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Prediction of Tumor Microenvironment Characteristics and Treatment Response in Lung Squamous Cell Carcinoma by Pseudogene OR7E47P-related Immune Genes

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Current Medical Science 2023年第6期43卷 1133-1150页

作者： Ya-qi ZHAO Hao-han zhang Jie WU Lan LI jing LI Hao zhong Yan JIN tian-yu LEI Xin-yi ZHAO Bin XU qi-bin SONG Jie HE Cancer Center Renmin Hospital of Wuhan UniversityWuhan430060China Department of Medical Oncology First Affiliated Hospital of Kunming Medical UniversityKunming650000China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100032China

Objective Pseudogenes are initially regarded as nonfunctional genomic sequences,but some pseudogenes regulate tumor initiation and progression by interacting with other genes to modulate their transcriptional *** receptor family 7 subfamily E member 47 pseudogene(OR7E47P)is expressed broadly in lung tissues and has been identified as a positive regulator in the tumor microenvironment(TME)of lung adenocarcinoma(LUAD).This study aimed to elucidate the correlation between OR7E47P and tumor immunity in lung squamous cell carcinoma(LUSC).Methods Clinical and molecular information from The Cancer Genome Atlas(TCGA)LUSC cohort was used to identify OR7E47P-related immune genes(ORIGs)by weighted gene correlation network analysis(WGCNA).Based on the ORIGs,2 OR7E47P clusters were identified using non-negative matrix factorization(NMF)clustering,and the stability of the clustering was tested by an extreme gradient boosting classifier(XGBoost).LASSO-Cox and stepwise regressions were applied to further select prognostic ORIGs and to construct a predictive model(ORPScore)for *** Botling cohorts and 8 immunotherapy cohorts(the Samstein,Braun,Jung,Gide,IMvigor210,Lauss,Van Allen,and Cho cohorts)were included as independent validation *** OR7E47P expression was positively correlated with immune cell infiltration and enrichment of immune-related pathways in LUSC.A total of 57 ORIGs were identified to classify the patients into 2 OR7E47P clusters(Cluster 1 and Cluster 2)with distinct immune,mutation,and stromal *** to Cluster 1,Cluster 2 had more infiltration by immune and stromal cells,lower mutation rates of driver genes,and higher expression of immune-related *** clustering performed well in the internal and 5 external validation *** on the 7 ORIGs(HOPX,STX2,WFS,DUSP22,SLFN13,GGCT,and CCSER2),the ORPScore was constructed to predict the prognosis and the treatment *** addition,the ORPScore was a bette

关键词： pseudogene olfactory receptor family 7 subfamily E member 47 pseudogene-related immune gene tumor microenvironment immunotherapy lung squamous cell carcinoma

XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： qiu-zhong Pan jing-jing Zhao liang Liu Dong-Sheng zhang Li-ping Wang Wen-Wei hu De-Sheng Weng Xiang Xu yi-Zhuo Li Yan Tang Wei-Hong zhang Jie-Yao Li Xiao Zheng qi-jing Wang Yong-qiang Li Tong Xiang Li Zhou shuang-Ning Yang Chen Wu Rong-Xing huang jia He Wei-jiao Du Lu-Jun Chen Yue-Na Wu Bin Xu qiong Shen yi zhang jing-Ting jiang Xiu-Bao Ren jian-Chuan Xia State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China Institute for Cell Therapy of Soochow University ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains *** phase 3 trial(***:NCT03950154)assessed the efficacy and adverse events(AEs)of the combination of PD-1 blockade-activated DC-CIK(PD1-T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of 202 participants were enrolled and randomly assigned in a 1:1 ratio to receive either first-line XELOX plus bevacizumab(the control group,n=102)or the same regimen plus autologous PD1-T cell immunotherapy(the immunotherapy group,n=100)every 21 days for up to 6 cycles,followed by maintenance treatment with capecitabine and *** main endpoint of the trial was progression-free survival(PFS).The median follow-up was 19.5 *** PFS was 14.8 months(95%CI,11.6-18.0)for the immunotherapy group compared with 9.9 months(8.0-11.8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and 25.6 months(95%CI,18.3-32.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in 20.0%of patients in the immunotherapy group and 23.5%in the control groups,with no toxicity-associated deaths *** addition of PD1-T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

Identification of genetic loci for grain yield-related traits in the wheat population zhongmai 578/Jimai 22

