检索结果-南通市图书馆

Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota

引用

Acta Pharmaceutica Sinica B 2022年第8期12卷 3298-3312页

作者： Zheng-Wei zhang Chun-Sheng Gao Heng zhang Jian Yang Ya-Ping Wang Li-Bin Pan Hang Yu Chi-Yu He Hai-Bin Luo Zhen-Xiong Zhao Xin-bo Zhou Yu-Li Wang Jie Fu Pei Han Yu-Hui Dong Gang Wang Song Li Yan Wang Jian-Dong Jiang Wu Zhong State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China Beijing Institute of Pharmacology and Toxicology Beijing 100000China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China School of Pharmaceutical sciences Hainan UniversityHainan 570228China National Engineering Research Center for the Emergence Drugs Beijing 100000China

Morinda officinalis oligosaccharides(MOO) are an oral drug approved in china for the treatment of depression in china. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota.

关键词： Depression Morinda oficinalis oligosaccharides Gut microbiota Tryptophan hydroxylase 5-Hydroxytryptophan decarboxylase 5-Hydroxytryptophan Serotonin Drug metabolism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Immunogenicity of the recombinant adenovirus type 5 vector with type 35 fiber containing HIV-1 gag gene

引用

Journal of Microbiology and Immunology 2006年第4期4卷 306-312页

作者： XIN LEI LIU SHUNAG QING YU XIA FENG XIAO LI WANG HONG MEI LIU XIAO MEI zhang HONG XIA LI ling ZHOU YI ZENG college of Life science and Bio-engineering Beijing University of Technology Beijing P. R. China State Key Laboratory for Infectious Disease Prevention and Control National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing P. R. China

The immune efficiency of a recombinant adenovirus type 5 with type 35 fiber containing HIV-1 gag gene （rAd5/F35-mod. gag） was investigated in BALB/c mice, in which the rAd5/F35-mod, gag was firstly identified with PCR, then transfected to 293 cells and the in vitro expression level of Gag protein was determined by Western blotting and indirect immuno-fluorescent assay. Mice were immunized with intramuscular injections of rAd5/F35-mod, gag, rAd5-mod, gag or DNA and were boosted after 3 weeks. To test the effect of pre-existing anti-viral immunity on immunization, mice were also injected with Ad5- GFP vector and then immunized 4 and 7 weeks later with Ad5/F35-mod. gag vector. The P24-specific IgG antibody in sera of immunized mice was determined by ELISA and the specific cytotoxic T lymphocyte （CTL） response was assayed by intracellular cytokine staining. It was demonstrated that the rAd5/F35- rood. gag vector could express efficiently the HIV Gag protein in 293 cells in vitro and induce strong HIV- specific immune responses in vivo. The strongest CTL and serum IgG response occurred when mice were immunized twice with injection of rAd5/F35 alone, but the anti-Ad5 antibody after primary infection with adenovirus could inhibit the specific immune responses induced by rAd5/F35 vector. It is concluded that single immunization with recombinant adenovirus rAd5/F35-mod, gag can induce specific CTL and serum IgG antibody responses in mice, but the immunogenicity of rAd5/F35 is comparably weaker than that of rAd5.

关键词： H1V-1 AIDS vaccines Adenoviridae

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一个小波域上各向异性扩散去噪算法

引用

西北大学学报（自然科学版） 2008年第5期38卷 689-692页

作者：许永峰张书玲张博苏永利西北大学数学系陕西西安710127

目的给出一个图像去噪的算法。方法利用小波变换把图像分解为高频子图和低频子图,再根据子图像的特点,采用不同的各向异性扩散方法处理各个子图,最后重构图像。结果各向异性扩散在图像平滑中,不但能够较好地抑制噪声,而且能够很好地保... 详细信息

