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口腔颗粒细胞瘤的临床病理分析

口腔医学 2024年第3期44卷 168-172页

作者：刘梅张磊蒲玉梅黄晓峰徐万田孙国文南京大学医学院附属口腔医院南京市口腔医院第三门诊部江苏南京210036 南京大学医学院附属口腔医院南京市口腔医院口腔病理科江苏南京210008 南京大学医学院附属口腔医院南京市口腔医院口腔颌面外科江苏南京210008

目的探讨口腔颗粒细胞瘤的临床表现、病理特征及治疗方案,旨在为其诊断及治疗方案提供参考依据。方法对我院诊断为颗粒细胞瘤病例的组织病理根据Fanburg-Smith的6项标准进行分类,分为良性、不典型性及恶性肿瘤,并对所有病例的临床表... 详细信息

目的探讨口腔颗粒细胞瘤的临床表现、病理特征及治疗方案,旨在为其诊断及治疗方案提供参考依据。方法对我院诊断为颗粒细胞瘤病例的组织病理根据Fanburg-Smith的6项标准进行分类,分为良性、不典型性及恶性肿瘤,并对所有病例的临床表现、病理特征及治疗方案进行回顾性分析。结果本组共14例,好发年龄40~60岁(8例,57.14%),男女比例1:1,舌部12.(85.71%),颊部和舌下腺各1例。主要表现为无痛性缓慢生长的结节或肿块,9例(64.2.%)无明显临床症状,4例(2..57%)表现为疼痛、舌体麻木,1例出现舌体固定,造成吞咽及语音困难。病理表现为肿瘤由丰满的嗜酸性粒细胞构成,胞质内含大量均质颗粒,良性8例(57.14%),不典型性2.(14.2.%),恶性4例(2..57%)。所有病例均行手术治疗,1例恶性病例随访2.后失访,其余预后良好。结论口腔颗粒细胞瘤主要表现为舌部良性肿瘤,根据其组织病理分型不同其治疗要点有所不同,手术彻底切除是其主要治疗方案,总体预后良好。

关键词：颗粒细胞瘤临床病理特点治疗方案

Concrescence of maxillary second molar and impacted third molar:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10286-10292页

作者： Jun Su Li-Mei Shao Lian-Cheng Wang Li-Jia He Ya-liu pu Yan-Bo Li Wen-Yun {2. department of Stomatology 920th Hospital of the Joint Logistics Support ForceKunming 650032Yunnan ProvinceChina

BACKGROUND Morphological anomalies of teeth,including talon cusp,dens evaginatus,gemination,fusion,concrescence,root dilaceration,and taurodontism,always involve changes in the enamel,cementum and *** concrescent teeth through routine clinical examination alone is difficult,and most cases of concrescence are found accidentally during extraction.A definite preoperative diagnosis of concrescence would contribute to a better treatment plan and fewer undesirable complications CASE SUMMARY A 47-year-old woman who complained of left maxillary first molar loss for half a year presented to our department seeking treatment by dental implant *** radiography and cone-beam computed tomography(CBCT)showed an unclear boundary between the distal root of the second molar and the mesial root of the third *** teeth were extracted under local anesthesia,and a definite diagnosis of concrescence was made by histopathological *** CBCT is a useful tool for diagnosing and planning the management of tooth concrescence and may be beneficial for reducing unnecessary complications.

关键词： Concrescence Impacted tooth Concentrate growth factor Maxillary third molar Tooth anomalies Cone-beam computed tomography Case report

Point-defect-driven flattened polar phonon bands in fluorite ferroelectrics

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npj Computational Materials 2023年第1期9卷 1120-1128页

作者： pu Ai Fengjun Yan Wen Dong Shi liu Junlei Zhao Kan-Hao Xue Syed Ul Hasnain Bakhtiar Yilong liu Qi Ma Ling Miao Mengyuan Hua Guangzu zhang Shenglin Jiang Wei Luo Qiuyun Fu School of Integrated Circuits Engineering Research Centre for Functional Ceramics of the Ministry of Education&Wuhan National Lab for Optoelectronics&Optical Valley Laboratory Huazhong University of Science and Technology430074 WuhanChina department of Physics School of ScienceWestlake UniversityHangzhou310024 ZhejiangChina School of Optical and Electronic Information Research Centre&Wuhan National Lab for Optoelectronics&Optical Valley Laboratory Huazhong University of Science and Technology430074 WuhanChina department of Electrical and Electronic Engineering Southern University of Science and Technology518055 ShenzhenChina Shenzhen Huazhong university of Science and technology Research Institute 518000 ShenzhenP.R.China

The scale-free ferroelectric polarization of fluorite MO_(2.(M=Hf,Zr)due to flat polar phonon bands are promising for nonvolatile *** are also widely introduced to improve the emergent ***,their roles are still not fully understood at the ***,we report a significant effect of point-defect-driven flattening of polar phonon bands with more polar modes and polarization contribution in doped MO_(2..The polar phonon bands in La-doped MO_(2.(M=Hf,Zr)can be significantly flattened,compared with pure ***,the lower energy barrier with larger polarization of VO-only doped MO_(2. compared with La-doped cases suggest that VO and local lattice distortion should be balanced for high-performance fluorite *** work is believed to bridge the relation between point defects and the generally enhanced induced ferroelectricity in fluorite ferroelectrics at the atomic-level and inspire their further property optimization via defect-engineering.