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Journal of Integrative Agriculture 2023年第7期22卷 1985-1999页

作者： LIU Dan ZHAO De-hui ZENG jian-qi Rabiu Sani SHAWAI TONG jing-yang LI Ming LI Fa-ji ZHOU shuo hu Wen-li XIA Xian-chun tian Yu-bing Zhu qian WANG Chun-ping WANG De-sen HE zhong-hu LIU Jin-dong zhang Yong Institute of Crop Sciences National Wheat Improvement CenterChinese Academy of Agricultural Sciences(CAAS)Beijing 100081P.R.China College of Agriculture Henan University of Science&TechnologyLuoyang 471000P.R.China Department of Crop Science Faculty of Agriculture and Agricultural TechnologyAliko Dangote University of Science and Technology WudilKano 713281Nigeria Crop Research Institute Shandong Academy of Agricultural SciencesJinan 250100P.R.China Institute of Biotechnology and Food Science Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 050051P.R.China Gaoyi Stock Seed Station Shijiazhuang 053110P.R.China Shangqiu Academy of Agricultural and Forestry Sciences Shangqiu 476000P.R.China International Maize and Wheat Improvement Center(CIMMYT) China Officec/o CAASBeijing 100081P.R.China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518120P.R.China

The identification of stable quantitative trait locus(QTL)for yield-related traits and tightly linked molecular markers is important for improving wheat grain *** the present study,six yield-related traits in a recombinant inbred line(RIL)population derived from the zhongmai 578/Jimai 22 cross were phenotyped in five *** parents and 262 RILs were genotyped using the wheat 50K single nucleotide polymorphism(SNP)array.A high-density genetic map was constructed with 1501 non-redundant bin markers,spanning 2384.95 ***-three QTLs for six yield-related traits were mapped on chromosomes 1D(2),2A(9),2B(6),2D,3A(2),3B(2),4A(5),4D,5B(8),5D(2),7A(7),7B(3)and 7D(5),which explained 2.7-25.5%of the phenotypic *** the 53 QTLs,23 were detected in at least three environments,including seven for thousand-kernel weight(TKW),four for kernel length(KL),four for kernel width(KW),three for average grain filling rate(GFR),one for kernel number per spike(KNS)and four for plant height(PH).The stable QTLs ***-2A.1,***-7D,***-7D,***-2B.1,***-4A,***-7A and ***-2A.1 are likely to be new *** QTL-rich regions on 2A,2B,4A,5B,7A and 7D,showed pleiotropic effects on various yield ***2-2B and WAPO-A1 are potential candidate genes for the pleiotropic regions on 2B and 7A,*** pleiotropic QTL on 7D for TKW,KL,KW and PH was verified in a natural *** results of this study enrich our knowledge of the genetic basis underlying yield-related traits and provide molecular markers for high-yield wheat breeding.

关键词： grain yield KASP marker QTL mapping SNP chip

Timing and approaches in congenital cataract surgery:a four-year,two-layer randomized controlled trial

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1835-1843页

作者： Hao-tian Lin Er-ping Long jing-jing Chen Zhen-Zhen Liu Zhuo-Ling Lin qian-zhong Cao Xia-yin zhang Xiao-Hang Wu qi-Wei Wang Duo-Ru Lin Xiao-Yan Li Jin-Chao Liu Li-Xia Luo Bo Qu Wei-Rong Chen yi-Zhi Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Ya-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM：To compare visual prognoses and postoperative adverse events of congenital cataract surgery performed at different times and using different surgical ***：In this prospective,randomized controlled trial,we recruited congenital cataract patients aged 3 mo or younger before cataract ***-one eligible patients were randomly assigned to two groups according to surgical timing：a 3-month-old group and a 6-month-old *** eye underwent one of three randomly assigned surgical procedures,as follows：surgery A,lens aspiration（I/A）;surgery B,lens aspiration with posterior continuous curvilinear capsulorhexis（I/A＋PCCC）;and surgery C,lens aspiration with posterior continuous curvilinear capsulorhexis and anterior vitrectomy（I/A＋PCCC＋A-Vit）.The long-term best-corrected visual acuity（BCVA） and the incidence of complications in the different groups were compared and ***：A total of 57 participants（114 eyes） with a mean follow-up period of 48.7 mo were included in the final *** overall log MAR BCVA in the 6-month-old group was better than that in the 3-month-old group（0.81±0.28 vs 0.96±0.30;P=0.02）.The overall log MAR BCVA scores in the surgery B group were lower than the scores in the A and C groups（A：0.80±0.29,B：1.02±0.28,and C：0.84±0.28;P=0.007）.A multivariate linear regression revealed no significant relationships between the incidence of complications and long-term ***：It might be safer and more beneficial for bilateral total congenital cataract patients to undergosurgery at 6 mo of age than 3 ***,with rigorous follow-up and timely intervention,the postoperative complications in these patients are treatable and do not compromise visual outcomes.

