The clinical and immunological features of pediatric COVID-19 patients in China

作     者：Juan Chen Zhen-Zhen Zhang Yao-Kai Chen Quan-Xin Long Wen-Guang Tian Hai-Jun Deng Jie-Li Hu Xian-Xiang Zhang Pu-Liao Jiang-Lin Xiang Dao-Xin Wang Peng Hu Fa-Chun Zhou Zhi-Jie Li Hong-Mei Xu Xue-Fei Cai De-Qiang Wang Yuan Hu Ni Tang Bei-Zhong Liu Gui-Cheng Wu Ai-Long Huang 

作者机构：The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of EducationDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqingChina Department of Infectious DiseasesNational Clinical Research Center for Child Health and DisordersThe Children’s Hospital of Chongqing Medical UniversityChongqingChina Division of Infectious DiseasesChonqging Public Health Medical CenterChongqingChina Department of Infectious DiseasesYongchuan Hospital Affiliated to Chongqing Medical UniversityChongqingChina Department of EndocrinologyChongqing Three Gorges Central HospitalChongqingChina Department of Clinical LaboratoryChongqing People’s HospitalChongqingChina Department of Infectious DiseasesChongqing Three Gorges Central HospitalChongqingChina Department of RespirationThe First Affiliated HospitalChongqing Medical UniversityChongqingChina Department of EmergencyThe First Affiliated HospitalChongqing Medical UniversityChongqingChina Department of Clinical LaboratoryYongchuan Hospital Affiliated to Chongqing Medical UniversityChongqingChina Department of Liver DiseaseChongqing Three Gorges Central HospitalChongqingChina 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2020年第7卷第4期

页      面：535-541页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0703[理学-化学] 10[医学] 

基　　金：This work was supported by National Natural Science Foundation of China(Grant No.81871656 and 8181101099 to J C) National Science and Technology Major Project(Grant No.2017ZX10202203 to AL H) 

主　　题：Clinical features COVID-19 Immune Paediatrics SARS-CoV-2 

摘      要：In December 2019,the corona virus disease 2019(COVID-19)caused by novel coronavirus(SARS-CoV-2)emerged in Wuhan,China and rapidly spread *** information on clinical features and immunological profile of COVID-19 in *** clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were *** immunological features of children patients was investigated and compared with twenty adult *** median age was 14.5-years(range from 0.64 to 17),and six of the patients were *** average incubation period was 8 ***,cough(9/12,75%)and fever(7/12,58.3%)were the most common *** patients(33.3%)had diarrhea during the *** to the immune profile,children had higher amount of total T cell,CD8t T cell and B cell but lower CRP levels than adults(P0.05).Ground-glass opacity(GGO)and local patchy shadowing were the typical radiological findings on chest CT *** patients received antiviral and symptomatic treatment and the symptom relieved in 3e4 days after admitted to *** paediatric patients showed mild symptom but with longer incubation *** infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level,which might ascribed to the mild clinical *** advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom.