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High-frequency repetitive transcranial magnetic stimulation promotes neural stem cell proliferation after ischemic stroke

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Neural Regeneration Research 2024年第8期19卷 1772-1780页

作者： Jing Luo Yuan Feng Zhongqiu Hong Mingyu Yin Haiqing Zheng liying zhang Xiquan Hu Department of Rehabilitation Medicine The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Hepatobiliary Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Prolife ration of neural stem cells is crucial for promoting neuronal regeneration and repairing cerebral infarction *** magnetic stimulation(TMS)has recently emerged as a tool for inducing endogenous neural stem cell regeneration,but its underlying mechanisms remain unclea r In this study,we found that repetitive TMS effectively promotes the proliferation of oxygen-glucose deprived neural stem ***,repetitive TMS reduced the volume of cerebral infa rction in a rat model of ischemic stro ke caused by middle cerebral artery occlusion,im p roved rat cognitive function,and promoted the proliferation of neural stem cells in the ischemic ***-sequencing found that repetitive TMS activated the Wnt signaling pathway in the ischemic penumbra of rats with cerebral ***,PCR analysis revealed that repetitive TMS promoted AKT phosphorylation,leading to an increase in mRNA levels of cell cycle-related proteins such as Cdk2 and *** effect was also associated with activation of the glycogen synthase kinase 3β/β-catenin signaling pathway,which ultimately promotes the prolife ration of neural stem ***,we validated the effect of repetitive TMS on AKT *** found that repetitive TMS promoted Ca2+influx into neural stem cells by activating the P2 calcium channel/calmodulin pathway,thereby promoting AKT phosphorylation and activating the glycogen synthase kinase 3β/β-catenin *** findings indicate that repetitive TMS can promote the proliferation of endogenous neural stem cells through a Ca2+influx-dependent phosphorylated AKT/glycogen synthase kinase 3β/β-catenin signaling *** study has produced pioneering res ults on the intrinsic mechanism of repetitive TMS to promote neural function recove ry after ischemic stro *** results provide a stro ng scientific foundation for the clinical application of repetitive ***,repetitive TMS treatment may not only be an efficient an

关键词： AKT/β-catenin signaling brain stimulation Ca2+influx cell proliferation ischemic stroke middle cerebral artery occlusion neural stem cells neurological rehabilitation repetitive transcranial magnetic stimulation

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Research paper Air atmosphere available fast one-pot synthesis of VO_(2)nanoparticles with excellent thermochromic properties by a novel liquid-shielding method

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Journal of Materiomics 2024年第1期10卷 17-26页

作者： Zhi Cao Jin Li Chunhui zhang Ke Jiao Yunxiang Chen Yifei Liu Xinghui Hou Haipeng Ji liying zhang Shasha Yi Yu Wang zhang Chen Yanfeng Gao Zongtao zhang School of Materials Science and Engineering Zhengzhou UniversityKexue Ave 100Zhengzhou450001China School of Materials Science and Engineering Shanghai UniversityShangda Rd 99Shanghai200444China

As a typical strongly correlated transition oxide,vanadium dioxide(VO_(2))based nanomaterials have drawn many research attentions these years due to the giant metal-to-insulator phase transition(MIPT)at around 68℃.However,due to the complexities of the V-O system and interplays between various vanadium oxide phases,the synthesis of high-quality VO_(2)nanopowders is still fraught with many challenges,especially in air *** this paper,we report a novel air atmosphere available liquid-shielding synthesis method for thermochromic VO_(2)nanoparticles,by using low-eutectic molten-salt(LiCl-KCl)as the liquid-state air-insulation medium at elevated temperature and high-pressure pressed VOSO_(4)-KCl pillars immersed in these liquid salts as the *** amounts of glucose are added to introduce a slight reductive environment,and well dispersed VO_(2)nanoparticles with excellent ther-mochromic properties can be directly synthesized at an ultra-low temperature of 375℃.This feasible and atmosphere-available mass-production method is rarely reported in the related fields,which may provide a novel protocol strategy for the synthesis of high performance thermochromic VO_(2)and other functional oxide powders.

