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Effects of insurance status on long-term survival among non-small cell lung cancer(NSCLC) patients in beijing,china: A population-based study

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Chinese Journal of Cancer Research 2020年第5期32卷 596-604页

作者： Zheng Wang lei yang Shuo {2.u Huichao {2. Xi {4. Ning Wang Jiafu Ji department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/beijing) Beijing Office for Cancer Prevention and ControlPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/beijing) Center of Gastrointestinal SurgeryPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: To evaluate the effects of health insurance status on long-term cancer-specific survival of non-small cell lung cancer(NSCLC) in beijing, china, using a population-based cancer registry ***: Information on NSCLC patients diagnosed in 2.08 was derived from the beijing Cancer *** medical records of 1,134.cases were sampled and re-surveyed to obtain information on potential risk ***-insured status was defined as Uninsured and New Rural Cooperative Medical Insurance Scheme(NRCMS),while well-insured included Urban Employees Basic Medical Insurance(UEBMI) and Free Medical Care(FMC).To estimate survival outcomes, individuals were followed-up until December 31, 2.18. Cancer-specific survival probabilities at 5 and 10 years after diagnosis were estimated using the Kaplan-Meier method. Log-rank test was used to compare long-term survival with different characteristics. Multivariable Cox proportional hazard regression model was used to examine the relative effect of insurance status on cancer-specific ***: Well-insured NSCLC patients have longer cancer-specific survival than poorly-insured individuals[hazard ratio(HR)=0.81;95% confidence interval(95% CI): 0.67-0.97), even after adjusting for age, gender, cancer stage, smoking status, family history and residential area. Older age and rural residence were associated with a higher risk of cancer-specific mortality(HR=1.03;95% CI: 1.02.1.03 and HR=1.2.;95% CI: 1.07-1.4.,respectively). Smoking individuals had a 4.% higher long-term cancer-specific mortality risk than non-smoking ones(HR=1.4.;95% CI: 1.2.-1.66).Conclusions: NSCLC patients with good insurance status had better survival rates than those with poor insurance. An association was significant even after 10 years. Large population-based studies are needed to validate that high reimbursement insurance status can lead to the improvement of long-term cancer prognosis in china.

关键词： Non-small cell lung cancer health insurance status long-term survival

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中国急诊医学影像现状调查分析

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中华放射学杂志 2024年第6期58卷 661-666页

作者：王静苗政杨琪张磊王浩袁慧书孙浩然蒋薇田源李明洋王雅宁马兆毅张惠茅吉林大学第一医院放射科长春130021 中国食品药品检定研究院医疗器械检定所北京102629 北京大学第三医院放射科北京100191 天津医科大学总医院放射科天津300052 国家卫生健康委员会能力建设和继续教育中心北京100191

目的调研中国急诊医学影像现状,为急诊医学影像的规范发展、科学管理和大数据研究提供数据支持。方法本研究由中国急诊医学影像数据库协作组发起,于2.2.年8月12.至10月19日,通过问卷调查的方式全面调查国内以数字化X线摄影术(DR)和CT... 详细信息