关键词： pediatric cataract surgery postoperativecomplications long-term visual function

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

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Signal Transduction and Targeted Therapy 2022年第2期7卷 502-518页

作者： Zhen Wang Fan-lian Zeng Ya-wen hu Xiao-yan Wang Fu-lei Zhao Pei Zhou jing hu Yuan-yuan Xiao zhong-lan hu Ming-feng Guo Xiao-qiong Wei Xiao Liu Nong-yu huang Jun zhang shu-wen Chen Juan Cheng hua-ping Zheng Hong Zhou qi-xiang Zhao Chen zhang Yan Hao Song Zou yi-yue Gui jia-dong Yu Lin-na Gu Cheng-cheng Yue Hao-zhou zhang Wen-ling Wu yi-fan Zhou Xi-kun Zhou Guo-bo Shen Xiu Teng Jiong Li State Key Laboratory of Biotherapy and Cancer Center West China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengduSichuan 610041China Department of Liver Surgery&Liver Transplantation West China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuan 610041China Laboratory of Liver Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationSichuan UniversityChengdu 610041China Department of Cardiovascular Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Laboratory of human Disease and Immunotherapies West China HospitalSichuan UniversityChengduSichuan 610041China

Interleukin-37b(hereafter called IL-37)was identified as fundamental inhibitor of natural and acquired *** molecular mechanism and function of IL-37 in colorectal cancer(CRC)has been ***,we found that IL-37 transgenic(IL-37tg)mice were highly susceptible to colitis-associated colorectal cancer(CAC)and suffered from dramatically increased tumor burdens in ***,IL-37 is dispensable for intestinal mutagenesis,and CRC cell proliferation,apoptosis,and ***,IL-37 dampened protective cytotoxic T cell-mediated immunity in CAC and B16-OVA ***8^(+)T cell dysfunction is defined by reduced retention and activation as well as failure to proliferate and produce cytotoxic cytokines in IL-37tg mice,enabling tumor evasion of immune *** dysfunction led by IL-37 antagonizes IL-18–induced proliferation and effector function of CD8+T cells,which was dependent on SIGIRR(single immunoglobulin interleukin-1 receptor-related protein).Finally,we observed that IL-37 levels were significantly increased in CRC patients,and positively correlated with serum CRC biomarker CEA levels,but negatively correlated with the CD8+T cell infiltration in CRC *** findings highlight the role of IL-37 in harnessing antitumor immunity by inactivation of cytotoxic T cells and establish a new defined inhibitory factor IL-37/SIGIRR in cancerimmunity cycle as therapeutic targets in CRC.

关键词： immunity cytotoxic Interleukin

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)

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Research in Astronomy and Astrophysics 2012年第9期12卷 1197-1242页

作者： Xiang-Qun Cui Yong-Heng Zhao Yao-Quan Chu Guo-ping Li qi Li Li-ping zhang Hong-Jun Su Zheng-qiu Yao Ya-Nan Wang Xiao-Zheng Xing Xin-Nan Li Yong-tian Zhu Gang Wang Bo-zhong Gu A-Li Luo Xin-qi Xu Zhen-Chao zhang Gen-Rong Liu Hao-Tong zhang De-hua Yang shu-Yun Cao Hai-Yuan Chen jian-Jun Chen Kun-Xin Chen ying Chen jia-Ru Chu Lei Feng Xue-Fei Gong Yong-hui Hou Hong-Zhuan hu Ning-Sheng hu zhong-Wen hu Lei jia Fang-hua jiang Xiang jiang Zi-Bo jiang Ge Jin Ai-hua Li Yan Li Ye-ping Li Guan-QunLiu Zhi-Gang Liu huo-Ming Shi Zheng-Hong Tang qing-Sheng Tao Xiang-Yan Yuan Chao Zhai jing zhang Yan-Xia zhang Yong zhang Ming Zhao Fang Zhou Guo-hua Zhou Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China yzhao @ *** Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Tecfinologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou jing Telescope) is a special reflecting Schmidt telescope. LAMOST’s special design allows both a large aperture (effective aperture of 3.6 m–4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror’s surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects.