关键词： Vanadium dioxide Nanoparticle Molten salt Liquid shielding Thermochromic properties

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Gene expression profiles in early leaf of rice(Oryza sativa)and foxtail millet(Setaria italica)

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The Crop Journal 2024年第3期12卷 776-787页

作者： Jing Sun Chen Deng Xiuru Dai Haoshu Li liying zhang Jingke Wang Hang Zhao Yirong Yang NghiVan Phung Zhiguo zhang Pinghua Li Xuehui Sun Tiegang Lu Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China College of Agronomy Shandong Agricultural UniversityTai’an 271018ShandongChina Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101ShandongChina

Plant anatomy is patterned early during leaf development which suggests studying the spatial–temporal transcriptomes of primordia will help identify critical regulative and functional *** successfully isolated the leaf primordia tissues from the C3grass rice and the C4grass foxtail millet by laser capture microdissection(LCM)and studied the gene expression throughout leaf developmental *** data analysis uncovered the conserved expression patterns of certain gene clusters both in rice and foxtail millet during leaf *** revealed genes and transcription factors involved in vein formation,stomatal development,and suberin *** identified 79 candidate genes associated with functional regulation of C4anatomy *** phenotype of the candidate genes revealed that knock-out of a putative polar auxin transport related gene NAL1 resulted significantly reduced veinal space in rice *** present work provides a foundation for future analyses of genes with novel functions in grasses and their role in leaf development,in particular the role in leaves with a contrasting C3vs.C4biosynthetic pathway.

关键词： Rice Foxtail millet Leaf development RNA-seq LCM

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The Largest Chinese Cohort Study Indicates Homologous Recombination Pathway Gene Mutations as Another Major Genetic Risk Factor for Colorectal Cancer with Heterogeneous Clinical Phenotypes

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Research 2024年第3期6卷 191-203页

作者： Yun Xu Kai Liu Cong Li Minghan Li Fangqi Liu Xiaoyan Zhou Menghong Sun Megha Ranganathan liying zhang Sheng Wang Xin Hu Ye Xu Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Pathology Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Pathology Tissue BankFudan University Shanghai Cancer CenterShanghaiP.R.China Department of Medicine Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Department of Pathology and Laboratory Medicine David Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA Precision Cancer Medical Center Fudan University Shanghai Cancer CenterShanghaiP.R.China

While genetic factors were associated with over 30% of colorectal cancer (CRC) patients, mutations in CRC-susceptibility genes were identified in only 5% to 10% of these patients. Besides, previous studies on hereditary CRC were largely designed to analyze germline mutations in patients with single genetic high-risk factor, which limited understanding of the association between genotype and phenotypes. From January 2015 to December 2018, we retrospectively enrolled 2,181 patients from 8,270 consecutive CRC cases, covering 5 categories of genetic high-risk factors. Leukocyte genomic DNA was analyzed for germline mutations in cancer predisposition genes. The germline mutations under each category were detected and analyzed in association with CRC susceptibility, clinical phenotypes, and prognoses. A total of 462 pathogenic variants were detected in 19.3% of enrolled CRC patients. Mismatch repair gene mutation was identified in 9.1% of patients, most prevalent across all high-risk groups. Homologous recombination (HR) gene mutations were detected in 6.5% of cases, penetrated in early-onset and extra-colonic cancer risk groups. Mutations in HR genes, including BARD1, RAD50, and ATM, were found to increase CRC risk with odds ratios of 2.8-, 3.1-, and 3.1-fold, respectively. CRC patients with distinct germline mutations manifested heterogeneous phenotypes in clinicopathology and long-term prognoses. Thus, germline mutation screenings should be performed for CRC patients with any of those genetic risk factors. This study also reveals that HR gene mutations may be another major driver for increased CRC risk.