目的调研中国急诊医学影像现状,为急诊医学影像的规范发展、科学管理和大数据研究提供数据支持。方法本研究由中国急诊医学影像数据库协作组发起,于2.2.年8月12.至10月19日,通过问卷调查的方式全面调查国内以数字化X线摄影术(DR)和CT为主的急诊医学影像现状的相关数据,包括急诊影像人员、设备、工作量、危急值报告流程、人工智能(AI)应用现状5个方面。结果全国共12.家医院参与完成了调查。调查显示69.1%的急诊DR/CT报告由住院医师及以上人员完成。应用于急诊患者影像检查的DR品牌有2.家,CT品牌有10家,MR品牌有8家。调研的三级医院及二级医院2.2.年1月至6月DR检查量中位数分别为4.4.0}2.15例,CT检查量中位数分别为16512.3762.。三级医院急诊白班、夜班DR平均单班次工作量主要为≤2.、2.~50份,急诊白班、夜班CT平均单班次工作量主要为2.~50、51~100份,而二级医院急诊白班/夜班DR/CT平均单班次工作量均主要为≤2.份。危急值报告流程方面,74.8%的急诊影像医师和84.6%的急诊影像技师采取电话/短信通知临床医师或患者家属。AI在急诊影像的整体部署率为60.2.。有75%的受访者认为未来AI能够从急诊筛查、辅助诊断和流程优化等方面改善急诊影像工作。结论DR和CT为主的急诊影像存在报告医师年资普遍偏低,影像设备品牌丰富多样,检查量及医师人均工作量大,尤以三级医院为著,危急值报告流程仍主要依赖传统手段等现状。目前AI在急诊影像领域初露头角,未来发挥AI在急诊影像智能全流程方面的巨大潜能仍任重道远。

关键词：急诊处理医学影像调研报告数字化X线摄影术体层摄影术,X线计算机

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LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppressor to an oncoprotein

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Science china(life Sciences) 2022年第1期65卷 129-141页

作者： Siyuan yang Weizhi Xu Cheng liu Jiaqi Jin Xueying li Yuhan Jiang lei {4. Xianbin Meng Jun Zhan Hongquan {4. department of Human Anatomy Histology and EmbryologyMOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic DrugsPeking University Health Science CenterBeijing 100191China MOE Key Laboratory of Bioinformatics School of Life SciencesTsinghua UniversityBeijing 100084China

Large tumor suppressor 1(LATS1)is the key kinase controlling activation of Hippo signalling ***-translational modifications of LATS1 modulate its kinase ***,detailed mechanism underlying LATS1 stability and activation remains *** we report that LATS1 is acetylated by acetyltransferase CBP at K751 and is deacetylated by deacetylases SIRT3 and *** at K751 stabilized LATS1 by decreasing LATS1 ubiquitination and inhibited LATS1 activation by reducing its ***,LATS1 acetylation resulted in inhibition of YAP phosphorylation and degradation,leading to increased YAP nucleus translocation and promoted target gene ***,LATS1-K751 Q,the acetylation mimic mutant potentiated lung cancer cell migration,invasion and tumor growth,whereas LATS1-K751 R,the acetylation deficient mutant inhibited these *** together,we demonstrated a previously unidentified post-translational modification of LATS1 that converts LATS1 from a tumor suppressor to a tumor promoter by suppression of Hippo signalling through acetylation of LATS1.

关键词： LATS1 acetylation LATS1 activation and inhibition Hippo signalling pathway lung adenocarcinoma

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Elastic scattering of ^(13)C and ^(14.C isotopes on a ^(2.8)Pb target at energies of approximately five times the Coulomb barriers

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Chinese Physics C 2024年第3期48卷 65-71页

作者：杨过段芳芳王康杨彦云孙志宇 Valdir Guimarães 庞丹阳陈文棣金磊许世伟马军兵马朋白真汪凌昊刘泉王惠仁吕冰锋郭松 Mukhi Kumar Raju 王秀华李荣华张玉虎周小红胡正国徐瑚珊 CAS Key Laboratory of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100080China Instituto de Física Universidade de São PauloRua do Matão1371São Paulo 05508-090SPBrazil School of Physics and beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Physics Science and Engineering Tongji UniversityShanghai 200092China School of physics and Optoelectronic Engineering Anhui UniversityHefei 230601China department of Physics GITAM School of ScienceGITAM UniversityVisakhapatnam 530045India

The elastic scattering angular distributions of ^(13)C at 34. MeV and ^(14.C at 2.4.MeV and 34.0}MeV on a ^(2.8)Pb target,which correspond to approximately five times the Coulomb barriers,were measured at the Radioactive Ion Beam line in *** data were analyzed within the optical model and continuum-discretized coupled-channels(CDCC)framework,and the results of both calculations could effectively account for the experimental *** differential cross sections of elastic scattering revealed no particular suppression at the Coulomb nuclear interference peak angles,suggesting that the breakup coupling effects on the elastic scattering angular distributions were negligibly small in this incident energy *** contributions from the couplings with inelastic states to the elastic cross sections were of minor importance within the angular range covered by these experiments.

