检索结果-南通市图书馆

Three-dimensional-printed titanium prostheses with bone trabeculae enable mechanical-biological reconstruction after resection of bone tumours

在线全文

学校读者我要写书评

暂无评论

Biomaterials Translational 2022年第2期3卷 134-141页

作者： Feifei pu Wei Wu Doudou Jing Yihan Yu Yizhong Peng Jianxiang liu Qiang Wu Baichuan Wang Zhicai zhang Zengwu Shao department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Reconstruction after resection has always been an urgent problem in the treatment of bone *** are many methods that can be used to reconstruct bone defects;however,there are also many complications,and it is difficult to develop a safe and effective reconstruction plan for the treatment of bone *** the rapid development of digital orthopaedics,three-dimensional printing technology can solve this *** three-dimensional printing of personalised prostheses has many *** can be used to print complex structures that are difficult to fabricate using traditional processes and overcome the problems of stress shielding and low biological activity of conventional *** this study,12 patients with bone tumours were selected as research subjects,and based on individualised reverse-engineering design technology,a three-dimensional model of each prosthesis was designed and installed using medical image ***6Al4V was used as the raw material to prepare the prostheses,which were used to repair bone defects after surgical *** operation time was 266.43±21.08 minutes(range 180-390 minutes),and intraoperative blood loss was 857.26±84.28 mL(range 800-2500 mL).One patient had delayed wound healing after surgery,but all patients survived without local tumour recurrence,and no tumour metastasis was *** aseptic loosening or structural fracture of the prosthesis,and no non-mechanical prosthesis failure caused by infection,tumour recurrence,or progression was *** Musculo-Skeletal Tumour Society(MSTS)score of limb function was 22.53±2.09(range 16-26),and ten of the 12 patients scored≥20 and were able to function *** results showed that three-dimensional printed prostheses with an individualised design can achieve satisfactory short-term clinical efficacy in the reconstruction of large bone defects after bone tumour resection.

关键词： bone defect bone tumour printed biomechanical reconstruction prostheses three-dimensional

Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo- controlled trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2021年第2期6卷 160-169页

作者： Jingyi liu Ximing Nie Hongqiu Gu Qi Zhou Haixin Sun Ying Tan Dacheng liu Lina Zheng Jiahui Zhao Yan Wang Yibin Cao Haomeng Zhu Yunpeng zhang Lijin Yi Yuehua pu Miao Wen Zhonghua Yang Shengjun Sun Wenzhi Wang Xingquan Zhao Liping liu Yongjun Wang department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina china National Clinical Research Center for Neurological Diseases BeijingChina Beijing Neurosurgical Institute Beijing Tiantan HospitalCapital Medical UniversityBeijingChina department of Neurology The First Affiliated Hospital of Xi'an Jiaotong UniversityBeijingChina department of Medicine and Therapeutics Prince of Wales HospitalShatinHong Kong department of Neurology Tangshan People’s HospitalTangshanChina department of Neurology Tangshan Gongren HospitalTangshanChina department of Neurology Beijing Luhe HospitalCapital Medical UniversityBeijingChina department of Neurology Beijing Pinggu HospitalBeijingChina department of Neurology Liangxiang Hospital of Beijing Fangshan DistrictBeijingChina department of Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background Studies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial *** aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral haemorrhage patients susceptible to haemorrhage *** We did a prospective,double-blind,randomised,placebo-controlled trial at 10 stroke centres in *** supratentorial intracerebral haemorrhage patients were eligible if they had indication of haemorrhage expansion on admission imaging(eg,spot sign,black hole sign or blend sign),and were treatable within 8 hours of symptom *** were randomly assigned(1:1)to receive either tranexamic acid or a matching *** primary outcome was intracerebral haematoma growth(>33% relative or>6 mL absolute)at 24 *** outcomes were assessed at 90 *** Of the 171 included patients,124(72.5%)were male,and the mean age was 55.9±11.6 years.89 patients received tranexamic acid and 82 received *** primary outcome did not differ significantly between the groups:36(40.4%)patients in the tranexamic acid group and 34(41.5%)patients in the placebo group had intracranial haemorrhage growth(OR 0.96,95% CI 0.52 to 1.77,p=0.89).The proportion of death was lower in the tranexamic acid treatment group than placebo group(8.1%vs 10.0%),but there were no significant differences in secondary outcomes including absolute intracranial haemorrhage growth,death and *** Among patients susceptible to haemorrhage expansion treated within 8 hours of stroke onset,tranexamic acid did not significantly prevent intracerebral haemorrhage *** studies are needed to assess safety and efficacy of tranexamic acid in intracerebral haemorrhage patients.