关键词： techniques: wide field telescope - active optics - multi fiber - spectroscopy survey - data reduction

Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou Ren yi-Wei Yang Yong-Hao Chen Rong Liu Bang-jiao Ye Jie Wen Hai-Rui Guo Zi-Jie Han qi-ping Chen zhong-Wei Wen Wei-Li Sun Han yi Xing-Yan Liu Tao Ye jiang-Bo Bai qi An Jie Bao Yu Bao ping Cao Hao-Lei Chen Zhen Chen Zeng-qi Cui Rui-Rui Fan Chang-qing Feng Ke-qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai Han Guo-Zhu He Yong-Cheng He Yang Hong yi-Wei hu Han-Xiong huang Xi-Ru huang Hao-Yu jiang Wei jiang Zhi-Jie jiang Han-Tao jing Ling Kang Bo Li Chao Li jia-Wen Li qiang Li Xiao Li Yang Li Jie Liu shu-Bin Liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin qi Jie Ren Xi-Chao Ruan Zhao-hui Song Kang Sun Zhi-jia Sun Zhi-Xin Tan jing-Yu Tang Xin-yi Tang Bin-Bin tian Li-jiao Wang Peng-Cheng Wang Zhao-hui Wang Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun Yang Li Yu Tao Yu Yong-Ji Yu Guo-hui zhang Lin-Hao zhang qi-Wei zhang Xian-Peng zhang Yu-liang zhang Zhi-Yong zhang Lu-ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： qiang Li Li‑jiao Wang Xiang‑Biao qiu jing‑Wen Li Wei Xu Tao Li Ze‑Bin Lin Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun jing‑Yu Tang Rong zhang Han‑Tao jing Bo Mei qi An Hao‑Fan Bai jiang‑Bo Bai Jie Bao ping Cao qi‑ping Chen Zhen Chen Zeng‑qi Cui An‑Chuan Fan Chang‑qing Feng Fan‑Zhen Feng Ke‑qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong yi‑Wei hu Han‑Xiong huang Wei‑hua jia Hao‑Yu jiang Wei jiang Zhi‑Jie jiang Zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li jia‑Wen Li Xiao Li Yang Li Jie Liu Rong Liu shu‑Bin Liu Guang‑Yuan Luan Bin‑Bin qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng Wang Zhao‑hui Wang zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Li‑Kun Xie yi‑Wei Yang Han yi Yong‑Ji Yu Guo‑hui zhang Lin‑Hao zhang Mo‑Han zhang qi‑Wei zhang Xian‑Peng zhang Yu‑liang zhang Yue zhang Zhi‑Yong zhang Mao‑Yuan Zhao Lu‑ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

Back-n white neutron source at CSNS and its applications

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Nuclear Science and Techniques 2021年第1期32卷 95-104页

作者： jing-Yu Tang qi An jiang-Bo Bai Jie Bao Yu Bao ping Cao Hao-Lei Chen qi-ping Chen Yong-Hao Chen Zhen Chen Zeng-qi Cui Rui-Rui Fan Chang-qing Feng Ke-qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong yi-Wei hu Han-Xiong huang Xi-Ru huang Hao-Yu jiang Wei jiang Zhi-Jie jiang Han-Tao jing Ling Kang Bo Li Chao Li jia-Wen Li qiang Li Xiao Li Yang Li Jie Liu Rong Liu shu-Bin Liu Xing-Yan Liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-hui Song Kang Sun Zhi-jia Sun Zhi-Xin Tan Xin-yi Tang Bin-Bin tian Li-jiao Wang Peng-Cheng Wang Zhao-hui Wang zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun Yang yi-Wei Yang Han yi Li Yu Tao Yu Yong-Ji Yu Guo-hui zhang Lin-Hao zhang qi-Wei zhang Xian-Peng zhang Yu-liang zhang Zhi-Yong zhang Lu-ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China The CSNS Back-n Collaboration

Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March *** Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the *** addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the *** with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional *** article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn.

关键词： White neutron source Nuclear data measurements Experimental setups Neutron applications