目的给出一个图像去噪的算法。方法利用小波变换把图像分解为高频子图和低频子图,再根据子图像的特点,采用不同的各向异性扩散方法处理各个子图,最后重构图像。结果各向异性扩散在图像平滑中,不但能够较好地抑制噪声,而且能够很好地保留图像原有的边缘和纹理特征,因而解决了图像去噪时高频部分和低频部分抑制噪声和保留边缘之间的矛盾问题。结论与已有的方法比较,该方法不但能够有效地去除噪声,而且能够保持图像中的细节。

关键词：各向异性扩散小波变换偏微分方程图像去噪

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

吡非尼酮及其衍生物的研究进展

引用

云南化工 2024年第7期51卷 17-20页

作者：张讯陈聪地姚莎王小月杜琳王洁雪常波成都师范学院化学与生命科学学院功能分子结构优化与应用四川省高校重点实验室四川成都611130

综述了吡非尼酮的研发历程,并对吡非尼酮的药理活性研究进行了总结。以吡非尼酮为先导物,发展了多个系列的衍生物,这些衍生物具有较好的生物活性,为开发设计结构更独特、活性更好的新药提供理论依据。

关键词：吡非尼酮衍生物药理纤维化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

亚甲基蓝与鲱鱼精DNA相互作用的光谱法研究

引用

化学学报 2008年第4期66卷 443-448页

作者：费丹王兴明黎泓波丁立生胡亚敏张欢赵仕林西南科技大学材料科学与工程学院化学系绵阳621010 中国科学院成都生物研究所成都610041 四川师范大学化学学院成都610066

以吖啶橙(AO)作为光谱探针,采用UV和荧光光谱等方法研究了亚甲基蓝(MB)与鲱鱼精DNA的作用机制.确定了在低浓度MB时,MB与DNA以嵌插方式作用;而在高浓度MB时,MB与DNA之间为混合作用方式.结合比n(MB)∶n(DNA)=10∶1,结合常数K26℃=2.46×... 详细信息

以吖啶橙(AO)作为光谱探针,采用UV和荧光光谱等方法研究了亚甲基蓝(MB)与鲱鱼精DNA的作用机制.确定了在低浓度MB时,MB与DNA以嵌插方式作用;而在高浓度MB时,MB与DNA之间为混合作用方式.结合比n(MB)∶n(DNA)=10∶1,结合常数K26℃=2.46×105L·mol-1,MB-DNA复合物的表观摩尔吸光系数ε=5.70×106L·mol-1·cm-1.同时研究了酸度和温度等对MB与DNA相互作用的影响,热力学研究推导了MB结合DNA为焓驱动反应.

关键词：亚甲基蓝吖啶橙鲱鱼精DNA 作用方式

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一维反转对称光子结构中界面态的可调控特性

引用

物理学报 2022年第20期71卷 107-114页

作者：代美芹张清悦赵秋玲 †王茂榕王霞青岛科技大学数理学院青岛266061 青岛科技大学山东省新型光电材料与技术工程实验室青岛266061

利用传输矩阵法,计算研究了一维反转对称光子结构通过不同的组合方式产生界面态的可调控特性,并通过电子束蒸镀技术制备样品进行了实验验证.由两种材料构成的反转对称层状光子结构,根据元胞的反转对称中心不同分别对应PCⅠ和PCⅡ两种结... 详细信息

利用传输矩阵法,计算研究了一维反转对称光子结构通过不同的组合方式产生界面态的可调控特性,并通过电子束蒸镀技术制备样品进行了实验验证.由两种材料构成的反转对称层状光子结构,根据元胞的反转对称中心不同分别对应PCⅠ和PCⅡ两种结构.研究结果表明,对于由PCⅠ和PCⅡ构成的组合结构,在满足两个结构的表面阻抗虚部之和等于零的特征频率处存在一个界面态,该界面态频率与结构元胞数无关;若在此基础上再增加一个PCⅠ,构成PCⅠ+PCⅡ+PCⅠ组合结构,则在同一个带隙中会产生两个界面态;改变组合结构中每部分或者其中一部分结构的元胞数可以对两个界面态频率实现调控,实验研究结果充分表明调控的可行性,这为设计满足不同应用需求的窄带滤波器、多通道滤波器等提供了更灵活的思路.