关键词： susceptibility category Major

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A simple and efficient CRISPR/Cas9 system permits ultra-multiplex genome editing in plants

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The Crop Journal 2024年第2期12卷 569-582页

作者： Suting Wu Htin Kyaw Zhijun Tong Yirong Yang Zhiwei Wang liying zhang Lihua Deng Zhiguo zhang Bingguang Xiao William Paul Quick Tiegang Lu Guoying Xiao Guannan Qin Xue'an Cui Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Biological Breeding for Fujian and Taiwan Crops Ministry of Agriculture and Rural AffairsCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina School of Biosciences The University of SheffieldFirth CourtWestern BankSheffield S102TNUK Key Laboratory of Tobacco Biotechnological Breeding National Tobacco Genetic Engineering Research CenterYunnan Academy of Tobacco Agricultural SciencesKunming 650021YunnanChina

The development and maturation of the CRISPR/Cas genome editing system provides a valuable tool for plant functional genomics and genetic *** available genome-editing tools have a limited number of targets,restricting their application in genetic *** this study,we developed a novel CRISPR/Cas9 plant ultra-multiplex genome editing system consisting of two template vectors,eight donor vectors,four destination vectors,and one primer-design software *** combining the advantages of Golden Gate cloning to assemble multiple repetitive fragments and Gateway recombination to assemble large fragments and by changing the structure of the amplicons used to assemble sg RNA expression cassettes,the plant ultra-multiplex genome editing system can assemble a single binary vector targeting more than 40 genomic loci.A rice knockout vector containing 49 sg RNA expression cassettes was assembled and a high co-editing efficiency was *** plant ultra-multiplex genome editing system advances synthetic biology and plant genetic engineering.

关键词： CRISPR/Cas9 Multiplex genome editing Assembly system Plant

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A novel traditional Chinese medicine combination for radiation

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Radiation Medicine and Protection 2024年第1期5卷 37-42页

作者： Ming Shang Yicheng Ke Jiangyun Liu Zhifei Cao liying zhang Wenyang zhang Weiwei Pei Guangming Zhou Yongqi Liu Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities Gansu University of Chinese MedicineLanzhou 730000China School of Radiation Medicine and Protection Medical College of Soochow UniversitySuzhou 215123China Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou 215123China College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Department of Pathology The Second Affiliated HospitalMedical College of Soochow UniversitySuzhou 215123China

Objective:To formulate an efficacious radioprotective combination of Chinese medicines with minimal ***:Aqueous and alcoholic extracts from 38 traditional Chinese herbs were *** produce drugcontaining sera,rats received six doses of each extract via oral gavage at 12-h ***,human lung epithelial BEAS-2B cells were cultured in these drug-containing *** cell viability was assessed after different doses of irradiation to identify the radioprotective effects of Chinese herbal *** efficacy of a selected Chinese herbal extract combination was further confirmed through cell viability analysis via in vitro colony formation and survival rate assessments in C57BL/6 mice ***:Extracts from Angelicae Sinensis Radix(ASR;two extracts),Citri Reticulatae Pericarpium(CRP),Platycladi Cacumen(PC),Schisandrae chinensis Fructus(SF),Scutellariae Radix(SR),and Glycyrrhizae Radix et Rhizome(GRR)demonstrated radioprotective *** combination of the seven Chinese herbal extracts notably increased the survival and viability of the BEAS-2B cells exposed to varying doses of ***,the group of mice receiving Chinese medicine combination and irradiation exhibited prolonged survival after exposure to 6.5 Gy Xrays with a median survival of(14=2)d compared to(11=2)d in the irradiated group without the herbal ***,the Chinese medicine combination group displayed a significantly higher 28 d survival rate(30%)compared to the irradiation-only group(16.6%,P<0.05).Conclusion:The novel combination of Chinese herbal extracts from ASR,CRP,PC,SF,SR,and GRR has the potential for radiation protection applications.

关键词： Radiation protection Acute radiation syndrome Chinese medicine Drug-containing serum

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主发射波长大于631 nm的Mn^(4+)激活氟化物荧光粉

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发光学报 2024年第10期45卷 1613-1621页

作者：董效良张明欣张丽莹姬海鹏郑州大学材料科学与工程学院河南郑州450001

利用比目前商用Mn^(4+)激活氟化物红粉主发射波长更长的红粉封装所得白光LED为背光源的液晶显示可以实现更广的显色色域。本文对已报道的主发射波长较长(632~637 nm)的Mn^(4+)激活氟化物红粉进行总结,并对其发射波长如何受被取代离子价... 详细信息

