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The clinical and immunological features of pediatric COVID-19 patients in china

Genes & Diseases 2020年第4期7卷 535-541页

作者： Juan Chen Zhen-Zhen zhang Yao-Kai Chen Quan-Xin Long Wen-Guang Tian Hai-Jun Deng Jie-Li Hu Xian-Xiang zhang pu-Liao Jiang-Lin Xiang Dao-Xin Wang Peng Hu Fa-Chun Zhou Zhi-Jie Li Hong-Mei Xu Xue-Fei Cai De-Qiang Wang Yuan Hu Ni Tang Bei-Zhong liu Gui-Cheng Wu Ai-Long Huang The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education Department of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqingChina department of Infectious Diseases National Clinical Research Center for Child Health and DisordersThe Children’s Hospital of Chongqing Medical UniversityChongqingChina Division of Infectious Diseases Chonqging Public Health Medical CenterChongqingChina department of Infectious Diseases Yongchuan Hospital Affiliated to Chongqing Medical UniversityChongqingChina department of Endocrinology Chongqing Three Gorges Central HospitalChongqingChina department of Clinical Laboratory Chongqing People’s HospitalChongqingChina department of Infectious Diseases Chongqing Three Gorges Central HospitalChongqingChina department of Respiration The First Affiliated HospitalChongqing Medical UniversityChongqingChina department of Emergency The First Affiliated HospitalChongqing Medical UniversityChongqingChina department of Clinical Laboratory Yongchuan Hospital Affiliated to Chongqing Medical UniversityChongqingChina department of Liver Disease Chongqing Three Gorges Central HospitalChongqingChina

In December 2019,the corona virus disease 2019(COVID-19)caused by novel coronavirus(SARS-CoV-2)emerged in Wuhan,china and rapidly spread *** information on clinical features and immunological profile of COVID-19 in *** clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were *** immunological features of children patients was investigated and compared with twenty adult *** median age was 14.5-years(range from 0.64 to 17),and six of the patients were *** average incubation period was 8 ***,cough(9/12,75%)and fever(7/12,58.3%)were the most common *** patients(33.3%)had diarrhea during the *** to the immune profile,children had higher amount of total T cell,CD8t T cell and B cell but lower CRP levels than adults(P<0.05).Ground-glass opacity(GGO)and local patchy shadowing were the typical radiological findings on chest CT *** patients received antiviral and symptomatic treatment and the symptom relieved in 3e4 days after admitted to *** paediatric patients showed mild symptom but with longer incubation *** infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level,which might ascribed to the mild clinical *** advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom.

关键词： Clinical features COVID-19 Immune Paediatrics SARS-CoV-2

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基于深度学习的小电流接地系统故障选线方法

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发电技术 2019年第6期40卷 548-554页

作者：张国栋蒲海涛刘凯山东科技大学电气信息系山东省济南市253500 洛阳供电公司河南省洛阳市471000

小电流接地系统的单相接地故障选线问题目前仍没有完全解决。为了提高单相接地故障选线成功率,提出一种基于深度学习网络的选线方法。首先,利用PSCAD搭建了中性点不接地系统仿真模型,通过设置每条线路在不同接地电阻下的故障,得到基于... 详细信息

小电流接地系统的单相接地故障选线问题目前仍没有完全解决。为了提高单相接地故障选线成功率,提出一种基于深度学习网络的选线方法。首先,利用PSCAD搭建了中性点不接地系统仿真模型,通过设置每条线路在不同接地电阻下的故障,得到基于各出线零序电流幅值和相角的样本数据,并将样本数据分为训练集、验证集和测试集3部分。其次,基于Keras搭建了深度学习神经网络,利用训练集和验证集数据对该网络进行训练。最后,利用测试集数据对训练好的模型进行测试。结果表明,该方法具有建模简单、成功率高及选线不受过渡电阻影响的特点。

关键词：小电流接地系统单相接地故障故障选线深度学习

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Study of the asymmetry of hot-spot self-emission imaging of inertial confinement fusion implosion driven by high-power laser facilities

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Plasma science and technology 2020年第8期22卷 20-26页

作者： Yunsong DONG Dongguo KANG Wei JIANG Zhicheng liu Zhongjing CHEN Xing zhang Xin LI Chuankui SUN Chuansheng YIN Jianjun DONG Zhiwen YANG Yudong pu Ji YAN Bo YU Tianxuan HUANG Wenyong MIAO Zhensheng DAI Fengjun GE Dong YANG Feng WANG Jiamin YANG Shaoen JIANG Research Center of Laser Fusion Chinese Academy of Engineering PhysicsMianyang 621900People's Republic of China Institute of Applied Physics and Computational mathematics Beijing 100088People's Republic of China department of Engineering Physics Tsinghua UniversityBeijing 100086People's Republic of China

