.0质粒载体、目的质粒载体与293T细胞共同培养并转染,获得慢病毒原液进行包装和滴度测定;在此基础上,通过体外培养RAW264.7细胞,确定嘌呤霉素工作质量浓度;不同滴度的慢病毒分别与RAW264.7细胞共同培养,根据荧光强度确定转染效率;用嘌呤霉素挑选出稳定转染细胞,实时荧光定量聚合酶链反应和蛋白免疫印迹方法检测稳定转染细胞株的SLC1A5基因和蛋白表达水平。结果与结论:(1)测序序列与目的序列一致提示重组慢病毒载体构建成功;(2)过表达SLC1A5慢病毒的滴度为1×10~9 TU/mL,敲低SLC1A5慢病毒的滴度为3×10~9 TU/mL;(3)确定RAW264.7细胞嘌呤霉素工作质量浓度为3μg/mL;(4)过表达/敲低SLC1A5慢病毒转染RAW264.7细胞的最佳条件皆为HiTransG P转染增强液且感染复数值等于50;(5)过表达SLC1A5稳转细胞株中SLC1A5基因和蛋白的表达量明显上调,而敲低SLC1A5稳转细胞株中SLC1A5基因和蛋白的表达量显著下调。结果表明,成功构建了小鼠SLC1A5过表达和敲低的慢病毒载体并获得稳定转染的RAW264.7细胞株。

关键词：慢病毒载体溶质载体家族1成员5 SLC1A5 过表达敲低 RAW264.7细胞稳转细胞株

A New Partial Task Offloading Method in a Cooperation Mode under Multi-Constraints for Multi-UE

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Computers, Materials & Continua 2023年第9期76卷 2879-2900页

作者： Shengyao Sun Ying Du Jiajun Chen xuan zhang Jiwei zhang Yiyi Xu School of Information Science and Technology Zhengzhou Normal UniversityZhengzhou450044China Henan Key Laboratory of Big Data Analysis and Processing Henan UniversityKaifeng475004China School of Geography and Tourism Zhengzhou Normal UniversityZhengzhou450044China Science and Engineering College South China University of TechnologyGuangzhou510641China Department of Electrical and Electronic Engineering Luohe Vocational Technology CollegeLuohe462002China School of Computer Science Beijing University of Posts and TelecommunicationsBeijing100876China Cardiff School of Engineering Cardiff UniversityCardiffCF103XQ 15UK

In Multi-access Edge Computing(MEC),to deal with multiple user equipment(UE)’s task offloading problem of parallel relationships under the multi-constraints,this paper proposes a cooperation partial task offloading method(named CPMM),aiming to reduce UE’s energy and computation consumption,while meeting the task completion delay as much as *** first studies the task offloading of single-UE and then considers the task offloading ofmulti-UE based on single-UE task *** the critical path algorithmto divide the modules into key and non-key *** to some constraints of UE-self when offloading tasks,it gives priority to non-key modules for offloading and uses the evaluation decision method to select some appropriate key modules for *** on fully considering the competition between multiple UEs for communication resources and MEC service resources,CPMM uses the weighted queuing method to alleviate the competition for communication resources and uses the branch decision algorithm to determine the location of module offloading by BS according to the MEC servers’*** achieves its goal by selecting reasonable modules to offload and using the cooperation ofUE,MEC,andCloudCenter to determine the execution location of *** experiments demonstrate that CPMM obtains superior performances in task computation consumption reducing around 6%on average,task completion delay reducing around 5%on average,and better task execution success rate than other similar methods.

关键词： MEC partial task offloading parallel dependencies completion delay

A multiscale adaptive framework based on convolutional neural network:Application to fluid catalytic cracking product yield prediction

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Petroleum Science 2024年第4期21卷 2849-2869页

作者： Nan Liu Chun-Meng Zhu Meng-xuan zhang Xing-Ying Lan College of Artificial Intelligence China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing102249China

Since chemical processes are highly non-linear and multiscale,it is vital to deeply mine the multiscale coupling relationships embedded in the massive process data for the prediction and anomaly tracing of crucial process parameters and production *** the integrated method of adaptive signal decomposition combined with time series models could effectively predict process variables,it does have limitations in capturing the high-frequency detail of the operation state when applied to complex chemical *** light of this,a novel Multiscale Multi-radius Multi-step Convolutional Neural Network(Msrt Net)is proposed for mining spatiotemporal multiscale ***,the industrial data from the Fluid Catalytic Cracking(FCC)process decomposition using Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)extract the multi-energy scale information of the feature ***,convolution kernels with varying stride and padding structures are established to decouple the long-period operation process information encapsulated within the multi-energy scale ***,a reconciliation network is trained to reconstruct the multiscale prediction results and obtain the final *** Net is initially assessed for its capability to untangle the spatiotemporal multiscale relationships among variables in the Tennessee Eastman Process(TEP).Subsequently,the performance of Msrt Net is evaluated in predicting product yield for a 2.80×10^(6) t/a FCC unit,taking diesel and gasoline yield as *** conclusion,Msrt Net can decouple and effectively extract spatiotemporal multiscale information from chemical process data and achieve a approximately reduction of 30%in prediction error compared to other time-series ***,its robustness and transferability underscore its promising potential for broader applications.