关键词： bands phonon ferroelectric

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张宁辨治糖尿病性腹泻经验浅析

辽宁中医杂志 2024年第3期51卷 34-37页

作者：李心怡张宁闫璞高艺玮刘武中国中医科学院望京医院肾病内分泌科北京100102

糖尿病性腹泻是糖尿病中较为常见的一种慢性并发症,发病率逐年升高,属中医学“消渴病”“泄泻病”等疾病范畴。张宁教授从事糖尿病相关临床研究30余年,积累了丰富的理论知识和临床经验,治疗糖尿病性腹泻临床效果显著。张宁教授认为糖尿... 详细信息

糖尿病性腹泻是糖尿病中较为常见的一种慢性并发症,发病率逐年升高,属中医学“消渴病”“泄泻病”等疾病范畴。张宁教授从事糖尿病相关临床研究30余年,积累了丰富的理论知识和临床经验,治疗糖尿病性腹泻临床效果显著。张宁教授认为糖尿病性腹泻既然从糖尿病发展而来,其基本病机离不开阴虚内热这四个字,此外还包括脾肾阳虚、肝郁气滞、水湿内停。临证用药中张宁教授注重标本兼治,既病防变,同时少量加入活血药物,以防瘀血内生。文章将浅述张宁教授临证辨治糖尿病性腹泻的经验。

关键词：张宁糖尿病性腹泻经验医案

Calcitriol attenuates liver fibrosis through hepatitis C virus nonstructural protein 3-transactivated protein 1-mediated TGF β1/Smad3 and NF-κB signaling pathways

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World Journal of Gastroenterology 2023年第18期29卷 2798-2817页

作者： liu Shi Li Zhou Ming Han Yu zhang Yang zhang Xiao-Xue Yuan Hong-Ping Lu Yun Wang Xue-Liang Yang Chen liu Jun Wang pu Liang Shun-Ai liu Xiao-Jing liu Jun Cheng Shu-Mei Lin department of Infectious Disease Medicine The First Hospital Affiliated to Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina china-Japan Friendship Hospital Department of Infectious Disease China-Japan Friendship HospitalBeijing 100029China Institute of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China The Division of Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Institute of Liver Diseases Beijing Pan-Asia Tongze Institute of Biomedicine Co.LtdBeijing 100015China department of Rehabilitation Medicine The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Beijing Key Laboratory of Emerging Infectious Diseases Peking University Ditan Teaching HospitalBeijing 100015China

BACKGROUND Hepatic fibrosis is a serious condition,and the development of hepatic fibrosis can lead to a series of ***,the pathogenesis of hepatic fibrosis remains unclear,and effective therapy options are still *** group identified hepatitis C virus nonstructural protein 3-transactivated protein 1(NS3TP1) by suppressive subtractive hybridization and bioinformatics analysis,but its role in diseases including hepatic fibrosis remains ***,additional studies on the function of NS3TP1 in hepatic fibrosis are urgently needed to provide new targets for *** To elucidate the mechanism of NS3TP1 in hepatic fibrosis and the regulatory effects of calcitriol on *** Twenty-four male C57BL/6 mice were randomized and separated into three groups,comprising the normal,fibrosis,and calcitriol treatment groups,and liver fibrosis was modeled by carbon tetrachloride(CCl4).To evaluate the level of hepatic fibrosis in every group,serological and pathological examinations of the liver were ***-β1 was administered to boost the in vitro cultivation of LX-2.***3TP1,α-smooth muscle actin(α-SMA),collagen I,and collagen Ⅲ in every group were examined using a Western blot and real-time quantitative polymerase chain *** activity of the transforming growth factor beta 1(TGFβ1)/Smad3 and NF-κB signaling pathways in each group of cells transfected with pcDNA-NS3TP1 or siRNA-NS3TP1 was *** statistical analysis of the data was performed using the Student’s t *** NS3TP1 promoted the activation,proliferation,and differentiation of hepatic stellate cells(HSCs)and enhanced hepatic fibrosis via the TGFβ1/Smad3 and NF-κB signaling pathways,as evidenced by the presence of α-SMA,collagen I,collagen Ⅲ,p-smad3,and p-p65 in LX-2.cells,which were upregulated after NS3TP1 overexpression and downregulated after NS3TP1 *** proliferation of HSCs was lowered after NS3TP1 interference and elevated after

