The cardiovascular protective effect and mechanism of calycosin and its derivatives

作     者：PAN Li ZHANG Xuan-Fen WEI Wan-Sheng ZHANG Jing LI Zhen-Zhen PAN Li;ZHANG Xuan-Fen;WEI Wan-Sheng;ZHANG Jing;LI Zhen-Zhen

作者机构：Department of Cardiopulmonary BypassLanzhou University Second HospitalLanzhou 730000China Department of Orthopaedic SurgeryLanzhou University Second HospitalLanzhou 730000China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2020年第18卷第12期

页      面：907-915页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 100706[医学-药理学] 1002[医学-临床医学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Cardiovascular disease Calycosin Cadiac myocytes Vascular endothelial cells Protective effect 

摘      要：Cardiovascular disease is the main cause of mortality and morbidity in the world,especially in developing *** therapy is one of the main ways to treat cardiovascular *** them,great progress has been made in the treatment of cardiovascular diseases with traditional Chinese *** terms of experimental research,the mechanism of traditional Chinese medicine in the treatment of cardiovascular diseases has been thoroughly discussed in vitro and in *** terms of clinical treatment,traditional Chinese medicine with flavonoids,saponins and alkaloids as the main effective components has a definite effect on the treatment of cardiovascular diseases such as arrhythmia,myocardial ischemia,angina pectoris and myocardial infarction,with high safety and good application *** the further research on the effective ingredients,mechanism and adverse reactions of traditional Chinese medicine,it will be beneficial to the effectiveness of traditional Chinese medicine,reduce side effects and promote the modernization of traditional Chinese *** and its derivatives,the main bioactive flavonoids in Astragalus membranaceus have multiple biological effects,such as antioxidant,pro-angiogenesis,anti-tumour,and anti-inflammatory *** on the above biological effects,calycosin has been shown to have good potential for cardiovascular *** potent antioxidant effect of calycosin may play an important role in the cardiovascular protective *** injured cardiac myocytes,calycosin and its derivatives can alleviate the cell damage mainly marked by the release of myocardial enzymes and reduce the death level of cardiac myocytes mainly characterized by apoptosis through various *** vascular endothelial cells,calycosin also has multiple effects and multiple mechanisms,such as promoting vascular endothelial cell proliferation,exerting vasodilating effect and directly affecting the synthesis function of endothelial cel