关键词： elastic scattering radioactive ion beam angular distribution optical model coupling effects

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Evaluation of SARS-CoV-2.Neutralizing Nanobody Using Virus Receptor Binding Domain-Administered Model Mice

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Research 2022年第2期2022卷 85-98页

作者： Song liu Guanghui li {2. Ding Jin Ding Qian zhang Dan li Xingguo Hou Xiangxing Kong Jing Zou Shiming zhang Hongbin Han Yakun Wan Zhi yang Hua Zhu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education beijing)NMPA Key Laboratony for Research and Evaluation of Radiopharmaceuticals Department of Nuclear MedicinePeking University Cancer HospialInstituteBeijing 100142China Instiute of Biomedial Engineering Peking University Shenzhen Graduate SchoolShenzhenGuangdong 518055China Shanghai Novamab Biopharmaceuticals Co.L.td ShanghaiChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing).department of Anesthesiology.peking university Cancer Hospital 6 Institut Beijing 100142China Instilute of Medical Technology Peking Universily Health Science CenterBeijing 100191China Bejig Key Laboratory of Magnetic Resonance Imaging Devices and Technology Peking University Third HospitalBeijing 100191China department of Radiology Peking University Third HospitalPeking UniversilyBejjing 100191China

Due to the rapid spread of coronavirus disease 2.19(COVID-19),there is an urgent requirement for the development of additional diagnostic tools for further analysis of the *** isolated nanobody Nb11-59 binds to the severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.reeptor-binding domain[RBD]with high afinity to neutralize the virus and block the angiotensin-converting enzyme 2.(ACE2.)RBD ***,we introduce a novel nanobody-based radiotracer named^(68)*** radiotracer retained high affinity for the RBD and showed reliable radiochemical characteristics both in vitro and in *** positron emission tomography(PET)studies of Ga-Nb1159 in mice revealed is rapid dearance from circulation and robust uptake into the renal and urinary ***,^(68)Ga-Nb1159 could speifcally reveal the distribution of the RBD in *** sudy also helped to evaluate the pharmacodynamic efects of the neutralizing ***,^(68)Ga-Nb1159 may be a promising l0ol lo explore the distribution of the RBD and improve the understanding of the *** particular,this study identified a novel molecular radioagent and established a reliable evaluation method for speifially investigating the RBD through noninvasive and visual PET technology.

关键词： urinary acute neutral

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Killing effect of TNF-related apoptosis inducing ligand regulated by tetracycline on gastric cancer cell line NCI-N87

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World Journal of Gastroenterology 2001年第4期7卷 559-562页

作者： Xiao-Chao Wei Xin-Juan Wang Kai-Chen lei zhang Yu {2.ang Xin-{2. {2.n department of Biochemistry and Molecular Biology,peking university Health Science Center,beijing 100083,chinaProtein Studies,Oklahoma Medical Research Foundation,Oklahoma City,OK 73104.USA department of Biochemistry and Molecular Biology Peking University Health Science Center 38 Xue Yuan Road Haidian District Beijing 100083 China. xinjuan@***