关键词： Nonstructural protein 3-transactivated protein 1 Calcitriol Liver fibrosis Hepatic stellate cells Mouse model TGFβ1/Smad3 NF-κB Signaling pathway

Polyoxometalate-encapsulated metal-organic frameworks with diverse cages for the C-H bond oxidation of alkylbenzenes

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Chinese Journal of Structural Chemistry 2023年第2期42卷 35-42页

作者： Yue Wang Ze-Xuan liu Xing-pu Zhao Yuan-Yuan Ma Si-Meng {2. Wen-Jing Cui Jing Du Zhan-Gang Han Hebei Key Laboratory of Organic Functional Molecules Hebei Key Laboratory of Inorganic NanomaterialsNational Demonstration Center for Experimental Chemistry EducationCollege of Chemistry and Materials ScienceHebei Normal UniversityShijiazhuangHebei050024PR China Testing and Analysis Center Hebei Normal UniversityShijiazhuangHebei050024PR China

Exploring new heterogeneous catalysts to achieve efficient C-H bond oxidation is momentous in industrial chemical ***,three Fe-incorporated polyoxometalate-encapsulated metal-organic frameworks(POM@MOFs),[Fe(H_(2.O)_(3)(dtb)][Fe(dtb)_(2.][HBW_(12.O_(40)]-12._(2.O(1),[Fe(H_(2.O)2.dtb)]_(2.[Fe(dtb)_(2.(Hdtb)][SiW^(Ⅵ)_(9)W^(Ⅴ)_(3)O_(40)]·16H_(2.O(2.,[Fe(H_(2.O)_(2.]_(4)(dtb)_(5)[PMo^(Ⅵ)_(11)Mo^(Ⅴ)O_(40)]_(2.·18H_(2.O(3),(dtb=1,4-di[4H-1,2.4-triazol-4-yl]-benzene),were hydrothermally synthesized for catalytic C-H bond *** exhibited three-dimensional(3-D)POM-based metal-organic host-guest frameworks with diverse *** compound 1,cationic metal-organic frameworks constructed by binuclear[Fe_(2.(dtb)_(6)(H_(2.O)_(2.]^(4+)clusters and dtb ligands present a pcu alpha-Po primitive cubic topological net and abundant twisted quadrangular prism-shaped cages,in which the monoprotonated[HBW_(12.O_(40)]^(4-)polyoxoanions are *** compound 2.two-dimensional(2.D)cationic metal-organic layers constructed by trinuclear[Fe_(3)(dtb)_(6)(H_(2.O)_(4)]^(6+)clusters and dtb ligands display a sql/Shubnikov tetragonal plane net topology,in which the rhomboid-shaped metal-organic windows in adjacent parallel-arranged 2.D layers are enclosed to form an open parallelepiped ***[SiW^(Ⅵ)_(9)W^(Ⅴ)_(3)O_(40)]^(7-)poly-oxoanions locate in the parallelepiped cages between 2.D *** compound 3,the 3-D cationic metal-organic frameworks constructed by binuclear[Fe_(2.(dtb)_(3)(H_(2.O)_(4)]^(4+)clusters and dtb ligands possess a bnn hexagonal BN topology,in which the hexagonal prismatic metal-organic cages accommodate four[PMo^(Ⅵ)_(11)Mo^(Ⅴ)O_(40)]^(4-)*** diphenylmethane(DPM)oxidation as C-H bond oxidation model reaction,compounds 1-3 displayed distinct catalytic activities owing to the synergistic effect of polynuclear Fe nodes and *** them,[PMo^(Ⅵ)_(11)Mo^(Ⅴ)O_(40)]^(4-)-contained compound 3 exhibited higher catalytic

关键词： Polyoxometalate Metal-organic framework Heterogeneous catalysis C-H bond oxidation

阴道哑铃结合热敏灸、Kegel运动训练治疗产后盆底功能障碍的效果

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临床误诊误治 2024年第15期37卷 80-85页

作者：王云贾贺张华杨慧琴蒲巍林康鑫玲姚向荣刘新禹中国人民解放军联勤保障部队第九四〇医院康复医学科兰州730050 中国人民解放军联勤保障部队第九四〇医院妇产科兰州730050 中国人民解放军联勤保障部队第九四〇医院军人门诊兰州730050 甘肃省妇幼保健院消毒供应科兰州730050 甘肃省妇幼保健院泌尿外科兰州730050

目的分析阴道哑铃结合热敏灸、Kegel运动训练治疗产后盆底功能障碍(PFD)的效果。方法选择2.2.年1月至2.2.年12.诊治的PFD初产妇118例,依照随机抽签法分为观察组和对照组,每组59例。对照组采用阴道哑铃结合Kegel运动训练,观察组给予阴... 详细信息