关键词： placebo centre absolute

A multiple-tissue-specific magnetic resonance imaging model for diagnosing Parkinson’s disease: a brain radiomics study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第12期17卷 2743-2749页

作者： Xiao-Jun Guan Tao Guo Cheng Zhou Ting Gao Jing-Jing Wu Victor Han Steven Cao Hong-Jiang Wei Yu-Yao zhang Min Xuan Quan-Quan Gu Pei-Yu Huang Chun-Lei liu Jia-Li pu Bao-Rong zhang Feng Cui Xiao-Jun Xu Min-Ming zhang department of Radiology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina department of Neurology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina department of Electrical Engineering and Computer sciences University of CaliforniaBerkeleyCAUSA Institute for Medical Imaging technology School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina School of Information science and technology ShanghaiTech UniversityShanghaiChina Helen Wills Neuroscience Institute University of CaliforniaBerkeleyCAUSA department of Radiology Hangzhou Hospital of Traditional Chinese MedicineHangzhouZhejiang ProvinceChina

Brain radiomics can reflect the characteristics of brain ***,the value of T1-weighted images,quantitative susceptibility mapping,and R2*mapping in the diagnosis of Parkinson’s disease(PD)was underestimated in previous *** this prospective study to establish a model for PD diagnosis based on brain imaging information,we collected high-resolution T1-weighted images,R2*mapping,and quantitative susceptibility imaging data from 171 patients with PD and 179 healthy controls recruited from August 2014 to August *** to the inclusion time,123 PD patients and 121 healthy controls were assigned to train the diagnostic model,while the remaining 106 subjects were assigned to the external validation *** extracted 1408 radiomics features,and then used data-driven feature selection to identify informative features that were significant for discriminating patients with PD from normal controls on the training *** informative features so identified were then used to construct a diagnostic model for *** constructed model contained 36 informative radiomics features,mainly representing abnormal subcortical iron distribution(especially in the substantia nigra),structural disorganization(e.g.,in the inferior temporal,paracentral,precuneus,insula,and precentral gyri),and texture misalignment in the subcortical nuclei(e.g.,caudate,globus pallidus,and thalamus).The predictive accuracy of the established model was 81.1±8.0%in the training *** the external validation dataset,the established model showed predictive accuracy of 78.5±2.1%.In the tests of identifying early and drug-naïve PD patients from healthy controls,the accuracies of the model constructed on the same 36 informative features were 80.3±7.1%and 79.1±6.5%,respectively,while the accuracies were 80.4±6.3%and 82.9±5.8%for diagnosing middle-to-late PD and those receiving drug management,*** accuracies for predicting tremor-dominant and non-tremor-dominant PD w

关键词： diagnosis imaging biomarker iron magnetic resonance imaging neuroimaging Parkinson’s disease quantitative susceptibility mapping R2*mapping radiomics T1-weighted imaging

Effects of Initial Conditions on Energy Distribution of Suprathermal Electrons in Interaction of Intense Ultrashort Laser pulse with a Preplasma

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 1999年第1期16卷 35-37页

作者： liu Shi-bing zhang Jie YU Wei zhang Guang-cai Institute of Physics Chinese Academy of SciencesBeijing 100080 CCAST(World Laboratory) P.O.Box 8730Beijing 100080 department of Physics University of OxfordOxfordOX13PUUK Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800

Relativistic momentum and energy equations of electrons in an intense laser field are derived with Hamilton-Jacobi *** initial electrons in non-equilibrium or Maxwellian equilibrium distributions in preplasmas,suprathermal electron energy distributions are obtained analytically and *** calculation results agree well with the experiments.

关键词： thermal equilibrium Electron

The HY5 transcription factor negatively regulates ethylene production by inhibiting ACS1 expression under blue light conditions in pear

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticultural Plant Journal 2023年第5期9卷 920-930页

作者： Weiting liu Lichao zhang Li Ma Hui Yuan Aide Wang Key Laboratory of Fruit Postharvest Biology Key Laboratory of Protected HorticultureNational&Local Joint Engineering Research Center of Northern Horticultural Facilities Design&Application TechnologyCollege of HorticultureShenyang Agricultural UniversityShenyangLiaoning 110866China department of Foreign Language Teaching Shenyang Agricultural UniversityShenyangLiaoning 110866China

Ethylene is the main factor controlling fruit ripening of pear(Pyrus ussuriensis).Ethylene production rate is negatively correlated with fruit shelf life;therefore,it is important to decrease the ethylene levels for optimal fruit ***,we observed that blue light treatment could inhibit ethylene production and promote the expression of ELONGATED HYPOCOTYL 5(puHY5),a basic leucine zipper domain(bZIP)transcription *** following studies showed that puHY5 could bind to the promoter of ACC synthase 1(puACS1),a rate-limiting enzyme in ethylene biosynthesis,and inhibit its *** pears in which pu HY5 was silenced,the ethylene production and puACS1 expression were much higher than those in the control *** results demonstrated that blue light inhibited ethylene production through the induction of pu HY5 in *** finding provides a new method for prolonging fruit shelf life.