Implosion asymmetry is a crucial problem quenching ignition in the field of inertial confinement fusion.A forward-calculation method based on 1D and 2D hydrodynamic simulations has been developed to generate and study the x-ray images of hot-spot self-emission,indicating asymmetry integrated over the entire drive *** is shown that the x-ray imaging photon energy should be higher to avoid the influence of the remaining *** contour level(percentage of the maximum emission intensity)and spatial resolution should be as low as possible,optimally less than 20%and 3μm,for characterization of higher-mode signatures such as Ps-P12 by x-ray self-emission *** the contrary,signatures of lower-mode such as P2 remain clear at all contour levels and spatial *** key results can help determine the optimal diagnostics,laser,and target parameters for implosion *** typical hot-spot asymmetry measurements and applications on the Shenguang 100 kJ class laser facility are also reported.

关键词： inertial confinement fusion implosion x-ray self-emission hot-spot asymmetry

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GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson's disease:a two-cohort case-control study

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Translational Neurodegeneration 2020年第3期9卷 409-420页

作者： Hong-xu Pan Yu-wen Zhao Jun-pu Mei Zheng-huan Fang Yige Wang Xun Zhou Yang-jie Zhou Rui zhang Kai-lin zhang Li Jiang Qian Zeng Yan He Zheng Wang Zhen-hua liu Qian Xu Qi-ying Sun Yang Yang Ya-cen Hu Ya-se Chen Juan Du Li-fang Lei Hai-nan zhang Chun-yu Wang Xin-xiang Yan Lu Shen Hong Jiang Jie-qiong Tan Jin-chen Li Bei-sha Tang Ji-feng Guo department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China department of Geriatrics Xiangya HospitalCentral South UniversityChangsha 410008China department of Neurology The Third Xiangya HospitalCentral South UniversityChangsha 410013China department of Neurology The Second Xiangya HospitalCentral South UniversityChangsha 410011China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangsha 410008China

Background:Common and rare variants of guanosine triphosphate cyclohydrolase 1(GCH1)gene may play important roles in Parkinson's disease(PD).However,there is a lack of comprehensive analysis of GCH1 genotypes,especially in non-coding *** aim of this study was to explore the genetic characteristics of GCH1,including rare and common variants in coding and non-coding regions,in a large population of PD patients in Chinese mainland,as well as the phenotypic characteristics of GCH1 variant ***:In the first cohort of this case-control study,we performed whole-exome sequencing in 1555 patients with early-onset or familial PD and 2234 healthy controls;then in the second cohort,whole-genome sequencing was performed in sporadic late-onset PD samples(1962 patients),as well as 1279 *** at target GCH1 regions were extracted,and then genetic and detailed phenotypic data were analyzed using regression models and the sequence kernel association *** also performed a meta-analysis to correlate deleterious GCH1 variants with age at onset(AAO)in PD ***:For coding variants,we identified a significant burden of GCH1 deleterious variants in early-onset or familial PD cases compared to controls(1.2%VS 0.1%,P1).In the analysis of possible regulatory variants in GCH1 non-coding regions,rs12323905(P=0.001,odds ratio=1.19,95%CI 1.07-1.32)was significantly associated with PD,and variant sets in untranslated regions and intron regions,GCH1 brain-specific expression quantitative trait loci,and two possible promoter/enhancer(GH14J054857 and GH14J054880)were suggestively associated with *** phenotype correlation analysis revealed that the carriers of GCH1 deleterious variants manifested younger AAO(P1),and had milder motor symptoms,milder fatigue symptoms and more autonomic nervous ***-analysis of six studies demonstrated 6.4-year earlier onset in GCH1 deleterious variant carriers(P=0.0009).Conclusions:The results

关键词： Parkinson's disease Age at onset GCH1 Deleterious variants Non-coding variants

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折射率线性调制晶体中超快倍频的数值分析

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光子学报 2018年第9期47卷 200-206页

作者：张留洋杨莹曲玉秋程广真赵子健浦绍质哈尔滨理工大学理学院物理系哈尔滨150080 黑龙江大学物理科学与技术学院哈尔滨150080

对折射率线性调制晶体中超短脉冲倍频特性进行了数值计算,在泵浦衰减的情况下,研究了转换效率和脉冲宽度随匹配带宽和晶体长度的变化.大信号时各频率成份在晶体不同位置的不平衡转换致使脉冲展宽,且由于折射率的调制,脉冲宽度和转换效... 详细信息

