Application of nanotechnology in reversing therapeutic resistance and controlling metastasis of colorectal cancer
作者机构：Nanomedicine and Translational Research CenterChina-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Bethune Third Clinical Medical CollegeJilin UniversityChangchun 130021Jilin ProvinceChina Department of GastrointestinalColorectal and Anal SurgeryChina-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2023年第29卷第13期
页 面：1911-1941页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the Natural Science Foundation of Jilin Province No.20210101433JC
主 题：Colorectal cancer Therapeutic resistance Nanotechnology Drug delivery system Combined treatment
摘 要：Colorectal cancer(CRC)is the most common digestive malignancy across the *** first-line treatments applied in the routine clinical setting include surgery,chemotherapy,radiotherapy,targeted therapy,and ***,resistance to therapy has been identified as the major clinical challenge that fails the treatment method,leading to recurrence and distant *** increasing number of studies have been attempting to explore the underlying mechanisms of the resistance of CRC cells to different therapies,which can be summarized into two aspects:(1)The intrinsic characters and adapted alterations of CRC cells before and during treatment that regulate the drug metabolism,drug transport,drug target,and the activation of signaling pathways;and(2)the suppressive features of the tumor microenvironment(TME).To combat the issue of therapeutic resistance,effective strategies are warranted with a focus on the restoration of CRC cells’sensitivity to specific treatments as well as reprogramming impressive TME into stimulatory *** date,nanotechnology seems promising with scope for improvement of drug mobility,treatment efficacy,and reduction of systemic *** instinctive advantages offered by nanomaterials enable the diversity of loading cargoes to increase drug concentration and targeting specificity,as well as offer a platform for trying the combination of different treatments to eventually prevent tumor recurrence,metastasis,and reversion of therapy *** present review intends to summarize the known mechanisms of CRC resistance to chemotherapy,radiotherapy,immunotherapy,and targeted therapy,as well as the process of *** have also emphasized the recent application of nanomaterials in combating therapeutic resistance and preventing metastasis either by combining with other treatment approaches or *** summary,nanomedicine is an emerging technology with potential for CRC treatment;hence,efforts should be devoted to targetin
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