利用比目前商用Mn^(4+)激活氟化物红粉主发射波长更长的红粉封装所得白光LED为背光源的液晶显示可以实现更广的显色色域。本文对已报道的主发射波长较长(632~637 nm)的Mn^(4+)激活氟化物红粉进行总结,并对其发射波长如何受被取代离子价态与半径、所形成八面体畸变程度、邻位阳离子的极化力等因素的影响进行了讨论。

关键词： Mn^(4+) 红光荧光粉氟化物长发射波长

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欧盟贸易政策“武器化”的逻辑解构与法律回应——以《反经济胁迫条例》为例

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欧洲研究 2024年第3期42卷 82-110,I0004页

作者：张丽英巩文昊中国政法大学国际法学院

贸易政策“武器化”是地缘政治经济转型背景下,欧盟基于以规则为基础的国际秩序观实施的单边主义战略。《反经济胁迫条例》的出台再次印证了其贸易政策“武器化”实质,政策工具多元化、相互依赖制度化、规则攻防并重化的动态特征也引发... 详细信息

贸易政策“武器化”是地缘政治经济转型背景下,欧盟基于以规则为基础的国际秩序观实施的单边主义战略。《反经济胁迫条例》的出台再次印证了其贸易政策“武器化”实质,政策工具多元化、相互依赖制度化、规则攻防并重化的动态特征也引发了国际社会的广泛争议及对贸易系统性风险的隐忧。对逻辑进路的解析表明,其发挥作用缘于单边法律规范、结构性权力与国家利益博弈的结合,对目标国产生威慑、阻断与要求赔偿的预期效果。从合法属性来看,其有违一般国际法原则与WTO规则。为进一步加强涉外法治建设,中国应当捍卫以国际法为基础的国际秩序,完善国内反制裁法律体系、强化国际合作,充分利用并推动健全WTO争端解决与贸易政策审议机制。

关键词：贸易政策武器化《反经济胁迫条例》贸易制裁涉外法治

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中医术语翻译语境研究的现状与展望

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中华中医药杂志 2024年第4期39卷 1893-1896页

作者：高芸张李赢戴乐上海中医药大学上海201203

文章对以往国内外关于中医术语翻译语境的研究进行分析,并以此为基础进行展望。结果表明,相关研究日益增多,但是与中医术语翻译的本质属性和内部规律研究相比,语境研究相对比较薄弱;研究领域逐渐扩大,但仍呈现碎片状,无法从整体上考察... 详细信息

文章对以往国内外关于中医术语翻译语境的研究进行分析,并以此为基础进行展望。结果表明,相关研究日益增多,但是与中医术语翻译的本质属性和内部规律研究相比,语境研究相对比较薄弱;研究领域逐渐扩大,但仍呈现碎片状,无法从整体上考察中医术语翻译的语境;研究方法和视角日益多元,但实证研究数量较少,从传播学、社会学视角的研究尚不多见,缺乏更具系统性、整体性研究方法和视角的介入。鉴于此,文章提出提高对中医术语翻译语境因素的重视度,加强研究的系统性、整体性和实证性。

关键词：中医术语翻译语境现状展望社会历史文化语境情境语境语言语境

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电网规划与电力设计对电网安全影响分析

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电力设备管理 2024年第9期 219-221页

作者：张丽瑛晋城市华港电力科技有限公司

电力是现代社会的重要基础设施之一,电网作为电力输送和分配的核心,对社会的正常运行和经济的发展至关重要。然而,随着能源需求的增长和新能源技术的发展,电网面临着越来越复杂的挑战。本文旨在深入探讨电网规划与电力设计对电网安全的... 详细信息

电力是现代社会的重要基础设施之一,电网作为电力输送和分配的核心,对社会的正常运行和经济的发展至关重要。然而,随着能源需求的增长和新能源技术的发展,电网面临着越来越复杂的挑战。本文旨在深入探讨电网规划与电力设计对电网安全的影响,以及如何通过改进策略来提高电网的安全性和可靠性。通过对电网规划、电力设计和安全改进策略的综合分析,可以更好地理解电网运营中的关键问题,为电网的未来发展提供有益的指导和建议。

关键词：电网规划电力设计电网安全

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