AIM: To clone the cDNA fragment of human TRAIL (TNF-related apoptosis inducing ligand) into a tetracycline-regulated gene expression system, the RevTet-On system, transduce expression vectors into a gastric carcinoma cell line-NCI-N87 and examine the effects of controlled expression of TRAIL in vitro on the gastric carcinoma cells. METHODS: The full-length cDNA of TRAIL was inserted into a vector under the control of the tetracycline-responsive element (TRE) to obtain the plasmid pRevTRE-TRAIL, which was transfected into a packaging cell line PT67. In addition, vector pRev-Tet On and pRevTRE were also transfected into PT67 separately. After hygromycin and G4.8 selection, the viral titer was determined. The medium containing retroviral vectors was collected and used to transduce a gastric carcinoma cell line NCI-N87. The resulting cell line NCI-N87-Tet On TRE-TRAIL and a control cell line, NCI-N87 Tet On-TRE, were established. TRAIL expression in the cell line was induced by incubating cells with doxycycline (Dox), which is a tetracycline analogue. The killing effect on gastric carcinoma cells was analyzed after induction. RESULTS: The recombinant plasmid pRev-TRE-TRAIL was constructed. After hygromycin or G4.8 selection, the producer cell lines PT67-TRE, PT67-TRE-TRAIL and PT67-Tet On were obtained,with titers of about 10(8)CFU.L(-1). By transducing NCI-N87 cells with retroviral vectors from these cell lines, stable cell lines NCI-N87-Tet-On TRE-TRAIL (NN3T) and control cell line NCI-N87-Tet-On-TRE (NN2.) were established. The growth curves of the selected cell lines were the same with the wild type NCI-N87. When Dox was added, cell death was obvious in the test groups (2.%-77%), whereas no difference was observed in control and wild type cell lines. With the addition of a medium from the test group, human leukemia cell line Jurkat was activated till death (83%), indicating the secretion of active TRAIL proteins from the test cells to the medium. CONCLUSION: With th

关键词： Stomach Neoplasms 3T3 Cells Animals Anti-Bacterial Agents Apoptosis Apoptosis Regulatory Proteins Doxycycline Gene Expression Regulation, Neoplastic Genetic Vectors Humans Jurkat Cells Membrane Glycoproteins Mice Research Support, Non-U.S. Gov't Retroviridae Transfection Tumor Necrosis Factor-alpha

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SARS-CoV-2.impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation

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Protein & Cell 2022年第8期13卷 602-614页

作者： Yichen li Shuaiyao Lu Jinge Gu Wencheng Xia Shengnan zhang Shenqing zhang Yan Wang Chong zhang Yunpeng Sun Jian {4. Cong liu Zhaoming Su Juntao yang Xiaozhong Peng Dan li Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China School of life Sciences and Biotechnology Shanghai Jiao Tong UniversityShanghai 200030China National Kunming High-level Biosafety Primate Research Center Institute of Medical BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeKunming 650031China State Key Laboratory of Medical Molecular Biology Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China State Key Laboratory of Medical Molecular Biology Department of Biochemistry and Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 201210China university of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Biotherapy Department of Geriatrics and National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversitChengdu 610041China Bio-X-Renji Hospital Research Center Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China zhangjiang Institute for Advanced Study Shanghai Jiao Tong UniversityShanghai 200240China

The nucleocapsid(N)protein of SARS-CoV-2.has been reported to have a high ability of liquid-liquid phase separation,which enables its incorporation into stress granules(SGs)of host ***,whether SG invasion by N protein occurs in the scenario of SARS-CoV-2.infection is unknow,neither do we know its ***,we used SARS-CoV-2.to infect mam-malian cells and observed the incorporation of N protein into SGs,which resulted in markedly impaired self-dis-assembly but stimulated cell cellular clearance of *** experiments further showed that N protein binds to the SG-related amyloid proteins via non-specific tran-sient interactions,which not only expedites the phase transition of these proteins to aberrant amyloid aggre-gation in vitro,but also promotes the aggregation of FUS with ALS-associated P52.L mutation in *** addition,we found that ACE2.is not necessary for the infection of SARS-CoV-2.to mammalian *** work indicates that SARS-CoV-2.infection can impair the dis-assembly of host SGs and promote the aggregation of SG-related amyloid proteins,which may lead to an increased risk of neurodegeneration.