关键词：光子带隙材料传输矩阵电子束蒸镀技术滤波器界面态

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Analysis of herbs use law and mechanism of traditional Chinese medicine in preventing and treating postoperative complications of breast cancer

引用

Drug Combination Therapy 2019年第2期1卷 40-55页

作者： Yao Yang Li-Hui zhang Mei-Ting Liu Miao-Miao Lin Guo-Wei zhang college of Traditional Chinese Medicine Hebei UniversityBaodingHebei province071000China

Objective:Excavate the compatibility rules of traditional Chinese medicine for preventing and treating postoperative complications of breast cancer,study the potential mechanism of prevention and treatment with traditional Chinese ***:Collate and analyze the relevant prescriptions collected from CNKI and the core drug combination and the new formula are obtained by adopting the traditional Chinese medicine inheritance auxiliary system(TCMISSV2.5).Use BATMAN-TCM online analysis tool to analyze KEGG pathways of high frequency drugs and predict the potential signal ***:Data mining has selected 10 pairs of core herb combinations and 5 new recipes of 133 *** the network pharmacology analysis of bai zhu,huang qi,fu ling,the potential signaling pathways of its action are the neuroactive ligand-receptor interaction pathway and calcium signaling ***:Herbs for invigorating spleen and qi and herbs for nourishing blood and activating blood are commonly used to prevent and treat postoperative complications of breast *** herbs may play their role by interfering with the neuroactive ligand-receptor interaction pathway and calcium signaling pathway.

关键词： Postoperative breast cancer Complications Data mining Path analysis Medication law Mechanism of action

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tandem Molecular Self-Assembly Selectively Inhibits Lung Cancer Cells by Inducing Endoplasmic Reticulum Stress

引用

Research 2019年第1期2019卷 31-41页

作者： Debin Zheng Yumiao Chen Sifan Ai Renshu zhang Zhengfeng Gao Chunhui Liang Li Cao Yaoxia Chen zhangyong Hong Yang Shi ling Wang Xingyi Li Zhimou Yang Key Laboratory of Bioactive Materials Ministry of EducationCollege of Life SciencesKey Laboratory of Medicinal Chemical BiologyCollaborative Innovation Center of Chemical Science and Engineeringand National Institute of Functional MaterialsNankai UniversityTianjin 300071China School of Ophthalmology&Optometry and Eye Hospital Wenzhou Medical Universityand Wenzhou Institute of Biomaterials and EngineeringCNITECHCASWenzhou 325035China college of Pharmacy Nankai UniversityTianjin 300071China Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer InstituteXuzhou Medical UniversityXuzhouJiangsuChina

The selective formation of nanomaterials in cancer cells and tumors holds great promise for cancer diagnostics and *** now,most strategies rely on a single trigger to control the formation of nanomaterials in *** combination of two or more triggers may provide for more sophisticated means of *** this study,we rationally designed a molecule(Comp.1)capable of responding to two enzymes,alkaline phosphatase(ALP),and *** the A549 lung cancer cell line showed elevated levels of extracellular ALP and intracellular reductase,we demonstrated that Comp.1 responded in a stepwise fashion to those two enzymes and displayed a tandem molecular self-assembly *** selective formation of nanofibers in the mitochondria of the lung cancer cells led to the disruption of the mitochondrial membrane,resulting in an increased level of reactive oxygen species(ROS)and the release of cytochrome C(Cyt C).ROS can react with proteins,resulting in endoplasmic reticulum(ER)stress and the unfolded protein response(UPR).This severe ER stress led to disruption of the ER,formation of vacuoles,and ultimately,apoptosis of the A549 ***,Comp.1 could selectively inhibit lung cancer cells in vitro and A549 xenograft tumors in *** study provides a novel strategy for the selective formation of nanomaterials in lung cancer cells,which is powerful and promising for the diagnosis and treatment of lung cancer.

