检索结果-南通市图书馆

Topological Structure-Modulated Collagen Carbon as Two-in-One Energy Storage Configuration toward Ultrahigh Power and Energy Density

在线全文

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第2期7卷 18-29页

作者： Li Yuan Wenlong Cai Yunhong Wei Yiran pu Can liu Yun {2. Hao Wu College of Materials Science and Engineering Sichuan UniversityChengdu 610065China department of Applied Chemistry University of Science and Technology of ChinaHefei 230026China

Efficient energy storage devices with suitable electrode materials,that integrate high power and high energy,are the crucial requisites of the renewable power source,which have unwrapped new possibilities in the sustainable development of energy and the ***,a facile collagen microstructure modulation strategy is proposed to construct a nitrogen/oxygen dual-doped hierarchically porous carbon fiber with ultrahigh specific surface area(2.88 m^(2.g^(-1))and large pore volume(4.56 cm^(3)g^(-1))via local microfibrous breakage/disassembly of natural structured *** operando spectroscopy and density functional theory unveil that the dual-heteroatom doping could effectively regulate the electronic structure of carbon atom framework with enhanced electric conductivity and electronegativity as well as decreased diffusion resistance in favor of rapid pseudocapacitive-dominated Li^(+)-storage(353 mAh g^(-1)at 10 A g^(-1)).Theoretical calculations reveal that the tailored micro-/mesoporous structures favor the rapid charge transfer and ion storage,synergistically realizing high capacity and superior rate performance for NPCF-H cathode(75.0 mAh g^(-1)at 30 A g^(-1)).The assembled device with NPCF-H as both anode and cathode achieves extremely high energy density(2.0 Wh kg^(-1))with maximum power density(42.00 W kg^(-1))and ultralong lifespan(80%capacity retention over 10000 cycles).

关键词： collagen carbon energy storage device theoretical calculations topological structure modulation ultrahigh power and energy density

An Integral Method for Solving Dynamic Equations with Fluid–Solid Coupling

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2024年第1期37卷 99-108页

作者： Xin zhang Jie liu {2. Xue Shuowen Yan Yahao Xu M.S.Zahran School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China department of Civil Engineering Military Technical CollegeCairo 11435Egypt

In this work,a new methodology is presented to mainly solve the fluid–solid interaction(FSI)*** methodology combines the advantages of the Newmark precise integral method(NPIM)and the dual neural network(DNN)*** NPIM is employed to modify the exponential matrix and loading vector based on the DNN integral *** involves incorporating the basic assumption of the Newmark-βmethod into the dynamic equation and eliminating the acceleration term from the dynamic equilibrium *** a result,the equation is reduced to a first-order linear equation ***,the PIM is applied to integrate the system step by step within the *** DNN method is adopted to solve the inhomogeneous term through fitting the integrand and the original function with a pair of neural networks,and the integral term is solved using the Newton–Leibniz *** examples demonstrate that the proposed methodology significantly improves computing efficiency and provides sufficient precision compared to the DNN *** is particularly evident when analyzing large-scale structures under blast loading conditions.

关键词： Newmark precise integral method(NPIM) Dual neural networks(DNN) Fluid-solid interaction(FSI) Dynamic time-history analysis Blast loading

Integrated bulk and single-cell transcriptome data identify clinically relevant cell populations in clear cell renal cell carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 42-45页

作者： Pingbao zhang pu zhang Jun Gao Xiaosong Li Chengcheng Wei Weihui liu Qingliu He Yuan zhang department of Urology Zhongshan HospitalFudan UniversityShanghai 200032China department of Urology Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China Clinical Molecular Medicine Testing Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China department of Urology The Second Affiliated Hospital of Fujian Medical UniversityQuanzhouFujian 362000China department of Nephrology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China

Renal cell carcinoma,which consists of three main histological subtypes,namely,clear cell renal cell carcinoma(ccRCC),papillary RCC(pRCC),and chromophobe RCC(chRCC),accounts for most kidney cancer *** accounts for approximately 85%of all RcC cases,1 and it is a malignant tumor with multiple molecular features and a poor *** have shown that ccRCC is one of the most immune and vaso-invasive cancer types.2.Considering that ccRCC is not sensitive to either radiotherapy or chemotherapy,targeted therapies.

