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A 630dpi dynamic LED display array in standard Si-based CMOS technology

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Science china(Information sciences) 2012年第10期55卷 2409-2416页

作者： DONG Zan ,WANG Wei,huang beiju,zhang xu,{2.,Institute of semiconductors,chinese academy of sciences,beijing 1.0083.china state key {2. on integrated optoelectronics Institute of Semiconductors Chinese Academy of Sciences Beijing China

A novel silicon light emitting diode(LED) display array has been fabricated using 0.35 μm standard CMOS *** this array,an LED and static random access memory(SRAM) are integrated together in a special *** SRAM in each pixel can store the state of the pixel and ensure that the pixel remains lit without persistent *** a result,the control logic is perfectly integrated on the same *** power sources are used to drive the display array because the LEDs operate at high voltage(supply voltage of 9 V),and the current of the whole display array is about 30-60 mA to display common *** display circuit includes digital control logic circuits and SRAM,and requires a supply voltage of 3.3 *** area of a single pixel is 40×40 μm 2.the area of the whole 16×16 LED array is 1 mm 2.and the display density is 630 dpi.

关键词： light emitting diode silicon-based CMOS technology display array

Response characteristics of PWR primary circuit under SBLOCAs considering steam bypass discharging

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Nuclear Science and Techniques 2024年第6期35卷 189-201页

作者： Shuai Yang Xiang-Bin Li Yu-Sheng Liu Jia-ning xu De-{2. zhang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China beijing key {2. of Passive Safety Technology for Nuclear Energy Beijing 102206China Nuclear and Radiation Safety Center MEPBeijing 100084China

Small-break superposed station blackout(SBO)accidents are the basic design accidents of nuclear power *** the condition of a small break in the cold leg,SBO further increases the severity of the accident,and the steam bypass discharg-ing system(GCT)in the second circuit can play an important role in guaranteeing core *** explore the influence of the GCT on the thermal-hydraulic characteristics of the primary circuit,RELAP5 software was used to establish a numerical model based on a typical pressurized water reactor nuclear power *** different small breaks in the cold-leg super-posed SBO were selected,and the impact of the GCT operation on the transient response characteristics of the primary and secondary circuit systems was *** results show that the GCT plays an indispensable role in core heat removal during an accident;otherwise,core safety cannot be *** GCT was used in conjunction with the primary safety injection system during the placement *** the break diameter was greater than a certain critical value,the core cooling rate could not be guaranteed to be less than 100 K/h;however,the core remained in a safe state.

关键词： Steam bypass discharging Pressurized water reactor SBLOCA Numerical simulation

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CMOS image sensor with optimal video sampling scheme

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Science china(Information sciences) 2012年第6期55卷 1429-1435页

作者： guan ning,{2.,LIU Bo,DONG Zan,huang beiju,GUI Yun,HAN JianQiang,WANG Yuan,zhang ZanYun & chen hongda state key laboratory on integrated optoelectronics,Institute of {12.,chinese academy of Science,beijing 1.0083.china state key {2. on integrated optoelectronics Institute of Semiconductors Chinese Academy of Science Beijing China

Time-varying illumination on the focal plane is a three-dimensional *** sam-pling theory proves that the temporal resolution can be optimally improved by a factor of 2.(1/2. while the spatial resolution is reserved by changing the sampling *** on the theory,a prototype multi-field CMOS image sensor (CIS) is designed for a 0.35-μm 2.4M CMOS *** pixels in 4×4-pixel clusters are assembled into 16 fields over the whole *** pins (resets and shutters) of pixels are separated which provides the ability of sampling the illumination with the optimal sampling scheme.