关键词： Pear Pyrus ussuriensis Fruit ripening Blue light Ethylene synthesis puHY5 puACS1

Identification of a novel mutation in POU3F4 for prenatal diagnosis in a Chinese family with X-linked nonsyndromic hearing loss

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2010年第12期37卷 787-793页

作者： Jianzhong Li Jing Cheng Yanping Lu Yu Lu Airing Chen YiSun Dongyang Kang Xin zhang pu Dai Dongyi Han Huijun Yuan Institute of Otolaryngology Chinese PLA General Hospital Beijing 100853 China department of Otolaryngology Fuzhou General Hospital of Nanjing Command PLA Fuzhou 350025 China department of Obstetrics and Gynecology General Hospital of PLA Beijing 100853 China

We present the clinical and genetic findings for a Chinese family with X-linked non-syndromic hearing loss in which the affected males showed congenital profound sensorineural hearing impairment. In two affected brothers, the computer tomography of temporal bone showed bilateral dilation of the internal auditory canal with fistulous communication between the lateral canal and the basal cochlear turn, which is consistent with the typical DFNX2 phenotype. A missense mutation （c.647G→A） in the POU3F4 gene caused a substitu- tion from glycine to glutamic acid at position 216 （p.G216E）, and this mutation was found to consistently cosegregate with the deafness phenotype in the family. The mutation resulted in the loss of function of the POU3F4 by decreasing the affinity between the protein and DNA, as shown in silico by the structural analysis. Prenatal diagnosis of pregnant proband of this family revealed the c.647G→A mutation in DNA extracted from the amniotic fluid surrounding the fetus. The appropriate use of genetic testing and prenatal diagnosis plays a key role in reducing the recurrence of genetic defects in high-risk families.

关键词： DFNX2 POU3F4 mutation prenatal diagnosis

在线全文

学校读者我要写书评

暂无评论

原子制造的物质科学基础

科学通报 2024年第19期69卷 2777-2788页

作者：戴庆宋凤麒潘曹峰刘开辉姚广保郑浩谭元植潘金波杜灵杰黄璞王曾晖陈辉张晨栋费付聪徐红星戴亚飞国家纳米科学中心北京100190 南京大学原子制造研究院南京210093 北京航空航天大学原子制造研究院北京100191 上海交通大学化学化工学院上海200240 上海交通大学物理与天文学院上海200240 厦门大学化学化工学院厦门361005 北京大学物理学院北京100871 电子科技大学基础与前沿研究院成都611731 中国科学院物理研究所北京100190 武汉大学物理科学与技术学院武汉430072 武汉大学微电子学院武汉430072 国家自然科学基金委员会交叉科学部北京100085

近年来,原子制造技术备受关注,已成为各国积极追求的前沿制造技术领域.一代物质科学,一代制造革新,原子制造技术的发展不仅仰赖于深厚的物质科学底蕴,还需要解决高效的原子精准操控与测量、原子尺度结构的物性设计等多个方面的基础科学... 详细信息

近年来,原子制造技术备受关注,已成为各国积极追求的前沿制造技术领域.一代物质科学,一代制造革新,原子制造技术的发展不仅仰赖于深厚的物质科学底蕴,还需要解决高效的原子精准操控与测量、原子尺度结构的物性设计等多个方面的基础科学问题.2023年3月,国家自然科学基金委员会交叉科学部在武汉召开了主题为“原子制造的物质科学基础”的战略研讨会.本文基于会议研讨的相关内容,对原子制造技术的发展背景、概念内涵以及面临的挑战进行了凝练,并提出如何利用该技术推动物质科学的快速发展,同时也就国家自然科学基金委员会对该领域的顶层设计和战略规划提出了政策建议.