关键词： chemotherapy cancer cases

Microfluidic thermotaxic selection of highlymotile sperm and in vitro fertilization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2024年第5期7卷 687-700页

作者： Sihan Chen Jiemin Chen Zihan Qin Jibo Wang Yuwen Wang Rong liu Wen Zhao Ming zhang Yuanzhen zhang Mengcheng Luo pu Chen Tissue Engineering and Organ Manufacturing(TEOM)Lab Department of Biomedical EngineeringTaiKang Medical School(School of Basic Medical Sciences)Wuhan UniversityWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease TaiKangMedical School(School of Basic Medical Sciences)Wuhan UniversityWuhan 430071China Reproductive Medicine Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhan 430071China

The selection of the most motile and functionally competent sperm is an essential basis for in vitro fertilization(IVF)and normal embryonic *** adopted clinical approaches for sperm sample processing intensely rely on centrifugation and wash steps that may induce mechanical damage and oxidative stress to *** a few microfluidic sperm sorting devices may avoid these adverse effects by exploiting intrinsic guidance mechanisms of sperm swimming,none of these approaches have been fully validated by clinical-grade assessment *** this study,a microfluidic sperm sorting device that enables the selection of highly motile and functional sperm via their intrinsic thermotaxis is *** by the temperature microenvironment in the fallopian tube during natural sperm selection,a microfluidic device with controllable temperature gradients along the sperm separation channel was designed and *** study investigated the optimal temperature conditions for human sperm selection and fully characterized thermotaxis-selected sperm with 45 human sperm *** indicated that a temperature range of 35–36.5℃along the separation channel significantly improves human sperm motility rate((85.2.±6.2.)%vs.(60.72.1.37)%;P=0.0484),increases normal sperm morphology rate((16.42.1.43)%vs.(12.55±0.88)%;P1),and reduces DNA fragmentation((7.44±0.79)%vs.(10.36±0.72.%;P=0.0485)compared to the nonthermotaxis *** thermotaxis is species-specific,and selected mouse sperm displayed the highest motility in response to a temperature range of 36–37.5℃ along the separation ***,IVF experiments indicated that the selected sperm permitted an increased fertilization rate and improved embryonic development from zygote to *** microfluidic thermotaxic selection approach will be translated into clinical practice to improve the IVF success rate for patients with oligozoospermia and asthenozoospermia.

关键词： Microfluidic device Thermotaxis Sperm sorting Assisted reproductive technology In vitro fertilization

The generation and use of animal models of osteosarcoma in cancer research

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第2期11卷 664-674页

作者： Feifei pu Haoyu Guo Deyao Shi Fengxia Chen Yizhong Peng Xin Huang Jianxiang liu Zhicai {2. Zengwu Shao department of Orthopedics Wuhan Hospital of Traditional Chinese and Western Medicine (Wuhan No.1 Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China department of Radiation and Medical Oncology Zhongnan HospitalWuhan UniversityWuhanHubei 430071China Hubei Cancer Clinical Study Center Zhongnan HospitalWuhan UniversityWuhanHubei 430071China

Osteosarcoma is the most common malignant bone tumor affecting children and ***,the most common treatment is surgery combined with neoadjuvant *** the survival rate of patients with osteosarcoma has improved in recent years,it remains poor when the tumor(s)progress and distant metastases ***,better animal models that more accurately replicate the natural progression of the disease are needed to develop improved prognostic and diagnostic markers,as well as targeted therapies for both primary and metastatic *** present review described animal models currently being used in research investigating osteosarcoma,and their characteristics,advantages,and *** models may help elucidate the pathogenic mechanism(s)of osteosarcoma and provide evidence to support and develop clinical treatment strategies.