关键词： CMOS image sensors sampling methods deinterlacing high speed photography selective readout

Boosting the catalytic performance of Cu-SAPO-34in NO_(x) removal via hydrothermal treatment

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Journal of Environmental sciences 2024年第1期135卷 640-655页

作者： Xiaoyan Tian Huimin Wang Siyuan xu Lianyun Gao Jinyan Cao Jianjun chen Qiulin {2. Ping ning Jiming Hao Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China National-Regional Engineering Center for Recovery of Waste Gases from Metallurgical and Chemical Industries Kunming University of Science and TechnologyKunming 650500China School of Environment State Key Joint Laboratory of Environment Simulation and Pollution ControlTsinghua UniversityBeijing 100084China

Phosphate ions promoted Cu-SAPO-34(P-Cu-SAPO-34)were prepared using bulk CuO particles as Cu^(2.)precursor by a solid-state ion exchange technique for the selective catalytic reduction of NO_(x) with NH_3(NH_3-SCR).The effects of high temperature(H-T)hydrothermal aging on the NO_(x) removal(de-NO_(x))performance of Cu-SAPO-34 with and without phosphate ions were systematically investigated at atomic *** results displayed that both Cu-SAPO-34 and P-Cu-SAPO-34 presented relatively poor NO_(x) removal activity with a low conversion(2.0-500℃.However,after H-T hydrothermal treatment(800℃ for 10 hr at 10%H_2.),these two samples showed significantly satisfied NO_(x) elimination performance with a quite high conversion(70%-90%)at 2.0-500℃.Additionally,phosphate ions decoration can further enhance the catalytic performance of Cu-SAPO-34 after hydrothermal treatment(Cu-SAPO-34H).The textural properties,morphologies,structural feature,acidity,redox characteristic,and surface-active species of the fresh and hydrothermally aged samples were analyzed using various characterization *** systematical characterization results revealed that increases of 2.%of the isolated Cu^(2.)active species(Cu^(2.)-2.,Cu(OH)^(+)-Z)mainly from bulk CuO and 50%of the Bronsted acid sites,the high dispersion of isolated Cu^(2.)active component as well as the Bronsted acid sites were mainly responsible for the accepted catalytic activity of these two hydrothermally aged samples,especially for P-Cu-SAPO-34H.

关键词： NH_(3)-SCR Cu-SAPO-34 Hydrothermal induced Phosphate ions

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Peroxidase-like active Cu-ZIF-8 with rich copper(I)-nitrogen sites for excellent antibacterial performances toward drug-resistant bacteria

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Nano Research 2024年第8期17卷 7427-7435页

作者： Xiaoze Wang Hui Wang Jingkun zhang ning Han Wenjun Ma Donghai zhang Mingshui Yao Xianliang Wang Yunfa chen state key {2. of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of the chinese academy of sciences Beijing 100049China laboratory of Theoretical and Computational Nanoscience CAS Key Laboratory of Nanosystem and Hierarchial FabricationCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China china CDC key {2. of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China

Bacterial pathogens pose a serious threat to human health,and there is an urgent need to develop highly effective antibacterial materials to eliminate the increasingly serious contamination of drug-resistant ***,a Cu-doped ZIF-8 particle with unsaturated copper exhibits high peroxidase-like activity.99.998%antibacterial efficiency against *** can be achieved for 30 min at a low concentration of 50μg·mL^(−1),as well as complete sterilization against ***(up to 8 log).99.999%antibacterial efficiency against Methicillin-resistant Staphylococcus aureus can be achieved,performing orders of magnitude higher than *** mechanism shows that the unsaturated Cu-Nx sites are enzyme-like active centers,which could promote the consumption of bacteria reducing substances by H_(2.O_(2.,and the generated*OH further aggravates bacterial oxidative stress and membrane *** importantly,the oxidation activity of adsorbed oxygen species on Cu-ZIF-8 is enhanced by charge transfer and structural changes between the ligand and copper center like natural ***-doped ZIF-8 with peroxidase-like activity shows great potential in antibacterial application and the revealed catalytic mechanism is helpful for understanding the high antibacterial activity of nanoparticles with Cu-Nx sites.