关键词：原子制造物质科学原子操控原子级制造单原子器件物质创制

Antihepatoma peptide,scolopentide,derived from the centipede scolopendra subspinipes mutilans

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第12期29卷 1875-1898页

作者： Yu-Xing Hu Zhuo liu Zhen zhang Zhe Deng Zhen Huang Ting Feng Qing-Hong Zhou Si Mei Chun Yi Qing Zhou pu-Hua Zeng Gang Pei Sha Tian Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina department of Scientific Research Hunan Academy of Traditional Chinese Medicine Affiliated HospitalChangsha 410208Hunan ProvinceChina Hunan Province university Key Laboratory of Oncology of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina department of Pediatric Shenzhen Hospital of Beijing University of Chinese MedicineShenzhen 518000Guangdong ProvinceChina department of Physiology Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina department of Pathology Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina department of Andrology First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina department of Oncology Hunan Academy of Traditional Chinese Medicine Affiliated HospitalChangsha 410208Hunan ProvinceChina College of Pharmacy Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery Macao University of Science and TechnologyMacao 999078China

BACKGROUND Centipedes have been used to treat tumors for hundreds of years in ***,current studies focus on antimicrobial and anticoagulation agents rather than *** molecular identities of antihepatoma bioactive components in centipedes have not yet been extensively *** is a challenge to isolate and characterize the effective components of centipedes due to limited peptide purification technologies for animal-derived *** To purify,characterize,and synthesize the bioactive components with the strongest antihepatoma activity from centipedes and determine the antihepatoma *** An antihepatoma peptide(scolopentide)was isolated and identified from the centipede scolopendra subspinipes mutilans using a combination of enzymatic hydrolysis,a Sephadex G-25 column,and two steps of high-performance liquid chromatography(HPLC).Additionally,the CCK8 assay was used to select the extracted fraction with the strongest antihepatoma *** molecular weight of the extracted scolopentide was characterized by quadrupole time of flight mass spectrometry(QTOF MS),and the sequence was matched by using the Mascot search *** on the sequence and molecular weight,scolopentide was synthesized using solid-phase peptide synthesis *** synthetic scolopentide was confirmed by MS and *** antineoplastic effect of extracted scolopentide was confirmed by CCK8 assay and morphological changes again in *** antihepatoma effect of synthetic scolopentide was assessed by the CCK8 assay and Hoechst staining in vitro and tumor volume and tumor weight in *** the tumor xenograft experiments,qualified model mice(male 5-week-old BALB/c nude mice)were randomly divided into 2 groups(n=6):The scolopentide group(0.15 mL/d,via intraperitoneal injection of synthetic scolopentide,500 mg/kg/d)and the vehicle group(0.15 mL/d,via intraperitoneal injection of normal saline).The mice were euthanized by cervical dislocation after 14 d of con

关键词： Scolopendra Centipede Antihepatom peptide Hepatocellular carcinoma Death receptor 4 Death receptor 5

Characterization of SARS-CoV-2 worldwide transmission based on evolutionary dynamics and specific viral mutations in the spike protein

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2021年第4期10卷 3-17页

作者： Jiluo liu Xi Chen Yan liu Jiansheng Lin Jiaying Shen Hongwei zhang Jianhua Yin Rui pu Yibo Ding Guangwen Cao department of Epidemiology Second Military Medical University800 Xiangyin RoadShanghai 200433China

Background:The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome-related coronavirus-2(SARS-CoV-2)is ***,the origins and global transmission pattern of SARS-CoV-2 remain largely *** aimed to characterize the origination and transmission of SARS-CoV-2 based on evolutionary ***:Using the full-length sequences of SARS-CoV-2 with intact geographic,demographic,and temporal information worldwide from the GISAID database during 26 December 2019 and 30 November 2020,we constructed the transmission tree to depict the evolutionary process by the R package"outbreaker".The affinity of the mutated receptor-binding region of the spike protein to angiotensin-converting enzyme 2(ACE2)was predicted using mCSM-PPI2 *** infectivity and antigenicity were tested in ACE2-transfected HEK293T cells by pseudovirus transfection and neutralizing antibody ***:From 26 December 2019 to 8 March 2020,early stage of the COVID-19 pandemic,SARS-CoV-2 strains identified worldwide were mainly composed of three clusters:the Europe-based cluster including two USA-based subclusters;the Asia-based cluster including isolates in china,Japan,the USA,Singapore,Australia,Malaysia,and Italy;and the USA-based *** SARS-CoV-2 strains identified in the USA formed four independent clades while those identified in china formed one *** 8 March 2020,the clusters of SARS-CoV-2 strains tended to be independent and became"pure"in each of the major ***-two of 60 mutations in the receptor-binding domain of the spike protein were predicted to increase the binding affinity of SARS-CoV-2 to *** all predicted mutants,the number of E484K was the largest one with 86585 sequences,followed by S477N with 55442 sequences *** more than ten countries,the frequencies of the isolates with E484K and S477N increased significantly.V367F and N354D mutations increased the infectivity of SARS-CoV-2 pseudoviruses(P1).SA

关键词： COVID-19 SARS-CoV-2 Evolutionary dynamics Transmission