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不确定时延输出反馈网络化系统保性能控制

控制理论与应用 2007年第2期24卷 274-278页

作者：邱占芝张庆灵刘明东北大学系统科学研究所辽宁沈阳110004 大连交通大学软件学院香港城市大学数学系中国香港

研究了一类具有不确定时延的动态输出反馈网络控制系统的保性能控制问题．针对小于等于一个采样周期的不确定时延,利用Lyapunov理论和线性矩阵不等式方法,推导出了动态输出反馈网络控制系统保性能控制律存在的条件,给出了动态输出反馈... 详细信息

研究了一类具有不确定时延的动态输出反馈网络控制系统的保性能控制问题．针对小于等于一个采样周期的不确定时延,利用Lyapunov理论和线性矩阵不等式方法,推导出了动态输出反馈网络控制系统保性能控制律存在的条件,给出了动态输出反馈保性能控制律设计方法．利用LMI工具箱中的目标函数最小化工具,可以求得该类系统优化的保性能控制律参数和优化的性能指标,从而获得该系统的保性能控制律．给出的仿真算例说明了设计方法是有效的所得结果是可行的．

关键词：网络控制系统保性能控制线性矩阵不等式动态输出反馈不确定时延

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广义区间动力系统脉冲模存在性判据

控制理论与应用 2005年第5期22卷 843-845页

作者：何希勤柳萍张大庆张庆灵鞍山科技大学应用数学研究所辽宁鞍山114044 东北大学理学院辽宁沈阳110006

系统有无脉冲行为直接影响到系统性质,本文针对广义区间动力系统首先给出了区间矩阵奇异值变化范围的判定定理,然后得到判别区间矩阵秩的变化范围的充分条件,进而得到判别广义区间动力系统具有脉冲模的判据.

关键词：区间动力系统广义区间系统区间矩阵区间矩阵奇异值脉冲模区间矩阵秩

Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

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World Journal of Gastroenterology 2024年第14期30卷 2018-2037页

作者： Qi-Long Wu Xiao-Ting Fang Xin-Xin Wan qing-Yong Ding Yan-Jun zhang ling Ji Yong-Liang Lou Xiang Li School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityKey Laboratory of Laboratory MedicineMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sciences Institute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesInstitute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)ranks among the most prevalent malignant tumors *** reports suggest that Fusobacterium nucleatum(***)contributes to the initiation,progression,and prognosis of ***,a short-chain fatty acid derived from the bacterial fermentation of soluble dietary fiber,is known to inhibit various *** study is designed to explore whether *** influences the onset and progression of CRC by impacting the intestinal metabolite butyric *** To investigate the mechanism by which *** affects CRC occurrence and *** Alterations in the gut microbiota of BALB/c mice were observed following the oral administration of ***,DLD-1 and HCT116 cell lines were exposed to sodium butyrate(NaB)and *** in vitro to examine the effects on proliferative proteins and mitochondrial *** Our research indicates that the prevalence of *** in fecal samples from CRC patients is significantly greater than in healthy counterparts,while the prevalence of butyrate-producing bacteria is notably *** mice colonized with ***,the population of butyrate-producing bacteria decreased,resulting in altered levels of butyric acid,a key intestinal metabolite of *** to NaB can impair mitochondrial morphology and diminish mitochondrial membrane potential in DLD-1 and HCT116 CRC ***,this leads to modulated production of adenosine triphosphate and reactive oxygen species,thereby inhibiting cancer cell ***,NaB triggers the adenosine monophosphate-activated protein kinase(AMPK)signaling pathway,blocks the cell cycle in HCT116 and DLD-1 cells,and curtails the proliferation of CRC *** combined presence of *** and NaB attenuated the effects of the *** employing small interfering RNA to suppress AMPK,it was demonstrated that AMPK is essential for NaB’s inhibition of CRC cell *** F.n

关键词： Colorectal cancer Fusobacterium nucleatum Butyric acid Gut microbiota Adenosine monophosphate-activated protein kinase signal pathway

Integration of bio-inspired limb-like structure damping into motor suspension of high-speed trains to enhance bogie hunting stability

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Railway Engineering Science 2024年第3期32卷 324-343页

作者： Heng zhang Liang ling Sebastian Stichel Wanming Zhai State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu 610031China Department of Engineering Mechanics KTH Royal Institute of TechnologyStockholmSweden