关键词： Cu-doped ZIF-8 peroxidase-like reactive oxygen species(ROS) catalytic mechanism antibacterial activity

Decoding the chromatin accessibility in Andrographis paniculata genome,a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4179-4182页

作者： Mingkun huang Yufang Hu Ling zhang Hua Yang {2. Feng Chunhong Jiang ning Xie Difa Liu Shilin {2. Jihua Wang Wei Sun Jiangxi Provincial key laboratory of Ex Situ Plant Conservation and Utilization Lushan Botanical GardenChinese Academy of SciencesJiujiang 332900China key laboratory of {2. for Identification and Safety Evaluation of chinese Medicine China Academy of Chinese Medical SciencesInstitute of Chinese Materia Medic1Beijing 100070China state key {2. for Quality Ensurance and Sustainable Use of Dao-di Herbs Institute of Chinese Materia Medic1China Academy of Chinese Medical SciencesBeijing 100700China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China guangdong Provincial key {2. of Crops Genetics and Improvement Crop Research InstituteGuangdong Academy of Agriculture SciencesGuangzhou 510640China state key {2. of Innovative Natural Medicine and TCM Injections Jiangxi Qingfeng Pharmaceutical Co.Ltd.Ganzhou 341008China

To the Editor:Medicinal plants have the ability to synthesize a large number of pharmaceutical metabolites,the production and regulation of which are influenced by both intrinsic signals(e.g.,the spatial and temporal stage)and extrinsic environmental conditions(e.g.,temperature,light availability,and water availability)*** to the Encyclopedia of DNA Elements(ENCODE)project2.accessible chromatin regions(ACRs)served essential roles in maintaining the genome architecture and gene regulation in both mammals and ***,identifying ACRs within medicinal plant genomes remains a challenge,as genomic sequences have been determined for numerous species yet the characterization of such functional elements *** this study,we selected Andrographis paniculata(APA)3 as a model system to map ACRs genome-wide by the assay for transposase-accessible chromatin with sequencing(ATAC-seq)*** aimed to uncover the genomic features of ACRs as well as their association with the expression of genes involved in secondary metabolite biosynthesis(e.g.,andrographolide)within medicinal plants(Supporting Information Fig.S1).

关键词： Andrographis paniculata Chromatin accessibility Medicinal plant Epigenetics ENCODE cis-regulatory elements

Modeling and prediction of tribological properties of copper/aluminum-graphite self-lubricating composites using machine learning algorithms

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Friction 2024年第6期12卷 1322-1340页

作者： Huifeng ning Faqiang chen Yunfeng SU Hongbin LI Hengzhong FAN Junjie SONG Yongsheng {2. Litian HU School of Electrical and Mechanical Engineering Lanzhou University of TechnologyLanzhou 730050China state key {2. of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Center of Materials Science and optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The tribological properties of self-lubricating composites are influenced by many variables and complex ***-driven methods,including machine learning(ML)algorithms,can yield a better comprehensive understanding of complex problems under the influence of multiple parameters,typically for how tribological performances and material properties *** of friction coefficients and wear rates of copper/aluminum-graphite(Cu/Al-graphite)self-lubricating composites with their inherent material properties(composition,lubricant content,particle size,processing process,and interfacial bonding strength)and the variables related to the testing method(normal load,sliding speed,and sliding distance)were analyzed using traditional approaches,followed by modeling and prediction of tribological properties through five different ML algorithms,namely support vector machine(SVM),K-Nearest neighbor(KNN),random forest(RF),eXtreme gradient boosting(XGBoost),and least-squares boosting(LSBoost),based on the tribology experimental *** demonstrated that ML models could satisfactorily predict friction coefficient and wear rate from the material properties and testing method variables ***,the LSBoost model based on the integrated learning algorithm presented the best prediction performance for friction coefficients and wear rates,with R^(2. of 0.92.9 and 0.92.3,*** importance analysis also revealed that the content of graphite and the hardness of the matrix have the greatest influence on the friction coefficients,and the normal load,the content of graphite,and the hardness of the matrix influence the wear rates the most.