关键词： Animal model Cancer Osteosarcoma Pathogenic mechanism Translational research

CRISPR/CasRx-mediated resistance to Soybean mosaic virus in soybean

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Crop Journal 2024年第4期12卷 1093-1101页

作者： Le Gao Lijun Xie Yanmin Xiao Xinge Cheng Ruosi pu Ziheng zhang Yu {2. Shaopei Gao Zilong zhang Haoran Qu Haijian Zhi Kai Li MARA Key Laboratory of Biology and Genetics Improvement of Soybean Zhongshan Biological Breeding Laboratory(ZSBBL)National Innovation Platform for Soybean Breeding and Industry-Education IntegrationState Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationNanjing Agricultural UniversityNanjing 210095JiangsuChina department of Horticulture Beijing Vocational College of AgricultureBeijing 102442China College of Agronomy&Biotechnology China Agricultural UniversityBeijing 100193China College of Bioscience and Biotechnology Shenyang Agricultural UniversityShenyang 110866LiaoningChina

Soybean mosaic virus(SMV),an RNA virus,is the most common and destructive pathogenic virus in soybean *** newly developed CRISPR/Cas immune system has provided a novel strategy for improving plant resistance to viruses;hence,this study aimed to engineer SMV resistance in soybean using this ***,multiple sgRNAs were designed to target positive-and/or negative-sense strands of the SMV HC-Pro ***,the corresponding CRISPR/CasRx vectors were constructed and transformed into *** inoculation with SMV,39.02.,35.77%,and 18.70%of T_(1)plants were confirmed to be highly resistant(HR),resistant(R),and mildly resistant(MR)to SMV,respectively,whereas only 6.50%were identified as susceptible(S).Additionally,qRT-PCR and DAS-ELISA showed that,both at 15 and 30 d post-inoculation(dpi),SMV accumulation significantly decreased or was even undetectable in HR and R plants,followed by MR and S ***,the expression level of the CasRx gene varied in almost all T_(1)plants with different resistance level,both at 15 and 30 ***,when SMV resistance was evaluated in the T_(2.generation,the results were similar to those recorded for the T_(1)*** findings provide new insights into the application of the CRISPR/CasRx system for soybean improvement and offer a promising alternative strategy for breeding for resistance to biotic stress that will contribute to the development of SMV-immune soybean germplasm to accelerate progress towards greater soybean crop productivity.

关键词： Soybean RNA virus Soybean mosaic virus Resistance CRISPR/CasRx

Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke:Insights from Network Pharmacology and in vivo Experiments

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第8期30卷 713-720页

作者： LI Zhong-hao pu Xiao-qi LI Sha-sha DONG Xiao-ke zhang Guo-qiang WANG Yu {2. Jin-min department of Emergency China-Japan Friendship HospitalBeijing100029China department of Neurology Beijing University of Chinese Medicine Dongfang HospitalBeijing100078China department of Radiology China-Japan Friendship HospitalBeijing100029China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To explore the neuroprotective effects and mechanism of Tanreqing Injection(TRQ)on treating ischemic stroke based on network pharmacology and in vivo experimental *** The chemical compounds of TRQ were retrieved based on published data,with targets retrieved from pubChem,Therapeutic Target Database and *** visualization and analysis were performed using Cytoscape,with protein-protein interaction networks derived from the STRING *** analysis was performed using Kyoto Encyclopedia of Genes Genomes pathway and Gene Ontology *** in vivo experiments,the middle cerebral artery occlusion(MCAO)model was *** volume was determined by 2.3,5-triphenyltetrazo{2.m hydrochloride staining and protein expressions were analyzed by Western *** docking was performed to predict ligand-receptor *** We screened 81 chemical compounds in TRQ and retrieved their therapeutic *** the targets,116 were therapeutic targets for *** enrichment analysis showed that the apelin signaling pathway was a key pathway for ischemic ***,in in vivo experiment we found that administering with intraperitoneal injection of 2.5 mL/kg TRQ every 6 h could significantly reduce the infarct volume of MCAO rats(P1 chemical compounds in TRQ could bind to *** The neuroprotective effect of TRQ may be related to the APJ/PI3K/AKT signaling ***,further studies are needed to confirm the findings.