Hunting stability is an important performance criterion in railway *** study proposes an incorporation of a bio-inspired limb-like structure(LLS)-based nonlinear damping into the motor suspension system for traction units to improve the nonlinear critical speed and hunting stability of high-speed trains(HSTs).Initially,a vibration transmission analysis is conducted on a HST vehicle and a metro vehicle that suffered from hunting motion to explore the effect of different motor suspension systems from on-track ***,a simplified lateral dynamics model of an HST bogie is established to investigate the influence of the motor suspension on the bogie hunting *** bifurcation analysis is applied to optimize the motor suspension parameters for high critical ***,the nonlinear damping of the bio-inspired LLS,which has a positive correlation with the relative displacement,can further improve the modal damping of hunting motion and nonlinear critical speed compared with the linear motor suspension ***,a comprehensive numerical model of a high-speed train,considering all nonlinearities,is established to investigate the influence of different types of motor *** simulation results are well consistent with the theoretical *** benefits of employing nonlinear damping of the bio-inspired LLS into the motor suspension of HSTs to enhance bogie hunting stability are thoroughly validated.

关键词： High-speed train Hunting stability Bio-inspired limb-like structure Motor suspension Nonlinear damping

不确定Lorenz系统的参数识别与异结构同步

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信息与控制 2008年第2期37卷 146-149页

作者：张庆灵吕翎东北大学系统科学研究所辽宁沈阳110004

设计了一种参数识别器和同步控制器,研究了不确定混沌系统的参数识别与异结构同步问题.根据稳定性原理,确定了参数识别器和同步控制器的结构,以不确定Lorenz混沌系统和Rossler混沌系统为例,验证了其有效性.仿真模拟结果表明,在参数识别... 详细信息

设计了一种参数识别器和同步控制器,研究了不确定混沌系统的参数识别与异结构同步问题.根据稳定性原理,确定了参数识别器和同步控制器的结构,以不确定Lorenz混沌系统和Rossler混沌系统为例,验证了其有效性.仿真模拟结果表明,在参数识别器和同步控制器的共同作用下,异结构不确定Lorenz混沌系统和Rossler混沌系统可以达到完全同步,并且不确定Lorenz混沌系统的参数全部可以得到识别.

关键词：混沌同步参数识别控制器不确定Lorenz系统 Rossler系统

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基于线性可逆性变换的混沌同步控制

信息与控制 2008年第1期37卷 68-72页

作者：张庆灵吕翎东北大学系统科学研究所辽宁沈阳110004

基于线性可逆性变换方法,提出一种提高变量耦合控制混沌同步有效性的方案.通过将系统的部分状态变量在相应的子空间做线性可逆性变换,增强系统状态变量之间的关联,从而用单一变量信号实现了对整个混沌系统的同步控制.以洛伦兹系统为例,... 详细信息

基于线性可逆性变换方法,提出一种提高变量耦合控制混沌同步有效性的方案.通过将系统的部分状态变量在相应的子空间做线性可逆性变换,增强系统状态变量之间的关联,从而用单一变量信号实现了对整个混沌系统的同步控制.以洛伦兹系统为例,仿真模拟了这种方案的有效性.

关键词：混沌同步线性可逆性变换李亚普诺夫指数洛伦兹系统

Protein neddylation and its role in health and diseases

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1869-1904页

作者： Shizhen zhang qing Yu Zhijian Li Yongchao Zhao Yi Sun Department of Breast Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Institute of Translational Medicine Zhejiang University School of MedicineHangzhou 310029China Department of Thyroid Surgery Zhejiang Cancer HospitalInstitute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Key Laboratory of Head&Neck Cancer Translational Research of Zhejiang Province Hangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery Zhejiang University School of MedicineHangzhou 310029China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Zhejiang University Cancer Center Hangzhou 310029China Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang Hangzhou 310024China Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

NEDD8(Neural precursor cell expressed developmentally downregulated protein 8)is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a process known as neddylation,catalyzed by the enzyme cascade,namely NEDD8 activating enzyme(E1),NEDD8 conjugating enzyme(E2),and NEDD8 ligase(E3).The substrates of neddylation are categorized into cullins and non-cullin *** of cullins activates CRLs(cullin RING ligases),the largest family of E3 ligases,whereas neddylation of non-cullin substrates alters their stability and activity,as well as subcellular ***,the neddylation pathway and/or many neddylation substrates are abnormally activated or over-expressed in various human diseases,such as metabolic disorders,liver dysfunction,neurodegenerative disorders,and cancers,among ***,targeting neddylation becomes an attractive strategy for the treatment of these *** this review,we first provide a general introduction on the neddylation cascade,its biochemical process and regulation,and the crystal structures of neddylation enzymes in complex with cullin substrates;then discuss how neddylation governs various key biological processes via the modification of cullins and non-cullin *** further review the literature data on dysregulated neddylation in several human diseases,particularly cancer,followed by an outline of current efforts in the discovery of small molecule inhibitors of neddylation as a promising therapeutic ***,few perspectives were proposed for extensive future investigations.