关键词： self-lubricating composites machine learning(ML) tribological properties prediction

Implantable CMOS neuro-stimulus chip for visual prosthesis

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Science china(Information sciences) 2011年第4期54卷 898-908页

作者： zhang xu 1,pei weihua 1,{2. 1,WANG ShuJing 1,guan ning 1,GUO Kai 1,WANG Yu 1,GUI Qiang 1,chen Jin 1,WANG Kai 2.WU HuiJuan 2.LI XiaoXin 2.LI Kai 3 & chen hongda 1 1 state key laboratory on integrated {12.,Institute of semiconductors,chinese academy of sciences,beijing 1.0083.china 2.Department of Ophthalmology,People’s Hospital of Peking University,beijing 100044,china 3 Department of Epidemiology and Biostatistics,Health Science Center,Peking University,beijing 1.0083.china state key {2. on integrated optoelectronics Institute of Semiconductors Chinese Academy of Sciences Beijing China Department of Ophthalmology People’s Hospital of Peking University Beijing China Department of Epidemiology and Biostatistics Health Science Center Peking University Beijing China

A prototype chip with 2.2.pixels for implanting in blind patients affected by outer retinal degeneration is presented in this *** visual prosthesis chip imitates the degenerated photoreceptor cells,senses the incident light and stimulates the remaining healthy layers of retina or optic *** pixel integrates photodiode and stimulus pulse generator,converting the illumination on the eyes into 3-bit resolution bi-phasic current ***-chip charge cancellation modules are used to discharge each electrode site for tissue *** prototype chip is designed and fabricated in 0.18-μm N-well CMOS (complementary metal oxide semiconductor) 1P6M Mix-signal process,with a ±2.5 V dual voltage *** functionality of the fabricated chip is demonstrated on anesthetized *** responses in visual cortex are successfully evoked by the neuro-stimulus chip through an on-board trigger interface and flexible electrode.

关键词： biomedical microelectronics visual prosthesis functional electrical stimulation acute animal ex- periment electrical evoked potential (EEP) test

circRNAs deregulation in exosomes derived from BEAS-2. cells is associated with vascular stiffness induced by PM_(2.5)

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Journal of Environmental sciences 2024年第3期137卷 527-539页

作者： Qingping Liu Yaling zhang Bin Han Mengruo Wang Huaifang Hu Jie ning Wentao Hu Meiyu {2. Yaxian Pang Yuanyuan {2. Lei Bao Yujie Niu Rong zhang Department of Toxicology Hebei Medical UniversityShijiazhuang 050017China state key {2. of Environment Health(Incubation) Key Laboratory of Environment and HealthMinistry of EducationKey Laboratory of Environment and Health(Wuhan)Ministry of Environmental ProtectionSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China china CDC key {2. of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Occupational Health and Environmental Health Hebei Medical UniversityShijiazhuang 050017China Hebei key laboratory of Environment and Human Health Hebei Medical UniversityShijiazhuang 050017China

As an environmental pollutant,ambient fine particulate matter (PM_(2.5)) was linked to cardiovascular *** molecular mechanisms underlying PM_(2.5)-induced extrapulmonary disease has not been elucidated *** this study the ambient PM_(2.5)exposure mice model we established was to explore adverse effects of vessel and potential ***-term PM_(2.5)exposure caused reduced lung function and vascular stiffness in *** chronic PM_(2.5)induced migration and epithelial-mesenchymal transition (EMT) phenotype in BEAS-2. *** PM_(2.5)treatment,the circRNAs and mRNAs levels of exosomes released by BEAS-2. cells were detected by competing endogenous RNA (ceRNA) array,which contained 1664 differentially expressed circRNAs (DE-circRNAs) and 308 differentially expressed m RNAs (DE-mRNAs).By bioinformatics analysis on host genes of DE-circRNAs,vascular diseases and some pathways related to vascular diseases including focal adhesion,tight junction and adherens junction were ***,ceRNA network was constructed,and DE-mRNAs in ceRNA network were conducted functional enrichment analysis by Ingenuity Pathway Analysis,which indicated that hsa_circ_0012.2.,hsa_circ_00532.1and hsa_circ_0052.10 were related to vascular endothelial ***,it was verified experimentally that Exo^(PM2.5)could induce endothelial dysfunction by increased endothelial permeability and decreased relaxation in *** present study,we investigated in-depth knowledge into the molecule events related to PM_(2.5) toxicity and pathogenesis of vascular diseases.

关键词： Fine particulate matter Vascular stiffness Exosome ceRNA microarray Endothelial dysfunction

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