关键词： Tanreqing Injection Chinese medicine ischemic stroke middle cerebral artery occlusion quantitative estimate of drug-likeness

1,6-Conjugate addition of para-quinone methides using gem-diborylcarbanions: Practical access to gem-diborylalkanes bearing vicinal tertiary/quaternary stereocenters

在线全文

学校读者我要写书评

暂无评论

Green Synthesis and Catalysis 2024年第1期5卷 68-72页

作者： pu-zhang Zi Xing-Bang {2. Quan-Hong Zhao Min He Yuan Huang department of Medicinal Chemistry School of PharmacyXi'an Jiaotong UniversityXi'an710061China

A novel,efficient and pragmatic method to prepare gem-diboron products with vicinal tertiary/quaternary stereocenters using LiTMP-mediated 1,6-conjugate addition of gem-diborylalkanes to para-quinone methides was described for the first *** results showed that various gem-diboron products with vicinal tertiary and quaternary stereocenters could be formed within 15 min at ambient *** simple protocol has also been applied for the efficient synthesis of the analogue of Bedaquiline.

关键词： gem-Diborylalkanes Quaternary stereocenter Conjugate addition para-Quinone methides Organoboron compounds

Syringa pubescens Turcz ethyl acetate extract improves non-alcoholic steatohepatitis by regulating the Nrf2. IκBα and TGF-β1 signaling pathways

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Weidong Xu Yanfang Wu Jiameng zhang Zichen zhang Xinyi Guan Suya zhang Xinsheng Wang pu liu Enguo Fan College of Chemistry and Chemical Engineering， Henan university of Science and technology College of Basic Medical and Forensic Medicine， Henan university of Science and technology department of Microbiology and Parasitology， Institute of Basic Medical Sciences， Chinese Academy of Medical Sciences/School of Basic Medicine， Peking Union Medical College

The flower of Syringa pubescens Turcz. （SP）， was used as both medicine and food in china， exhibited a variety of biological activities. However， it remains unknown whether SP has an effect on ameliorative nonalcoholic fatty liver disease （NASH）. In this study， the improvement of SP ethyl acetate extract （SPE） on NASH was evaluated and the potential mechanisms were explored. The glycosides of SPE were determined by an HPLC method. HepG2.cell lines were treated with free fatty acid to clarify the improvement effect and mechanisms of SPE on NASH in vitro. C57BL/6J mice were treated by 60 kcal% high-fat diet （HFD） combined with carbon tetrachloride (CCl4) to establish the NASH model in vivo. The results showed SPE could inhibited the hepatic injury and lipid steatosis by decreasing the levels of ALT， AST， TG and TC in vitro and vivo. The SPE suppressed the oxidative stress and inflammation by restraining the generation of ROS， MDA， IL-1β， IL-6 and TNF-α and enhancing the activity of antioxidant enzymes including SOD， CAT and GSH-Px in NASH model. Moreover， SPE declined the level of fibrosis markers including HYP， Col Ⅰ and α-SMA in HFD combined CCl4（HC）-induced mice. Mechanically， SPE inhibited hepatocellular Keap1 expression and promoted Nrf2.nuclear translocation， which suppressing the phosphorylation of IκBα/NF-κB. In addition， SPE down-regulated the level of TGF-β1 and phosphorylation of Smad2.to mitigate fibrosis. In brief， SPE could significantly alleviate lipid accumulation， oxidative stress， inflammation and fibrosis via regulating Nrf2.HO-1， IκBα/NFκB and TGF-β1/Smad2.pathways in the progression of NASH， which indicated that SPE had the potential to be a novel and effective drug or food supplements for the improvement of NASH.

关键词：