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Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study

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Journal of Sport and Health Science 2024年第2期13卷 222-232页

作者： Xinyi Jin Yilin chen hongliang Feng Mingqing Zhou Joey W.Y.Chang Yaping liu Alice Pik Shan Kong Xiao Tan Yun-Kwok Wing Yannis Yan Liang Jihui zhang Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention Guangdong Cardiovascular InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China school of Medicine South China University of TechnologyGuangzhou 510641China Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510180China The Second school of Clinical Medicine Southern Medical UniversityGuangzhou 510282China Guangdong Mental Health Center Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510120China Li Chiu Kong Family Sleep Assessment Unit Department of PsychiatryFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Psychiatry Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Medical Sciences Uppsala UniversityUppsala 75185Sweden Department of Big Data in Health Science Zhejiang University School of Public HealthHangzhou 310058China Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of china Guangzhou 510260China

Purpose:The aim of the current study was to investigate the association of accelerometer-measured sleep duration and different intensities of physical activity(PA)with the risk of incident type 2 diabetes in a population-based prospective cohort ***:Altogether,88,000 participants(mean age=62.2±7.9 years,mean±SD)were included from the UK *** duration(short:8 h/day)and PA of different intensities were measured using a wrist-won accelerometer over a 7-day period between 2013 and *** was classified according to the median or World Health Organization-recommendation:total volume of PA(high,low),moderate-to-vigorous PA(MVPA)(recommended,not recommended),and light-intensity PA(high,low).Incidence of type 2diabetes was ascertained using hospital records or death ***:During a median follow-up of 7.0 years,1615 incident type 2 diabetes cases were *** with normal sleep duration,short(hazard ratio(HR)=1.21,95%confidence interval(95%CI):1.03-1.41)but not long sleep duration(HR=1.01,95%CI:0.89-1.15)was associated with excessive type 2 diabetes *** increased risk among short sleepers seems to be protected against by *** with normal sleepers with high or recommended PA,short sleepers with low volume of PA(HR=1.81,95%CI:1.46-2.25),not recommended(below the World Health Organization-recommended level of)MVPA(HR=1.92,95%CI:1.55-2.36),or low light-intensity PA(HR=1.49,95%CI:1.13-1.90)had a higher risk of type 2 diabetes,while short sleepers with a high volume of PA(HR=1.14,95%CI:0.88-1.49),recommended MVPA(HR=1.02,95%CI:0.71-1.48),or high light-intensity PA(HR=1.14,95%CI:0.92-1.41)did ***:Accelerometer-measured short but not long sleep duration was associated with a higher risk of incident type 2 diabetes.A higher level of PA,regardless of intensity,potentially ameliorates this excessive risk.

关键词： Light physical activity Sleep duration Triaxial accelerometer Type 2 diabetes UK Biobank

Magnetic resonance imaging of knees:a novel approach to predict recombinant human growth hormone therapy response in short-stature children in late puberty

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World Journal of Pediatrics 2024年第7期20卷 723-734页

作者： Xi Bai Zhi‑Bo Zhou Xiao‑Yuan Guo Yi‑Ling He Yue‑Lun zhang Feng‑Dan Wang Feng Feng hong‑Bo Yang Shi chen Feng‑Ying Gong Hui‑Juan Zhu Hui Pan Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Key Laboratory of Endocrinology of National Health Commission Department of EndocrinologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina

Background There is no appropriate tool to predict recombinant human growth hormone(rhGH)response before therapy initiation in short-stature children in late *** current study aimed to explore the associations between magnetic resonance imaging(MRI)stages of the knee growth plates and rhGH response in short-stature children in late *** In this prospective cohort study,short-stature children in late puberty were treated with rhGH and followed up for 6 *** proposed a novel knee MRI staging system according to the growth plate states of distal femurs or proximal tibias and divided the participants into three groups:unclosed growth plate group,marginally closed growth plate group,and nearly closed growth plate *** primary outcomes were height gain and growth velocity(GV),which were assessed three months *** Fifty participants were enrolled,including 23 boys and 27 *** and height gain after 6 months of rhGH therapy decreased successively in the three groups with an increased degree of growth plate fusion,especially when grouped by proximal tibias(GV_(1-3 mon)from 9.38 to 6.08 to 4.56 cm/year,GV_(4-6 mon)from 6.75 to 4.92 to 3.25 cm/year,and height gain from 4.03 to 2.75 to 1.95 cm,all P1).Moreover,the MRI stages of growth plates independently served as a significant variable for GV and height gain after therapy,especially when grouped by proximal tibias(all P1).Conclusion The MRI staging method is expected to be an effective tool for predicting rhGH response before therapy initiation in short-stature children in late puberty.