关键词： SARS-CoV-2 nucleocapsid protein stress granule

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术前血清尿酸/白蛋白比值对心脏瓣膜术后急性肾损伤的预测价值

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中华肾脏病杂志 2024年第3期40卷 201-208页

作者：赵晓茹邵泽华张文雯邓小宇李涵阎磊顾玥邵凤民郑州大学人民医院(河南省人民医院)肾内科郑州450003 河南省肾病临床医学研究中心、河南省肾脏病免疫重点实验室郑州450003 中国医学科学院、北京协和医学院、国家心血管病中心、阜外医院心血管外科北京100037

目的探讨术前血清尿酸/白蛋白比值(serum uric acid/albumin ratio,sUAR)对心脏瓣膜术后急性肾损伤(acute kidney injury,AKI)的预测价值。方法采用回顾性分析方法,收集2.2.年1月至2.2.年12.于河南省人民医院心脏中心在体外循环下行心... 详细信息

目的探讨术前血清尿酸/白蛋白比值(serum uric acid/albumin ratio,sUAR)对心脏瓣膜术后急性肾损伤(acute kidney injury,AKI)的预测价值。方法采用回顾性分析方法,收集2.2.年1月至2.2.年12.于河南省人民医院心脏中心在体外循环下行心脏瓣膜术的成年患者的临床资料,并计算sUAR。根据术后7 d内是否发生AKI将患者分为AKI组和非AKI组,比较两组之间临床资料的差异。采用多因素Logistic回归模型分析心脏瓣膜术后发生AKI的独立相关因素。采用受试者工作特征曲线(receiver operating characteristic curve,ROC曲线)评价相关指标的预测效能。结果共4.0}例行心脏瓣膜术患者入选本研究,其中女性194.(4..0%),高血压14.例(33.4.),心房颤动172.(4..8%),年龄57(50,65)岁,sUAR 8.13(6.57,9.54.μmol/g,血红蛋白135(12.,14.)g/L;AKI组14.0},非AKI组2.0例;心脏瓣膜术后AKI的发生率为33.6%。AKI组年龄、心房颤动比例、基线血肌酐、N端脑利钠肽前体、血尿素、血尿酸、血糖、sUAR均高于非AKI组(均P159(12.,192.min比151(12.,193)min,Z=-0.797,P=0.4.0}],其他指标两组间差异均无统计学意义。多因素Logistic回归分析结果显示,sUAR(OR=1.4.7,95%CI 1.308~1.64.,P1)、年龄(OR=1.04.,95%CI 1.02.~1.072.P1)、心房颤动(OR=2.52.,95%CI 1.580~4.02.,P1)、血红蛋白(OR=0.984.95%CI 0.971~0.997,P=0.015)是心脏瓣膜术后发生AKI的独立相关因素。ROC曲线分析结果显示sUAR预测心脏瓣膜术后发生AKI的曲线下面积为0.710(95%CI 0.659~0.760,P1),截断值为7.2.μmol/g,敏感度为85.2.,特异度为4..0%。sUAR联合年龄、血红蛋白、心房颤动预测心脏瓣膜术后发生AKI的曲线下面积为0.780(95%CI 0.734.0.82.,P1),敏感度为72.5%,特异度为71.8%。结论术前sUAR高是体外循环下心脏瓣膜术后发生AKI的独立危险因素,sUAR对术后发生AKI具有一定预测价值。

关键词：尿酸血清白蛋白心脏外科手术急性肾损伤心脏瓣膜术

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基于人工智能的全自动化一站式CT血流储备分数在冠心病患者中的诊断与预后价值

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Science Bulletin 2024年第10期69卷 1472-1485页