关键词： Lung holds stepwise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Application of nanotechnology in reversing therapeutic resistance and controlling metastasis of colorectal cancer

引用

World Journal of Gastroenterology 2023年第13期29卷 1911-1941页

作者： Sheng-Nan Ren Zhan-Yi zhang Rui-Jie Guo Da-Ren Wang Fang-Fang Chen Xue-bo Chen Xue-Dong Fang Nanomedicine and Translational Research Center China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Bethune Third Clinical Medical college Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Gastrointestinal Colorectal and Anal SurgeryChina-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

Colorectal cancer(CRC)is the most common digestive malignancy across the *** first-line treatments applied in the routine clinical setting include surgery,chemotherapy,radiotherapy,targeted therapy,and ***,resistance to therapy has been identified as the major clinical challenge that fails the treatment method,leading to recurrence and distant *** increasing number of studies have been attempting to explore the underlying mechanisms of the resistance of CRC cells to different therapies,which can be summarized into two aspects:(1)The intrinsic characters and adapted alterations of CRC cells before and during treatment that regulate the drug metabolism,drug transport,drug target,and the activation of signaling pathways;and(2)the suppressive features of the tumor microenvironment(TME).To combat the issue of therapeutic resistance,effective strategies are warranted with a focus on the restoration of CRC cells’sensitivity to specific treatments as well as reprogramming impressive TME into stimulatory *** date,nanotechnology seems promising with scope for improvement of drug mobility,treatment efficacy,and reduction of systemic *** instinctive advantages offered by nanomaterials enable the diversity of loading cargoes to increase drug concentration and targeting specificity,as well as offer a platform for trying the combination of different treatments to eventually prevent tumor recurrence,metastasis,and reversion of therapy *** present review intends to summarize the known mechanisms of CRC resistance to chemotherapy,radiotherapy,immunotherapy,and targeted therapy,as well as the process of *** have also emphasized the recent application of nanomaterials in combating therapeutic resistance and preventing metastasis either by combining with other treatment approaches or *** summary,nanomedicine is an emerging technology with potential for CRC treatment;hence,efforts should be devoted to targetin

关键词： Colorectal cancer Therapeutic resistance Nanotechnology Drug delivery system Combined treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

茶树害虫挥发性化学信息物质的研究进展

引用

应用昆虫学报 2023年第2期60卷 449-462页

作者：雷子寅蔺松波张瑾张新于广威孙晓玲孙小玲天津农学院园艺园林学院天津300384 中国农业科学院茶叶研究所杭州310008 青岛罗素生物技术有限公司青岛266000 潍坊科技学院潍坊261000

植食性昆虫利用种内化学信息物质进行求偶和交配,从而维持其田间的种群数量;植物在识别植食性昆虫的为害后,可产生直接和间接防御反应来抵御植食性昆虫的为害。相应地,植食性昆虫亦可利用植物的虫害诱导化学信息物质选择嗜好寄主,从而... 详细信息

植食性昆虫利用种内化学信息物质进行求偶和交配,从而维持其田间的种群数量;植物在识别植食性昆虫的为害后,可产生直接和间接防御反应来抵御植食性昆虫的为害。相应地,植食性昆虫亦可利用植物的虫害诱导化学信息物质选择嗜好寄主,从而提高其生长适应度。茶树是多年生常绿木本经济作物,常年病虫害发生严重。据不完全统计,茶树病虫害每年给茶叶带来的经济损失就高达20%-50%,严重影响茶产业的绿色、健康和可持续发展。近20年,科研工作者在调控茶树害虫行为和种群动态的主要化学信息物质、作用方式及调控机理等方面展开了较为系统的研究,取得了一些研究成果。本文着重从茶树害虫性信息素的种类及其特异性、寄主和非寄主植物挥发物对害虫种群的调控作用等方面对目前的研究进展进行了综述,并对利用挥发性化学信息物质构建茶树害虫的生态调控技术进行了展望,以期为茶树害虫化学信息物质的研究提供参考。

关键词：茶树害虫昆虫性信息素虫害诱导茶树挥发物

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：