关键词： Growth hormone Growth velocity Late puberty Magnetic resonance imaging Short stature

Desiccation tolerance in bryophytes： the rehydration proteomes of Bryum argenteum provide insights into the resuscitation mechanism

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Journal of Arid Land 2018年第1期10卷 152-167页

作者： GAO Bei zhang Daoyuan LI Xiaoshuang YANG honglan LIANG Yuqing chen Moxian zhang Yuanming zhang Jianhua Andrew WOOD Key Laboratory of Biogeography and Bioresource in Arid Land Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China school of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongHong KongChina Department of Biology Faculty of ScienceHong Kong Baptist UniversityHong KongChina Department of Plant Biology Southern Illinois University-CarbondaleCarbondaleIL 62901-6509USA

Bryum argenteum Hedw. is a desiccation tolerant bryophyte and belongs to one of the most important components of the biological soil crusts （BSCs） found in the deserts of Central Asia. Limited information is available on rehydration-responsive proteins in desiccation tolerant plants. As a complement to our previous research analyzing the rehydration transcriptome, we present a parallel quantitative proteomic effort to study rehydration-responsive proteins. Bryophyte gametophores were desiccated （Dry） and rehydrated for 2 h （R2） and 24 h （R24）. Proteins from Dry, R2 and R24 gametophores were labeled by isobaric tags for relative and absolute quantitation （iTRAQ） to determine the relative abundance of rehydration-responsive proteins. A total of 5503 non-redundant protein sequences were identified and 4772 （86.7%） protein sequences were annotated using Gene Ontology （GO） terms and Pfam classifications. Upon rehydration 239 proteins were elevated and 461 proteins were reduced as compared to the desiccated protein sample. Differentially up-regulated proteins were classified into a number of categories including reactive oxygen species scavenging enzymes, detoxifying enzymes, Late Embryogenesis Abundant （LEA） proteins, heat shock proteins, proteasome components and proteases, and photosynthesis and translation related proteins. Furthermore, the results of the correlation between transcriptome and proteome revealed the discordant changes in the expression between protein and mRNA.

关键词： desiccation tolerance B*Tum Physcomitrellapatens proteome iTRAQ rehydration

Advancing large-scale thin-film PPLN nonlinear photonics with segmented tunable micro-heaters

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Photonics Research 2024年第8期12卷 1703-1708页

作者： XIAOTING LI HAOCHUAN LI ZHENZHENG WANG ZHAOXI chen FEI MA KE zhang WENZHAO SUN chenG WANG Department of Electrical Engineering City University of Hong KongHong KongChina school of Physics Sun Yat-sen UniversityGuangzhou 510275China City university of hong Kong(Dongguan) Dongguan 523808China Center of Information and Communication Technology City University of Hong Kong Shenzhen Research InstituteShenzhen 518057China State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongHong KongChina

Thin-film periodically poled lithium niobate(TF-PPLN)devices have recently gained prominence for efficient wavelength conversion processes in both classical and quantum ***,the patterning and poling of TF-PPLN devices today are mostly performed at chip scales,presenting a significant bottleneck for future largescale nonlinear photonic systems that require the integration of multiple nonlinear components with consistent performance and low ***,we take a pivotal step towards this goal by developing a wafer-scale TF-PPLN nonlinear photonic platform,leveraging ultraviolet stepper lithography and an automated poling *** address the inhomogeneous broadening of the quasi-phase matching(QPM)spectrum induced by film thickness variations across the wafer,we propose and demonstrate segmented thermal optic tuning modules that can precisely adjust and align the QPM peak wavelengths in each *** the segmented micro-heaters,we show the successful realignment of inhomogeneously broadened multi-peak QPM spectra with up to 57%enhancement of conversion *** achieve a high normalized conversion efficiency of 3802%W-1cm-2in a 6 mm long PPLN waveguide,recovering 84%of the theoretically predicted efficiency in this *** advanced fabrication techniques and segmented tuning architectures presented herein pave the way for wafer-scale integration of complex functional nonlinear photonic circuits with applications in quantum information processing,precision sensing and metrology,and low-noise-figure optical signal amplification.