对折射率线性调制晶体中超短脉冲倍频特性进行了数值计算,在泵浦衰减的情况下,研究了转换效率和脉冲宽度随匹配带宽和晶体长度的变化.大信号时各频率成份在晶体不同位置的不平衡转换致使脉冲展宽,且由于折射率的调制,脉冲宽度和转换效率出现了周期性变化.同时,分析了谐波脉冲啁啾随晶体长度和带宽的变化,发现随着晶体长度的增大,归一化最佳啁啾系数先增大后减小,在长晶体时趋于1,其极大值位置决定于本征带宽和调制带宽.讨论了相位失配量对转换效率和脉宽的影响,结果表明失配因子y决定了中心频率的匹配位置,当y=0时,中心频率在晶体中心匹配,这有利于提高转换效率并减小脉冲宽度.

关键词：非线性光学频率变换数值计算折射率调制群速度匹配局域化相位匹配

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Engineering of multiferroic BiFeO grain boundaries with head-to-head polarization configurations

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science Bulletin 2021年第8期66卷 771-776,M0003页

作者： Mingqiang Li Shuzhen Yang Ruochen Shi Linglong Li Ruixue Zhu Xiaomei Li Yang Cheng Xiumei Ma Jingmin zhang Kaihui liu pu Yu Peng Gao Electron Microscopy Laboratory School of PhysicsPeking UniversityBeijing 100871China International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Peking university Shenzhen Graduate School Peking UniversityShenzhen 518055China TCL china Star Optoelectronics technology Co. Ltd.Shenzhen 518132China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China State Key Laboratory for Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Centre of Quantum Matter Beijing 100871China State Key Laboratory of Low Dimensional Quantum Physics and department of Physics Tsinghua UniversityBeijing 100084China.

Confined low dimensional charges with high density such as two-dimensional electron gas(2 DEG)at interfaces and charged domain walls in ferroelectrics show great potential to serve as functional elements in future ***,stabilization and control of low dimensional charges is challenging,as they are usually subject to enormous depolarization ***,we demonstrate a method to fabricate tunable charged interfaces with~77°,86°and 94°head-to-head polarization configurations in multiferroic Bi Fe O_(3) thin films by grain boundary *** adjacent grains are cohesively bonded and the boundary is about 1 nm in width and devoid of any amorphous ***,the polarization remains almost unchanged near the grain boundaries,indicating the polarization charges are well compensated,i.e.,there should be two-dimensional charge gas confined at grain *** the tilt angle of the grain boundaries enables tuning the angle of polarization configurations from 71°to 109°,which in turn allows the control of charge density at the grain *** general and feasible method opens new doors for the application of charged interfaces in next generation nanoelectronics.

关键词： Head-to-head Grain boundaries Atomic structure BiFeO_(3)

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Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in china

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Biomedical and Environmental sciences 2020年第12期33卷 893-905页

作者： MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan liu Si Hong FAN Yi Pin WU Gui Hui YANG pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong liu Hong De liu Jin Ping liu zhang MA Yu Ting MAO Ya MO liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li zhang Gong Qi zhang Jin Bo zhang Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing zhang Hua Min WANG Yan Ping WANG Yong Yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in china. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

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N6-Methyladenine DNA Methylation in Japonica and Indica Rice Genomes and Its Association with Gene Expression, Plant Development, and Stress Responses

N6-Methyladenine DNA Methylation in Japonica and Indica Rice...

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中国生物工程学会第十三届学术年会暨2019年全国生物技术大会

作者： Qian zhang Zhe Liang Xuean Cui Changmian Ji Yun Li Pingxian zhang Jingrong liu Adeel Riaz pu Yao Min liu Yunpeng Wang Tiegang Lu Hao Yu Donglei Yang Hongkun Zheng Xiaofeng Gu Biotechnology Research Institute Chinese Academy of Agricultural Sciences department of Biological sciences and Temasek Life sciences Laboratory National University of Singapore Biomarker Technologies State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University Institute of Clinical Medicine University of Oslo

