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针灸治疗腰椎管狭窄的研究进展

新疆中医药 2019年第6期37卷 93-96页

作者：马熙蘭王秀华张志星辽宁中医药大学辽宁沈阳110847 辽宁中医药大学附属医院辽宁沈阳110032

腰椎管狭窄作为一种老年人的常见腰椎疾病,其发病率逐渐上升。中医治疗腰椎管狭窄上有着独特的优势。针灸作为临床中最常见的一种治疗方式,可以达到使病情缓解或是临床治愈的效果。为了更好地降低其发病率,并探求更好的治疗方式,文章就... 详细信息

腰椎管狭窄作为一种老年人的常见腰椎疾病,其发病率逐渐上升。中医治疗腰椎管狭窄上有着独特的优势。针灸作为临床中最常见的一种治疗方式,可以达到使病情缓解或是临床治愈的效果。为了更好地降低其发病率,并探求更好的治疗方式,文章就近十年的针灸诊治腰椎狭窄概况做一总结综述,希望有利于临床医生对治疗本病的认识。

关键词：椎管狭窄针灸中医治疗综述

A Light Weight Traffic Volume Prediction Approach Based on Finite Traffic Volume Data

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Journal of Systems Science and Systems Engineering 2023年第5期32卷 603-622页

作者： xing Su Minghui Fan zhi Cai Qing Liu Xiaojun zhang Faculty of Information Technology Bering University of TechnologyBeijing100124China Shanghai Ocean University Shanghai201306China Academy of Opto-electronics Chinese Academy of SciencesBeijing100094China

As one of the key technologies of intelligent transportation systems, short-term traffic volume prediction plays an increasingly important role in solving urban traffic problems. In the last decade, many approaches were proposed for the traffic volume prediction from different perspectives. However, most of these approaches are based on a large amount of historical data. When there are only finite collected traffic data, they cannot be well trained, so the prediction accuracy of these approaches will be poor. In this paper, a tensor model is proposed to capture the change patterns of continuous traffic volumes. From collected traffic volume data, the element data are extracted to update the corresponding elements of the tensor model. Then, a tucker decomposition and gradient descent based algorithm is employed to impute the missing elements of the tensor model. After missing element imputation, the tensor model can be directly applied to the short-term traffic volume prediction through searching the corresponding elements of the model and the storage cost of the model is low. Our model is evaluated on real traffic volume data from PeMS dataset, which indicates that our model has higher traffic volume prediction accuracy than other approaches in the situation of finite traffic volume data.

关键词： Short-term traffic volume prediction tensor Tucker decomposition finite traffic volume data

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局部晚期食管癌三维适形放疗初探

现代肿瘤医学 2007年第12期15卷 1775-1777页

作者：宋文军张志新周丽华湘潭市第一人民医院放疗中心湖南湘潭411100

目的:对局部晚期食管癌三维适形放疗方法、疗效及毒副作用进行探讨。方法:50例病例分为3DCRT组(三维适形放疗)和CF组(常规等中心三野放疗),比较其疗效和毒副反应。结果:3DCRT在摆位、剂量分布、正常组织损伤等方面均优于CF组。讨论:3DCR... 详细信息

目的:对局部晚期食管癌三维适形放疗方法、疗效及毒副作用进行探讨。方法:50例病例分为3DCRT组(三维适形放疗)和CF组(常规等中心三野放疗),比较其疗效和毒副反应。结果:3DCRT在摆位、剂量分布、正常组织损伤等方面均优于CF组。讨论:3DCRT方法在食管癌放疗中既可增强疗效又减少了毒副作用,是一种食管癌放疗的较好方法。

关键词：食管癌三维适形放疗常规放疗

Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui zhang zhi-Lai Zhan Guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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我国应急能力提升信息化建设初探

灾害学 2025年第1期40卷 135-139,152页

作者：肖甜甜张志王毅王棚飞狄瑞晟邢晓毅应急管理部大数据中心北京100013

围绕“大安全、大应急”框架,在分析了国内外应急管理信息化建设的进展后,结合我国应急管理信息化的现状和国际发展趋势,通过复盘2021年7月河南郑州“7·20”特大暴雨灾害与2023年7月京津冀地区洪涝灾害应急处置过程,发现主要存在灾害... 详细信息

围绕“大安全、大应急”框架,在分析了国内外应急管理信息化建设的进展后,结合我国应急管理信息化的现状和国际发展趋势,通过复盘2021年7月河南郑州“7·20”特大暴雨灾害与2023年7月京津冀地区洪涝灾害应急处置过程,发现主要存在灾害预警响应、统一指挥调度和综合研判能力不足三大问题。提出构建灾后应急管理“神经网络”“血管脉络”“骨骼肌肉”“五脏六腑”总体建设思路,采用基于感传知用的“四横四纵”系统架构,贯穿灾害监测、预警、响应、处置全过程,并针对实战中存在的问题提出了加强与多部门数据共建共享共用机制,制定应对方法,构建灾后应急能力提升体系,提升应急处置效能及防灾减灾救灾水平。

关键词：应急管理信息化系统架构郑州“7·20”特大暴雨灾害京津冀洪涝灾害

综合管廊内天然气爆炸对地面人体影响的数值模拟研究

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建筑技术 2018年第6期49卷 672-674页

作者：夏阳龚燚董雪花张志兴南京理工大学南京210094 南京理工大学理学院南京210094

结合综合管廊实例,运用Fluent软件进行综合管廊内燃气舱室爆炸模拟,研究综合管廊内燃气舱室发生爆炸时地面冲击波传播规律以及对人体的毁伤范围,提出运用泄压法减小爆炸对地面人体毁伤范围的相关内容。