关键词： tuning tunable waveguide

Surface demineralized freeze-dried bone allograft followed by reimplantation in a failed mandibular dental implant

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Regenerative Biomaterials 2024年第1期3卷 82-93页

作者： Jing zhang Jie Wang Jiayi You Xuan Qin Huimin chen Xiantong Hu Yantao Zhao Yang Xia Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjingJiangsu 210029PR China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing Medical UniversityNanjingJiangsu 210029PR China Department of Restorative Dental Sciences Faculty of DentistryThe University of Hong KongHong Kong SARPR China Senior Department of Orthopedics The Fourth Medical Center of PLA General HospitalBeijing100048PR China Beijing Engineering Research Center of Orthopedics Implants Beijing 100048PR China State Key Laboratory of Military Stomatology Xi'an 710032PR China

The removal of a failed implant with high torque causes significant damage to the surrounding tissue,compromising bone regeneration and subsequent osseointegration in the defect ***,we report a case of carrier screw fracture followed by immediate implant removal,bone grafting and delayed reimplantation.A dental implant with a fractured central carrier screw was removed using the bur-forceps *** resulting three-wall bone defect was filled with granular surface demineralized freeze-dried bone allograft(SD-FDBA).Cone-beam computerized tomography was performed at 1week,6months and 15months postoperatively and standardized for quantitative *** alveolar bone width and height at 15months post-surgery were about 91%of the original values,with a slightly lower bone density,calculated using the gray value *** graft site was reopened and was found to be completely healed with dense and vascularized bone along with some residual bone *** followed by restoration was performed 8months *** quality of regenerated bone following SD-FDBA grafting was adequate for osseointegration and longterm implant *** excellent osteogenic properties of SD-FDBA are attributed to its human origin,cortical bone-like structure,partly demineralized surfaces and bone morphogenetic protein-2-containing *** investigation with more cases and longer follow-up was required to confirm the final clinical effect.

关键词： dental implant implant failure allogeneic bone bone regeneration reimplantation

Identification of ciliary neurotrophic factor receptor alpha as a mediator of neurotoxicity induced by extracellularα-synuclein

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Identification of ciliary neurotrophic factor receptor alpha...

The Design of GECAM Scientific Ground Segment

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Jun liu~(1,2),Zhen hong~(1,2),Min SHI~2,Jian-Peng zhang~2,Sheng-Di chen~(1,*),Jing zhang~(2,*) 1 Department of Neurology & Institute of Neurology,Ruijin Hospital affiliated to Shanghai Jiaotong university school of Medicine,Shanghai,china 2 Department of Pathology,university of Washington school of Medicine,Seattle,Washington,USA

＜正＞Objective Accumulating evidence suggests that extracellularα-synuclein（eSNCA） plays an important role in the pathogenesis of Parkinson’s disease（PD） or related synucleinopathies by inducing neurotoxicity directly or indirectly via microglial or astroglial ***,the mechanisms by which this occurs remain to be *** To explore these mechanisms,we combined three powerful biochemical techniques—Stable Isotope Labeling of Amino acid in Cell cultures（SILAC）;biotin labeling of plasma membrane proteins followed by affinity purification;and analysis of unique proteins binding to SNCA peptides on membrane *** The SILAC proteomic analysis identified 457 proteins,of which,245 or 172 proteins belong to membrane or membrane associated proteins,depending on the various bioinformatics tools used for *** dopamine neuronal cells treated with eSNCA,the levels of 86 membrane proteins were increased and 35 were decreased compared with untreated *** peptide array analysis,127 proteins were identified as possibly interacting with *** those,seven proteins were overlapped with the membrane proteins that displayed alterations in relative abundance after eSNCA *** One was ciliary neurotrophic factor receptor alpha（CNTFR-α）,which appeared to modulate eSNCA-mediated neurotoxicity via mechanisms related to JAK1/ STAT3 signaling but independent of eSNCA endocytosis.