作者：郭邦俊姜孟春郭翔唐春香钟健陆梦洁刘春雨张晓蕾乔红艳周帆许棚棚薛艺郑敏文侯阳王怡宁张佳胤张波张代民徐磊胡秀华周长圣李建华杨志文毛新生卢光明张龙江 department of Radiology Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China department of Radiology Affiliated Hospital of Jining Medical UniversityJining 272007China department of Radiology Xijing HospitalFourth Military Medical UniversityXi’an 733399China department of Radiology Shengjing Hospital of China Medical UniversityShenyang 110022China department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Institute of Diagnostic and Interventional Radiology and Department of CardiologyShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200235China department of Radiology Jiangsu Taizhou People’s HospitalTaizhou 225399China department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjing 210012China department of Radiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China department of Radiology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020China department of Cardiology Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Shukun(beijing)Network Technology Co. Ltd.Beijing 102200China

Currently,clinically available coronary CT angiography(CCTA)derived fractional flow reserve(CT-FFR)is time-consuming and *** propose a novel artificial intelligence-based fully-automated,on-site CT-FFR technology,which combines the automated coronary plaque segmentation and luminal extraction model with reduced order 3 dimentional(3D)computational fluid dynamics.A total of 4.3 consecutive patients with 600 vessels from the updated {2. CT-FFR study in Cohort 1 undergoing both CCTA and invasive fractional flow reserve(FFR)within 90 d were collected for diagnostic performance *** Cohort 2.a total of 901 chronic coronary syndromes patients with index CT-FFR and clinical outcomes at 3-year follow-up were retrospectively *** Cohort 3,the association between index CT-FFR from triple-rule-out CTA and major adverse cardiac events in patients with acute chest pain from the emergency department was further *** diagnostic accuracy of this CT-FFR in Cohort 1 was 0.82.with an area under the curve of 0.82.on a per-patient *** with the manually dependent CT-FFR techniques,the operation time of this technique was substantially shortened by 3 times and the number of clicks from about 60 to *** CT-FFR technique has a highly successful(>99%)calculation rate and also provides superior prediction value for major adverse cardiac events than CCTA alone both in patients with chronic coronary syndromes and acute chest ***,the novel artificial intelligencebased fully automated,on-site CT-FFR technique can function as an objective and convenient tool for coronary stenosis functional evaluation in the real-world clinical setting.

关键词： Artificial intelligence Coronary CTA CT-derived fractional flow reserve Fully-automated Outcomes

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Gastric cancer: Epidemiology, risk factors and prevention strategies

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Chinese Journal of Cancer Research 2020年第6期32卷 695-704页

作者： lei yang Xiangji Ying Shuo {2.u Guoqing Lyu Zekuan Xu Xi zhang Huichao {2. Qingyu {2. Ning Wang Jiafu Ji Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/beijing) Beijing Office for Cancer Prevention and ControlPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/beijing) Center of Gastrointestinal CancerPeking University Cancer Hospital&InstituteBeijing 100142China department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036China department of General Surgery the First Affiliated Hospital of Nanjing Medical UniversityCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing 210029China

Gastric cancer(GC) is a global health problem, with more than 1 million people newly diagnosed with GC worldwide each year. GC is more prevalent in less developed countries than in more developed countries. About half of all GC cases worldwide occur in East Asia, notably china. Globally, overall incidence rates of GC are declining, which is potentially attributed to a decrease in Helicobacter pylori(H. pylori) infection and the use of refrigeration to preserve foods rather than salt. GC is a multifactorial disease, and its occurrence and development were impacted by environmental and genetic factors. H. pylori infection is the primary risk factor for GC, especially for non-cardia. The prognosis of GC is poor due to stages at the first diagnosis. The 5-year survival rate is less than 10% when patients are diagnosed at an advanced stage, but the rate is as high as 85% if patients are detected at an earlier stage. Endoscopic screening can potentially prevent GC by early diagnosis and early treatment and has been widely adopted in screening programs in East Asian countries, such as Japan and Korea. This review summarizes updated epidemiological aspects, risk factors, and prevention strategies of GC in recent years to help researchers determine the most effective intervention strategies for reducing risk of GC.

关键词： Gastric cancer epidemiology risk factor prevention strategy

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