关键词：综合管廊燃气舱室爆炸损伤范围泄压

凡纳滨对虾性腺差异表达miRNA分析鉴定及靶基因验证

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广东海洋大学学报 2022年第6期42卷 47-55页

作者：许尤厚李鑫彭金霞李蔚张兴志官俊良何庆松陈泳先张立张彬韦嫔媛何苹萍北部湾大学海洋学院广西钦州535011 广西水产科学研究院广西水产遗传育种与健康养殖重点实验室广西南宁530021

【目的】鉴定筛选出与凡纳滨对虾(itopenaeus vannmei)性腺发育相关的miRNA及靶基因,为揭示其性腺分化的分子调控机制提供基础。【方法】通过高通量测序平台对凡纳滨对虾性腺进行miRNA测序分析。利用DESeq 2筛选出差异表达miRNA,并使用M... 详细信息

【目的】鉴定筛选出与凡纳滨对虾(itopenaeus vannmei)性腺发育相关的miRNA及靶基因,为揭示其性腺分化的分子调控机制提供基础。【方法】通过高通量测序平台对凡纳滨对虾性腺进行miRNA测序分析。利用DESeq 2筛选出差异表达miRNA,并使用MiRanda对其进行靶基因预测,对靶基因进行GO功能注释和KEGG富集分析;运用实时荧光定量PCR(RT-qPCR)验证4个显著差异表达miRNAs及6个候选靶基因的表达模式。【结果】分别从精巢和卵巢小RNA文库获得18~30 nt的高质量序列27665604和28431611条,其中精巢中鉴定出117个已知的成熟miRNAs和214个未知miRNAs;卵巢中鉴定出106个已知的成熟miRNAs和159个未知miRNAs。分析获得153个精巢和卵巢显著差异表达的miRNAs,共预测得到57412个差异表达miRNAs的靶基因。KEGG分析表明,这些靶基因显著富集的前20条KEGG通路包括白细胞介素-17信号通路、磷脂酶D信号通路、ECM-受体相互作用和Hedgehog信号通路等。RT-qPCR结果显示,miR-92b-3p_3、miR-263a-5p_1、novel_mir23及novel_mir67等miRNAs及其靶基因的表达模式与高通量测序结果基本一致,表明测序数据准确可靠。FoxL2、Dsx、NR1D1以及Octβ2R为精巢上调基因,在精巢中高表达;Vitellogenin为卵巢上调基因,在卵巢中特异性表达;而Huntingtin在精巢和卵巢中均高表达。【结论】miR-92b-3p_3和miR-263a-5p_1等4个差异表达miRNAs以及FoxL2、Dsx、NR1D1和Vitellogenin等6个靶基因与凡纳滨对虾性腺发育密切相关,共同调节性腺的成熟过程。

关键词：凡纳滨对虾性腺 miRNA 靶基因 RT-qPCR

Low-thermal-conductivity thermal barrier coatings with a multi-scale pore design and sintering resistance following thermal exposure

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Rare Metals 2020年第4期39卷 352-367页

作者： Wei-Wei zhang zhi-Yuan Wei Li-Yuan zhang Ya-Zhe xing Qiang zhang School of Materials Science and Engineering Chang'an UniversityXi'an 710064China State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi'an 710049China College of Chemistry and Chemical Engineering Neijiang Normal UniversityNeijiang 641112China AECC Beijing Institute of Aeronautical Material Beijing 100095China

High-insulation,long-life thermal barrier coatings(TBCs)decrease the service temperature of superalloys and improve the service life of gas *** in the thermal insulation properties of the coating mainly depends on the optimization of the TBC *** important challenge for TBCs is maintaining a high performance during thermal exposure without degradation,as the pore-rich structure of the topcoat would inevitably be transformed by sintering.A low-thermalconductivity anti-sintering coating can overcome the tradeoff between thermal insulation and sinter *** this review,the design,preparation,and serviceability evaluation of a low-thermal-conductivity anti-sintering coating will be ***,directions for potential development are *** paper provides a comprehensive understanding of the structured tailoring of TBCs for better thermal insulation and anti-sintering performance.

关键词： Thermal barrier coatings Multi-scale pore Sintering resistance Low thermal conductivity

Inhibition of Na^+,K^+-ATPase in Housefly (Musca domestica L.) by Terpinen-4-ol and Its Ester Derivatives

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Agricultural Sciences in China 2009年第12期8卷 1492-1497页

作者： GUO zhi-bo MA zhi-qing FENG Jun-tao zhang xing Research ＆ Development Center of Biorational Pesticide Northwest A＆F University/Technology and Engineering Center of Biopesticide Shaanxi Province Yangling 712100 P.R. China College of Traditional Chinese Medicines China Pharmaceutical University Nanjing 210009 P.R.China

To reveal the insecticidal mechanism of terpinen-4-ol, the activity of Na＋,K＋-ATPase in insects tested were determined in vivo and in vitro. The results showed that terpinen-4-ol and its ester derivatives had strong contact activity to housefly and the contact toxicities of its derivatives except Z3 were all superior or equivalent to terpinen-4-ol. All the 7 compounds had strong inhibition towards activity of Na＋,K＋-ATPase. With poisoning symptom exacerbating, the inhibition rates were gradually increased. In vitro, the IC50 of terpinen-4-ol, Z1, Z2, Z4, Z5, and Z6 was 155.89, 197.98, 96.02, 121.36, 124.85, and 153.74 μg mL% respectively. There was well correlation between the LDs0 of terpinen-4-ol derivatives to housefly and the IC50 of terpinen-4-ol derivatives to Na＋,K＋-ATPase in housefly. In conclusion, Na＋,K＋-ATPase was likely the target of terpinen-4-ol against insects.

关键词： terpinen-4-ol terpinen-4-ol ester derivatives Na+,K+-ATPase Musca domestica L.