关键词： Parkinson’s disease α-synuclein ciliary neurotrophic factor receptor alpha

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Research in Astronomy and Astrophysics 2024年第10期24卷 1-10页

作者： Shijie Zheng Liming Song Xiang Ma Ping Wang Rui Qiao Yue Huang Xiaoyun Zhao hongmei zhang Xiaobo Li Mingyu Ge Gang chen Gongxing Sun Wenxi Peng Ce Cai Wei chen Yanqi Du Dongya Guo Bing Li Chaoyang Li Jianhui Li Qingxin Li Jing Liang Jiacong liu Ge Ou Dongli Shi Jingyan Shi Xinying Song Jin Wang Wenshuai Wang hong Wu Shuo Xiao Wangchen Xue Min Yao Jianying Ye Kai zhang Peng zhang Xiaolu zhang Yanqiu zhang Guoying Zhao Shiyi Zhao Chao Zheng Shaolin Xiong Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Southwest Jiaotong university Chengdu 611756China Xiangtan university Changsha 411105China Qufu Normal university Qufu 273165China

The Gravitational wave burst high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)is a dedicated mission for monitoring high-energy *** we report the design of the GECAM Scientific Ground Segment(GSGS)in terms of the scientific requirements,including the architecture,the external interfaces,the main function,and *** from the analysis and verification results during the commissioning phase,the GSGS functions well and is able to monitor the status of the payloads,adjust the parameters,develop the scientific observation plans,generate the scientific data products,analyze the data,***,the on-orbit operation and scientific researches of GECAM are guaranteed.

关键词： gravitational waves gamma-rays:general telescopes

The Mechanics of Tumor Cells Dictate Malignancy via Cytoskeleton-Mediated APC/Wnt/β-Catenin Signaling

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Research 2024年第2期2023卷 659-673页

作者： Xi chen Zichen Xu Kai Tang Guanshuo Hu Pengyu Du Junfang Wang Cunyu zhang Ying Xin Keming Li Qiantang zhang Jianjun Hu Zhuxue zhang Mo Yang Guixue Wang Youhua Tan The hong Kong Polytechnic university Shenzhen Research Institute Shenzhen518057China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing400030China Research Institute of Smart Ageing The Hong Kong Polytechnic UniversityHong KongChina Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Pathology Guizhou Provincial People's HospitalGuiyangGuizhou550002China

Tumor cells progressively remodel cytoskeletal structures and reduce cellular stiffness during tumor progression,implicating the correlation between cell mechanics and ***,the roles of tumor cell cytoskeleton and the mechanics in tumor progression remain incompletely *** report that softening/stiffening tumor cells by targeting actomyosin promotes/suppresses self-renewal in vitro and tumorigenic potential in ***/strengthening actin cytoskeleton impairs/reinforces the interaction between adenomatous polyposis coli(APC)andβ-catenin,which facilitatesβ-catenin nuclear/cytoplasmic ***β-catenin binds to the promoter of Oct4,which enhances its transcription that is crucial in sustaining self-renewal and *** results demonstrate that the mechanics of tumor cells dictate self-renewal through cytoskeleton-APC-Wnt/β-catenin-Oct4 signaling,which are correlated with tumor differentiation and patient *** study unveils an uncovered regulatory role of cell mechanics in self-renewal and malignancy,and identifies tumor cell mechanics as a hallmark not only for cancer diagnosis but also for mechanotargeting.

关键词： diagnosis skeleton APC

DCCP and DICP: Construction and Analyses of Databases for Copper-and Iron-Chelating Proteins

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Genomics,Proteomics & Bioinformatics 2005年第1期 60-65页

作者： Hao Wu1*, Yan Yang1,2*, Sheng-Juan Jiang1, Ling-Ling chen1#, Hai-Xia Gao1, Qing-Shan Fu1,3, Feng Li1,2,Bin-Guang Ma1, and hong-Yu zhang1*1 Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong university ofTechnology, Zibo 255049, china 2 Isotope Research Laboratory, Sichuan Agriculture university, Yaan 625014,china 3 College of Life Sciences, Shandong Normal university, Jinan 250014, china.

Copper and iron play important roles in a variety of biological processes, especiallywhen being chelated with proteins. The proteins involved in the metal binding,transporting and metabolism have aroused much interest. To facilitate the studyon this topic, we constructed two databases (DCCP and DICP) containing theknown copper- and iron-chelating proteins, which are freely available from thewebsite http://***/en. Users can conveniently search and browse allof the entries in the databases. Based on the two databases, bioinformatic analyseswere performed, which provided some novel insights into metalloproteins.

关键词： copper and iron database primary sequence analysis secondary structure predic-tion SCOP classification