关键词： Fluid catalytic cracking Product yield Data-driven modeling Multiscale prediction Data decomposition Convolution neural network

Relationship between dynamic characteristics of air film of aerostatic spindle and mid-frequency of surface topography

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Advances in Manufacturing 2022年第3期10卷 428-442页

作者： Dong-Ju Chen Shu-Pei Li xuan zhang Jin-Wei Fan Mechanical Industry Key Laboratory of Heavy Machine Tool Digital Design and Testing Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124People's Republic of China

The dynamic characteristics of the gas film of an aerostatic spindle primary affect workpiece waviness in ultra-precision *** improve the machining accuracy of the machine tool and provide a firm theoretical basis for the design of an aerostatic spindle,a simulation model combining transient computational fluid dynamics(CFD)analysis and transient dynamic analysis is established in this study to investigate the dynamic characteristics of the spindle under unstable operating *** on a large eddy simulation,a three-dimensional flow model of an air film in an aerostatic spindle is *** simulation results show that the gas flow in the throttle chamber is turbulent,and that complex vortices are *** dynamic grid modeling technology,a CFD numerical model for the unsteady calculation of the spindle is established,and the dynamic characteristics of the gas film are obtained.A transient dynamic simulation model of an aerostatic spindle is established,and the effect of the nonlinear dynamic characteristics of the gas film on the spindle displacement response is ***,a surface morphology prediction model is *** show that film fluctuation significantly affects the dynamic characteristics of the spindle and subsequently affects the generation of surface ripples on the workpiece.

关键词： Dynamic characteristics Aerostatic spindle Surface formation Ultra-precision flying cutting

Preparation and photocatalytic activity of Cu^(2+)-doped TiO_2/SiO_2

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International Journal of Minerals,Metallurgy and Materials 2009年第2期16卷 220-225页

作者： Ru-fen Chen Cui-xuan zhang Juan Deng Guo-qiang Song College of Chemistry and Material Science Hebei Normal University Shijiazhuang 050016 China

Cu^2＋-doped nanostructured TiO2-coated SiO2 （TiO2/SiO2） particles were prepared by the layer-by-layer assembly technique and their photocatalytic property was studied. TiO2 colloids were synthesized by the sol-gel method using TiOSO4 as a precursor. The experimental results showed that TiO2 nanopowders on the surface of SiO2 particles were well distributed and compact. The amount of TiO2 increased with the increase in coating layers. The shell structure appeared to be composed of anatase titania nanocrystals at 550℃. The 2-layer coated TiO2 particles on the surface showed a higher degradation rate compared with all the different-layer samples. The photocatalytic activity of Cu^2＋-doped TiO2/SiO2 was higher than that ofundoped TiO2/SiO2. The optimum dopant content was about 0.10wt%.

关键词： nanostructured TiO2 SiO2 particles layer-byqayer assembly Cu^2+ -doped photocatalytic activity

Stud Pose Detection Based on Photometric Stereo and Lightweight YOLOv4

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Journal of Artificial Intelligence and Technology 2022年第1期2卷 32-37页

作者： xuan zhang Guohui Wang School of Opto-Electronic Engineering Xi’an Technological UniversityXi’an 710021China

There are hundreds of welded studs in a *** posture of a welded stud determines the quality of the body assembly,thus affecting the safety of *** is crucial to detect the posture of the welded *** the lack of accurate method in detecting the position of welded studs,this paper aims to detect the weld stud’s pose based on photometric stereo and neural ***,a machine vision-based stud dataset collection system is built to achieve the stud dataset labelling ***,photometric stereo algorithm is applied to estimate the stud normal map which as input is fed to neural ***,we improve a lightweight YOLOv4 neural network which is applied to achieve the detection of stud position,thus overcoming the shortcomings of traditional testing *** research and experimental results show that the stud pose detection system designed achieves rapid detection and high accuracy positioning of the *** research provides the foundation combining the photometric stereo and deep learning for object detection in industrial production.

关键词： Stud pose photometric stereo neural network machine vision

The cardiovascular protective effect and mechanism of calycosin and its derivatives

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Chinese Journal of Natural Medicines 2020年第12期18卷 907-915页

作者： PAN Li zhang xuan-Fen WEI Wan-Sheng zhang Jing LI Zhen-Zhen Department of Cardiopulmonary Bypass Lanzhou University Second HospitalLanzhou 730000China Department of Orthopaedic Surgery Lanzhou University Second HospitalLanzhou 730000China

Cardiovascular disease is the main cause of mortality and morbidity in the world,especially in developing *** therapy is one of the main ways to treat cardiovascular *** them,great progress has been made in the treatment of cardiovascular diseases with traditional Chinese *** terms of experimental research,the mechanism of traditional Chinese medicine in the treatment of cardiovascular diseases has been thoroughly discussed in vitro and in *** terms of clinical treatment,traditional Chinese medicine with flavonoids,saponins and alkaloids as the main effective components has a definite effect on the treatment of cardiovascular diseases such as arrhythmia,myocardial ischemia,angina pectoris and myocardial infarction,with high safety and good application *** the further research on the effective ingredients,mechanism and adverse reactions of traditional Chinese medicine,it will be beneficial to the effectiveness of traditional Chinese medicine,reduce side effects and promote the modernization of traditional Chinese *** and its derivatives,the main bioactive flavonoids in Astragalus membranaceus have multiple biological effects,such as antioxidant,pro-angiogenesis,anti-tumour,and anti-inflammatory *** on the above biological effects,calycosin has been shown to have good potential for cardiovascular *** potent antioxidant effect of calycosin may play an important role in the cardiovascular protective *** injured cardiac myocytes,calycosin and its derivatives can alleviate the cell damage mainly marked by the release of myocardial enzymes and reduce the death level of cardiac myocytes mainly characterized by apoptosis through various *** vascular endothelial cells,calycosin also has multiple effects and multiple mechanisms,such as promoting vascular endothelial cell proliferation,exerting vasodilating effect and directly affecting the synthesis function of endothelial cel

关键词： Cardiovascular disease Calycosin Cadiac myocytes Vascular endothelial cells Protective effect