关键词： NEDD8 attached attractive

基于Wash-Out-Filter方法控制非线性系统Hopf分岔

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东北大学学报（自然科学版） 2008年第10期29卷 1381-1384页

作者：安春张庆灵张艳苏湛东北大学理学院辽宁沈阳110004

Hopf分岔往往导致系统的周期性振荡直至失稳,为此,基于wash-out-filter方法为非线性系统设计Hopf分岔状态反馈控制器.在保持平衡点不变的情况下,使得系统在期望的参数值处,将原来发生的亚临界Hopf分岔转化为超临界Hopf分岔,并保证系统... 详细信息

Hopf分岔往往导致系统的周期性振荡直至失稳,为此,基于wash-out-filter方法为非线性系统设计Hopf分岔状态反馈控制器.在保持平衡点不变的情况下,使得系统在期望的参数值处,将原来发生的亚临界Hopf分岔转化为超临界Hopf分岔,并保证系统在参数值范围内是渐近稳定的.分别以一维和二维非线性系统为例,仿真结果验证了所提方法的正确性和有效性.

关键词： wash-out-filter Hopf分岔非线性系统状态反馈控制渐近稳定

Impact of climate and human activity on NDVI of various vegetation types in the Three-River Source Region, China

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Journal of Arid Land 2024年第8期16卷 1080-1097页

作者： LU qing KANG Haili zhang Fuqing XIA Yuanping YAN Bing Research Center of Resource and Environment Economics East China University of TechnologyNanchang 330013China Jiangxi Key Laboratory of Watershed Ecological Process and Information East China University of TechnologyNanchang 330013China School of Surveying and Geoinformation Engineering East China University of TechnologyNanchang 330013China Nanchang Key Laboratory of Landscape Process and Territorial Spatial Ecological Restoration East China University of TechnologyNanchang 330013China Institute of Energy Research Jiangxi Academy of SciencesNanchang 330096China

The Three-River Source Region(TRSR)in China holds a vital position and exhibits an irreplaceable strategic importance in ecological preservation at the national *** the basis of an in-depth study of the vegetation evolution in the TRSR from 2000 to 2022,we conducted a detailed analysis of the feedback mechanism of vegetation growth to climate change and human activity for different vegetation *** the growing season,the spatiotemporal variations of normalized difference vegetation index(NDVI)for different vegetation types in the TRSR were analyzed using the Moderate Resolution Imaging Spectroradiometer(MODIS)-NDVI data and meteorological data from 2000 to *** addition,the response characteristics of vegetation to temperature,precipitation,and human activity were assessed using trend analysis,partial correlation analysis,and residual *** indicated that,after in-depth research,from 2000 to 2022,the TRSR's average NDVI during the growing season was *** preliminary ranking of the average NDVI for different vegetation types was as follows:shrubland(0.5762)>forest(0.5443)>meadow(0.4219)>highland vegetation(0.2223)>steppe(0.2159).The NDVI during the growing season exhibited a fluctuating growth trend,with an average growth rate of 0.0018/10a(P<0.01).Notably,forests displayed a significant development trend throughout the growing season,possessing the fastest rate of change in NDVI(0.0028/10a).Moreover,the upward trends in NDVI for forests and steppes exhibited extensive spatial distributions,with significant increases accounting for 95.23%and 93.80%,*** sensitivity to precipitation was significantly enhanced in other vegetation types other than highland *** contrast,steppes,meadows,and highland vegetation demonstrated relatively high vulnerability to temperature fluctuations.A further detailed analysis revealed that climate change had a significant positive impact on the TRSR from 2000 to 2022,particularly in its

关键词： growing season normalized difference vegetation index(NDVI) highland vegetation trend analysis partial correlation analysis residual analysis contribution rate