N6-Methyladenine(6 mA) DNA methylation has recently been implicated as a potential new epigenetic marker in eukaryotes, including the dicot model Arabidopsis thaliana. However, the conservation and divergence of 6 mA distribution patterns and functions in plants remain elusive. Here we report high-quality 6 mA methylomes at single-nucleotide resolution in rice based on substantially improved genome sequences of two rice cultivars, Nipponbare(Nip;Japonica) and 93-11(Indica). Analysis of 6 mA genomic distribution and its association with transcription suggest that 6 mA distribution and function is rather conserved between rice and Arabidopsis. We found that 6 mA levels are positively correlated with the expression of key stressrelated genes, which may be responsible for the difference in stress tolerance between Nip and ***, we showed that mutations in DDM1 cause defects in plant growth and decreased 6 mA *** results reveal that 6 mA is a conserved DNA modification that is positively associated with gene expression and contributes to key agronomic traits in plants.

关键词： N6-methyladenine 6mA DNA methylation Methylome Oryza sativa Stress

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Bioinspired polyimide film with fire retardant and gas barrier properties by gravity-induced deposition of montmorillonite

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Aggregate 2023年第6期4卷 200-208页

作者： Qiao-Xi Yu Run-Xin Bei Jia-Hui liu Yan-Wei He Si-Wei liu Zhen-Guo Chi Jia-Rui Xu Yi zhang PCFM Lab GD HPPC LabGuangdong Engineering Technology Research Centre for High-performance Organic and Polymer Photoelectric Functional FilmsState Key Laboratory of Optoelectronic Materials and TechnologiesSchool of ChemistrySun Yat-sen UniversityGuangzhouChina

Flame retardants play a crucial role in improving theﬂame retardant properties of polymer *** recent years,environmental problems caused byﬂame retar-dants have attracted widespread *** is urgent to use green and effective methods to prepareﬂame retardant *** nanocomposites with lay-ered structures seem to provide effective ideas,but in general,their hydrophilic raw materials limit their applications in certainﬁ***,we prepared biomimetic composites with a layered“brick-and-mortar”structure by gravity-induced depo-sition using polyimide as the polymer matrix and montmorillonite(MMT)as theﬁ*** well-arranged structures of the composite material could isolate oxygen and prevent combustible gases from *** gas barrier performance has been greatly improved,in which the water vapor transmission rate and the oxygen trans-mission rate decreased by 99.18%and three orders of magnitude,***ﬂame retardant performance has also been improved,and its limiting oxygen index can reach 67.9%.The polyimide matrix can be converted to water-insoluble by ther-mal imidization of water-soluble poly(amic acid)salt precursors,which endows the composites with low *** coating containing MMT can protect against polyurethane(pu)foam fromﬁ*** the conical calorimetric test,the coated sample self-extinguished,and the peak heat release rate,total heat release,and total smoke production are signiﬁcantly decreased by 53.39%,40.69%,and 53.03%,*** advantage of these properties,this work utilizes a facile method to prepare biomimetic composites with low moisture absorption,excellent gas barrier properties,andﬂame retardancy,which have great application potential.

关键词： bioinspired composite ﬁre retardant gas barrier gravity-induced deposition polyimide

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Artificial Intelligence to Diagnose Tibial Plateau Fractures: An Intelligent Assistant for Orthopedic Physicians

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Current Medical science 2021年第6期41卷 1158-1164页

作者： Peng-ran liu Jia-yao zhang Ming-di XUE Yu-yu DUAN Jia-lang HU Song-xiang liu Yi XIE Hong-lin WANG Jun-wen WANG Tong-tong HUO Zhe-wei YE department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei university of Chinese Medicine Wuhan 430070China department of Orthopedics Wuhan Pu’ai HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:To explore a new artificial intelligence(AI)-aided method to assist the clinical diagnosis of tibial plateau fractures(TPFs)and further measure its validity and ***:A total of 542 X-rays of TPFs were collected as a reference *** AI algorithm(RetinaNet)was trained to analyze and detect TPF on the *** ability of the AI algorithm was determined by indexes such as detection accuracy and time taken for *** algorithm performance was also compared with orthopedic ***:The AI algorithm showed a detection accuracy of 0.91 for the identification of TPF,which was similar to the performance of orthopedic physicians(0.92±0.03).The average time spent for analysis of the AI was 0.56 s,which was 16 times faster than human performance(8.44±3.26 s).Conclusion:The AI algorithm is a valid and efficient method for the clinical diagnosis of *** can be a useful assistant for orthopedic physicians,which largely promotes clinical workflow and further guarantees the health and security of patients.

关键词： artificial intelligence tibial plateau fracture diagnosis

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