目的分析阴道哑铃结合热敏灸、Kegel运动训练治疗产后盆底功能障碍(PFD)的效果。方法选择2.2.年1月至2.2.年12.诊治的PFD初产妇118例,依照随机抽签法分为观察组和对照组,每组59例。对照组采用阴道哑铃结合Kegel运动训练,观察组给予阴道哑铃结合热敏灸、Kegel运动训练。比较2.治疗效果,干预前后阴道收缩力、盆底肌力、盆底功能、女性性功能指数、尿失禁分级情况。结果观察组总有效率[98.31%(58/59)]高于对照组[84.75%(50/59)](P1);干预后,观察组盆底功能相关评分低于对照组(P1);干预后,观察组尿失禁分级优于对照组(P<0.05)。结论PFD患者经阴道哑铃结合热敏灸、Kegel运动训练干预盆底肌力、盆底功能、尿失禁分级得到了改善,女性性功能指数、阴道收缩力得到了提升,效果较好。

关键词：阴道哑铃热敏灸 Kegel运动训练盆底疾病女性盆底功能障碍尿失禁盆底功能影响问卷简表盆腔器官脱垂-尿失禁性功能问卷

Effects of plasma ghrelin, obestatin, and ghrelin/obestatin ratio on blood pressure circadian rhythms in patients with obstructive sleep apnea syndrome

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Chinese Medical Journal 2014年第5期127卷 850-855页

作者： liu Weiying Yue Hongmei zhang Jiabin {2. Jiayuan Yu Qin department of Respiratory Medicine First Hospital of Lanzhou University Lanzhou Gansu 730000 China

Background Obstructive sleep apnea syndrome （OSAS） is strongly associated with obesity and with cardiovascular *** and obestatin are two peptides from the same source but have opposite *** of them can affect feeding and regulate vascular *** aim of this study was to investigate the relationship between plasma ghrelin,obestatin,the ratio of ghrelin and obestatin （G/O） and sleep parameters and blood pressure circadian rhythms in patients with *** This study enrolled 95 newly diagnosed over-weight OSAS patients （OSAS group）,30 body mass index （BMI）-match non-OSAS adults （over-weight group） and 30 non-OSAS normal weight adults （control group）.Polysomnography （PSG） was performed in the OSAS group and over-weight *** pressure of all subjects was monitored by means of 2.-hour ambulatory blood pressure *** concentration of plasma ghrelin and obestatin was detected by enzyme-linked immunosorbent assay （ELISA）.Results Plasma ghrelin levels in the OSAS group and over-weight group were significantly lower than that of the control group （P ＜0.05）.Plasma obestatin levels were lower in the over-weight group and OSAS group,but there was no significant difference among the three *** blood pressure in OSAS patients was higher,and there was a significant difference in all blood pressure parameters compared to the control group,and in the daytime average diastolic blood pressure （DBP）,nocturnal average systolic blood pressure （SBP） and DBP,DBP variability values as compared to over-weight ***,there were significantly more non-dipper patterns of blood pressure （including hypertension and normotension） in the OSAS group than in the other two groups （P ＜0.01）.Correlation analysis showed that ghrelin levels had a significant correlation with BMI and nocturnal average DBP but not with PSG *** contrast,the G/O ratio had a negative correlation with apnea-hypopnea index （AHI）（P ＜0.05）,as well as a strong pos

关键词： obstructive sleep apnea syndrome ghrelin obestatin ghrelin/obestatin ratio blood pressure circadian rhythms

Study on the Clinical Effectiveness of Thymectomy for Myasthenia Gravis

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The Chinese-German Journal of Clinical Oncology 2002年第1期1卷 36-37页

作者： PAN Tiecheng, YAN Hua, zhang Ni, PAN Youming, TANG Yingxiong, WEN Xiang, SONG Dingwei, HU Ming, liu Ligang, liu Zixiong, YANG Mingshan, XU Jinzhi, pu Bitao, GAO Boting department of Thoracis Surgery, Tongji Hospital, Tongji Medical College, Huazhong university of Science and technology, Wuhan 430030, china department of Thoracis Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective To investigate the theoretical basis and clinical significance of thymectomy in the treatment of myasthenia gravis (MG). Methods Analyze the changes in the contents of serum AchRab and sIL-2., lymphocyte subtypes in peripheral blood lymphocytes before and after thymectomy in 69 patients.Results In the study group significant changes were found in serum contents of AchRab and sIL-2. before and after operation and there was also remarkable change in the number and constitution of peripheral blood lymphocyte subtypes. Conclusion Thymectomy is an effective therapy for MG.

关键词： myasthenia gravis thymectomy